Decoding mechanisms of diarrhea induction by enteric viruses

Gaopeng Hou, Siyuan Ding

PLOS Pathogens: published August 8, 2024 | https://doi.org/10.1371/journal.ppat.1012414

Data alchemy, from lab to insight: Transforming in vivo experiments into data science gold

Troy J. Kieran, Taronna R. Maines, Jessica A. Belser

PLOS Pathogens: published August 29, 2024 | https://doi.org/10.1371/journal.ppat.1012460

Exploring viral neuropathic pain: Molecular mechanisms and therapeutic implications

Songchao Xu, Huili Li, Zhangran Ai, Ruijuan Guo, Hao Cheng, Yun Wang

PLOS Pathogens: published August 8, 2024 | https://doi.org/10.1371/journal.ppat.1012397

Gut mycobiome alterations and implications for liver diseases

Suling Zeng, Bernd Schnabl

PLOS Pathogens: published August 8, 2024 | https://doi.org/10.1371/journal.ppat.1012377

Biomolecular condensates as stress sensors and modulators of bacterial signaling

Moeka Sasazawa, Dylan T. Tomares, W. Seth Childers, Saumya Saurabh

PLOS Pathogens: published August 15, 2024 | https://doi.org/10.1371/journal.ppat.1012413

The skin I live in: Pathogenesis of white-nose syndrome of bats

Marcos Isidoro-Ayza, Jeffrey M. Lorch, Bruce S. Klein

PLOS Pathogens: published August 29, 2024 | https://doi.org/10.1371/journal.ppat.1012342

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection

Jillian E. Milanes, Victoria C. Yan, Cong-Dat Pham, Florian Muller, Samuel Kwain, Kerrick C. Rees, Brian N. Dominy, Daniel C. Whitehead, Steven W. Millward, Madison Bolejack, Roger Shek, Logan Tillery, Isabelle Q. Phan, Bart Staker, E. Ashley Moseman, Xiang Zhang, Xipeng Ma, Audriy Jebet, Xinmin Yin, James C. Morris

PLOS Pathogens: published August 1, 2024 | https://doi.org/10.1371/journal.ppat.1012412

Genes required for phosphosphingolipid formation in Caulobacter crescentus contribute to bacterial virulence

Roberto Jhonatan Olea-Ozuna, Sebastian Poggio, Ed Bergström, Aurora Osorio, Temidayo Oluyomi Elufisan, Jonathan Padilla-Gómez, Lourdes Martínez-Aguilar, Isabel M. López-Lara, Jane Thomas-Oates, Otto Geiger

PLOS Pathogens: published August 2, 2024 | https://doi.org/10.1371/journal.ppat.1012401

The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2

Jamie Guenthoer, Meghan E. Garrett, Michelle Lilly, Delphine M. Depierreux, Felicitas Ruiz, Margaret Chi, Caitlin I. Stoddard, Vrasha Chohan, Zak A. Yaffe, Kevin Sung, Duncan Ralph, Helen Y. Chu, Frederick A. Matsen IV, Julie Overbaugh

PLOS Pathogens: published August 2, 2024 | https://doi.org/10.1371/journal.ppat.1012383

Single-cell analysis of VACV infection reveals pathogen-driven timing of early and late phases and host-limited dynamics of virus production

Liam Michael Howell, Nicholas Peter Gracie, Timothy Peter Newsome

PLOS Pathogens: published August 2, 2024 | https://doi.org/10.1371/journal.ppat.1012423

Within-plant genetic drift to control virus adaptation to host resistance genes

Lucie Tamisier, Frédéric Fabre, Marion Szadkowski, Lola Chateau, Ghislaine Nemouchi, Grégory Girardot, Pauline Millot, Alain Palloix, Benoît Moury

PLOS Pathogens: published August 5, 2024 | https://doi.org/10.1371/journal.ppat.1012424

Transinfection of Wolbachia wAlbB into Culex quinquefasciatus mosquitoes does not alter vector competence for Hawaiian avian malaria (Plasmodium relictum GRW4)

