WHO Pandemic Agreement: The need for scientific implementation

Hao Wang, Min Yue

PLOS Pathogens: published November 25, 2025 | https://doi.org/10.1371/journal.ppat.1013729

Shedding light on receptor kinase processing

Anna Bannmüller, Adithya Acharya, Martina K. Ried-Lasi, Mariana Schuster

PLOS Pathogens: published November 3, 2025 | https://doi.org/10.1371/journal.ppat.1013648

Cryptococcus: Emerging host risk factors for infection

Alejandro L. Antonia, J. Andrew Alspaugh

PLOS Pathogens: published November 5, 2025 | https://doi.org/10.1371/journal.ppat.1013602

Mycotoxins: An ongoing challenge to food safety and security

Neriman Yilmaz, Carol Verheecke-Vaessen, Chibundu N. Ezekiel

PLOS Pathogens: published November 10, 2025 | https://doi.org/10.1371/journal.ppat.1013672

How transcriptional networks control Verticillium plants infection

Ying-Yu Chen, Rebekka Harting, Gerhard H. Braus

PLOS Pathogens: published November 10, 2025 | https://doi.org/10.1371/journal.ppat.1013673

Breaking down the wall: Solid-state NMR illuminates how fungi build and remodel diverse cell walls

Isha Gautam, Ankur Ankur, Kalpana Singh, Anand Jacob, Tamara L. Doering, Neil A. R Gow, Jean-Paul Latgé, Tuo Wang

PLOS Pathogens: published November 11, 2025 | https://doi.org/10.1371/journal.ppat.1013678

Ebola’s hidden front: Neurological involvement and pathogenesis

Blake Bernauer, Jack Siemering, Chen Sabrina Tan

PLOS Pathogens: published November 21, 2025 | https://doi.org/10.1371/journal.ppat.1013725

The metabolic, microbial and immunological demands of pneumococcal colonisation

Daniel R. Neill, Thomas B. Clarke

PLOS Pathogens: published November 13, 2025 | https://doi.org/10.1371/journal.ppat.1013675

Extensive diversity of unusual microorganisms associated with severe pneumonia in kidney transplant recipients

Jia-Xin Lv, Yuan-Yuan Pei, Cheng Yang, Xiang Liu, Min-Jie Ju, Edward C. Holmes, Yan-Mei Chen, Tong-Yu Zhu, Yong-Zhen Zhang

PLOS Pathogens: published November 3, 2025 | https://doi.org/10.1371/journal.ppat.1013667

The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice

F. Christopher Peritore-Galve, Heather K. Kroh, John A. Shupe, Alyssa G. Ehni, Rubén Cano Rodríguez, Shannon L. Kordus, M. Kay Washington, Reece J. Knippel, Ann Marie Stanley, Adam Gamson, Christine Tkaczyk, D. Borden Lacy

PLOS Pathogens: published November 3, 2025 | https://doi.org/10.1371/journal.ppat.1013651

Successful in vitro propagation of porcine bocavirus: Demonstrating dual respiratory-enteric tropism and pathogenicity

Zhaoyang Ji, Xin Zhang, Mei Xue, Jianfei Chen, Da Shi, Hongyan Shi, Hongliang Zhang, Liaoyuan Zhang, Tingshuai Feng, Xiaoyuan Zhu, Xiuwen Li, Dakai Liu, Mengting Wang, Miaomiao Zeng, Li Feng

PLOS Pathogens: published November 3, 2025 | https://doi.org/10.1371/journal.ppat.1013631

On campus dormitories as viral transmission sinks: Phylodynamic insights into student housing networks during the COVID-19 pandemic

Juan Bolanos, Alex Dornburg, April Harris, Samuel Kunkleman, Jannatul Ferdous, William Taylor, Jessica Schlueter, Cynthia Gibas

PLOS Pathogens: published November 3, 2025 | https://doi.org/10.1371/journal.ppat.1013666

