About the Authors

Jingchun Sun

Affiliations School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Min Zhao

Affiliation Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Peilin Jia

Affiliation Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Lily Wang

Affiliation Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Yonghui Wu

Affiliation School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Carissa Iverson

Affiliations Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

Yubo Zhou

Affiliation National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China

Erica Bowton

Affiliation Institute for Clinical and Translational Research, School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Dan M. Roden

Affiliations Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Joshua C. Denny

Affiliation Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Melinda C. Aldrich

Affiliations Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Hua Xu

hua.xu@uth.tmc.edu (HX); zhongming.zhao@vanderbilt.edu (ZZ)

Affiliation School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Zhongming Zhao

hua.xu@uth.tmc.edu (HX); zhongming.zhao@vanderbilt.edu (ZZ)

Affiliations Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JS HX ZZ. Performed the experiments: JS. Analyzed the data: JS MZ. Contributed reagents/materials/analysis tools: JS PJ LW YW CI EB DMR JCD MCA ZZ. Wrote the paper: JS YZ MCA HX ZZ. Edited and revised the manuscript: JS MZ PJ LW YW CI YZ EB DMR JCD MCA HX ZZ.