A. Marm Kilpatrick, Christa M. Seidl, Isaiah J. Ipsaro, Chris E. Garrison, Giulia Fabbri, Paul I. Howell, Austin G. McGowan, Bradley J. White, Sara N. Mitchell

PLOS Pathogens: published August 5, 2024 | https://doi.org/10.1371/journal.ppat.1012052

In vitro reconstitution reveals membrane clustering and RNA recruitment by the enteroviral AAA+ ATPase 2C

Kasturika Shankar, Marie N. Sorin, Himanshu Sharma, Oskar Skoglund, Selma Dahmane, Josy ter Beek, Solomon Tesfalidet, Louise Nenzén, Lars-Anders Carlson

PLOS Pathogens: published August 5, 2024 | https://doi.org/10.1371/journal.ppat.1012388

EGFR-MEK1/2 cascade negatively regulates bactericidal function of bone marrow macrophages in mice with Staphylococcus aureus osteomyelitis

Mingchao Jin, Xiaohu Wu, Jin Hu, Yijie Chen, Bingsheng Yang, Chubin Cheng, Mankai Yang, Xianrong Zhang

PLOS Pathogens: published August 5, 2024 | https://doi.org/10.1371/journal.ppat.1012437

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

Huilong Li, Luming Wan, Muyi Liu, Enhao Ma, Linfei Huang, Yilong Yang, Qihong Li, Yi Fang, Jingfei Li, Bingqing Han, Chang Zhang, Lijuan Sun, Xufeng Hou, Haiyang Li, Mingyu Sun, Sichong Qian, Xuejing Duan, Ruzhou Zhao, Xiaopan Yang, Yi Chen, Shipo Wu, Xuhui Zhang, Yanhong Zhang, Gong Cheng, Gengye Chen, Qi Gao, Junjie Xu, Lihua Hou, Congwen Wei, Hui Zhong

PLOS Pathogens: published August 5, 2024 | https://doi.org/10.1371/journal.ppat.1012291

In vivo multiscale analyses of spring viremia of carp virus (SVCV) infection: From model organism to target species

Sandra Souto, Raquel Lama, Emilie Mérour, Manon Mehraz, Julie Bernard, Annie Lamoureux, Sarah Massaad, Maxence Frétaud, Dimitri Rigaudeau, Jean K. Millet, Christelle Langevin, Stéphane Biacchesi

PLOS Pathogens: published August 5, 2024 | https://doi.org/10.1371/journal.ppat.1012328

Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses

Shivam. K. Purohit, Lauren Stern, Alexandra J. Corbett, Jeffrey Y. W. Mak, David P. Fairlie, Barry Slobedman, Allison Abendroth

PLOS Pathogens: published August 7, 2024 | https://doi.org/10.1371/journal.ppat.1012372

Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling

Denise Ohnezeit, Jiabin Huang, Ute Westerkamp, Veronika Brinschwitz, Claudia Schmidt, Thomas Günther, Manja Czech-Sioli, Samira Weißelberg, Tabea Schlemeyer, Jacqueline Nakel, Julia Mai, Sabrina Schreiner, Carola Schneider, Caroline C. Friedel, Hella Schwanke, Melanie M. Brinkmann, Adam Grundhoff, Nicole Fischer

PLOS Pathogens: published August 7, 2024 | https://doi.org/10.1371/journal.ppat.1012426

Evaluation of a novel intramuscular prime/intranasal boost vaccination strategy against influenza in the pig model

Robin Avanthay, Obdulio Garcia-Nicolas, Nicolas Ruggli, Llorenç Grau-Roma, Ester Párraga-Ros, Artur Summerfield, Gert Zimmer

PLOS Pathogens: published August 8, 2024 | https://doi.org/10.1371/journal.ppat.1012393

Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen

Nadia Neuner-Jehle, Marius Zeeb, Christian W. Thorball, Jacques Fellay, Karin J. Metzner, Paul Frischknecht, Kathrin Neumann, Christine Leeman, Andri Rauch, Marcel Stöckle, Michael Huber, Matthieu Perreau, Enos Bernasconi, Julia Notter, Matthias Hoffmann, Karoline Leuzinger, Huldrych F. Günthard, Chloé Pasin, Roger D. Kouyos, the Swiss HIV Cohort Study (SHCS)

PLOS Pathogens: published August 8, 2024 | https://doi.org/10.1371/journal.ppat.1012385

HIV transcription persists in the brain of virally suppressed people with HIV

Janna Jamal Eddine, Thomas A. Angelovich, Jingling Zhou, Sarah J. Byrnes, Carolin Tumpach, Nadia Saraya, Emily Chalmers, Rory A. Shepherd, Abigail Tan, Stephanie Marinis, Paul R. Gorry, Jacob D. Estes, Bruce J. Brew, Sharon R. Lewin, Sushama Telwatte, Michael Roche, Melissa J. Churchill

PLOS Pathogens: published August 8, 2024 | https://doi.org/10.1371/journal.ppat.1012446

Genomic and functional determinants of host spectrum in Group B Streptococcus

Chiara Crestani, Taya L. Forde, John Bell, Samantha J. Lycett, Laura M. A. Oliveira, Tatiana C. A. Pinto, Claudia G. Cobo-Ángel, Alejandro Ceballos-Márquez, Nguyen N. Phuoc, Wanna Sirimanapong, Swaine L. Chen, Dorota Jamrozy, Stephen D. Bentley, Michael Fontaine, Ruth N. Zadoks

PLOS Pathogens: published August 12, 2024 | https://doi.org/10.1371/journal.ppat.1012400

High sugar diets can increase susceptibility to bacterial infection in Drosophila melanogaster

Andrea M. Darby, Destiny O. Okoro, Sophia Aredas, Ashley M. Frank, William H. Pearson, Marc S. Dionne, Brian P. Lazzaro

PLOS Pathogens: published August 12, 2024 | https://doi.org/10.1371/journal.ppat.1012447

NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage

Harikrishnan Balachandran, Kyle Kroll, Karen Terry, Cordelia Manickam, Rhianna Jones, Griffin Woolley, Tammy Hayes, Amanda J. Martinot, Ankur Sharma, Mark Lewis, Stephanie Jost, R. Keith Reeves

PLOS Pathogens: published August 12, 2024 | https://doi.org/10.1371/journal.ppat.1012439

A small protein encoded by PCBP1-AS1 is identified as a key regulator of influenza virus replication via enhancing autophagy

Xiaojuan Chi, Guiying Huang, Liwei Wang, Xinge Zhang, Jiayin Liu, Zhihui Yin, Guijie Guo, Yuhai Chen, Song Wang, Ji-Long Chen

PLOS Pathogens: published August 13, 2024 | https://doi.org/10.1371/journal.ppat.1012461

Structure defining of ultrapotent neutralizing nanobodies against MERS-CoV with novel epitopes on receptor binding domain

Sen Ma, Doudou Zhang, Qiwei Wang, Linjing Zhu, Xilin Wu, Sheng Ye, Yaxin Wang

PLOS Pathogens: published August 14, 2024 | https://doi.org/10.1371/journal.ppat.1012438

Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons

Haozhe Wang, Kristian Barry, Aidil Zaini, Gillian Coakley, Mati Moyat, Carmel P. Daunt, Lakshanie C. Wickramasinghe, Rossana Azzoni, Roxanne Chatzis, Bibek Yumnam, Mali Camberis, Graham Le Gros, Olaf Perdijk, Jaime P. P. Foong, Joel C. Bornstein, Benjamin J. Marsland, Nicola L. Harris

PLOS Pathogens: published August 14, 2024 | https://doi.org/10.1371/journal.ppat.1011766

Vibrio splendidus infection promotes circRNA-FGL1-regulated coelomocyte apoptosis via competitive binding to Myc with the deubiquitinase OTUB1 in Apostichopus japonicus

