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Live T7 plaque formation
Phage T7 predation on an E. coli MG1655 growing population was live-imaged as a large-field composite (1 × 10 fields, 100× magnification) over 2 hours at 37 °C in lysogeny broth (LB) medium containing 0.5% agar. Phase-contrast microscopy was performed using a Nikon TiE inverted microscope. Time frames correspond to t=0, 24, 48, 96, and 120 minutes. Bulssico et al. 2025
Image Credit: Julián Bulssico
Opinion
Here we go again: More diseases dubiously attributed to pegivirus infection
PLOS Pathogens: published October 28, 2025 | https://doi.org/10.1371/journal.ppat.1013641
Pearls
Re-emergence of chikungunya virus in China by 2025: What we know and what to do?
PLOS Pathogens: published October 6, 2025 | https://doi.org/10.1371/journal.ppat.1013556
Promiscuity and specificity in ligand sensing by plant cell surface receptors
PLOS Pathogens: published October 8, 2025 | https://doi.org/10.1371/journal.ppat.1013548
Regulation of arbuscular mycorrhiza development by environmental stimuli: Many roads lead to strigolactones
PLOS Pathogens: published October 8, 2025 | https://doi.org/10.1371/journal.ppat.1013555
Vimig: The virus-induced migrasome as a novel mechanism for viral transmission and communication
PLOS Pathogens: published October 9, 2025 | https://doi.org/10.1371/journal.ppat.1013557
Is vaccination a feasible public health strategy against fatal Borna disease virus 1 (BoDV-1) encephalitis? An epidemiological perspective
PLOS Pathogens: published October 13, 2025 | https://doi.org/10.1371/journal.ppat.1013571
The interplay of RALF structural and signaling functions in plant-microbe interactions
PLOS Pathogens: published October 15, 2025 | https://doi.org/10.1371/journal.ppat.1013588
Starve or share? Phosphate availability shapes plant–microbe interactions
PLOS Pathogens: published October 21, 2025 | https://doi.org/10.1371/journal.ppat.1013601
Persister cells in human fungal pathogens
PLOS Pathogens: published October 23, 2025 | https://doi.org/10.1371/journal.ppat.1013483
Microbial links to Alzheimer’s disease
PLOS Pathogens: published October 23, 2025 | https://doi.org/10.1371/journal.ppat.1013599
Cellular and molecular keys to entry: Mechanisms mediating Orthoflavivirus infection of the mosquito midgut
PLOS Pathogens: published October 27, 2025 | https://doi.org/10.1371/journal.ppat.1013617
Cultivating awareness: How botanical gardens can foster public engagement with plant pathogens
PLOS Pathogens: published October 28, 2025 | https://doi.org/10.1371/journal.ppat.1013629
Reviews
Viral interferon antagonism shapes host tropism
PLOS Pathogens: published October 7, 2025 | https://doi.org/10.1371/journal.ppat.1013544
The microbiome and gut–lung axis in nontuberculous mycobacterial pulmonary disease
PLOS Pathogens: published October 17, 2025 | https://doi.org/10.1371/journal.ppat.1013603
tRNA modifications as regulators of bacterial virulence and stress responses
PLOS Pathogens: published October 23, 2025 | https://doi.org/10.1371/journal.ppat.1013600
The exploitation of nutrient metals by bacteria for survival and infection in the gut
PLOS Pathogens: published October 30, 2025 | https://doi.org/10.1371/journal.ppat.1013580
Research Articles
Antibiotic-induced morphological changes enhance phage predation
PLOS Pathogens: published October 3, 2025 | https://doi.org/10.1371/journal.ppat.1013546
Single-cell analysis reveals an important role of CD137L+ macrophages in the host response to uropathogenic Escherichia coli infection in the bladder
PLOS Pathogens: published October 3, 2025 | https://doi.org/10.1371/journal.ppat.1013543
Host- and microbial-mediated mucin degradation differentially shape Pseudomonas aeruginosa physiology and gene expression