RegIIIβ promotes Salmonella Typhimurium colonization of the gut in the early-stage gastrointestinal infection by enhancing flagella-driven locomotion

Tsuyoshi Miki, Hana Yamaguchi, Momoko Kobayashi, Masahiro Ito, Takeshi Haneda, Nobuhiko Okada, Yun-Gi Kim

PLOS Pathogens: published November 3, 2025 | https://doi.org/10.1371/journal.ppat.1013665

Adenovirus E1B-55K regulates p53-dependent and -independent gene expression during infection

Laura Seddar, Konstantin von Stromberg, Luca D. Bertzbach, Adam Grundhoff, Thomas Dobner, Wing Hang Ip

PLOS Pathogens: published November 3, 2025 | https://doi.org/10.1371/journal.ppat.1013622

PI3Kdelta-driven expansion of regulatory B cells impairs protective immune responses to Trypanosoma congolense parasite infection

Folayemi Olayinka-Adefemi, Xun Wu, Sen Hou, Milad Sabzevary-ghahfarokhi, Michelle N. Wray-Dutra, David J. Rawlings, Jude Uzonna, Aaron J. Marshall

PLOS Pathogens: published November 5, 2025 | https://doi.org/10.1371/journal.ppat.1013663

Alpha-herpesvirus US1 interacts with cGAS to suppress type I IFN responses and antiviral defense

Weiyu Qu, Ye Yuan, Dongdong Shen, Jiwen Zhang, Xiangyu Huang, Lei Wu, Hongyan Yin, Zhenchao Zhao, Haiwei Wang, Lvye Chai, Jiayang Wu, Xijun He, Cheng Zhu, Dongming Zhao, Xin Li

PLOS Pathogens: published November 6, 2025 | https://doi.org/10.1371/journal.ppat.1013669

Identification and characterization of a ubiquitin E3 RING ligase of the Chlamydia-like bacterium Simkania negevensis

Eva-Maria Hörner, Vanessa Lachmayer, Thomas Hermanns, Adriana Moldovan, Kay Hofmann, Vera Kozjak-Pavlovic

PLOS Pathogens: published November 6, 2025 | https://doi.org/10.1371/journal.ppat.1013626

Genome reannotation and gland-specific transcriptome analysis identify new effector candidates in Meloidogyne chitwoodi

Marcella Teixeira, Itsuhiro Ko, Sapinder Bali, Paulo Vieira, Thomas R. Maier, Thomas J. Baum, Cynthia Gleason

PLOS Pathogens: published November 7, 2025 | https://doi.org/10.1371/journal.ppat.1013075

CHIP/STUB1 suppresses the transcription and latent reactivation of HIV-1 via the TRAF6-NF-κB-HIV-LTR axis

Wei-Hua Zheng, Sen-Ying Lin, Ze-Lan He, Run-Ze Ni, Dan Mu

PLOS Pathogens: published November 7, 2025 | https://doi.org/10.1371/journal.ppat.1013683

Genomic and epidemiologic characteristics of SARS-CoV-2 persistent infections in California, January 2021 - July 2023

John M. Bell, Jesse Elder, Rahil Ryder, Emily A. Smith, Michelle Scribner, Sabrina Gilliam, Deva Borthwick, Megan Crumpler, Jacek Skarbinski, Christina Morales, Debra A. Wadford

PLOS Pathogens: published November 10, 2025 | https://doi.org/10.1371/journal.ppat.1013365

Plasmodium actin-like proteins are essential for DNA segregation during male gametogenesis and malaria transmission

Aastha Varshney, Eisha Pandey, Nirdosh, Satish Mishra

PLOS Pathogens: published November 11, 2025 | https://doi.org/10.1371/journal.ppat.1013687

Epstein-Barr virus-transformed B-cells from a hypoxia model of the germinal center requires external unsaturated fatty acids

Larissa Havey, Haixi You, Huimin Xian, John M. Asara, Rui Guo

PLOS Pathogens: published November 11, 2025 | https://doi.org/10.1371/journal.ppat.1013694

