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August 2025

Representation of a frozen-hydrated solution of immature rotavirus particles, illustrating the architecture of the virion prior to proteolytic activation. Rendered visualization based on atomic models from cryo-EM reconstructions of the non-trypsinized spike and triple-layered particle (PDB IDs: 8OLE and 8OLB) described in the manuscript by Asensio-Cob D et al (2025). Structural determinants of rotavirus proteolytic activation.

Image Credit: Daniel Luque

Pearls

You can go your own way: The targeting signals of trypanosomatid parasites

Max Pendlebury, Julius Lukeš, Michael J. Hammond

Plants, fungi, and antifungals: A little less talk, a little more action

George Ly, James M. Bradley, Dario Bonetta, Shelley Lumba

Host-induced climate change: Carbon dioxide tolerance as a Cryptococcus neoformans virulence trait

Emma E. Blackburn, Laura C. Ristow, Xiaorong Lin, Damian J. Krysan

Stenotrophomonas maltophilia complex: A broadly distributed emerging pathogen

Cristian V. Crisan, Joanna B. Goldberg

Review

Emerging challenges for mosquito-borne disease control and the promise of symbiont-based transmission-blocking strategies

Han Gao, Wenqian Hu, Chunlai Cui, Yiguan Wang, Yitong Zheng, Marcelo Jacobs-Lorena, Sibao Wang

Research Articles

Search for a genetic cause of variably protease-sensitive prionopathy

Yuan Lian, Keisi Kotobelli, Stacey Hall, Michael E. Talkowski, Anne O’Donnell-Luria, Sonia Minikel Vallabh, Brian S. Appleby, Eric Vallabh Minikel

NK cell-macrophage interactions in granulomas correlate with limited tuberculosis pathology

Paula Niewold, Marieke E. IJsselsteijn, Karin Dijkman, Noel de Miranda, Tom H. M. Ottenhoff, Frank A. W. Verreck, Simone A. Joosten

Secreted LysM proteins are required for niche competition and full virulence in Pseudomonas savastanoi during host plant infection

Hilario Domínguez-Cerván, Laura Barrientos-Moreno, Luis Díaz-Martínez, Jesús Murillo, Inmaculada Pérez-Dorado, Cayo Ramos, Luis Rodríguez-Moreno

Cell type differences in human cytomegalovirus transcription and epigenetic regulation with insights into major immediate-early enhancer-promoter control

Qiaolin Hu, Ming Li, Mrutyunjaya Parida, Benjamin M. Spector, Juan F. Santana, Arya Zandvakili, David H. Price, Jeffery L. Meier

Screening of different species reveals cat hepatocytes support HBV infection

Zaichao Xu, Kaitao Zhao, Jingjing Wang, Lu Zhang, Jiatong Yin, Nijing Chen, Sijia Chen, Gaihong Zhao, Mengfei Wang, Tailai Xin, Chengliang Zhu, Xiaoming Cheng, Yuchen Xia

Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells

Alexandra Wilson, Wael Kamel, Kelsey Davies, Zaydah R. De Laurent, Rozeena Arif, Andrew T. Clarke, Lesley Bell-Sakyi, Douglas Lamont, Yana Demyanenko, Marko Noerenberg, Alain Kohl, Shabaz Mohammed, Alfredo Castello, Benjamin Brennan

Mapping Bornavirus encephalitis—A comparative study of viral spread and immune response in human and animal dead-end hosts

Yannik Vollmuth, Nicola Jungbäck, Przemyslaw Grochowski, Tatiana Mögele, Leonhard Stark, Niku S. Zarrabi, Jürgen Schlegel, Tina Schaller, Bruno Märkl, Kaspar Matiasek, Friederike Liesche-Starnecker

Two-pore channels in MR1-dependent presentation of Mycobacterium tuberculosis infection

Elham Karamooz, Se-Jin Kim, Jessie C. Peterson, Allison E. Tammen, Shogo Soma, Aviva C.R. Soll, Erin W. Meermeier, Sharon Khuzwayo, David M. Lewinsohn

Identification and characterization of novel bat coronaviruses in Spain

Clàudia Soriano-Tordera, Jaime Buigues, Adrià Viñals, Elena Muscolino, Raquel Martínez-Recio, Juana Díez, Juan S. Monrós, José M. Cuevas, Jérémy Dufloo, Rafael Sanjuán

Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions

Xiu-Yuan Li, Ping He, Shaomeng Wang, Yusong Wang, Dingfei Yan, Xiaohui Liu, Haiteng Deng, Zhixing Feng, Juanjuan Wang, Jing-Ren Zhang

Patterns and functional consequences of antibody speciation in maternal-fetal transfer of coronavirus-specific humoral immunity

