July 2025

A Streptomyces natural product, dealanylascamycin (DACM, yellow), inhibits a key Plasmodium enzyme by mimicking its natural substrate. It hijacks the enzymatic reaction, leading to the formation of a DACM-aspartic acid adduct that occupies the enzyme’s active site, thereby blocking protein synthesis. This novel mechanism represents a promising new strategy for antimalarial therapy. Ketprasit et al. 2025

Image Credit: Nutpakal Ketprasit, Leann Tilley, Stanley C. Xie

Opinions

The spread of highly pathogenic avian influenza virus is a social network problem

Jamie Dunning, Josh A. Firth, Alastair I. Ward

PLOS Pathogens: published July 7, 2025 | https://doi.org/10.1371/journal.ppat.1013233

SUMOylation: Interplaying with the plant disease triangle

Chi Li, Chengwei Yang, Jianbin Lai

PLOS Pathogens: published July 10, 2025 | https://doi.org/10.1371/journal.ppat.1013327

Myco-Ed: Mycological curriculum for education and discovery

Sara Branco, Peter G. Avis, Kerrie Barry, Scott Bates, Gerald M. Cobián, Ellen G. Dow, Sara Gremillion, Amy Honan, Chinyere A. Knight, Kurt LaButti, C. Alisha Quandt, Jane E. Stewart, Jayson Talag, Andrew W. Wilson, Lotus Lofgren, Stephen James Mondo

PLOS Pathogens: published July 18, 2025 | https://doi.org/10.1371/journal.ppat.1013303

Pearls

Through thick and thin: The vaginal microbiome as both occupant and healer

Mart Sillen, Sarah Lebeer, Patrick Van Dijck

PLOS Pathogens: published July 22, 2025 | https://doi.org/10.1371/journal.ppat.1013346

Reviews

Advances in understanding multifunctionality of Barley stripe mosaic virus γb protein

Zhihao Jiang, Meng Yang, Dawei Li

PLOS Pathogens: published July 2, 2025 | https://doi.org/10.1371/journal.ppat.1013299

The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection?

Lei Na, Yang Zheng, Jian-Bo Yang, Hao-Lin Bao, Yan-Dong Tang

PLOS Pathogens: published July 7, 2025 | https://doi.org/10.1371/journal.ppat.1013285

Pelota: A double-edged sword in virus infection

Xue Li, Xueping Zhou, Fangfang Li

PLOS Pathogens: published July 10, 2025 | https://doi.org/10.1371/journal.ppat.1013328

Lactylation and viral infections: A novel link between metabolic reprogramming and immune regulation

Shanshan Chen, Tongxue Qin, Shengrui Luo, Fengyi Wang, Feirong Chen, Hailun Wei, Yuting Wu, Rongfeng Chen, Wudi Wei, Jingzhen Lai, Hao Liang, Li Ye, Zongxiang Yuan, Junjun Jiang

PLOS Pathogens: published July 28, 2025 | https://doi.org/10.1371/journal.ppat.1013366

Convergent mechanisms of epithelial cell structure manipulation by intestinal pathogens

Elena Rodrigues, N. Bishara Marzook, Mitchell A. Pallett, Adam Sateriale

PLOS Pathogens: published July 31, 2025 | https://doi.org/10.1371/journal.ppat.1013367

Is “pre-sepsis” the new sepsis? A narrative review

Rémy Gerard, Antoine Dewitte, Fridolin Gross, Thomas Pradeu, Maël Lemoine, Julien Goret, Maria Mamani-Matsuda

PLOS Pathogens: published July 31, 2025 | https://doi.org/10.1371/journal.ppat.1013372

Research Articles

Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists

Melissa D. Chengalroyen, Nurudeen Oketade, Aneta Worley, Megan Lucas, Luisa Maria Nieto Ramirez, Mabule L. Raphela, Gwendolyn M. Swarbrick, Paul S. Soma, Mandisa Zuma, Digby F. Warner, Deborah A. Lewinsohn, Carolina Mehaffy, Erin J. Adams, William Hildebrand, Karen M. Dobos, Valerie Mizrahi, David M. Lewinsohn