The cervicovaginal microbiome associates with spatially restricted host transcriptional signatures throughout the human ectocervical epithelium and submucosa

Vilde Kaldhusdal, Mathias Franzén Boger, Adam D. Burgener, Julie Lajoie, Kenneth Omollo, Joshua Kimani, Annelie Tjernlund, Keith R. Fowke, Douglas S. Kwon, Gabriella Edfeldt, Kristina Broliden

PLOS Pathogens: published November 11, 2025 | https://doi.org/10.1371/journal.ppat.1013677

Dengue virus NS1 protein does not activate TLR4 and has a modest effect on endothelial monolayer integrity compared to TNF

Parimala R. Vajjhala, Jaehyeon Kim, Adriana Pliego Zamora, Helen Mostafavi, Larisa I. Labzin, Katryn J. Stacey

PLOS Pathogens: published November 11, 2025 | https://doi.org/10.1371/journal.ppat.1013695

Novel ACE2 binding in bat merbecoviruses expands potential host range

Xiaoguang Zhang, Xing Ma, Ye Chen, Yabo You, Xin-Xin Li, Jie Chen, Shuhan Kong, Dawei Guo, Xiaoling Li, Michael Veit, Xiaofeng Zhai, Jin Tian

PLOS Pathogens: published November 11, 2025 | https://doi.org/10.1371/journal.ppat.1013436

Functional synergy of heteropentameric B subunits underlies virulence in a Salmonella A₂B₅ toxin

Dongdong Wang, Zhe Chen, Chunyu Xu, Xuyao Jiao, Min Yue, Xiang Gao

PLOS Pathogens: published November 12, 2025 | https://doi.org/10.1371/journal.ppat.1013684

Comparative genomics, integrated with single-cell sequencing and genetic analyses, reveal roles of transcription factor AP2-M2 in asexual replication of Babesia parasite

Jinming Wang, Yijun Chai, Yuxin Ye, Jifei Yang, Xinxin Zhang, Hong Yin, Guiquan Guan

PLOS Pathogens: published November 13, 2025 | https://doi.org/10.1371/journal.ppat.1013699

The B169L protein of African swine fever virus functions as a viroporin that activates the calcium-mediated inflammasome

Jiaqi Li, Qiguang Li, Yanjin Wang, Zhanhao Guo, Yuxin Qu, Xiao Wang, Hao Deng, Jingwen Dai, Lian-Feng Li, Wen-Rui He, Haojie Ren, Zhaobing Gao, Bingqing Xia, Su Li, Hua-Ji Qiu

PLOS Pathogens: published November 14, 2025 | https://doi.org/10.1371/journal.ppat.1013686

Divergent roles of macrophage subsets, FoxP3, and IL-17A in HSV-1–induced CNS pathology

Ujjaldeep Jaggi, Satoshi Hirose, Shaohui Wang, Homayon Ghiasi

PLOS Pathogens: published November 17, 2025 | https://doi.org/10.1371/journal.ppat.1013696

Discovery and molecular mechanism of potent neutralizing antibody from humanized mice with respiratory syncytial virus

Zheng Zhang, Rui Feng, Long Zhang, Qi Yang, Xuehua Chen, Xiaoxiao Wang, Cui Nie, Wei Peng, Xiangxi Wang, Ling Zhu, Yu Guo, Zixian Sun

PLOS Pathogens: published November 17, 2025 | https://doi.org/10.1371/journal.ppat.1013674

Salmonella enterica exploits the auxin signaling pathway to overcome stomatal immunity

Brianna Fochs, Zachariah Jaramillo, Ho-Wen Yang, Jirachaya Yeemin, Maeli Melotto

PLOS Pathogens: published November 17, 2025 | https://doi.org/10.1371/journal.ppat.1013662

High-resolution genome assembly and linkage mapping in Meloidogyne hapla reveal non-canonical telomere repeats and recombination hotspots associated with effector proteins

