A Biophysical Model of the Mitochondrial Respiratory System and Oxidative Phosphorylation
Figure 6
Behavior of Model at Low Oxygen Concentration
Predicted rate of oxygen consumption (MVO2) normalized to maximal rate of oxygen consumption and fraction of cytochome c reduced are plotted against oxygen concentration, which is expressed in micromoles (lower axis) and oxygen partial pressure (upper axis). The oxygen consumption curve was computed for state-3 respiration, corresponding to experimental conditions reported in [18] and [19]. The cytochrome c curve corresponds to state-4 experimental conditions reported in [17]. Inset shows predicted curves for oxygen concentrations from 0 to 5 μM.