Skip to main content
Advertisement
Table of Contents

November 2023

Scanning electron microscopy image of a human natural killer (NK) cell (in blue) contacting a P. falciparum infected erythrocyte (red) in the presence of antibodies from individuals exposed to malaria. The initial contact shown here precedes the formation of tight immunological synapses that depend on specific receptor–ligand interactions between NK cells and infected erythrocytes. NK cells inflict damage to the erythrocyte plasma membrane and kill parasites that develop within intracellular vacuoles. Sekar et al 2023

Image Credit: David Dorward and Anita Mora (Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases)

Editorial

Open Science at PLOS Pathogens

Lauren Cadwallader, Kasturi Haldar, Rebecca Kirk, Neil A. Mabbott, Michael H. Malim

Pearls

Insights and advances in recurrent vulvovaginal candidiasis

Javier San Juan Galán, Vanessa Poliquin, Aleeza Cara Gerstein

The RNA world of fungal pathogens

Srimeenakshi Sankaranarayanan, Seomun Kwon, Kai Heimel, Michael Feldbrügge

Review

The biological functions of sphingolipids in plant pathogenic fungi

Xue-Ming Zhu, Lin Li, Jian-Dong Bao, Jiao-Yu Wang, Asen Daskalov, Xiao-Hong Liu, Maurizio Del Poeta, Fu-Cheng Lin

Research Articles

Immunogenicity and safety of heterologous boost immunization with PastoCovac Plus against COVID-19 in ChAdOx1-S or BBIBP-CorV primed individuals

Sana Eybpoosh, Alireza Biglari, Rahim Sorouri, Fatemeh Ashrafian, Mona Sadat Larijani, Vicente Verez-Bencomo, Maria Eugenia Toledo-Romani, Carmen Valenzuela Silva, Mostafa Salehi-Vaziri, Sarah Dahmardeh, Delaram Doroud, Mohammad Banifazl, Ehsan Mostafavi, Anahita Bavand, Amitis Ramezani

Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer

Toshihiko Suzuki, Kotchakorn Boonyaleka, Tokuju Okano, Tamako Iida, Mitsunori Yoshida, Hanako Fukano, Yoshihiko Hoshino, Yoichiro Iwakura, Anthony S. Ablordey, Hiroshi Ashida

Proline catabolism is a key factor facilitating Candida albicans pathogenicity

Fitz Gerald S. Silao, Tong Jiang, Biborka Bereczky-Veress, Andreas Kühbacher, Kicki Ryman, Nathalie Uwamohoro, Sabrina Jenull, Filomena Nogueira, Meliza Ward, Thomas Lion, Constantin F. Urban, Steffen Rupp, Karl Kuchler, Changbin Chen, Christiane Peuckert, Per O. Ljungdahl

KSHV vIL-6 enhances inflammatory responses by epigenetic reprogramming

Tomoki Inagaki, Kang-Hsin Wang, Ashish Kumar, Chie Izumiya, Hiroki Miura, Somayeh Komaki, Ryan R. Davis, Clifford G. Tepper, Harutaka Katano, Michiko Shimoda, Yoshihiro Izumiya

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning

Gavin R. Meehan, Vanessa Herder, Jay Allan, Xinyi Huang, Karen Kerr, Diogo Correa Mendonca, Georgios Ilia, Derek W. Wright, Kyriaki Nomikou, Quan Gu, Sergi Molina Arias, Florian Hansmann, Alexandros Hardas, Charalampos Attipa, Giuditta De Lorenzo, Vanessa Cowton, Nicole Upfold, Natasha Palmalux, Jonathan C. Brown, Wendy S. Barclay, Ana Da Silva Filipe, Wilhelm Furnon, Arvind H. Patel, Massimo Palmarini

Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection

Grace P. Carreno-Florez, Brian R. Kocak, Matthew R. Hendricks, Jeffrey A. Melvin, Katrina B. Mar, Jessica Kosanovich, Rachel L. Cumberland, Greg M. Delgoffe, Sruti Shiva, Kerry M. Empey, John W. Schoggins, Jennifer M. Bomberger

NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG

Padmapriya Sekar, Sumati Rajagopalan, Estela Shabani, Usheer Kanjee, Marc A. Schureck, Gunjan Arora, Mary E. Peterson, Boubacar Traore, Peter D. Crompton, Manoj T. Duraisingh, Sanjay A. Desai, Eric O. Long

Cryo-electron tomography reveals the binding and release states of the major adhesion complex from Mycoplasma genitalium

Lasse Sprankel, Margot P. Scheffer, Sina Manger, Utz H. Ermel, Achilleas S. Frangakis

Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection

Thandeka Moyo-Gwete, Simone I. Richardson, Roanne Keeton, Tandile Hermanus, Holly Spencer, Nelia P. Manamela, Frances Ayres, Zanele Makhado, Thopisang Motlou, Marius B. Tincho, Ntombi Benede, Amkele Ngomti, Richard Baguma, Masego V. Chauke, Mathilda Mennen, Marguerite Adriaanse, Sango Skelem, Ameena Goga, Nigel Garrett, Linda-Gail Bekker, Glenda Gray, Ntobeko A. B. Ntusi, Catherine Riou, Wendy A. Burgers, Penny L. Moore

COVID-19: A complex disease with a unique metabolic signature

Veronica Ghini, Walter Vieri, Tommaso Celli, Valentina Pecchioli, Nunzia Boccia, Tania Alonso-Vásquez, Lorenzo Pelagatti, Marco Fondi, Claudio Luchinat, Laura Bertini, Vieri Vannucchi, Giancarlo Landini, Paola Turano

Effects of N-glycan modifications on spike expression, virus infectivity, and neutralization sensitivity in ancestral compared to Omicron SARS-CoV-2 variants

Sabrina Lusvarghi, Charles B. Stauft, Russell Vassell, Brittany Williams, Haseebullah Baha, Wei Wang, Sabari Nath Neerukonda, Tony Wang, Carol D. Weiss

Hexadecanamide alleviates Staphylococcus aureus-induced mastitis in mice by inhibiting inflammatory responses and restoring blood-milk barrier integrity

Lijuan Bao, Hao Sun, Yihong Zhao, Lianjun Feng, Keyi Wu, Shan Shang, Jiawen Xu, Ruping Shan, Shiyu Duan, Min Qiu, Naisheng Zhang, Xiaoyu Hu, Caijun Zhao, Yunhe Fu

Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations

Chi-Fei Kao, Min-Hsin Tsai, Kathleen Joyce Carillo, Der-Lii Tzou, Wen Chang

Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2

Shi Yu, Xu Zheng, Yanqiu Zhou, Yuhui Gao, Bingjie Zhou, Yapei Zhao, Tingting Li, Yunyi Li, Jiabin Mou, Xiaoxian Cui, Yuying Yang, Dianfan Li, Min Chen, Dimitri Lavillette, Guangxun Meng

Evasion of host antioxidative response via disruption of NRF2 signaling in fatal Ehrlichia-induced liver injury

Aditya Kumar Sharma, Abdeljabar El Andaloussi, Nahed Ismail

A sporulation signature protease is required for assembly of the spore surface layers, germination and host colonization in Clostridioides difficile

Eleonora Marini, Carmen Olivença, Sara Ramalhete, Andrea Martinez Aguirre, Patrick Ingle, Manuel N. Melo, Wilson Antunes, Nigel P. Minton, Guillem Hernandez, Tiago N. Cordeiro, Joseph A. Sorg, Mónica Serrano, Adriano O. Henriques

Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis

Thomas J. C. Sauters, Cullen Roth, Debra Murray, Sheng Sun, Anna Floyd Averette, Chinaemerem U. Onyishi, Robin C. May, Joseph Heitman, Paul M. Magwene

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

Shiromani Jayawardhana, Alexander I. Ward, Amanda F. Francisco, Michael D. Lewis, Martin C. Taylor, John M. Kelly, Francisco Olmo

SARS-CoV-2 Nsp8 suppresses MDA5 antiviral immune responses by impairing TRIM4-mediated K63-linked polyubiquitination

Xiaolin Zhang, Ziwei Yang, Ting Pan, Qinqin Sun, Qingyang Chen, Pei-Hui Wang, Xiaojuan Li, Ersheng Kuang

The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity

Belén Carriquí-Madroñal, Julie Sheldon, Mara Duven, Cora Stegmann, Karsten Cirksena, Emanuel Wyler, Francisco J. Zapatero-Belinchón, Florian W. R. Vondran, Gisa Gerold

Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells

Rafaela Holtappels, Sara Becker, Sara Hamdan, Kirsten Freitag, Jürgen Podlech, Niels A. Lemmermann, Matthias J. Reddehase

Virulent strains of Zymoseptoria tritici suppress the host immune response and facilitate the success of avirulent strains in mixed infections

Alessio Bernasconi, Cécile Lorrain, Priska Flury, Julien Alassimone, Bruce A. McDonald, Andrea Sánchez-Vallet

A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex

Han Chen, Ming F. Lye, Christoph Gorgulla, Scott B. Ficarro, Gregory D. Cuny, David A. Scott, Fan Wu, Paul W. Rothlauf, Xiaoou Wang, Rosio Fernandez, Jean M. Pesola, Sorin Draga, Jarrod A. Marto, James M. Hogle, Haribabu Arthanari, Donald M. Coen

Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection

Geoffrey T. Norris, Joshua M. Ames, Steven F. Ziegler, Andrew Oberst

Arabidopsis eIF4E1 protects the translational machinery during TuMV infection and restricts virus accumulation