Andrew P. Hederman, Hannah M. Brookes, Harini Natarajan, Leo Heyndrickx, Kevin K. Ariën, Joshua A. Weiner, Amihai Rottenstreich, Gila Zarbiv, Dana Wolf, Tessa Goetghebuer, Arnaud Marchant, Margaret E. Ackerman

Comparison of HIV-1 A6 dispersal dynamics in Poland before and after the war in Ukraine

Karol Serwin, Kaja Mielczak, Anna Urbańska, Bogusz Aksak-Wąs, Malwina Karasińska-Cieślak, Piotr Ząbek, Ewa Siwak, Iwona Cielniak, Elżbieta Jabłonowska, Paweł Jakubowski, Błażej Rozpłochowski, Aleksandra Szymczak, Bartosz Szetela, Anna Kalinowska-Nowak, Monika Bociąga-Jasik, Elżbieta Mularska, Adam Witor, Anita Olczak, Władysław Łojewski, Maria Hlebowicz, Miłosz Parczewski

A novel combination therapy with Uridine and Praziquantel effectively alleviates schistosomiasis-induced hepatic fibrosis through promoting adipogenic differentiation

Xiangyu Zhou, Qingkai Xue, Chengwei Wu, Xiaojing Li, Yuyan Wang, Yang Dai, Chunrong Xiong, Ying Zhang, Yongliang Xu, Xinjian Liu, Yuzheng Huang

E2F1 suppresses Epstein-Barr virus lytic reactivation through cellular and viral transcriptional networks

Joyanta Biswas, SK. Asif Ali, Samaresh Malik, Subhadeep Nag, Piyali Mukherjee, Abhik Saha

Inactivation of branched-chain amino acid uptake halts Staphylococcus aureus growth and induces bacterial quiescence within macrophages

Adriana Moldovan, Ronald S. Flannagan, Marcel Rühling, Kathrin Stelzner, Clara Hans, Kerstin Paprotka, Tobias C. Kunz, David E. Heinrichs, Thomas Rudel, Martin J. Fraunholz

CD24-Fc resolves inflammation and enhances anti-HIV CD8 T cells with polyfunctionality during HIV-1 infection under cART

Guangming Li, Jianping Ma, Haisheng Yu, Ourania Tsahouridis, Yaoxian Lou, Xiuting He, Masaya Funaki, Pan Zheng, Yang Liu, Lishan Su

Flies use acetic acid to protect their offspring from parasitoids

Kayla F. Reddy, Aleksey Prok, Corinne M. Stouthamer, Todd A. Schlenke

A hypovirulence-associated capsidless bi-segmented ssRNA mycovirus enhances melanin and microsclerotial production in a vascular phytopathogenic fungus

Jiamin Gao, Xuekun Zhang, Jichun Jia, Huang Huang, Jiasen Cheng, Yanping Fu, Xueqiong Xiao, Bo Li, Tao Chen, Xiao Yu, Longfu Zhu, Tom Hsiang, Daohong Jiang, Lili Zhang, Jiatao Xie

Structural determinants of rotavirus proteolytic activation

Dunia Asensio-Cob, Carlos P. Mata, Josue Gomez-Blanco, Javier Vargas, Javier M. Rodriguez, Daniel Luque

Transcriptome profiling of L. infantum-infected human macrophages reveals sex-specific type I interferon induction

Annika Bea, Helena Fehling, Fabian Hausmann, Fahten Margot Habib, Melanie Lütkemeyer, Lara Buer, Carola Schäfer, Charlotte Sophie Hansen, Barbara Honecker, Stefan Bonn, Bianca Elisabeth Schneider, Joachim Clos, Hanna Lotter

Yersinia actively downregulates type III secretion and adhesion at higher cell densities

Francesca Ermoli, Gabriele Malengo, Christoph Spahn, Corentin Brianceau, Timo Glatter, Andreas Diepold

Age-associated immune dysregulation and B cell dysfunction drive severe outcomes in SFTSV infection

Eun-Ha Kim, Ho Bin Jang, Se-Mi Kim, Dongbin Park, Young-Il Kim, Seung-Gyu Jang, Suhee Hwang, Woo-Hyun Kwon, Isaac Choi, Jaemoo Kim, Hee-Dong Yang, Hyunjoon Kim, Mark Anthony B. Casel, Min-Suk Song, Jae U. Jung, Young Ki Choi

ERK-METTL3 axis acts as a novel regulator of antiviral innate immunity combating pseudorabies virus infection

Lucai Wang, Xiangqi Qiu, Lele Wang, Xilong Yang, Mengjie Li, Xuyang Zhao, Wenhui Zhu, Lijie Lv, Yunzhe Kang, Lulu Yao, Gaiping Zhang, Aijun Sun, Guoqing Zhuang