Pallavi Shakya, Muhammad I. Maulana, Etienne G. J. Danchin, M. Laurens Voogt, Stefan J. S. van de Ruitenbeek, Jacinta Gimeno, Adam P. Taranto, Alison C. Blundell, Evelin Despot-Slade, Nevenka Meštrović, Ana Zotta Mota, Dadong Dai, Valerie M. Williamson, Mark G. Sterken, Shahid Siddique

PLOS Pathogens: published November 18, 2025 | https://doi.org/10.1371/journal.ppat.1013706

ATG-3 limits Orsay virus infection in C. elegans and regulates collagen pathways

Gowri Kalugotla, Vivien Marmerstein, Lawrence A. Schriefer, Leran Wang, Stephanie A. Morrison, Luis Casorla Perez, Gary A. Silverman, Tim Schedl, Stephen C. Pak, Megan T. Baldridge

PLOS Pathogens: published November 18, 2025 | https://doi.org/10.1371/journal.ppat.1012900

Disrupted glycosylphosphatidylinositol anchoring induces ER stress and restricts enterovirus infection

Shangrui Guo, Xinyu Li, Meng Xun, Yingli He, Andrew W. Tai, Hongliang Wang

PLOS Pathogens: published November 18, 2025 | https://doi.org/10.1371/journal.ppat.1013685

Non-canonical Metatranscriptomic analysis of COVID-19 and Dengue reveals an expanded microbial and AMR landscape in COVID-19 mortality patients

Aanchal Yadav, Raiyan Ali, Priti Devi, Pallawi Kumari, Jyoti Soni, Garima, Bansidhar Tarai, Sandeep Budhiraja, Uzma Shamim, Rajesh Pandey

PLOS Pathogens: published November 19, 2025 | https://doi.org/10.1371/journal.ppat.1013703

The pcnB gene sustains Shigella flexneri virulence

Thibault Frisch, Petra Geiser, Margarita Komi, Philip A. Karlsson, Anjeela Bhetwal, Laura Jenniches, Lars Barquist, Erik Holmqvist, André Mateus, Mikael E. Sellin, Maria Letizia Di Martino

PLOS Pathogens: published November 20, 2025 | https://doi.org/10.1371/journal.ppat.1013727

Poxvirus H5 mediates the formation of liquid-liquid phase separation condensates which promote virus factory assembly

Junda Zhu, Zihui Zhang, Yongxiang Fang, Jian Xu, Zhimin Jiang, Hua Li, Shijie Xie, Kang Niu, Zhizhong Jing, Baifen Song, Wenxue Wu, Chen Peng

PLOS Pathogens: published November 20, 2025 | https://doi.org/10.1371/journal.ppat.1013708

Mitochondrial targeting by measles virus nucleoprotein modulates viral spread in human airway epithelium

Lorellin A. Durnell-Bettis, Stephanie E. Clark, Camilla E. Hippee, Angela Liu, Justin W. Kaufman, Sydney R. Winecke, Kalpana Yadav, Brajesh K. Singh, Roberto Cattaneo, Patrick L. Sinn

PLOS Pathogens: published November 20, 2025 | https://doi.org/10.1371/journal.ppat.1013713

Reprogramming of lipid metabolism by ORF3a-induced microlipophagy enhances biogenesis of SARS-CoV-2 replication organelle

Zhifei Li, Xianfeng Hui, Miaomiao Zheng, Zhicheng He, Wenjing Huai, Binbin Ding, Meilin Jin, Yali Qin, Mingzhou Chen

PLOS Pathogens: published November 21, 2025 | https://doi.org/10.1371/journal.ppat.1013676

Zoonotic hepatitis E virus spreads through environmental routes in pig herds – A phylodynamic analysis