PLOS Pathogens: published July 1, 2025 | https://doi.org/10.1371/journal.ppat.1012632

Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells

Rita Berkachy, Vishwas Mishra, Priyanka Biswas, Gad Frankel

PLOS Pathogens: published July 1, 2025 | https://doi.org/10.1371/journal.ppat.1013276

Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection

Lonneke V. Nouwen, Esther A. Zaal, Inge Buitendijk, Marleen Zwaagstra, Chiara Aloise, Arno L. W. van Vliet, Jelle G. Schipper, Alain van Mil, Celia R. Berkers, Frank J. M. van Kuppeveld

PLOS Pathogens: published July 3, 2025 | https://doi.org/10.1371/journal.ppat.1013293

Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages

María Pía Alberione, Yunuen Avalos-Padilla, Gabriel W. Rangel, Miriam Ramírez, Tais Romero-Uruñuela, Àngel Fenollar, Jonathan Ortega-Barrionuevo, Marcell Crispim, Terry K. Smith, Manuel Llinás, Luis Izquierdo

PLOS Pathogens: published July 3, 2025 | https://doi.org/10.1371/journal.ppat.1012832

The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex

Pan-Pan Liu, Shu-Peng Jiang, Bang Li, Wen-Tao Gui, Xiang-Rong Qin, Xue-Jie Yu

PLOS Pathogens: published July 3, 2025 | https://doi.org/10.1371/journal.ppat.1013258

Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria

Alicer K. Andrew, Tara C. Bracken, Nicole Nazario-Maldonado, Brittany N. Russ, Kathyrn T. Gonzalvo, Benjamin M. Brainard, Nigel Mackman, Julie M. Moore

PLOS Pathogens: published July 3, 2025 | https://doi.org/10.1371/journal.ppat.1013259

TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae

George-Rafael Samantsidis, Hyeogsun Kwon, Megan Wendland, Catherine Fonder, Ryan C. Smith

PLOS Pathogens: published July 3, 2025 | https://doi.org/10.1371/journal.ppat.1013329

Bacterial and host enzymes modulate the pro-inflammatory response elicited by the peptidoglycan of Lyme disease agent Borrelia burgdorferi

Joshua W. McCausland, Zachary A. Kloos, Irnov Irnov, Nicole D. Sonnert, Junhui Zhou, Rachel Putnik, Elizabeth A. Mueller, Allen C. Steere, Noah W. Palm, Catherine L. Grimes, Christine Jacobs-Wagner

PLOS Pathogens: published July 7, 2025 | https://doi.org/10.1371/journal.ppat.1013324

Proximity labelling of internalizing influenza A viruses reveals a role for neogenin in virus uptake

Milagros Sempere Borau, Victor G. Gisbert, Josephine von Kempis, Laura M. Arroyo-Fernández, Samira Schiefer, David Alsteens, Silke Stertz

PLOS Pathogens: published July 7, 2025 | https://doi.org/10.1371/journal.ppat.1013338

Yersinia pseudotuberculosis growth arrest during type-III secretion system expression is associated with altered ribosomal protein expression and decreased gentamicin susceptibility

Justin Greene, Katherine L. Cotten, Rhett A. Snyder, Ryan C. Huiszoon, Sangwook Chu, Rezia Era D. Braza, Ashley A. Chapin, Justin M. Stine, William E. Bentley, Reza Ghodssi, Kimberly M. Davis

PLOS Pathogens: published July 7, 2025 | https://doi.org/10.1371/journal.ppat.1012548

Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite Plasmodium berghei

Yonghui Feng, Wenyan Gao, Chengqi Wang, Shuangrui Shi, Dan Zhou, Lin Sun, Liying Zhu, Liwang Cui, Yaming Cao, Xiaotong Zhu

PLOS Pathogens: published July 7, 2025 | https://doi.org/10.1371/journal.ppat.1013318

RNF213 regulates blood‒brain barrier integrity by targeting TRAF3 for type I interferon activation during A. baumannii infection

Yanfeng Li, Qingqing Xie, Luyu Yang, Qian Jiang, Zhiping Liu, Chengjiang Gao, Xiaopeng Qi, Tao Xu