Infection with Mycobacterium tuberculosis alters the antibody response to HIV-1

Marius Zeeb, Katharina Kusejko, Sonja Hartnack, Chloé Pasin, Irene A. Abela, Peter Rusert, Thomas Liechti, Claus Kadelka, Julia Notter, Anna Eichenberger, Matthias Hoffmann, Hans H. Hirsch, Alexandra Calmy, Matthias Cavassini, Niklaus D. Labhardt, Enos Bernasconi, Huldrych F. Günthard, Roger D. Kouyos, Alexandra Trkola, Johannes Nemeth, and the Swiss HIV Cohort Study

Pore-C sequencing identifies episome-driven chromosome conformation perturbations differentiating pneumococcal epigenetic variants

Tze Yee Lim, Samuel T. Horsfield, Catherine M. Troman, Stephen D. Bentley, Min Jung Kwun, Nicholas J. Croucher

Germinal Center B cells provide essential IL-1β signals to TFH cells via canonical NLRP3 inflammasome activity post influenza infection

Juliana Restrepo Munera, Cainan Riccio-Baum, Rebecca Kaddis Maldonado, S. Rameeza Allie

LANA-dependent transcription-replication conflicts and R-loops at the terminal repeats (TR) correlate with KSHV episome maintenance

Asim Asghar, Olga Vladimirova, Asher Sobotka, James Hayden, Jayamanna Wickramasinghe, Jayaraju Dheekollu, Moeko Minakuchi, Leena Yoon, Maureen E. Murphy, Kazuko Nishikura, Paul M. Lieberman

Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression

Monnette F. Summers, MegAnn K. Haubold, Marcel Morgenstern, Phoenix Shepherd, Clairine I. S. Larsen, Ava E. Bartz, Gopishankar Thirumoorthy, Robert N. Kirchdoerfer, Joshua J. Coon, Kavi P. M. Mehta, Kinjal Majumder

Pattern recognition receptor-associated immuno-thrombotic transcript changes in platelets and leukocytes with COVID19

Heather Learnard, Jason Core, Heather Corkrey, Anthony Sciaudone, Jeffrey Rade, Hardy Kornfeld, Jennifer P. Wang, Jane E. Freedman, Kahraman Tanriverdi, Milka Koupenova

Rice ragged stunt virus Pns10 induces mitochondrial-mediated apoptosis to promote viral infection in Nilaparvata lugens through disrupting the NlNDUFS1-NlPHB2 interaction

Lianshun Zheng, Shuai Fu, Ming Zeng, Liyan Li, Dan Wang, Shibo Gao, Yunge Zhang, Cui Zhang, Shifang Fei, Xuan Ye, Lele Chen, Qianhui Chen, Yaqin Wang, Xueping Zhou, Yan Xie, Boli Hu, Jianxiang Wu

The pUL47 tegument protein of Marek’s Disease Virus interacts with p32/C1QBP to promote horizontal transmission

Mallorie Durand, Aurélien Chuard, Sylvie Rémy, Katia Courvoisier-Guyader, Sébastien Leclercq, Julien Pichon, Caroline Denesvre, David Pasdeloup

Mobilization of nuclear antiviral factors by exportin XPO1 via the actin network inhibits RNA virus replication

Biao Sun, Cheng-Yu Wu, Paulina Alatriste Gonzalez, Peter D. Nagy

Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription

Ashley P. E. Roberts, Anne Orr, Victor Iliev, Lauren Orr, Steven McFarlane, Zhousiyu Yang, Ilaria Epifano, Colin Loney, Mila Collados Rodriguez, Anna R. Cliffe, Kristen L. Conn, Chris Boutell

Persistent type I interferon signaling within the brain of people with HIV on ART with cognitive impairment

Yuyang Tang, Ling Xie, Ciniso Sylvester Shabangu, Dajiang Li, Gabriela da Silva Prates, Ashokkumar Manickam, Lilly M. Wong, Antoine Chaillon, Edward P. Browne, Sara Gianella, Wenzhe Ho, David M. Margolis, Xian Chen, Wenhui Hu, Guochun Jiang

Abundant genetic variation is retained in many laboratory schistosome populations

Kathrin S. Jutzeler, Roy N. Platt, Robbie Diaz, Madison Morales, Julie Dunning Hotopp, Winka Le Clec’h, Frédéric D. Chevalier, Timothy J. C. Anderson

DCLK1 isoform (DCLK1-S) as a critical player in promoting inflammation, tissue remodeling, and EMT in mouse models of colitis

Kafayat Yusuf, Badal C Roy, William L Hauser, Mazin Al-Kasspooles, Sierra Sanchez, Thomas M Attard, Dong Pei, Venkatesh Sampath, Shrikant Anant, Shahid Umar

