A Biophysical Model of the Mitochondrial Respiratory System and Oxidative Phosphorylation
Figure 1
Illustration of the Components Included in the Model of Mitochondrial Oxidative Phosphorylation
(A) The major components of the electron transport system, which transfers reducing potential from NADH to oxygen, and the F1F0 ATPase, which transduces energy from proton motive force to ATP, are illustrated. Complexes I, III, and IV are labeled C1, C3, and C4, respectively.
(B) The substrate transport process included in the model is shown, including the ANT and PiHt on the inner membrane, and passive permeation of ATP, ADP, AMP, and phosphate across the outer membrane. The AK reaction in the IM space is shown.
(C) Transporters for hydrogen and potassium ions on the inner membrane, including K+/H+ antiporter and passive proton and potassium fluxes, are included. It is assumed that these cations rapidly equilibrate across the outer membrane.