Hidden viral proteins: How powerful are they?

Fangfang Li, Mingxuan Jia, Aiming Wang

PLOS Pathogens: published January 18, 2024 | https://doi.org/10.1371/journal.ppat.1011905

The role of α-synuclein prion strains in Parkinson’s disease and multiple system atrophy

Chase R. Khedmatgozar, Sara A. M. Holec, Amanda L. Woerman

PLOS Pathogens: published January 25, 2024 | https://doi.org/10.1371/journal.ppat.1011920

One species, many faces: The underappreciated importance of strain diversity

Jana Nysten, Dimitrios Sofras, Patrick Van Dijck

PLOS Pathogens: published January 25, 2024 | https://doi.org/10.1371/journal.ppat.1011931

Function and mechanism of TREM2 in bacterial infection

Zehua Wu, Shiyue Yang, Xiangming Fang, Qiang Shu, Qixing Chen

PLOS Pathogens: published January 18, 2024 | https://doi.org/10.1371/journal.ppat.1011895

The use of single-cell RNA-seq to study heterogeneity at varying levels of virus–host interactions

Sharmada Swaminath, Alistair B. Russell

PLOS Pathogens: published January 18, 2024 | https://doi.org/10.1371/journal.ppat.1011898

TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection

Guimin Zhao, Yanqi Li, Tian Chen, Feng Liu, Yi Zheng, Bingyu Liu, Wei Zhao, Xiaopeng Qi, Wanwei Sun, Chengjiang Gao

PLOS Pathogens: published January 2, 2024 | https://doi.org/10.1371/journal.ppat.1011902

Overproduction of mycotoxin biosynthetic enzymes triggers Fusarium toxisome-shaped structure formation via endoplasmic reticulum remodeling

Minhui Wang, Ningjie Wu, Huiyuan Wang, Chang Liu, Qiaowan Chen, Tianming Xu, Yun Chen, Youfu Zhao, Zhonghua Ma

PLOS Pathogens: published January 2, 2024 | https://doi.org/10.1371/journal.ppat.1011913

Trichinella spiralis -induced immunomodulation signatures on gut microbiota and metabolic pathways in mice

Xi-Meng Sun, Chun-Yue Hao, An-Qi Wu, Ze-Ni Luo, Saeed El-Ashram, Abdulaziz Alouffi, Yuan Gu, Sha Liu, Jing-Jing Huang, Xin-Ping Zhu

PLOS Pathogens: published January 2, 2024 | https://doi.org/10.1371/journal.ppat.1011893

Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells

Jordan A. Rixon, Kevin D. Fong, Claire Morris, Alana T. Nguyen, Claire E. Depew, Stephen J. McSorley

PLOS Pathogens: published January 2, 2024 | https://doi.org/10.1371/journal.ppat.1011914

Fungal chitin-binding glycoprotein induces Dectin-2-mediated allergic airway inflammation synergistically with chitin

Yasunori Muraosa, Yutaro Hino, Shogo Takatsuka, Akira Watanabe, Emiko Sakaida, Shinobu Saijo, Yoshitsugu Miyazaki, Sho Yamasaki, Katsuhiko Kamei

PLOS Pathogens: published January 3, 2024 | https://doi.org/10.1371/journal.ppat.1011878

Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing macrophage function

Zihao Wang, Ziming Jiang, Yu Zhang, Congwei Wang, Zhaoyang Liu, Zhankui Jia, Sudhanshu Bhushan, Jinjian Yang, Zhengguo Zhang

PLOS Pathogens: published January 8, 2024 | https://doi.org/10.1371/journal.ppat.1011926

Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin

Yuhang Shi, Sydney Simpson, Yuexuan Chen, Haley Aull, Jared Benjamin, Ruth Serra-Moreno

PLOS Pathogens: published January 8, 2024 | https://doi.org/10.1371/journal.ppat.1011912

Wilms’ tumor 1 (WT1) antigen is overexpressed in Kaposi Sarcoma and is regulated by KSHV vFLIP

Ayana E. Morales, Ruby Gumenick, Caitlyn M. Genovese, Yun Yeong Jang, Ariene Ouedraogo, Maite Ibáñez de Garayo, Tania Pannellini, Sanjay Patel, Matthew E. Bott, Julio Alvarez, Sung Soo Mun, Jennifer Totonchy, Archana Gautam, Jesus Delgado de la Mora, Stephanie Chang, Dagmar Wirth, Marcelo Horenstein, Tao Dao, David A. Scheinberg, Paul G. Rubinstein, Aggrey Semeere, Jeffrey Martin, Catherine C. Godfrey, Carlee B. Moser, Roy M. Matining, Thomas B. Campbell, Margaret Z. Borok, Susan E. Krown, Ethel Cesarman