PLOS Pathogens: published October 3, 2025 | https://doi.org/10.1371/journal.ppat.1013568
West Nile virus vaccine candidates attenuated by dinucleotide enrichment are immunogenic and protective against lethal infection
PLOS Pathogens: published October 3, 2025 | https://doi.org/10.1371/journal.ppat.1013560
Carabrone inhibits Gaeumannomyces tritici growth by targeting mitochondrial complex I and destabilizing NAD⁺/NADH homeostasis
PLOS Pathogens: published October 3, 2025 | https://doi.org/10.1371/journal.ppat.1013567
Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization
PLOS Pathogens: published October 6, 2025 | https://doi.org/10.1371/journal.ppat.1013563
The serine protease HtrA regulates Group B Streptococcus virulence and affects the host response to infection
PLOS Pathogens: published October 6, 2025 | https://doi.org/10.1371/journal.ppat.1013562
Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus
PLOS Pathogens: published October 6, 2025 | https://doi.org/10.1371/journal.ppat.1013578
Aviadenovirus structure: A highly thermostable capsid in the absence of stabilizing proteins
PLOS Pathogens: published October 9, 2025 | https://doi.org/10.1371/journal.ppat.1013553
Avian leukosis virus subgroup J evades innate immunity by activating miR-155 to dually target TRAF3 and STAT1
PLOS Pathogens: published October 9, 2025 | https://doi.org/10.1371/journal.ppat.1013552
“Pour some sugar on me”—Environmental Candida albicans isolates and the evolution of increased pathogenicity and antifungal resistance through sugar adaptation
PLOS Pathogens: published October 9, 2025 | https://doi.org/10.1371/journal.ppat.1013542
Insect-borne non-enveloped bluetongue virus utilizes discrete small vesicles for non-lytic release and cell-to-cell transmission
PLOS Pathogens: published October 9, 2025 | https://doi.org/10.1371/journal.ppat.1013582
Murine leukemia virus glycoGag antagonizes SERINC5 via ER-phagy receptor RETREG1
PLOS Pathogens: published October 9, 2025 | https://doi.org/10.1371/journal.ppat.1013023
Reoviruses hijack the SMARCB1-MYC transcriptional regulation complex to activate autophagy for persistent viral infection in leafhopper vector
PLOS Pathogens: published October 9, 2025 | https://doi.org/10.1371/journal.ppat.1013569
The gonococcal vaccine candidate antigen NGO1701 is a N. gonorrhoeae periplasmic copper storage protein
PLOS Pathogens: published October 9, 2025 | https://doi.org/10.1371/journal.ppat.1013559
HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission
PLOS Pathogens: published October 10, 2025 | https://doi.org/10.1371/journal.ppat.1013570
Lactic acid produced by optimal vaginal Lactobacillus spp. potently and specifically inactivates HIV-1 in vitro by targeting the viral RNA genome and reverse transcriptase
PLOS Pathogens: published October 10, 2025 | https://doi.org/10.1371/journal.ppat.1013594
TfR1 facilitates influenza virus endocytosis and uncoating by interacting with NA and M1 via extracellular and intracellular domains
PLOS Pathogens: published October 10, 2025 | https://doi.org/10.1371/journal.ppat.1013511
Highly accurate protein structure prediction-based virtual docking pipeline accelerating the identification of anti-schistosomal compounds
PLOS Pathogens: published October 13, 2025 | https://doi.org/10.1371/journal.ppat.1013274
Mucosal Taï Forest virus infection causes disease in ferrets
PLOS Pathogens: published October 13, 2025 | https://doi.org/10.1371/journal.ppat.1013579
Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment
PLOS Pathogens: published October 14, 2025 | https://doi.org/10.1371/journal.ppat.1013604
UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein
PLOS Pathogens: published October 14, 2025 | https://doi.org/10.1371/journal.ppat.1013593
Myosin-9 is required for lysosome-mediated nonlytic reovirus egress