Ming Guo, Xin Li, Wenjun Tao, Fei Teng, Chenghua Li

PLOS Pathogens: published August 15, 2024 | https://doi.org/10.1371/journal.ppat.1012463

Cytomegalovirus inhibitors of programmed cell death restrict antigen cross-presentation in the priming of antiviral CD8 T cells

Stefan Ebert, Verena Böhm, Julia K. Büttner, Wolfram Brune, Melanie M. Brinkmann, Rafaela Holtappels, Matthias J. Reddehase, Niels A. W. Lemmermann

PLOS Pathogens: published August 15, 2024 | https://doi.org/10.1371/journal.ppat.1012173

Importin-7-dependent nuclear translocation of the Flavivirus core protein is required for infectious virus production

Yumi Itoh, Yoichi Miyamoto, Makoto Tokunaga, Tatsuya Suzuki, Akira Takada, Akinori Ninomiya, Tomomi Hishinuma, Mami Matsuda, Yoshihiro Yoneda, Masahiro Oka, Ryosuke Suzuki, Yoshiharu Matsuura, Toru Okamoto

PLOS Pathogens: published August 15, 2024 | https://doi.org/10.1371/journal.ppat.1012409

Rapid adaptive evolution of avian leukosis virus subgroup J in response to biotechnologically induced host resistance

Magda Matoušková, Jiří Plachý, Dana Kučerová, Ľubomíra Pecnová, Markéta Reinišová, Josef Geryk, Vít Karafiát, Tomáš Hron, Jiří Hejnar

PLOS Pathogens: published August 15, 2024 | https://doi.org/10.1371/journal.ppat.1012468

Primary SARS-CoV-2 variant of concern infections elicit broad antibody Fc-mediated effector functions and memory B cell responses

Karlijn van der Straten, Denise Guerra, Gius Kerster, Mathieu Claireaux, Marloes Grobben, Angela I. Schriek, Anders Boyd, Jacqueline van Rijswijk, Khadija Tejjani, Dirk Eggink, Tim Beaumont, Steven W. de Taeye, Godelieve J. de Bree, Rogier W. Sanders, Marit J. van Gils

PLOS Pathogens: published August 15, 2024 | https://doi.org/10.1371/journal.ppat.1012453

Characterization of a CXCR4 antagonist TIQ-15 with dual tropic HIV entry inhibition properties

Zheng Zhou, Jia Guo, Brian Hetrick, Sameer Tiwari, Amrita Haikerwal, Yang Han, Vincent C. Bond, Ming B. Huang, Marie K. Mankowski, Beth A. Snyder, Priscilla A. Hogan, Savita K. Sharma, Dennis C. Liotta, Terry-Elinor Reid, Lawrence J. Wilson, Yuntao Wu

PLOS Pathogens: published August 15, 2024 | https://doi.org/10.1371/journal.ppat.1012448

Correlates of disease severity in bluetongue as a model of acute arbovirus infection

Vanessa Herder, Marco Caporale, Oscar A. MacLean, Davide Pintus, Xinyi Huang, Kyriaki Nomikou, Natasha Palmalux, Jenna Nichols, Rosario Scivoli, Chris Boutell, Aislynn Taggart, Jay Allan, Haris Malik, Georgios Ilia, Quan Gu, Gaetano Federico Ronchi, Wilhelm Furnon, Stephan Zientara, Emmanuel Bréard, Daniela Antonucci, Sara Capista, Daniele Giansante, Antonio Cocco, Maria Teresa Mercante, Mauro Di Ventura, Ana Da Silva Filipe, Giantonella Puggioni, Noemi Sevilla, Meredith E. Stewart, Ciriaco Ligios, Massimo Palmarini

PLOS Pathogens: published August 16, 2024 | https://doi.org/10.1371/journal.ppat.1012466

MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation

Aranzazu Arias-Rojas, Adini Q. Arifah, Georgia Angelidou, Belal Alshaar, Ursula Schombel, Emma Forest, Dagmar Frahm, Volker Brinkmann, Nicole Paczia, Chase L. Beisel, Nicolas Gisch, Igor Iatsenko

