Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action

• Jingchun Sun,

  Affiliations School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Min Zhao,

  Affiliation Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Peilin Jia,

  Affiliation Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Lily Wang,

  Affiliation Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Yonghui Wu,

  Affiliation School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Carissa Iverson,

  Affiliations Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

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• Yubo Zhou,

  Affiliation National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China

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• Erica Bowton,

  Affiliation Institute for Clinical and Translational Research, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

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• Dan M. Roden,

  Affiliations Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Joshua C. Denny,

  Affiliation Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Melinda C. Aldrich,

  Affiliations Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Hua Xu ,

  * E-mail: hua.xu@uth.tmc.edu (HX); zhongming.zhao@vanderbilt.edu (ZZ)

  Affiliation School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Zhongming Zhao

  * E-mail: hua.xu@uth.tmc.edu (HX); zhongming.zhao@vanderbilt.edu (ZZ)

  Affiliations Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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