PLOS Pathogens: published October 14, 2025 | https://doi.org/10.1371/journal.ppat.1013597
Dietary tannic acid promotes intestinal clearance of C. albicans by cross-linking hyphal chitosan
PLOS Pathogens: published October 15, 2025 | https://doi.org/10.1371/journal.ppat.1013596
Substitution of histidine 95 by tyrosine in the prion protein causes spontaneous neurodegeneration in transgenic mice
PLOS Pathogens: published October 16, 2025 | https://doi.org/10.1371/journal.ppat.1013554
Nutrient stress dramatically increases malaria parasite clag2 copy number to increase host cell permeability and enable pathogen survival
PLOS Pathogens: published October 16, 2025 | https://doi.org/10.1371/journal.ppat.1013321
HilE mediates motility thermoregulation in typhoidal Salmonella serovars at elevated physiological temperatures
PLOS Pathogens: published October 16, 2025 | https://doi.org/10.1371/journal.ppat.1013133
In vitro cultured malaria hypnozoites leave a footprint of specific metabolites
PLOS Pathogens: published October 16, 2025 | https://doi.org/10.1371/journal.ppat.1013577
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
PLOS Pathogens: published October 16, 2025 | https://doi.org/10.1371/journal.ppat.1013123
HBV p22-interacting protein C1QBP inhibits viral replication through impeding nucleocapsid formation and nuclear import
PLOS Pathogens: published October 17, 2025 | https://doi.org/10.1371/journal.ppat.1013581
Regulation of lipid metabolism in Spodoptera frugiperda by the symbiotic bracovirus of the gregarious parasitoid Cotesia ruficrus
PLOS Pathogens: published October 17, 2025 | https://doi.org/10.1371/journal.ppat.1013605
Follicular CD8+ T cells in Trypanosoma cruzi infection: helpers or killers depending on the target B cell population
PLOS Pathogens: published October 17, 2025 | https://doi.org/10.1371/journal.ppat.1013595
Eph receptor tyrosine kinases are functional entry receptors for murine gammaherpesvirus 68
PLOS Pathogens: published October 21, 2025 | https://doi.org/10.1371/journal.ppat.1013263
Disruption of undecaprenyl phosphate recycling suppresses ampC beta-lactamase induction in Pseudomonas aeruginosa
PLOS Pathogens: published October 21, 2025 | https://doi.org/10.1371/journal.ppat.1013633
Human monoclonal antibodies to HPV16 show evidence for common developmental pathways and public epitopes
PLOS Pathogens: published October 21, 2025 | https://doi.org/10.1371/journal.ppat.1013086
Induction of HIV-1-specific antibody-mediated effector functions by native-like envelope trimers in humans
PLOS Pathogens: published October 21, 2025 | https://doi.org/10.1371/journal.ppat.1013614
Pathogenicity and transmission of Morganella morganii in honey bees
PLOS Pathogens: published October 22, 2025 | https://doi.org/10.1371/journal.ppat.1013613
African swine fever virus pB318L suppresses inflammatory response by inhibiting NF-κB activation and NLRP3 inflammasome formation
PLOS Pathogens: published October 22, 2025 | https://doi.org/10.1371/journal.ppat.1013558
External factors influence intrinsic differences in Stx2e production by Porcine Shiga Toxin-producing Escherichia coli strains
PLOS Pathogens: published October 22, 2025 | https://doi.org/10.1371/journal.ppat.1013616
A mycovirus enhances fitness of an insect pathogenic fungus and potentially modulates virulence through interactions between viral and host proteins
PLOS Pathogens: published October 23, 2025 | https://doi.org/10.1371/journal.ppat.1013634
Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism
PLOS Pathogens: published October 23, 2025 | https://doi.org/10.1371/journal.ppat.1013273
Cryptosporidium oocyst wall proteins are true components of the oocyst wall and COWP8 is not required for parasite transmission
PLOS Pathogens: published October 23, 2025 | https://doi.org/10.1371/journal.ppat.1013561