PLOS Pathogens: published January 8, 2024 | https://doi.org/10.1371/journal.ppat.1011881

Collagen and actin network mediate antiviral immunity against Orsay virus in C. elegans intestinal cells

Ying Zhou, Hanqiao Chen, Weiwei Zhong, Yizhi Jane Tao

PLOS Pathogens: published January 8, 2024 | https://doi.org/10.1371/journal.ppat.1011366

Modulations in the host cell proteome by the hantavirus nucleocapsid protein

Austin Royster, Songyang Ren, Saima Ali, Sheema Mir, Mohammad Mir

PLOS Pathogens: published January 8, 2024 | https://doi.org/10.1371/journal.ppat.1011925

The role of species ecology in predicting Toxoplasma gondii prevalence in wild and domesticated mammals globally

Amy G. Wilson, David R. Lapen, Jennifer F. Provencher, Scott Wilson

PLOS Pathogens: published January 10, 2024 | https://doi.org/10.1371/journal.ppat.1011908

Higher temperature accelerates the aging-dependent weakening of the melanization immune response in mosquitoes

Lindsay E. Martin, Julián F. Hillyer

PLOS Pathogens: published January 10, 2024 | https://doi.org/10.1371/journal.ppat.1011935

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian hamsters

Juan García-Bernalt Diego, Gagandeep Singh, Sonia Jangra, Kim Handrejk, Manon Laporte, Lauren A. Chang, Sara S. El Zahed, Lars Pache, Max W. Chang, Prajakta Warang, Sadaf Aslam, Ignacio Mena, Brett T. Webb, Christopher Benner, Adolfo García-Sastre, Michael Schotsaert

PLOS Pathogens: published January 10, 2024 | https://doi.org/10.1371/journal.ppat.1011805

Pseudomonas aeruginosa two-component system CprRS regulates HigBA expression and bacterial cytotoxicity in response to LL-37 stress

Yingjie Song, Siping Zhang, Ninglin Zhao, Cheng Nong, Yongxing He, Rui Bao

PLOS Pathogens: published January 10, 2024 | https://doi.org/10.1371/journal.ppat.1011946

Mammalian orthoreovirus can exit cells in extracellular vesicles

Sydni Caet Smith, Evan Krystofiak, Kristen M. Ogden

PLOS Pathogens: published January 11, 2024 | https://doi.org/10.1371/journal.ppat.1011637

Revisiting the origins of the Sobemovirus genus: A case for ancient origins of plant viruses

Mahan Ghafari, Merike Sõmera, Cecilia Sarmiento, Annette Niehl, Eugénie Hébrard, Theocharis Tsoleridis, Jonathan Ball, Benoît Moury, Philippe Lemey, Aris Katzourakis, Denis Fargette

PLOS Pathogens: published January 11, 2024 | https://doi.org/10.1371/journal.ppat.1011911

The evolution of constitutively active humoral immune defenses in Drosophila populations under high parasite pressure

Shuyu Olivia Zhou, Ramesh Arunkumar, Amina Irfan, Shuai Dominique Ding, Alexandre B. Leitão, Francis M. Jiggins

PLOS Pathogens: published January 11, 2024 | https://doi.org/10.1371/journal.ppat.1011729

EBV abortive lytic cycle promotes nasopharyngeal carcinoma progression through recruiting monocytes and regulating their directed differentiation

Xiaoting Xu, Nannan Zhu, Junming Zheng, Yingying Peng, Mu-Sheng Zeng, Kai Deng, Chaohui Duan, Yan Yuan

PLOS Pathogens: published January 11, 2024 | https://doi.org/10.1371/journal.ppat.1011934

Deficiency in astrocyte CCL2 production reduces neuroimmune control of Toxoplasma gondii infection

Stephanie B. Orchanian, Katherine Still, Tajie H. Harris, Melissa B. Lodoen

PLOS Pathogens: published January 11, 2024 | https://doi.org/10.1371/journal.ppat.1011710

Pregnancy trained decidual NK cells protect pregnancies from harmful Fusobacterium nucleatum infection

Rebecca Kotzur, Shira Kahlon, Batya Isaacson, Moriya Gamliel, Yoav Charpak-Amikam, Judy Lieberman, Gilad Bachrach, Debra Goldman-Wohl, Simcha Yagel, Ofer Beharier, Ofer Mandelboim