PLOS Pathogens: published July 7, 2025 | https://doi.org/10.1371/journal.ppat.1013333

Integrative glycomic analysis reveals the crucial role of protein glycosylation in fungal pathogenesis

Heeji Moon, Eun Jung Thak, Yejin Choi, Sieun Kim, Jiyeun Park, Nahyun Lee, Soobin Shin, Hosung Jeon, Jessica Winarto, Soyoung Choi, Ji Young Shin, Jung-Eun Kim, Dae-Geun Song, Hun Kim, Gyung Ja Choi, Hyun Ah Kang, Hokyoung Son

PLOS Pathogens: published July 7, 2025 | https://doi.org/10.1371/journal.ppat.1013325

Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target

Nutpakal Ketprasit, Chia-Wei Tai, Vivek Kumar Sharma, Yogavel Manickam, Yogesh Khandokar, Xi Ye, Con Dogovski, David H. Hilko, Craig J. Morton, Anne-Sophie C. Braun, Michael G. Leeming, Bagale Siddharam, Gerald J. Shami, Pushpangadan Indira Pradeepkumar, Santosh Panjikar, Sally-Ann Poulsen, Michael D. W. Griffin, Amit Sharma, Leann Tilley, Stanley C. Xie

PLOS Pathogens: published July 8, 2025 | https://doi.org/10.1371/journal.ppat.1013057

Baculovirus enhances arginine uptake and induces mitochondrial autophagy to promote viral proliferation

Shigang Fei, Junming Xia, Yigui Huang, Minyang Zhou, Biying Xie, Yibing Kong, Luc Swevers, Jingchen Sun, Min Feng

PLOS Pathogens: published July 8, 2025 | https://doi.org/10.1371/journal.ppat.1013331

Essential role for PfHSP40 in asexual replication and thermotolerance of malaria parasites

Brianne Roper, Deepika Kannan, Emily S. Mathews, Audrey R. Odom John

PLOS Pathogens: published July 8, 2025 | https://doi.org/10.1371/journal.ppat.1013313

Biochemical and structural characterization of the human gut microbiome metallopeptidase IgAse provides insight into its unique specificity for the F_ab’ region of IgA1 and IgA2

Juan Sebastián Ramírez-Larrota, Pauline Juyoux, Pablo Guerra, Ulrich Eckhard, F. Xavier Gomis-Rüth

PLOS Pathogens: published July 8, 2025 | https://doi.org/10.1371/journal.ppat.1013292

In vitro HIV DNA integration in STAT3 drives T cell persistence—A model of HIV-associated T cell lymphoma

Michael Rist, Machika Kaku, John M. Coffin

PLOS Pathogens: published July 8, 2025 | https://doi.org/10.1371/journal.ppat.1013087

Secreted ISG15 induced by Chlamydia trachomatis infection exerts immunomodulatory effects on IFN-γ defense and inflammation

Yongxia Guo, Sigrun V. Stulz, David Komla Kessie, Nadine Vollmuth, Tommaso Torcellan, Klaus-Peter Knobeloch, Georg Gasteiger, Thomas Rudel

PLOS Pathogens: published July 8, 2025 | https://doi.org/10.1371/journal.ppat.1013315

Interleukin-17A signaling promotes CD8⁺ T cell cytotoxicity against West Nile virus infection through enhancing PI3K-mTOR-mediated metabolism

Farzana Nazneen, Biswas Neupane, Yao Chen, Shazeed-Ul Karim, Zongbing You, Weiguo Cui, Fengwei Bai

PLOS Pathogens: published July 9, 2025 | https://doi.org/10.1371/journal.ppat.1013218

Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition

Chu Xie, Xin-Yan Fang, Yuan-Tao Liu, Xian-Shu Tian, Lan-Yi Zhong, Pei-Huang Wu, Hang Zhou, Peng-Lin Li, Yan-Lin Yang, Zi-Ying Jiang, Sen-Fang Sui, Zheng Liu, Mu-Sheng Zeng, Cong Sun

PLOS Pathogens: published July 9, 2025 | https://doi.org/10.1371/journal.ppat.1013300