Marina Meester, Cecilia Valenzuela Agüí, Tijs J. Tobias, Renate W. Hakze van der Honing, Claire Guinat, Martijn Bouwknegt, Louis du Plessis, Egil A.J. Fischer, Mirlin Spaninks, Tanja Stadler, Wim H.M. van der Poel, Arjan Stegeman

PLOS Pathogens: published November 24, 2025 | https://doi.org/10.1371/journal.ppat.1013710

Filovirus infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids

Elizabeth Y. Flores, Adam J. Hume, Judith Olejnik, Aditya Mithal, Andrew D’Amico, MengWei Yang, Pushpinder Bawa, Feiya Wang, Aoife K. O’Connell, Anna Tseng, Nicholas A. Crossland, Gustavo Mostoslavsky, Elke Mühlberger

PLOS Pathogens: published November 24, 2025 | https://doi.org/10.1371/journal.ppat.1013698

The citrus tristeza virus p33 protein functions as a viroporin

Vicken Aknadibossian, Clare Stokes, Roger L. Papke, Hao Wei Teh, Ying Wang, Svetlana Y. Folimonova

PLOS Pathogens: published November 24, 2025 | https://doi.org/10.1371/journal.ppat.1013730

The relationships of viral and protozoal co-infections to Chlamydia pecorum infection and chlamydiosis outcomes in northern koalas (Phascolarctos cinereus)

Yasmine S. S. Muir, Belinda R. Wright, Andrea Casteriano, Mathew S. Crowther, Amber Gillett, Mark B. Krockenberger, Damien P. Higgins

PLOS Pathogens: published November 24, 2025 | https://doi.org/10.1371/journal.ppat.1013632

ORF45-induced Filamin A phosphorylation promotes cell motility and cell-contact dependent viral infection of Kaposi’s sarcoma-associated herpesvirus

Xiaojuan Li, Li Quan, Rihong Zhou, Xiangpeng Liu, Ronit Sarid, Ersheng Kuang

PLOS Pathogens: published November 24, 2025 | https://doi.org/10.1371/journal.ppat.1013737

Genome-wide characterization of Src Homology-3 (SH3) domain-containing proteins in the development and pathogenicity of Fusarium graminearum

Yakubu Saddeeq Abubakar, Shiqi Ji, Qiaoli Chen, Huawei Zheng, Zonghua Wang, Wenhui Zheng, Yi Lou

PLOS Pathogens: published November 24, 2025 | https://doi.org/10.1371/journal.ppat.1013726

Evolution of the HIV-1 integration site landscape and inducible reservoir in early-treated people

Tine Struyve, Marion Pardons, Jozefien De Clercq, Liesbet Termote, Laurens Lambrechts, Ytse Noppe, Mathias Lichterfeld, Sofie Rutsaert, Linos Vandekerckhove

PLOS Pathogens: published November 25, 2025 | https://doi.org/10.1371/journal.ppat.1013702

The efficiency of rotavirus A spread to extraintestinal tissues is not determined by the levels of its replication in the gut

Sergei A. Raev, Maryssa K. Kick, Maria Chellis, Linda J. Saif, Talita P. Resende, Anastasia N. Vlasova

PLOS Pathogens: published November 25, 2025 | https://doi.org/10.1371/journal.ppat.1013723

Assessing Ebola virus circulation in the Tshuapa province (Democratic Republic of the Congo): A One Health investigation of wildlife and human interactions

Rianne van Vredendaal, Léa Joffrin, Antea Paviotti, Claude Mande, Solange Milolo, Nicolas Laurent, Léa Fourchault, Douglas Adroabadrio, Pascal Baelo, Steve Ngoy, Papy Ansobi, Casimir Nebesse, Martine Peeters, Ahidjo Ayouba, Maeliss Champagne, Julie Bouillin, Jana Tĕšíková, Natalie Van Houtte, Sophie Gryseels, Maha Salloum, Freddy Bikioli, Séverine Thys, Jimmy Mpato, Ruben Ilonga, Henri Kimina, Ynke Larivière, Gwen Lemey, Pierre Van Damme, Jean-Pierre Van Geertruyden, Hypolite Muhindo-Mavoko, Patrick Mitashi, Herwig Leirs, Erik Verheyen, Guy-Crispin Gembu, Joachim Mariën