PLOS Pathogens: published January 12, 2024 | https://doi.org/10.1371/journal.ppat.1011923

Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases

Shaowei Wang, Xuezhang Tian, Yaru Zhou, Jun Xie, Ming Gao, Yunhong Zhong, Chuchu Zhang, Keying Yu, Lei Bai, Qingsong Qin, Bo Zhong, Dandan Lin, Pinghui Feng, Ke Lan, Junjie Zhang

PLOS Pathogens: published January 12, 2024 | https://doi.org/10.1371/journal.ppat.1011943

Transcriptome and small RNAome profiling uncovers how a recombinant begomovirus evades RDRγ-mediated silencing of viral genes and outcompetes its parental virus in mixed infection

Margaux Jammes, Victor Golyaev, Alejandro Fuentes, Nathalie Laboureau, Cica Urbino, Clemence Plissonneau, Michel Peterschmitt, Mikhail M. Pooggin

PLOS Pathogens: published January 12, 2024 | https://doi.org/10.1371/journal.ppat.1011941

Murine leukemia virus infection of non-dividing dendritic cells is dependent on nucleoporins

Karen Salas-Briceno, Wenming Zhao, Susan R. Ross

PLOS Pathogens: published January 12, 2024 | https://doi.org/10.1371/journal.ppat.1011640

γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control

Fiorella Ruchti, Meret Tuor, Liya Mathew, Neil E McCarthy, Salomé LeibundGut-Landmann

PLOS Pathogens: published January 12, 2024 | https://doi.org/10.1371/journal.ppat.1011668

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome

Senko Tsukuda, James M. Harris, Andrea Magri, Peter Balfe, Aleem Siddiqui, Peter A.C. Wing, Jane A. McKeating

PLOS Pathogens: published January 16, 2024 | https://doi.org/10.1371/journal.ppat.1011917

Histidine transport is essential for the growth of Staphylococcus aureus at low pH

Catrin M. Beetham, Christopher F. Schuster, Igor Kviatkovski, Marina Santiago, Suzanne Walker, Angelika Gründling

PLOS Pathogens: published January 16, 2024 | https://doi.org/10.1371/journal.ppat.1011927

ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus

Biao Chen, Guijie Guo, Guoqing Wang, Qianwen Zhu, Lulu Wang, Wenhao Shi, Song Wang, Yuhai Chen, Xiaojuan Chi, Faxin Wen, Mohamed Maarouf, Shile Huang, Zhou Yang, Ji-Long Chen

PLOS Pathogens: published January 16, 2024 | https://doi.org/10.1371/journal.ppat.1011958

The universal suppressor mutation restores membrane budding defects in the HSV-1 nuclear egress complex by stabilizing the oligomeric lattice

Elizabeth B. Draganova, Hui Wang, Melanie Wu, Shiqing Liao, Amber Vu, Gonzalo L. Gonzalez-Del Pino, Z. Hong Zhou, Richard J. Roller, Ekaterina E. Heldwein

PLOS Pathogens: published January 16, 2024 | https://doi.org/10.1371/journal.ppat.1011936

Kaposi’s sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection

Shijun Li, Mengbo Wang, Nicholas Van Sciver, Agnieszka Szymula, Vinayak Sadasivam Tumuluri, Athira George, Akshaya Ramachandran, Komal Raina, Catarina N. Costa, Bo Zhao, Majid Kazemian, J. Pedro Simas, Kenneth M. Kaye

PLOS Pathogens: published January 17, 2024 | https://doi.org/10.1371/journal.ppat.1011907

Naturally-associated bacteria modulate Orsay virus infection of Caenorhabditis elegans

Rubén González, Marie-Anne Félix

PLOS Pathogens: published January 17, 2024 | https://doi.org/10.1371/journal.ppat.1011947

Late-rising CD4 T cells resolve mouse cytomegalovirus persistent replication in the salivary gland

Simon Brunel, Gaelle Picarda, Ankan Gupta, Raima Ghosh, Bryan McDonald, Rachid El Morabiti, Wenjin Jiang, Jason A. Greenbaum, Barbara Adler, Gregory Seumois, Michael Croft, Pandurangan Vijayanand, Chris A. Benedict

PLOS Pathogens: published January 18, 2024 | https://doi.org/10.1371/journal.ppat.1011852

The soil-borne white root rot pathogen Rosellinia necatrix expresses antimicrobial proteins during host colonization

Edgar A. Chavarro-Carrero, Nick C. Snelders, David E. Torres, Anton Kraege, Ana López-Moral, Gabriella C. Petti, Wilko Punt, Jan Wieneke, Rómulo García-Velasco, Carlos J. López-Herrera, Michael F. Seidl, Bart P. H. J. Thomma