PLOS Pathogens: published August 19, 2024 | https://doi.org/10.1371/journal.ppat.1012462

RNase-mediated reprogramming of Yersinia virulence

Ines Meyer, Marcel Volk, Ileana Salto, Theresa Moesser, Paweena Chaoprasid, Anne-Sophie Herbrüggen, Manfred Rohde, Michael Beckstette, Ann Kathrin Heroven, Petra Dersch

PLOS Pathogens: published August 19, 2024 | https://doi.org/10.1371/journal.ppat.1011965

N⁶-methyladenosine RNA methyltransferase CpMTA1 mediates CpAphA mRNA stability through a YTHDF1-dependent m⁶A modification in the chestnut blight fungus

Lijiu Zhao, Xiangyu Wei, Fengyue Chen, Luying Yuan, Baoshan Chen, Ru Li

PLOS Pathogens: published August 19, 2024 | https://doi.org/10.1371/journal.ppat.1012476

The diadenosine tetraphosphate hydrolase ApaH contributes to Pseudomonas aeruginosa pathogenicity

Matteo Cervoni, Davide Sposato, Giulia Ferri, Heike Bähre, Livia Leoni, Giordano Rampioni, Paolo Visca, Antonio Recchiuti, Francesco Imperi

PLOS Pathogens: published August 19, 2024 | https://doi.org/10.1371/journal.ppat.1012486

Impact of alemtuzumab-mediated lymphocyte depletion on SIV reservoir establishment and persistence

Benjamin Varco-Merth, Morgan Chaunzwa, Derick M. Duell, Alejandra Marenco, William Goodwin, Rachel Dannay, Michael Nekorchuk, Danica Shao, Kathleen Busman-Sahay, Christine M. Fennessey, Lorna Silipino, Michael Hull, William J. Bosche, Randy Fast, Kelli Oswald, Rebecca Shoemaker, Rachele Bochart, Rhonda MacAllister, Caralyn S. Labriola, Jeremy V. Smedley, Michael K. Axthelm, Miles P. Davenport, Paul T. Edlefsen, Jacob D. Estes, Brandon F. Keele, Jeffrey D. Lifson, Sharon R. Lewin, Louis J. Picker, Afam A. Okoye

PLOS Pathogens: published August 22, 2024 | https://doi.org/10.1371/journal.ppat.1012496

Characterization of Entamoeba fatty acid elongases; validation as targets and provision of promising leads for new drugs against amebiasis

Fumika Mi-ichi, Hiroshi Tsugawa, Tam Kha Vo, Yuto Kurizaki, Hiroki Yoshida, Makoto Arita

PLOS Pathogens: published August 22, 2024 | https://doi.org/10.1371/journal.ppat.1012435

The assembly of neutrophil inflammasomes during COVID-19 is mediated by type I interferons

Luz E. Cabrera, Suvi T. Jokiranta, Sanna Mäki, Simo Miettinen, Ravi Kant, Lauri Kareinen, Tarja Sironen, Jukka-Pekka Pietilä, Anu Kantele, Eliisa Kekäläinen, Hanna Lindgren, Pirkko Mattila, Anja Kipar, Olli Vapalahti, Tomas Strandin

PLOS Pathogens: published August 22, 2024 | https://doi.org/10.1371/journal.ppat.1012368

Infection of human organoids supports an intestinal niche for Chlamydia trachomatis

Pargev Hovhannisyan, Kathrin Stelzner, Markus Keicher, Kerstin Paprotka, Mastura Neyazi, Mindaugas Pauzuolis, Waled Mohammed Ali, Karthika Rajeeve, Sina Bartfeld, Thomas Rudel

PLOS Pathogens: published August 22, 2024 | https://doi.org/10.1371/journal.ppat.1012144

Endogenous PGD₂ acting on DP2 receptor counter regulates Schistosoma mansoni infection-driven hepatic granulomatous fibrosis