Delyan Zafirov, Nathalie Giovinazzo, Cécile Lecampion, Ben Field, Julia Novion Ducassou, Yohann Couté, Karen S. Browning, Christophe Robaglia, Jean-Luc Gallois

Conserved antigen structures and antibody-driven variations on foot-and-mouth disease virus serotype A revealed by bovine neutralizing monoclonal antibodies

Kun Li, Yong He, Li Wang, Pinghua Li, Huifang Bao, Shulun Huang, Shasha Zhou, Guoqiang Zhu, Yali Song, Ying Li, Sheng Wang, Qianliang Zhang, Pu Sun, Xingwen Bai, Zhixun Zhao, Zhiyong Lou, Yimei Cao, Zengjun Lu, Zaixin Liu

Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite

Rahul Singh Rawat, Ankit Gupta, Neelam Antil, Sonika Bhatnagar, Monika Singh, Akanksha Rawat, T. S. Keshava Prasad, Pushkar Sharma

A chemosensory-like histidine kinase is dispensable for chemotaxis in vitro but regulates the virulence of Borrelia burgdorferi through modulating the stability of RpoS

Ching Wooen Sze, Kai Zhang, Michael J. Lynch, Radha Iyer, Brian R. Crane, Ira Schwartz, Chunhao Li

Dual function of Zika virus NS2B-NS3 protease

Sergey A. Shiryaev, Piotr Cieplak, Anton Cheltsov, Robert C. Liddington, Alexey V. Terskikh

Assessing vaccine-mediated protection in an ultra-low dose Mycobacterium tuberculosis murine model

Courtney R. Plumlee, Holly W. Barrett, Danica E. Shao, Katie A. Lien, Lauren M. Cross, Sara B. Cohen, Paul T. Edlefsen, Kevin B. Urdahl

RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection

Marissa Lindman, Juan P. Angel, Irving Estevez, Nydia P. Chang, Tsui-Wen Chou, Micheal McCourt, Colm Atkins, Brian P. Daniels

Neuropilin-1 identifies a subset of highly activated CD8+ T cells during parasitic and viral infections

Hanna Abberger, Matthias Hose, Anne Ninnemann, Christopher Menne, Mareike Eilbrecht, Karl S. Lang, Kai Matuschewski, Robert Geffers, Josephine Herz, Jan Buer, Astrid M. Westendorf, Wiebke Hansen

A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size

Ashok K. Dwivedi, Germán G. Gornalusse, David A. Siegel, Alton Barbehenn, Cassandra Thanh, Rebecca Hoh, Kristen S. Hobbs, Tony Pan, Erica A. Gibson, Jeffrey Martin, Frederick Hecht, Christopher Pilcher, Jeffrey Milush, Michael P. Busch, Mars Stone, Meei-Li Huang, Julieta Reppetti, Phuong M. Vo, Claire N. Levy, Pavitra Roychoudhury, Keith R. Jerome, Florian Hladik, Timothy J. Henrich, Steven G. Deeks, Sulggi A. Lee

Preferential selection of viral escape mutants by CD8+ T cell ‘sieving’ of SIV reactivation from latency

Steffen S. Docken, Kevin McCormick, M. Betina Pampena, Sadia Samer, Emily Lindemuth, Mykola Pinkevych, Elise G. Viox, Yuhuang Wu, Timothy E. Schlub, Deborah Cromer, Brandon F. Keele, Mirko Paiardini, Michael R. Betts, Katharine J. Bar, Miles P. Davenport

Antimicrobial peptide-producing dermal preadipocytes defend against Candida albicans skin infection via the FGFR-MEK-ERK pathway

Jianing Wang, Zhimin Duan, Rong Zeng, Lu Yang, Weizhao Liu, Yiman Liu, Qian Yao, Xu Chen, Ling-juan Zhang, Min Li

Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization

Jing Yang, Sheng Lin, Zimin Chen, Fanli Yang, Liyan Guo, Lingling Wang, Yanping Duan, Xindan Zhang, Yushan Dai, Keqing Yin, Chongzhang Yu, Xin Yuan, Honglu Sun, Bin He, Yu Cao, Haoyu Ye, Haohao Dong, Xianbo Liu, Bo Chen, Jian Li, Qi Zhao, Guangwen Lu

Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells

Ingo Fohmann, Alina Weinmann, Fabian Schumacher, Simon Peters, Agata Prell, Cynthia Weigel, Sarah Spiegel, Burkhard Kleuser, Alexandra Schubert-Unkmeir

Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis

Raffael Júnio Araújo de Castro, Clara Luna Marina, Aude Sturny-Leclère, Christian Hoffmann, Pedro Henrique Bürgel, Sarah Sze Wah Wong, Vishukumar Aimanianda, Hugo Varet, Ruchi Agrawal, Anamélia Lorenzetti Bocca, Alexandre Alanio