PLOS Pathogens: published November 26, 2025 | https://doi.org/10.1371/journal.ppat.1013628

Structural determinants of SlpA-mediated phage recognition in Clostridioides difficile

Alexia L.M. Royer, Émeline Dion, Andrew A. Umansky, Mariano Avino, Olga Soutourina, Louis-Charles Fortier

PLOS Pathogens: published November 26, 2025 | https://doi.org/10.1371/journal.ppat.1013724

The hemagglutinin-like proteins of basal vertebrate influenza-like viruses exhibit sialic-acid receptor binding disparity and their structural bases

Di Zhang, Kefang Liu, Yufeng Xie, Junqing Sun, Wei Zhang, Haixia Xiao, Yi Shi, William J. Liu, George F. Gao, Chuxia Deng, Feng Gao

PLOS Pathogens: published November 26, 2025 | https://doi.org/10.1371/journal.ppat.1013640

Thrombocytopenia in murine schistosomiasis is associated with platelet uptake by liver macrophages that have a distinct activation phenotype

Joanna H. Greenman, Shinjini Chakraborty, Lucie Moss, Paul C. Armstrong, Paul M. Kaye, Ian S. Hitchcock, James P. Hewitson

PLOS Pathogens: published November 26, 2025 | https://doi.org/10.1371/journal.ppat.1013732

Correction: Evolution of primate T-cell leukemia virus type 1 accessory genes and functional divergence of its antisense proteins

Osama Hussein, Mohamed Mahgoub, Takafumi Shichijo, So Nakagawa, Junko Tanabe, Hirofumi Akari, Tomoyuki Miura, Masao Matsuoka, Jun-ichirou Yasunaga

PLOS Pathogens: published November 7, 2025 | https://doi.org/10.1371/journal.ppat.1013668

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Correction: Transmitted/founder (T/F) HIV-1 derived from sexual contact exhibits greater transmission fitness in human cervical tissue than T/F HIV-1 from blood-to-blood contact: Unique glycan profiles on T/F envelopes associated with transmission phenotypes

Yiying Zhang, Katja Klein, Annette Ratcliff, Sashini Loku Galappaththi, Nicholas Hathaway, Nicholas Twells, Mukti Patel, Stephen Temesy, Jeffrey A. Bailey, Lara K. Mahal, Carole Creuzenet, Eric J. Arts

PLOS Pathogens: published November 18, 2025 | https://doi.org/10.1371/journal.ppat.1013697

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Correction: From darkness to light: Genetic manipulation of an atypical plant virus unveils key insights into kitavirus biology, highlighting capsid protein and eIF4A engagement to drive viral infection

The PLOS Pathogens Staff

PLOS Pathogens: published November 21, 2025 | https://doi.org/10.1371/journal.ppat.1013705

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Correction: Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern

Gonzalo Almanza, Alex E. Clark, Valentina Kouznetsova, Eduardo Olmedillas, Andrea Castro, Igor F. Tsigelny, Yan Wu, George F. Gao, Sandra L. Leibel, William Bray, Erica O. Saphire, Aaron F. Carlin, Maurizio Zanetti

PLOS Pathogens: published November 25, 2025 | https://doi.org/10.1371/journal.ppat.1013707

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Correction: Stomoxys flies (Diptera, Muscidae) are competent vectors of Trypanosoma evansi, Trypanosoma vivax, and other livestock hemopathogens

Julia W. Muita, Joel L. Bargul, JohnMark O. Makwatta, Ernest M. Ngatia, Simon K. Tawich, Daniel K. Masiga, Merid N. Getahun

PLOS Pathogens: published November 25, 2025 | https://doi.org/10.1371/journal.ppat.1013712

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