PLOS Pathogens: published January 18, 2024 | https://doi.org/10.1371/journal.ppat.1011866

Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection

Dat Mai, Ana Jahn, Tara Murray, Michael Morikubo, Pamelia N. Lim, Maritza M. Cervantes, Linh K. Pham, Johannes Nemeth, Kevin Urdahl, Alan H. Diercks, Alan Aderem, Alissa C. Rothchild

PLOS Pathogens: published January 18, 2024 | https://doi.org/10.1371/journal.ppat.1011871

JAK/STAT signaling regulated intestinal regeneration defends insect pests against pore-forming toxins produced by Bacillus thuringiensis

Zeyu Wang, Yanchao Yang, Sirui Li, Weihua Ma, Kui Wang, Mario Soberón, Shuo Yan, Jie Shen, Frederic Francis, Alejandra Bravo, Jie Zhang

PLOS Pathogens: published January 18, 2024 | https://doi.org/10.1371/journal.ppat.1011823

Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndrome

Emilie Pollenus, Hendrik Possemiers, Sofie Knoops, Fran Prenen, Leen Vandermosten, Chloë Thienpont, Saeed Abdurahiman, Sofie Demeyer, Jan Cools, Gianluca Matteoli, Jeroen A. J. Vanoirbeek, Greetje Vande Velde, Philippe E. Van den Steen

PLOS Pathogens: published January 18, 2024 | https://doi.org/10.1371/journal.ppat.1011929

Trained immunity in recurrent Staphylococcus aureus infection promotes bacterial persistence

Xiao-Qi Lin, Zhen-Zhen Liu, Cheng-Kai Zhou, Liang Zhang, Yu Gao, Xue-Yue Luo, Jian-Gang Zhang, Wei Chen, Yong-Jun Yang

PLOS Pathogens: published January 19, 2024 | https://doi.org/10.1371/journal.ppat.1011918

Unmutated but T cell dependent IgM antibodies targeting Streptococcus suis play an essential role in bacterial clearance

Dominic Dolbec, Mélanie Lehoux, Alexis Asselin de Beauville, Astrid Zahn, Javier Marcelo Di Noia, Mariela Segura

PLOS Pathogens: published January 19, 2024 | https://doi.org/10.1371/journal.ppat.1011957

The bZIP transcription factor BIP1 of the rice blast fungus is essential for infection and regulates a specific set of appressorium genes

Karine Lambou, Andrew Tag, Alexandre Lassagne, Jérôme Collemare, Pierre-Henri Clergeot, Crystel Barbisan, Philippe Perret, Didier Tharreau, Joelle Millazo, Elia Chartier, Ronald P. De Vries, Judith Hirsch, Jean-Benoit Morel, Roland Beffa, Thomas Kroj, Terry Thomas, Marc-Henri Lebrun

PLOS Pathogens: published January 22, 2024 | https://doi.org/10.1371/journal.ppat.1011945

Epitranscriptional m⁶A modification of rRNA negatively impacts translation and host colonization in Staphylococcus aureus

Kathryn E. Shields, David Ranava, Yongjun Tan, Dapeng Zhang, Mee-Ngan F. Yap

PLOS Pathogens: published January 22, 2024 | https://doi.org/10.1371/journal.ppat.1011968

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

Michael W. Grunst, Hwi Min Gil, Andres G. Grandea III, Brian J. Snow, Raiees Andrabi, Rebecca Nedellec, Iszac Burton, Natasha M. Clark, Sanath Kumar Janaka, Nida K. Keles, Ryan V. Moriarty, Andrea M. Weiler, Saverio Capuano III, Christine M. Fennessey, Thomas C. Friedrich, Shelby L. O’Connor, David H. O’Connor, Aimee T. Broman, Brandon F. Keele, Jeffrey D. Lifson, Lars Hangartner, Dennis R. Burton, David T. Evans

PLOS Pathogens: published January 22, 2024 | https://doi.org/10.1371/journal.ppat.1011819

West Nile virus spread in Europe: Phylogeographic pattern analysis and key drivers

Lu Lu, Feifei Zhang, Bas B. Oude Munnink, Emmanuelle Munger, Reina S. Sikkema, Styliani Pappa, Katerina Tsioka, Alessandro Sinigaglia, Emanuela Dal Molin, Barbara B. Shih, Anne Günther, Anne Pohlmann, Ute Ziegler, Martin Beer, Rachel A. Taylor, Frederic Bartumeus, Mark Woolhouse, Frank M. Aarestrup, Luisa Barzon, Anna Papa, Samantha Lycett, Marion P. G. Koopmans