Polyclonal B cells acquire LCMV antigens in a GP1-dependent manner

Gabriel Chamberlain, Guillaume L. Lopez, Léa Bourguignon, Xavier Laulhé, Yasmine Adda-Bouchard, Tania Charpentier, Rebekah Honce, Jason W. Botten, Alain Lamarre

PLOS Pathogens: published July 9, 2025 | https://doi.org/10.1371/journal.ppat.1013345

HIV-1 Vpr orchestrates ciTRAN upregulation through TGF-β induction

Aditi Choudhary, Katyayani Mallick, Rishikesh Dalavi, Ajit Chande

PLOS Pathogens: published July 9, 2025 | https://doi.org/10.1371/journal.ppat.1013332

Host environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics

Frédéric Fercoq, Clément Cormerais, Estelle Remion, Joséphine Gal, Julien Plisson, Arame Fall, Joy Alonso, Nathaly Lhermitte-Vallarino, Marc P. Hübner, Linda Kohl, Frédéric Landmann, Coralie Martin

PLOS Pathogens: published July 11, 2025 | https://doi.org/10.1371/journal.ppat.1013301

Role of individual and population heterogeneity in shaping dynamics of multi-pathogen shedding in an island endemic bat

Samantha Aguillon, Magali Turpin, Gildas Le Minter, Camille Lebarbenchon, Axel O. G. Hoarau, Céline Toty, Avril Duchet, Léa Joffrin, Riana V. Ramanantsalama, Pablo Tortosa, Patrick Mavingui, Muriel Dietrich

PLOS Pathogens: published July 11, 2025 | https://doi.org/10.1371/journal.ppat.1013334

Spatio-genetically coordinated TPR domain-containing proteins modulate c-di-GMP signaling in Vibrio vulnificus

Shobnom Mustaree, Ram Podicheti, Doug Rusch, Dean A. Rowe-Magnus

PLOS Pathogens: published July 16, 2025 | https://doi.org/10.1371/journal.ppat.1013353

SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation

Sisi Xia, Xiaoping Huo, Nanfang Liu, Xinyu Liu, Tianyou Wang, Muyi Guo, Chi Zeng, Pin Wan, Jun Chen

PLOS Pathogens: published July 16, 2025 | https://doi.org/10.1371/journal.ppat.1013344

The African swine fever virus p22 inhibits the JAK-STAT signaling pathway by promoting the TAX1BP1-mediated degradation of the type I interferon receptor

Haojie Ren, Yanjin Wang, Lian-Feng Li, Lan-Fang Shi, Yu-He Ma, Jun-Hao Fan, Xiao-Ya Pan, Han-Cheng Shao, Yuhang Zhang, Shichong Han, Bo Wan, Hua-Ji Qiu, Gai-Ping Zhang, Su Li, Wen-Rui He

PLOS Pathogens: published July 16, 2025 | https://doi.org/10.1371/journal.ppat.1013319

Profiling miRNA changes in Epstein-Barr virus lytic infection identifies a function for BZLF1 in upregulating miRNAs from the DLK1-DIO3 locus

Ashley M. Campbell, Victoria C. Taylor, Beata Cohan, Lori Frappier

PLOS Pathogens: published July 17, 2025 | https://doi.org/10.1371/journal.ppat.1013347

Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism

Ravi K. Dinesh, Chengkun Wang, Yuanhao Qu, Arjun Rustagi, Henry Cousins, James Zengel, Xiaotong Wang, Trisha R. Barnard, William A. Johnson, Guangxue Xu, Tianyi Zhang, Nicholas Magazine, Aimee Beck, Lucas Miecho Heilbroner, Grace Peters-Schulze, Aaron J. Wilk, Mengdi Wang, Weishan Huang, Brooke E. Howitt, Jan Carette, Russ Altman, Catherine A. Blish, Le Cong

PLOS Pathogens: published July 17, 2025 | https://doi.org/10.1371/journal.ppat.1013157

A second-generation molecular clamp stabilised bivalent candidate vaccine for protection against diseases caused by respiratory syncytial virus and human metapneumovirus