TRIM45 restricts influenza virus infection through modulating the chaperone-mediated autophagic degradation of viral PB2 protein
PLOS Pathogens: published October 23, 2025 | https://doi.org/10.1371/journal.ppat.1013630
A comprehensive PDCoV-host proteome interaction map reveals potential antiviral targets
PLOS Pathogens: published October 24, 2025 | https://doi.org/10.1371/journal.ppat.1013615
Influenza virus infection reprograms cholesterol biosynthesis to facilitate virus replication by the TAK1-RORγ axis
PLOS Pathogens: published October 24, 2025 | https://doi.org/10.1371/journal.ppat.1013646
The TRAPPIII complex regulates development and virulence of Fusarium graminearum by coordinating autophagy and intracellular transport
PLOS Pathogens: published October 24, 2025 | https://doi.org/10.1371/journal.ppat.1013627
Flavin affinity for the reductase HpaC differentially sensitizes Neisseria gonorrhoeae during Type IV pilus-dependent killing
PLOS Pathogens: published October 27, 2025 | https://doi.org/10.1371/journal.ppat.1013607
Retinol binding protein 4 enhances cellular cholesterol uptake to facilitate influenza A virus infection
PLOS Pathogens: published October 27, 2025 | https://doi.org/10.1371/journal.ppat.1013623
A broad-spectrum anti-fungal effector dictates bacterial-fungal interkingdom interactions
PLOS Pathogens: published October 27, 2025 | https://doi.org/10.1371/journal.ppat.1013598
PfATP2 is a flippase on the Plasmodium falciparum surface that is important for growth and influences parasite sensitivity to antiplasmodial compounds
PLOS Pathogens: published October 27, 2025 | https://doi.org/10.1371/journal.ppat.1013645
The adenovirus E4orf1 protein initiates a feedback loop involving insulin and growth factor receptors, AKT, and NF-κB, leading to abnormal DNA content in infected cells
PLOS Pathogens: published October 27, 2025 | https://doi.org/10.1371/journal.ppat.1013202
Structures of vesicular stomatitis virus glycoprotein G alone and bound to a neutralizing antibody
PLOS Pathogens: published October 27, 2025 | https://doi.org/10.1371/journal.ppat.1013589
ZNFX1 functions as a compensatory dsRNA recognition receptor to exert antiviral effect in orange-spotted grouper
PLOS Pathogens: published October 29, 2025 | https://doi.org/10.1371/journal.ppat.1013652
A bacterial effector protein targets plant ferredoxin-NADP+ reductase to promote infection
PLOS Pathogens: published October 30, 2025 | https://doi.org/10.1371/journal.ppat.1013664
Cytoplasmic sequestering of a fungal stress-activated MAPK in response to a host plant phenolic acid
PLOS Pathogens: published October 30, 2025 | https://doi.org/10.1371/journal.ppat.1013620
Corrections
Correction: IRF6 controls Epstein-Barr virus (EBV) lytic reactivation and differentiation in EBV-infected epithelial cells
PLOS Pathogens: published October 9, 2025 | https://doi.org/10.1371/journal.ppat.1013564
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Correction: The ESCRT-III machinery participates in the production of extracellular vesicles and protein export during Plasmodium falciparum infection
PLOS Pathogens: published October 22, 2025 | https://doi.org/10.1371/journal.ppat.1013606
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Correction: Myco-Ed: Mycological curriculum for education and discovery
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Correction: Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria
PLOS Pathogens: published October 24, 2025 | https://doi.org/10.1371/journal.ppat.1013624
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Correction: Trehalose supports the growth of Aedes aegypti cells and modifies gene expression and dengue virus type 2 replication
PLOS Pathogens: published October 30, 2025 | https://doi.org/10.1371/journal.ppat.1013644