PLOS Pathogens: published January 25, 2024 | https://doi.org/10.1371/journal.ppat.1011880

Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition

Amanda Brady, Katelyn R. Sheneman, Amanda R. Pulsifer, Sarah L. Price, Taylor M. Garrison, Krishna Rao Maddipati, Sobha R. Bodduluri, Jianmin Pan, Nolan L. Boyd, Jing-Juan Zheng, Shesh N. Rai, Jason Hellmann, Bodduluri Haribabu, Silvia M. Uriarte, Matthew B. Lawrenz

PLOS Pathogens: published January 25, 2024 | https://doi.org/10.1371/journal.ppat.1011280

Influenza virus infection enhances tumour-specific CD8⁺ T-cell immunity, facilitating tumour control

Philine Steinbach, Eva Pastille, Lara Kaumanns, Alexandra Adamczyk, Kathrin Sutter, Wiebke Hansen, Ulf Dittmer, Jan Buer, Astrid M. Westendorf, Torben Knuschke

PLOS Pathogens: published January 25, 2024 | https://doi.org/10.1371/journal.ppat.1011982

Cathelicidin peptide analogues inhibit EV71 infection through blocking viral entry and uncoating

Tingting Fan, Bing Liu, Haoyan Yao, Xinrui Chen, Hang Yang, Shangrui Guo, Bo Wu, Xiaozhen Li, Xinyu Li, Meng Xun, Hongliang Wang

PLOS Pathogens: published January 25, 2024 | https://doi.org/10.1371/journal.ppat.1011967

The genome formula of a multipartite virus is regulated both at the individual segment and the segment group levels

Mélia Bonnamy, Andy Brousse, Elodie Pirolles, Yannis Michalakis, Stéphane Blanc

PLOS Pathogens: published January 25, 2024 | https://doi.org/10.1371/journal.ppat.1011973

BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia

Miguel A. B. Mercado, Qiang Li, Charles M. Quick, Yejin Kim, Rachel Palmer, Lu Huang, Lin-Xi Li

PLOS Pathogens: published January 25, 2024 | https://doi.org/10.1371/journal.ppat.1011983

Beyond the MEP Pathway: A novel kinase required for prenol utilization by malaria parasites

Marcell Crispim, Ignasi Bofill Verdaguer, Agustín Hernández, Thales Kronenberger, Àngel Fenollar, Lydia Fumiko Yamaguchi, María Pía Alberione, Miriam Ramirez, Sandra Souza de Oliveira, Alejandro Miguel Katzin, Luis Izquierdo

PLOS Pathogens: published January 26, 2024 | https://doi.org/10.1371/journal.ppat.1011557

Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum

Shaoyun Cheng, Yanmin You, Xiaoling Wang, Cun Yi, Wei Zhang, Yuxiang Xie, Lei Xiu, Fang Luo, Yan Lu, Jipeng Wang, Wei Hu

PLOS Pathogens: published January 29, 2024 | https://doi.org/10.1371/journal.ppat.1011949

Autophagy and cell wall integrity pathways coordinately regulate the development and pathogenicity through MoAtg4 phosphorylation in Magnaporthe oryzae

Pusheng Guo, Yurong Wang, Jiayun Xu, Zhixiang Yang, Ziqi Zhang, Jinyi Qian, Jiexiong Hu, Ziyi Yin, Leiyun Yang, Muxing Liu, Xinyu Liu, Gang Li, Haifeng Zhang, Ryan Rumsey, Ping Wang, Zhengguang Zhang

PLOS Pathogens: published January 30, 2024 | https://doi.org/10.1371/journal.ppat.1011988

Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry

Bing-Qian Su, Guo-Yu Yang, Jiang Wang, Sheng-Li Ming, Bei-Bei Chu

PLOS Pathogens: published January 31, 2024 | https://doi.org/10.1371/journal.ppat.1011956

Correction: Emergence of Prions Selectively Resistant to Combination Drug Therapy

Cassandra M. Burke, Kenneth M. K. Mark, Judit Kun, Kathryn S. Beauchemin, Surachai Supattapone

PLOS Pathogens: published January 8, 2024 | https://doi.org/10.1371/journal.ppat.1011919

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Correction: A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?

Justin Y. A. Doritchamou, Jonathan P. Renn, Lars Hviid, Patrick E. Duffy

PLOS Pathogens: published January 29, 2024 | https://doi.org/10.1371/journal.ppat.1011503

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