Andrew Young, Sharada Kolekar, Carlos Alvarez Mendoza, Noushin Jaberolansar, Naphak Modhiran, Tim Webb, Robert McCuaig, Varsha Kommajosyula, Nicolas Tardiota, Quimbe Dy, Alberto A. Amarilla, Rhiannon L. Dalrymple, Marianne Gillard, Julie L. Dutton, Juana Magdalena, Frank Vandendriessche, Jean Smal, Paul R. Young, Daniel Watterson, Emmanuel J. Hanon, Keith J. Chappell

PLOS Pathogens: published July 17, 2025 | https://doi.org/10.1371/journal.ppat.1013312

Functional characterization of DPP4 and FcRn as receptor and coreceptor for classical human astroviruses in Caco-2 cells

Catalina Aguilera-Flores, María del Pilar Valencia-Morales, Tomás López, Joaquín Moreno-Contreras, Adam Lentz, Marco A. Espinoza, Rebecca M. DuBois, Susana López, Carlos F. Arias

PLOS Pathogens: published July 18, 2025 | https://doi.org/10.1371/journal.ppat.1013316

Mechanisms of AAV neutralization by human alpha-defensins

Jessica M. Porter, Kaitlin R. Hulce, Mackenzi S. Oswald, Kevin Busuttil, Shanan N. Emmanuel, Antonette Bennett, Robert McKenna, Jason G. Smith

PLOS Pathogens: published July 18, 2025 | https://doi.org/10.1371/journal.ppat.1013283

The conserved transcription factor PrlP modulates colonization and pathogenicity of Streptococcus suis in response to environmental stress

Yuhua Wang, Ran Liu, Weihua Lv, Kunlong Xia, Xi Lu, Xinyu Gao, Shulin Miao, Anding Zhang

PLOS Pathogens: published July 18, 2025 | https://doi.org/10.1371/journal.ppat.1013314

Hantaan virus-derived peptides that stabilize HLA-E could abrogate inhibition of CD56^dimNKG2A⁺ NK cells

Manling Xue, Kang Tang, Yusi Zhang, Xiaoyue Xu, Chunmei Zhang, Jiajia Zuo, Fenglan Wang, Xiyue Zhang, Xuyang Zheng, Ran Zhuang, Yun Zhang, Boquan Jin, Ying Ma

PLOS Pathogens: published July 18, 2025 | https://doi.org/10.1371/journal.ppat.1012717

A highly potent human antibody neutralizing all serotypes of BK polyomavirus

Marcel Weber, Simone Schmitt, Barbara Eicher, Jemima Seidenberg, Justina Rutkauskaite, Benedikt Stöckli, Catherine Townsend, Uyen Huynh-Do, Thomas Schachtner, Serena Delbue, Armin Mäder, Christoph Esslinger, Matthias Hillenbrand

PLOS Pathogens: published July 18, 2025 | https://doi.org/10.1371/journal.ppat.1013122

Early-life RSV infection modulates innate immune events, preferentially enhancing allergen-induced type 2 lung inflammation in females

Lydia Labrie, Rojine C. McVea, Rami Karkout, Haya Aldossary, Véronique Gaudreault, Brian J. Ward, Elizabeth D. Fixman

PLOS Pathogens: published July 21, 2025 | https://doi.org/10.1371/journal.ppat.1013340

Oligomerization of the Clostridioides difficile transferase B component proceeds through a stepwise mechanism

Robin M. Mullard, Michael J. Sheedlo

PLOS Pathogens: published July 21, 2025 | https://doi.org/10.1371/journal.ppat.1013186

Specific binding of human P[28] rotavirus VP8* protein to blood group ABH antigens on type 1 chains

Yi Zheng, Xiaoman Sun, Yuting Li, Beibei Huang, Yang Chen, Han Zhou, Cuiyan Cao, Wengang Chai, Zhaojun Duan, Dandi Li, Jingyu Yan, Xinmiao Liang

PLOS Pathogens: published July 21, 2025 | https://doi.org/10.1371/journal.ppat.1013298

A chaperonin complex regulates organelle proteostasis in malaria parasites

Amanda Tissawak, Yarden Rosin, Shirly Katz Galay, Alia Qasem, Michal Shahar, Nirit Trabelsi, Ora Furman-Schueler, Steven M. Johnson, Anat Florentin