Multivalent mpox protein nanoparticle vaccines confer cross-protection against orthopoxvirus infection

Lijun Zhang, Chuanyu Liu, Chenxi Yang, Xueqi Xiao, Senyu Xu, Shengfeng Wan, Kun Xu, Yan Li, Lianpan Dai

Human tonsil organoids reveal innate pathways modulating humoral and cellular responses to ChAdOx1

Maria Fransiska Pudjohartono, Kate Powell, Eleanor Barnes, Paul Klenerman, Nicholas M. Provine

Gap-free comparative genomics uncover virulence factors for Fusarium wilt of watermelons

Dilay Hazal Ayhan, Huan Wang, Lili Zhang, Guan Wang, Shu Yi, Dian Meng, Lifang Xue, Xin Geng, Zhijun Kong, Xinrui Wang, Lu Wang, Qingxian Yang, Xiangfeng Wang, Yun Deng, Xingping Zhang, Li Guo

High-fidelity long-read sequencing of an avian herpesvirus reveals extensive intrapopulation diversity in tandem repeat regions

Alejandro Ortigas-Vasquez, Christopher D. Bowen, Daniel W. Renner, Susan J. Baigent, Yaoyao Zhang, Yongxiu Yao, Venugopal Nair, David A. Kennedy, Moriah L. Szpara

The Egh16-like virulence factor TrsA of the nematode-trapping fungus Arthrobotrys flagrans facilitates intrusion into its host Caenorhabditis elegans

Jennifer Emser, Lena Seidler, Elma Kovačević, Kaiwei Yu, Tim Rudolf, Elke Wohlmann, Reinhard Fischer

Schistosoma japonicum leishmanolysin SjLLPi1 facilitates the invasion of cercariae into the host skin

Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei, Zechao Xue, Tao Shen, Sha Zhou, Xiaojun Chen, Lei Xu, Yalin Li, Jifeng Zhu, Wei Hu, Chuan Su

Differential tropisms of old and new world hantaviruses influence virulence and developing host-directed antiviral candidates

Arjit Vijey Jeyachandran, Joseph Ignatius Irudayam, Swati Dubey, Nikhil Chakravarty, Maria Daskou, Anne Zaiss, Gustavo Garcia, Bindu Konda, Aayushi Shah, Aditi Venkatraman, Baolong Su, Cheng Wang, Qi Cui, Kevin J. Williams, Sonal Srikanth, Ashok Kumar, Yanhong Shi, Arjun Deb, Robert Damoiseaux, Barry R. Stripp, Arunachalam Ramaiah, Vaithilingaraja Arumugaswami

The multifaceted role of the viral 2A protease in enterovirus replication and antagonism of host antiviral responses

Jelle G. Schipper, Chiara Aloise, Sereina O. Sutter, Marleen Zwaagstra, Arno L.W. van Vliet, Rana Abdelnabi, Bob Ignacio, Kimberly M. Bonger, Dagmar Roelofs, Judith M.A. van den Brand, Richard W. Wubbolts, Lucas J.M. Bruurs, Hendrik Jan Thibaut, Johan Neyts, Marvin E. Tanenbaum, Frank J. M. van Kuppeveld

Newcastle disease virus promotes spreading infection through vimentin-dependent tight junction injury mediated by MLC/p-MLC activation

Xiaolong Lu, Qiwen Zhou, Mingzhu Wang, Meiqi Li, Wenhao Yang, Kaituo Liu, Ruyi Gao, Tianxing Liao, Yu Chen, Jiao Hu, Min Gu, Shunlin Hu, Xinan Jiao, Xiaoquan Wang, Xiufan Liu, Chan Ding, Xiaowen Liu

Corrections

Correction: Gene deletion as a possible strategy adopted by New World Leishmania infantum to maximize geographic dispersion

Monique Florêncio, Marne Coimbra Batalha Chagas, Anderson Guimarães-Costa, Jullyanna Oliveira, Ingrid Waclawiak, Thamara K. F. Oliveira, Elvira Maria Saraiva, Anita Leocadio Freitas-Mesquita, José Roberto Meyer-Fernandes, Laura Aragão-Farias, Camilly Enes Trindade, Patricia Cuervo, Renata Azevedo do Nascimento, Otacilio C. Moreira, Flávia Lima Ribeiro-Gomes, Yara M. Traub-Csekö, Erich Loza Telleria, Slavica Vaselek, Tereza Leštinová, Petr Volf, Gerald F. Späth, Elisa Cupolillo, Mariana Côrtes Boité

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Short Reports

The use of X-ray computed tomography for advanced detection of Globodera pallida

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