Giovanna N. Pezzella-Ferreira, Camila R. R. Pão, Isaac Bellas, Tatiana Luna-Gomes, Valdirene S. Muniz, Ligia A. Paiva, Natalia R. T. Amorim, Claudio Canetti, Patricia T. Bozza, Bruno L. Diaz, Christianne Bandeira-Melo

PLOS Pathogens: published August 22, 2024 | https://doi.org/10.1371/journal.ppat.1011812

Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection

Mingli Gong, Cheng Peng, Chen Yang, Zhenhua Wang, Hongwu Qian, Xue Hu, Peng Zhou, Chao Shan, Qiang Ding

PLOS Pathogens: published August 22, 2024 | https://doi.org/10.1371/journal.ppat.1012444

Cell-intrinsic regulation of phagocyte function by interferon lambda during pulmonary viral, bacterial super-infection

Danielle Antos, Olivia B. Parks, Alexis M. Duray, Nevil Abraham, Joshua J. Michel, Saran Kupul, Rosemary Westcott, John F. Alcorn

PLOS Pathogens: published August 23, 2024 | https://doi.org/10.1371/journal.ppat.1012498

Fitness factor genes conserved within the multi-species core genome of Gram-negative Enterobacterales species contribute to bacteremia pathogenesis

Harry L. T. Mobley, Mark T. Anderson, Bridget S. Moricz, Geoffrey B. Severin, Caitlyn L. Holmes, Elizabeth N. Ottosen, Tad Eichler, Surbhi Gupta, Santosh Paudel, Ritam Sinha, Sophia Mason, Stephanie D. Himpsl, Aric N. Brown, Margaret Gaca, Christina M. Kiser, Thomas H. Clarke, Derrick E. Fouts, Victor J. DiRita, Michael A. Bachman

PLOS Pathogens: published August 23, 2024 | https://doi.org/10.1371/journal.ppat.1012495

HPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways

Conor W. Templeton, Laimonis A. Laimins

PLOS Pathogens: published August 23, 2024 | https://doi.org/10.1371/journal.ppat.1012454

Enhancing the therapeutic potential of P29 protein-targeted monoclonal antibodies in the management of alveolar echinococcosis through CDC-mediated mechanisms

Cuiying Zhang, Tao Li, Siyu Hou, Jing Tang, Rou Wen, Chan Wang, Shiqin Yuan, Zihua Li, Wei Zhao

PLOS Pathogens: published August 23, 2024 | https://doi.org/10.1371/journal.ppat.1012479

Permissive lung neutrophils facilitate tuberculosis immunopathogenesis in male phagocyte NADPH oxidase-deficient mice

Eunsol Choi, Hong-Hee Choi, Kee Woong Kwon, Hagyu Kim, Ji-Hwan Ryu, Jung Joo Hong, Sung Jae Shin

PLOS Pathogens: published August 23, 2024 | https://doi.org/10.1371/journal.ppat.1012500

Blockade of IKK signaling induces RIPK1-independent apoptosis in human macrophages

Neha M. Nataraj, Reyna Garcia Sillas, Beatrice I. Herrmann, Sunny Shin, Igor E. Brodsky

PLOS Pathogens: published August 26, 2024 | https://doi.org/10.1371/journal.ppat.1012469

C-ter100 peptide derived from Vibrio vEP-45 protease acts as a pathogen-associated molecular pattern to induce inflammation and innate immunity

Jung Eun Park, Ji-Hye Yun, Weontae Lee, Jung Sup Lee

PLOS Pathogens: published August 26, 2024 | https://doi.org/10.1371/journal.ppat.1012474

Genome-wide analysis of Brucella melitensis growth in spleen of infected mice allows rational selection of new vaccine candidates

Emeline Barbieux, Georges Potemberg, François-Xavier Stubbe, Audrey Fraikin, Katy Poncin, Angeline Reboul, Thomas Rouma, Amaia Zúñiga-Ripa, Xavier De Bolle, Eric Muraille