PLOS Pathogens: published July 22, 2025 | https://doi.org/10.1371/journal.ppat.1013275

Lumpy skin disease virus 001/156 protein is a virulence factor that suppresses interferon production through impairing IRF3 dimerization

Minmin Zhang, Yujie Shi, Xinyin Lu, Qiwei Zhang, Yubo Zhao, Shaohan Li, Zhiyuan Wen, Jinying Ge, Xijun Wang, Jie Li, Zhigao Bu, Xin Yin

PLOS Pathogens: published July 23, 2025 | https://doi.org/10.1371/journal.ppat.1013362

A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: Unveiling a novel virulence factor

Jeremy D. Volkening, Stephen J. Spatz, Maricarmen Garcia, Teresa A. Ross, Daniel A. Maekawa, Kenneth S. Rosenthal, Ana C. Zamora, April Skipper, Julia R. Blakey, Rashan Paudel

PLOS Pathogens: published July 23, 2025 | https://doi.org/10.1371/journal.ppat.1013219

Redefining the spliceosomal introns of the sexually transmitted parasite Trichomonas vaginalis and its close relative in columbid birds

Francisco Callejas-Hernández, Mari Shiratori, Steven A. Sullivan, Frances Blow, Jane M. Carlton

PLOS Pathogens: published July 23, 2025 | https://doi.org/10.1371/journal.ppat.1013282

BBK32 attenuates antibody-dependent complement-mediated killing of infectious Borreliella burgdorferi isolates

Alexandra D. Powell-Pierce, Charles E. Booth, Jr., Payton G. Smith, Brittany L. Shapiro, Shannon S. Allen, Brandon L. Garcia, Jon T. Skare

PLOS Pathogens: published July 24, 2025 | https://doi.org/10.1371/journal.ppat.1013361

Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates

Kristin A. Sauter, Gabriela M. Webb, Lindsay Bader, Craig N. Kreklywich, Diana L. Takahashi, Cicely Zaro, Casey M. McGuire, Anne D. Lewis, Lois M. A. Colgin, Melissa A. Kirigiti, Hannah Blomenkamp, Cleiton Pessoa, Matthew Humkey, Jesse Hulahan, Madeleine Sleeman, Robert C. Zweig, Sarah Thomas, Archana Thomas, Lina Gao, Alec J. Hirsch, Maayan Levy, Sara Cherry, Steven E. Kahn, Mark K. Slifka, Daniel N. Streblow, Jonah B. Sacha, Paul Kievit, Charles T. Roberts

PLOS Pathogens: published July 24, 2025 | https://doi.org/10.1371/journal.ppat.1012988

Identification of the human cytomegalovirus gHgLgO trimer as the central player in virion infectivity

Lena Thiessen, Roberto Garuti, Lucie Kubic, Miwako Kösters, Divya Amarambedu Selvakumar, Thomas Krey, Irene Görzer, Thomas Fröhlich, Barbara Adler

PLOS Pathogens: published July 24, 2025 | https://doi.org/10.1371/journal.ppat.1013341

Characterisation of guided entry of tail-anchored proteins in Magnaporthe oryzae

Felix Abah, Qiaojia Zheng, Xinru Chen, Linwan Huang, Xiaomin Chen, Jules Biregeya, Osakina Aron, Zonghua Wang, Wei Tang

PLOS Pathogens: published July 28, 2025 | https://doi.org/10.1371/journal.ppat.1013011

Splicing-dependent restriction of the HBZ gene by Tax underlies biphasic HTLV-1 infection

Yi Liang, Chenyang Lyu, Shuwen Xu, Chenxin Tan, Qian Jiang, Benquan Liu, Sikai Yang, Weijia Huang, Ruoning Zhou, Xiaoyi Yuan, Xiaorui Zuo, Masao Matsuoka, Guangyong Ma

PLOS Pathogens: published July 28, 2025 | https://doi.org/10.1371/journal.ppat.1013381

The plasmepsin-piperaquine paradox persists in Plasmodium falciparum

Breanna Walsh, Robert L. Summers, Gabriel W. Rangel, Laura M. Hagenah, Sachel Mok, Manuel Llinás, David A. Fidock, Dyann F. Wirth, Selina Bopp

