Scanning electron microscopy image of a human natural killer (NK) cell (in blue) contacting a P. falciparum infected erythrocyte (red) in the presence of antibodies from individuals exposed to malaria. The initial contact shown here precedes the formation of tight immunological synapses that depend on specific receptor–ligand interactions between NK cells and infected erythrocytes. NK cells inflict damage to the erythrocyte plasma membrane and kill parasites that develop within intracellular vacuoles. Sekar et al 2023
Image Credit: David Dorward and Anita Mora (Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases)
Editorial
Open Science at PLOS Pathogens
PLOS Pathogens: published November 30, 2023 | https://doi.org/10.1371/journal.ppat.1011776
Pearls
Insights and advances in recurrent vulvovaginal candidiasis
PLOS Pathogens: published November 10, 2023 | https://doi.org/10.1371/journal.ppat.1011684
The RNA world of fungal pathogens
PLOS Pathogens: published November 30, 2023 | https://doi.org/10.1371/journal.ppat.1011762
Review
The biological functions of sphingolipids in plant pathogenic fungi
PLOS Pathogens: published November 9, 2023 | https://doi.org/10.1371/journal.ppat.1011733
Research Articles
Immunogenicity and safety of heterologous boost immunization with PastoCovac Plus against COVID-19 in ChAdOx1-S or BBIBP-CorV primed individuals
PLOS Pathogens: published November 1, 2023 | https://doi.org/10.1371/journal.ppat.1011744
Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer
PLOS Pathogens: published November 1, 2023 | https://doi.org/10.1371/journal.ppat.1011747
Proline catabolism is a key factor facilitating Candida albicans pathogenicity
PLOS Pathogens: published November 2, 2023 | https://doi.org/10.1371/journal.ppat.1011677
KSHV vIL-6 enhances inflammatory responses by epigenetic reprogramming
PLOS Pathogens: published November 7, 2023 | https://doi.org/10.1371/journal.ppat.1011771
Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning
PLOS Pathogens: published November 7, 2023 | https://doi.org/10.1371/journal.ppat.1011589
Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection
PLOS Pathogens: published November 8, 2023 | https://doi.org/10.1371/journal.ppat.1011719
NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG
PLOS Pathogens: published November 8, 2023 | https://doi.org/10.1371/journal.ppat.1011585
Cryo-electron tomography reveals the binding and release states of the major adhesion complex from Mycoplasma genitalium
PLOS Pathogens: published November 8, 2023 | https://doi.org/10.1371/journal.ppat.1011761
Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection
PLOS Pathogens: published November 9, 2023 | https://doi.org/10.1371/journal.ppat.1011772
COVID-19: A complex disease with a unique metabolic signature
PLOS Pathogens: published November 9, 2023 | https://doi.org/10.1371/journal.ppat.1011787
Effects of N-glycan modifications on spike expression, virus infectivity, and neutralization sensitivity in ancestral compared to Omicron SARS-CoV-2 variants
PLOS Pathogens: published November 9, 2023 | https://doi.org/10.1371/journal.ppat.1011788
Hexadecanamide alleviates Staphylococcus aureus-induced mastitis in mice by inhibiting inflammatory responses and restoring blood-milk barrier integrity
PLOS Pathogens: published November 10, 2023 | https://doi.org/10.1371/journal.ppat.1011764
Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations
PLOS Pathogens: published November 10, 2023 | https://doi.org/10.1371/journal.ppat.1011500
Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2
PLOS Pathogens: published November 10, 2023 | https://doi.org/10.1371/journal.ppat.1011789
Evasion of host antioxidative response via disruption of NRF2 signaling in fatal Ehrlichia-induced liver injury
PLOS Pathogens: published November 13, 2023 | https://doi.org/10.1371/journal.ppat.1011791
A sporulation signature protease is required for assembly of the spore surface layers, germination and host colonization in Clostridioides difficile
PLOS Pathogens: published November 13, 2023 | https://doi.org/10.1371/journal.ppat.1011741
Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis
PLOS Pathogens: published November 13, 2023 | https://doi.org/10.1371/journal.ppat.1011763
Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice
PLOS Pathogens: published November 13, 2023 | https://doi.org/10.1371/journal.ppat.1011627
SARS-CoV-2 Nsp8 suppresses MDA5 antiviral immune responses by impairing TRIM4-mediated K63-linked polyubiquitination
PLOS Pathogens: published November 13, 2023 | https://doi.org/10.1371/journal.ppat.1011792
The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity
PLOS Pathogens: published November 15, 2023 | https://doi.org/10.1371/journal.ppat.1011759
Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells
PLOS Pathogens: published November 16, 2023 | https://doi.org/10.1371/journal.ppat.1011643
Virulent strains of Zymoseptoria tritici suppress the host immune response and facilitate the success of avirulent strains in mixed infections
PLOS Pathogens: published November 16, 2023 | https://doi.org/10.1371/journal.ppat.1011767
Combined reference-free and multi-reference based GWAS uncover cryptic variation underlying rapid adaptation in a fungal plant pathogen
PLOS Pathogens: published November 16, 2023 | https://doi.org/10.1371/journal.ppat.1011801
A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex
PLOS Pathogens: published November 17, 2023 | https://doi.org/10.1371/journal.ppat.1011781
Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection
PLOS Pathogens: published November 20, 2023 | https://doi.org/10.1371/journal.ppat.1011350
Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2
PLOS Pathogens: published November 20, 2023 | https://doi.org/10.1371/journal.ppat.1011806
Arabidopsis eIF4E1 protects the translational machinery during TuMV infection and restricts virus accumulation
PLOS Pathogens: published November 20, 2023 | https://doi.org/10.1371/journal.ppat.1011417
Conserved antigen structures and antibody-driven variations on foot-and-mouth disease virus serotype A revealed by bovine neutralizing monoclonal antibodies
PLOS Pathogens: published November 20, 2023 | https://doi.org/10.1371/journal.ppat.1011811
Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite
PLOS Pathogens: published November 21, 2023 | https://doi.org/10.1371/journal.ppat.1011770
A chemosensory-like histidine kinase is dispensable for chemotaxis in vitro but regulates the virulence of Borrelia burgdorferi through modulating the stability of RpoS
PLOS Pathogens: published November 27, 2023 | https://doi.org/10.1371/journal.ppat.1011752
Dual function of Zika virus NS2B-NS3 protease
PLOS Pathogens: published November 27, 2023 | https://doi.org/10.1371/journal.ppat.1011795
Assessing vaccine-mediated protection in an ultra-low dose Mycobacterium tuberculosis murine model
PLOS Pathogens: published November 27, 2023 | https://doi.org/10.1371/journal.ppat.1011825
RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection
PLOS Pathogens: published November 27, 2023 | https://doi.org/10.1371/journal.ppat.1011813
Neuropilin-1 identifies a subset of highly activated CD8+ T cells during parasitic and viral infections
PLOS Pathogens: published November 29, 2023 | https://doi.org/10.1371/journal.ppat.1011837
A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size
PLOS Pathogens: published November 29, 2023 | https://doi.org/10.1371/journal.ppat.1011114
Preferential selection of viral escape mutants by CD8+ T cell ‘sieving’ of SIV reactivation from latency
PLOS Pathogens: published November 30, 2023 | https://doi.org/10.1371/journal.ppat.1011755
Antimicrobial peptide-producing dermal preadipocytes defend against Candida albicans skin infection via the FGFR-MEK-ERK pathway
PLOS Pathogens: published November 30, 2023 | https://doi.org/10.1371/journal.ppat.1011754
Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization
PLOS Pathogens: published November 30, 2023 | https://doi.org/10.1371/journal.ppat.1011804
Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells
PLOS Pathogens: published November 30, 2023 | https://doi.org/10.1371/journal.ppat.1011842