PLOS Pathogens: published August 26, 2024 | https://doi.org/10.1371/journal.ppat.1012459

S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration

Thiago A. Patente, Thomas A. Gasan, Maaike Scheenstra, Arifa Ozir-Fazalalikhan, Katja Obieglo, Sjoerd Schetters, Stijn Verwaerde, Karl Vergote, Frank Otto, Ruud H. P. Wilbers, Eline van Bloois, Yolanda van Wijck, Christian Taube, Hamida Hammad, Arjen Schots, Bart Everts, Maria Yazdanbakhsh, Bruno Guigas, Cornelis H. Hokke, Hermelijn H. Smits

PLOS Pathogens: published August 26, 2024 | https://doi.org/10.1371/journal.ppat.1012457

Multiple resistance factors collectively promote inoculum-dependent dynamic survival during antimicrobial peptide exposure in Enterobacter cloacae

Andrew N. Murtha, Misha I. Kazi, Eileen Y. Kim, Facundo V. Torres, Kelly M. Rosch, Tobias Dörr

PLOS Pathogens: published August 26, 2024 | https://doi.org/10.1371/journal.ppat.1012488

ORF48 is required for optimal lytic replication of Kaposi’s sarcoma-associated herpesvirus

Beatriz H. S. Veronese, Amy Nguyen, Khushil Patel, Kimberly Paulsen, Zhe Ma

PLOS Pathogens: published August 26, 2024 | https://doi.org/10.1371/journal.ppat.1012081

Fitness adaptations of Japanese encephalitis virus in pigs following vector-free serial passaging

Andrea Marti, Alexander Nater, Jenny Pego Magalhaes, Lea Almeida, Marta Lewandowska, Matthias Liniger, Nicolas Ruggli, Llorenç Grau-Roma, Francisco Brito, Fadi G. Alnaji, Marco Vignuzzi, Obdulio García-Nicolás, Artur Summerfield

PLOS Pathogens: published August 26, 2024 | https://doi.org/10.1371/journal.ppat.1012059

Determinants of pegivirus persistence, cross-species infection, and adaptation in the laboratory mouse

Kylie Nennig, Satyapramod Murthy, Sara Maloney, Teressa M. Shaw, Mark Sharobim, Eduard Matkovic, Simi Fadiran, Malorie Larsen, Mitchell D. Ramuta, Arthur S. Kim, John R. Teijaro, Joe Grove, Matthew Stremlau, Himanshu Sharma, Sheetal Trivedi, Michael J. Blum, David H. O’Connor, Jennifer L. Hyde, Jack T. Stapleton, Amit Kapoor, Adam L. Bailey

PLOS Pathogens: published August 28, 2024 | https://doi.org/10.1371/journal.ppat.1012436

Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus

Sacha J. Pidot, Stephan Klatt, Louis S. Ates, Wafa Frigui, Fadel Sayes, Laleh Majlessi, Hiroshi Izumi, Ian R. Monk, Jessica L. Porter, Vicki Bennett-Wood, Torsten Seemann, Ashley Otter, George Taiaroa, Gregory M. Cook, Nicholas West, Nicholas J. Tobias, John A. Fuerst, Michael D. Stutz, Marc Pellegrini, Malcolm McConville, Roland Brosch, Timothy P. Stinear

PLOS Pathogens: published August 29, 2024 | https://doi.org/10.1371/journal.ppat.1012440

Different viral effectors hijack TCP17, a key transcription factor for host Auxin synthesis, to promote viral infection

Yanxiao Zhao, Yong He, Xinyue Chen, Ninghong Li, Tongqing Yang, Tingting Hu, Shujing Duan, Xuanjie Luo, Lei Jiang, Xiaoyang Chen, Xiaorong Tao, Jing Chen

PLOS Pathogens: published August 29, 2024 | https://doi.org/10.1371/journal.ppat.1012510

Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain

Hyewon Byun, Gurvani B. Singh, Wendy Kaichun Xu, Poulami Das, Alejandro Reyes, Anna Battenhouse, Dennis C. Wylie, Mario L. Santiago, Mary M. Lozano, Jaquelin P. Dudley

PLOS Pathogens: published August 29, 2024 | https://doi.org/10.1371/journal.ppat.1012505

Vancomycin-resistant Staphylococcus aureus (VRSA) can overcome the cost of antibiotic resistance and may threaten vancomycin’s clinical durability

Samuel E. Blechman, Erik S. Wright

PLOS Pathogens: published August 29, 2024 | https://doi.org/10.1371/journal.ppat.1012422

Positive selection analyses identify a single WWE domain residue that shapes ZAP into a more potent restriction factor against alphaviruses

Serina Huang, Juliana Girdner, LeAnn P. Nguyen, Carina Sandoval, Oliver I. Fregoso, David Enard, Melody M. H. Li

PLOS Pathogens: published August 29, 2024 | https://doi.org/10.1371/journal.ppat.1011836

Tissue resident cells differentiate S. aureus from S. epidermidis via IL-1β following barrier disruption in healthy human skin

Julia C. Lang, Andreas Brutscher, Marcus Ehrström, Keira Melican

PLOS Pathogens: published August 29, 2024 | https://doi.org/10.1371/journal.ppat.1012056

Rab27a GTPase and its effector Myosin Va are host factors required for efficient Oropouche virus cell egress

Juan O. Concha, Kristel Gutierrez, Natalia Barbosa, Roger L. Rodrigues, Andreia N. de Carvalho, Lucas A. Tavares, Jared S. Rudd, Cristina S. Costa, Barbara Y. G. Andrade, Enilza M. Espreafico, Colin M. Crump, Luis L. P. daSilva

PLOS Pathogens: published August 30, 2024 | https://doi.org/10.1371/journal.ppat.1012504

The small acid-soluble proteins of Clostridioides difficile regulate sporulation in a SpoIVB2-dependent manner

Hailee N. Nerber, Marko Baloh, Joshua N. Brehm, Joseph A. Sorg

PLOS Pathogens: published August 30, 2024 | https://doi.org/10.1371/journal.ppat.1012507

Re-routing MAP kinase signaling for penetration peg formation in predator yeasts

Mareike Rij, Yeseren Kayacan, Beatrice Bernardi, Jürgen Wendland

PLOS Pathogens: published August 30, 2024 | https://doi.org/10.1371/journal.ppat.1012503

Protective RBD-dimer vaccines against SARS-CoV-2 and its variants produced in glycoengineered Pichia pastoris

Tongxin Zhao, Sheng Liu, Pengyan Wang, Yanfang Zhang, Xinrui Kang, Xiaoqian Pan, Linjie Li, Dedong Li, Ping Gao, Yaling An, Hao Song, Kefang Liu, Jianxun Qi, Xin Zhao, Lianpan Dai, Peipei Liu, Peiyi Wang, Guizhen Wu, Taicheng Zhu, Kun Xu, Yin Li, George F. Gao

PLOS Pathogens: published August 30, 2024 | https://doi.org/10.1371/journal.ppat.1012487

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans

Pétra Vande Zande, Cécile Gautier, Nora Kawar, Corinne Maufrais, Katura Metzner, Elizabeth Wash, Annette K. Beach, Ryan Bracken, Eli Isael Maciel, Nívea Pereira de Sá, Caroline Mota Fernandes, Norma V. Solis, Maurizio Del Poeta, Scott G. Filler, Judith Berman, Iuliana V. Ene, Anna Selmecki

PLOS Pathogens: published August 30, 2024 | https://doi.org/10.1371/journal.ppat.1012497

RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis

Zhenqiong Guan, Huiling Li, Chongtao Zhang, Ziyan Huang, Meidi Ye, Yulan Zhang, Shufen Li, Ke Peng

PLOS Pathogens: published August 30, 2024 | https://doi.org/10.1371/journal.ppat.1012387

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1. Correction: RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis