About the Authors

Apichat Suratanee

Affiliation Department of Mathematics, Faculty of Applied Science, King Mongkut's University of Technology North Bangkok, Bangsue, Bangkok, Thailand

Martin H. Schaefer

Affiliation EMBL/CRG Systems Biology Research Unit, Center for Genomic Regulation, Barcelona, Spain

Matthew J. Betts

Affiliation Robert B. Russell, Cell Networks Protein Evolution, BioQuant, University of Heidelberg, Heidelberg, Germany

Zita Soons

Affiliations Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Jena, Germany, Department of Knowledge Engineering, Maastricht University, Maastricht, The Netherlands, Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany

Heiko Mannsperger

Affiliation Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany

Nathalie Harder

Affiliations Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany

Marcus Oswald

Affiliations Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Jena, Germany, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany, Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany

Markus Gipp

Affiliation Department of Computer Science V, Institute of Computer Engineering, University of Mannheim, Mannheim, Germany

Ellen Ramminger

Affiliation AG Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

Guillermo Marcus

Affiliation Department of Computer Science V, Institute of Computer Engineering, University of Mannheim, Mannheim, Germany

Reinhard Männer

Affiliation Department of Computer Science V, Institute of Computer Engineering, University of Mannheim, Mannheim, Germany

Karl Rohr

Affiliations Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany

Erich Wanker

Affiliation AG Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

Robert B. Russell

Affiliation Robert B. Russell, Cell Networks Protein Evolution, BioQuant, University of Heidelberg, Heidelberg, Germany

Miguel A. Andrade-Navarro

Affiliation Computational Biology and Data Mining Group, Max Delbrueck Center for Molecular Medicine, Berlin, Germany

Roland Eils

r.eils@dkfz.de (RE); r.koenig@dkfz.de (RK)

Affiliations Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany

Rainer König

r.eils@dkfz.de (RE); r.koenig@dkfz.de (RK)

Affiliations Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Jena, Germany, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany, Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS MHS MJB HM NH MO MG RR RE RK. Performed the experiments: ER. Analyzed the data: AS MHS ZS MJB HM NH MO MG RBR RK. Contributed reagents/materials/analysis tools: NH KR MG GM RM NH MHS EW. Wrote the paper: AS RBR MAAN RE RK.