PLOS Pathogens: published July 28, 2025 | https://doi.org/10.1371/journal.ppat.1012779

Targeting translation initiation yields fast-killing therapeutics against the zoonotic parasite Cryptosporidium parvum

Meng Li, Jigang Yin, Dongqiang Wang, Beibei Zou, Guan Zhu

PLOS Pathogens: published July 28, 2025 | https://doi.org/10.1371/journal.ppat.1012881

Heterogeneous impacts for malaria control from larviciding across villages and considerations for monitoring and evaluation

Ellie Sherrard-Smith, Ulrike Fillinger, Jean-Philippe B. Tia, Peter Winskill, Benjamin G. Koudou, Emile S. F. Tchicaya, Antoine Sanou, Fredros Okumu, Mercy Opiyo, Silas Majambere, Arran Hamlet, Giovanni Charles, Ben Lambert, Thomas S. Churcher

PLOS Pathogens: published July 28, 2025 | https://doi.org/10.1371/journal.ppat.1013287

The calcineurin pathway regulates extreme thermotolerance, cell membrane and wall integrity, antifungal resistance, and virulence in Candida auris

Hyunjin Cha, Doyeon Won, Seun Kang, Eui-Seong Kim, Kyung-Ah Lee, Won-Jae Lee, Kyung-Tae Lee, Yong-Sun Bahn

PLOS Pathogens: published July 28, 2025 | https://doi.org/10.1371/journal.ppat.1013363

Recent thymic emigrants preferentially undergo memory inflation after persistent infection

Zachary T. Hilt, Arnold Reynaldi, Megan Steinhilber, Shide Zhang, Samantha P. Wesnak, Norah L. Smith, Miles P. Davenport, Brian D. Rudd

PLOS Pathogens: published July 28, 2025 | https://doi.org/10.1371/journal.ppat.1013382

Over-expression and increased copy numbers of a cytochrome P450 and two UDP-glucuronosyltransferase genes in macrocyclic lactone resistant Psoroptes ovis of cattle

Jack Hearn, Wouter van Mol, Roel Meyermans, Kathryn Bartley, Tyler Alioto, Jèssica Gómez-Garrido, Fernando Cruz, Francisco Câmara Ferreira, Marta Gut, Ivo G. Gut, Nadine Buys, Steven Janssens, Karyn Adams, Sara Roose, Thomas Van Leeuwen, Wannes Dermauw, John S. Gilleard, Russell W. Avramenko, Peter Geldhof, Edwin Claerebout, Stewart T. G. Burgess

PLOS Pathogens: published July 29, 2025 | https://doi.org/10.1371/journal.ppat.1012963

VapC toxins promote the pathogenesis of Rickettsia heilongjiangensis by cleaving essential RNAs from both Rickettsia and its host

Yan Liu, Weiting Zhou, Jiaying Zhao, Qingyin Shi, Yu Xin, Xuan Ouyang, Yonghui Yu, Jun Jiao, Maozhang He, Yajun Song, Kehan Xu

PLOS Pathogens: published July 30, 2025 | https://doi.org/10.1371/journal.ppat.1013380

A non-classical PUF family protein in oomycetes functions as a pre-rRNA processing regulator and a target for RNAi-based disease control

Hui Feng, Tianli Liu, Chuanxu Wan, Zhichao Zhang, Yuanchao Wang, Xiaobo Zheng, Jie Wang, Wenwu Ye

PLOS Pathogens: published July 31, 2025 | https://doi.org/10.1371/journal.ppat.1013379

Correction

Correction: Brucella modulates secretory trafficking via multiple Type IV secretion effector proteins

Sebenzile Myeni, Robert Child, Tony W. Ng, John J. Kupko III, Tara D. Wehrly, Stephen F. Porcella, Leigh A. Knodler, Jean Celli

PLOS Pathogens: published July 10, 2025 | https://doi.org/10.1371/journal.ppat.1013302

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Hijacking Plasmodium AspRS to halt protein synthesis

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**Hijacking Plasmodium AspRS to halt protein synthesis**