Lodderomyces elongisporus: An emerging human fungal pathogen

Yue Wang, Jianping Xu

PLOS Pathogens: published September 7, 2023 | https://doi.org/10.1371/journal.ppat.1011613

Interplay between host and Candida albicans during commensal gut colonization

Andrew W. Day, Carol A. Kumamoto

PLOS Pathogens: published September 14, 2023 | https://doi.org/10.1371/journal.ppat.1011607

Marine fungi: A treasure trove of novel natural products and for biological discovery

Frank Kempken

PLOS Pathogens: published September 21, 2023 | https://doi.org/10.1371/journal.ppat.1011624

Contextual influence of mammalian macro-autophagy in virus-bacteria coinfected cell phenotypes

Christophe Viret, Aude Lavedrine, Guénaëlle Lamiral, Aurore Rozières, Mathias Faure

PLOS Pathogens: published September 21, 2023 | https://doi.org/10.1371/journal.ppat.1011625

Novel mechanistic insights underlying fungal allergic inflammation

Yufan Zheng, Eric V. Dang

PLOS Pathogens: published September 13, 2023 | https://doi.org/10.1371/journal.ppat.1011623

The emerging roles of MARCH8 in viral infections: A double-edged Sword

Changqing Yu, Qiang Liu, Zhuo Zhao, Jingbo Zhai, Mengzhou Xue, Yan-Dong Tang, Chengbao Wang, Chunfu Zheng

PLOS Pathogens: published September 14, 2023 | https://doi.org/10.1371/journal.ppat.1011619

LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities

Zhongyuan Tan, Jiqin Wu, Li Huang, Ting Wang, Zhenhua Zheng, Jianhui Zhang, Xianliang Ke, Yuan Zhang, Yan Liu, Hanzhong Wang, Jianping Tao, Peng Gong

PLOS Pathogens: published September 1, 2023 | https://doi.org/10.1371/journal.ppat.1011620

Evidence for preexisting prion substrain diversity in a biologically cloned prion strain

Tess Gunnels, Ronald A. Shikiya, Taylor C. York, Alyssa J. Block, Jason C. Bartz

PLOS Pathogens: published September 5, 2023 | https://doi.org/10.1371/journal.ppat.1011632

Coxsackievirus B3 elicits a sex-specific CD8⁺ T cell response which protects female mice

Adeeba H. Dhalech, Stephanie A. Condotta, Aryamav Pattnaik, Caleb Corn, Martin J. Richer, Christopher M. Robinson

PLOS Pathogens: published September 5, 2023 | https://doi.org/10.1371/journal.ppat.1011465

Inhibition of ATM-directed antiviral responses by HIV-1 Vif

Hoi Tong Wong, Adeline M. Luperchio, Sean Riley, Daniel J. Salamango

PLOS Pathogens: published September 5, 2023 | https://doi.org/10.1371/journal.ppat.1011634

Airway metabolic profiling during Streptococcus pneumoniae infection identifies branched chain amino acids as signatures of upper airway colonisation

Angharad E. Green, Sian Pottenger, Manal S. Monshi, Thomas E. Barton, Marie Phelan, Daniel R. Neill

PLOS Pathogens: published September 5, 2023 | https://doi.org/10.1371/journal.ppat.1011630

Role of succinyl substituents in the mannose-capping of lipoarabinomannan and control of inflammation in Mycobacterium tuberculosis infection

Zuzana Palčeková, Andrés Obregón-Henao, Kavita De, Amanda Walz, Ha Lam, Jamie Philp, Shiva Kumar Angala, Johnathan Patterson, Camron Pearce, Sophie Zuberogoitia, Charlotte Avanzi, Jérôme Nigou, Michael McNeil, Juan F. Muñoz Gutiérrez, Martine Gilleron, William H. Wheat, Mercedes Gonzalez-Juarrero, Mary Jackson

PLOS Pathogens: published September 5, 2023 | https://doi.org/10.1371/journal.ppat.1011636

Antagonism between viral infection and innate immunity at the single-cell level

Frederic Grabowski, Marek Kochańczyk, Zbigniew Korwek, Maciej Czerkies, Wiktor Prus, Tomasz Lipniacki

PLOS Pathogens: published September 5, 2023 | https://doi.org/10.1371/journal.ppat.1011597

Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism

Sho Sugawara, Brady Hueber, Griffin Woolley, Karen Terry, Kyle Kroll, Cordelia Manickam, Daniel R. Ram, Lishomwa C. Ndhlovu, Paul Goepfert, Stephanie Jost, R. Keith Reeves

PLOS Pathogens: published September 5, 2023 | https://doi.org/10.1371/journal.ppat.1011629

Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation

Annabel T. Olson, Yuqi Kang, Anushka M. Ladha, Songli Zhu, Chuan Bian Lim, Behnam Nabet, Michael Lagunoff, Taranjit S. Gujral, Adam P. Geballe

PLOS Pathogens: published September 5, 2023 | https://doi.org/10.1371/journal.ppat.1011169

Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: A new approach to prevent and treat bacterial infections

Kenneth Johnson, James C. Delaney, Thomas Guillard, Fany Reffuveille, Jennifer Varin-Simon, Kai Li, Andrew Wollacott, Eric Frapy, Surin Mong, Hamid Tissire, Karthik Viswanathan, Faycal Touti, Gregory J. Babcock, Zachary Shriver, Bradley L. Pentelute, Obadiah Plante, David Skurnik

PLOS Pathogens: published September 7, 2023 | https://doi.org/10.1371/journal.ppat.1011612

Replication cycle timing determines phage sensitivity to a cytidine deaminase toxin/antitoxin bacterial defense system

Brian Y. Hsueh, Micah J. Ferrell, Ram Sanath-Kumar, Amber M. Bedore, Christopher M. Waters

PLOS Pathogens: published September 8, 2023 | https://doi.org/10.1371/journal.ppat.1011195

A serpin gene from a parasitoid wasp disrupts host immunity and exhibits adaptive alternative splicing

Zhichao Yan, Qi Fang, Jiqiang Song, Lei Yang, Shan Xiao, Jiale Wang, Gongyin Ye

PLOS Pathogens: published September 11, 2023 | https://doi.org/10.1371/journal.ppat.1011649

Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial immunometabolic modulation

Yongxing Wang, Vikram V. Kulkarni, Jezreel Pantaleón García, Miguel M. Leiva-Juárez, David L. Goldblatt, Fahad Gulraiz, Lisandra Vila Ellis, Jichao Chen, Michael K. Longmire, Sri Ramya Donepudi, Philip L. Lorenzi, Hao Wang, Lee-Jun Wong, Michael J. Tuvim, Scott E. Evans

PLOS Pathogens: published September 11, 2023 | https://doi.org/10.1371/journal.ppat.1011138

Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae

Marie Le Naour—Vernet, Florian Charriat, Jérôme Gracy, Sandrine Cros-Arteil, Sébastien Ravel, Florian Veillet, Isabelle Meusnier, André Padilla, Thomas Kroj, Stella Cesari, Pierre Gladieux

PLOS Pathogens: published September 11, 2023 | https://doi.org/10.1371/journal.ppat.1011294

Noncanonical Rab9a action supports retromer-mediated endosomal exit of human papillomavirus during virus entry

Jeongjoon Choi, Daniel DiMaio

PLOS Pathogens: published September 13, 2023 | https://doi.org/10.1371/journal.ppat.1011648

Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responses

Edward A. Arnold, Robin J. Kaai, Katie Leung, Mia R. Brinkley, Laurel E. Kelnhofer-Millevolte, Monica S. Guo, Daphne C. Avgousti

PLOS Pathogens: published September 13, 2023 | https://doi.org/10.1371/journal.ppat.1011633

Phage-antibiotic synergy: Cell filamentation is a key driver of successful phage predation

Julián Bulssico, Irina PapukashvilI, Leon Espinosa, Sylvain Gandon, Mireille Ansaldi

PLOS Pathogens: published September 13, 2023 | https://doi.org/10.1371/journal.ppat.1011602

Distinct disease features of acute and persistent genotype 3 hepatitis E virus infection in immunocompetent and immunosuppressed Mongolian gerbils

Sakthivel Subramaniam, Rafaelle Fares-Gusmao, Shinya Sato, John M. Cullen, Kazuyo Takeda, Patrizia Farci, David R. McGivern

PLOS Pathogens: published September 13, 2023 | https://doi.org/10.1371/journal.ppat.1011664

Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing

Ya Yan, Lei Wu, Ye Yuan, Haiwei Wang, Hongyan Yin, Minjie Li, Lvye Chai, Ruiying Liang, Yanjie Liu, Dongming Zhao, Junji Xing, Pingwei Li, Xin Li

PLOS Pathogens: published September 14, 2023 | https://doi.org/10.1371/journal.ppat.1011641

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites

Greta E. Weiss, Robert J. Ragotte, Doris Quinkert, Amelia M. Lias, Madeline G. Dans, Coralie Boulet, Oliver Looker, Olivia D. Ventura, Barnabas G. Williams, Brendan S. Crabb, Simon J. Draper, Paul R. Gilson

PLOS Pathogens: published September 15, 2023 | https://doi.org/10.1371/journal.ppat.1011182

Interactions between B cells and T follicular regulatory cells enhance susceptibility to Brucella infection independent of the anti-Brucella humoral response

Alexis S. Dadelahi, Mostafa F. N. Abushahba, Bárbara Ponzilacqua-Silva, Catherine A. Chambers, Charles R. Moley, Carolyn A. Lacey, Alexander L. Dent, Jerod A. Skyberg

PLOS Pathogens: published September 18, 2023 | https://doi.org/10.1371/journal.ppat.1011672

The development of resistance to an inhibitor of a cellular protein reveals a critical interaction between the enterovirus protein 2C and a small GTPase Arf1

Ekaterina G. Viktorova, Samuel Gabaglio, Seyedehmahsa Moghimi, Anna Zimina, Bridge G. Wynn, Elizabeth Sztul, George A. Belov

PLOS Pathogens: published September 18, 2023 | https://doi.org/10.1371/journal.ppat.1011673

Broad protective RBD heterotrimer vaccines neutralize SARS-CoV-2 including Omicron sub-variants XBB/BQ.1.1/BF.7

Yanfang Zhang, Xinrui Kang, Sheng Liu, Pu Han, Wenwen Lei, Ke Xu, Zepeng Xu, Zhengrong Gao, Xuemei Zhou, Yaling An, Yuxuan Han, Kefang Liu, Xin Zhao, Lianpan Dai, Peiyi Wang, Guizhen Wu, Jianxun Qi, Kun Xu, George F. Gao

PLOS Pathogens: published September 18, 2023 | https://doi.org/10.1371/journal.ppat.1011659

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo

Marie Bourdon, Caroline Manet, Laurine Conquet, Corentin Ramaugé Parra, Etienne Kornobis, Eliette Bonnefoy, Xavier Montagutelli

PLOS Pathogens: published September 21, 2023 | https://doi.org/10.1371/journal.ppat.1011446

Vaccine-induced inflammation and inflammatory monocytes promote CD4⁺ T cell-dependent immunity against murine salmonellosis

Nancy Wang, Timothy A. Scott, Andreas Kupz, Meghanashree M. Shreenivas, Newton G. Peres, Dianna M. Hocking, Chenying Yang, Leila Jebeli, Lynette Beattie, Joanna R. Groom, Thomas P. Pierce, Linda M. Wakim, Sammy Bedoui, Richard A. Strugnell

PLOS Pathogens: published September 21, 2023 | https://doi.org/10.1371/journal.ppat.1011666

Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus

Li Ou, Steven J. Chen, I-Ting Teng, Lijuan Yang, Baoshan Zhang, Tongqing Zhou, Andrea Biju, Cheng Cheng, Wing-Pui Kong, Nicholas C. Morano, Erik-Stephane D. Stancofski, John-Paul Todd, Yaroslav Tsybovsky, Shuishu Wang, Cheng-Yan Zheng, John R. Mascola, Lawrence Shapiro, Ruth A. Woodward, Ursula J. Buchholz, Peter D. Kwong

PLOS Pathogens: published September 22, 2023 | https://doi.org/10.1371/journal.ppat.1011584

Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching

Amicha Robertson, Joseph Sall, Mericien Venzon, Janet J. Olivas, Xuhui Zheng, Michael Cammer, Noelle Antao, Chunyi Zhou, Joseph C. Devlin, Rafaela Saes Thur, Jeffrey Bethony, Peter Nejsum, Bo Shopsin, Victor J. Torres, Feng-Xia Liang, Ken Cadwell

PLOS Pathogens: published September 22, 2023 | https://doi.org/10.1371/journal.ppat.1011647

Binding of herpesvirus entry mediator (HVEM) and HSV-1 gD affect reactivation but not latency levels

Ujjaldeep Jaggi, Shaohui Wang, Kevin R. Mott, Homayon Ghiasi

PLOS Pathogens: published September 22, 2023 | https://doi.org/10.1371/journal.ppat.1011693

Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin

Magda Teixeira Nunes, Pascal Retailleau, Dorothée Raoux-Barbot, Martine Comisso, Anani Amegan Missinou, Christophe Velours, Stéphane Plancqueel, Daniel Ladant, Undine Mechold, Louis Renault

PLOS Pathogens: published September 25, 2023 | https://doi.org/10.1371/journal.ppat.1011654

Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection

Peyman Ghorbani, Sang Yong Kim, Tyler K. T. Smith, Lucía Minarrieta, Victoria Robert-Gostlin, Marisa K. Kilgour, Maja Ilijevska, Irina Alecu, Shayne A. Snider, Kaitlyn D. Margison, Julia R. C. Nunes, Daniel Woo, Ciara Pember, Conor O’Dwyer, Julie Ouellette, Pavel Kotchetkov, Julie St-Pierre, Steffany A. L. Bennett, Baptiste Lacoste, Alexandre Blais, Meera G. Nair, Morgan D. Fullerton

PLOS Pathogens: published September 25, 2023 | https://doi.org/10.1371/journal.ppat.1011658

Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors

Nicholas D. Clark, Christopher Pham, Kurni Kurniyati, Ching Wooen Sze, Laurynn Coleman, Qin Fu, Sheng Zhang, Michael G. Malkowski, Chunhao Li

PLOS Pathogens: published September 25, 2023 | https://doi.org/10.1371/journal.ppat.1011674

CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post-infection

Olivia E. Harwood, Lea M. Matschke, Ryan V. Moriarty, Alexis J. Balgeman, Abigail J. Weaver, Amy L. Ellis-Connell, Andrea M. Weiler, Lee C. Winchester, Courtney V. Fletcher, Thomas C. Friedrich, Brandon F. Keele, David H. O’Connor, Jessica D. Lang, Matthew R. Reynolds, Shelby L. O’Connor

PLOS Pathogens: published September 25, 2023 | https://doi.org/10.1371/journal.ppat.1011676

Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

Patricia Aguilar-Calvo, Adela Malik, Daniel R. Sandoval, Christopher Barback, Christina D. Orrù, Heidi G. Standke, Olivia R. Thomas, Chrissa A. Dwyer, Donald P. Pizzo, Jaidev Bapat, Katrin Soldau, Ryotaro Ogawa, Mckenzie B. Riley, K. Peter R. Nilsson, Allison Kraus, Byron Caughey, Jeffrey J. Iliff, David R. Vera, Jeffrey D. Esko, Christina J. Sigurdson

PLOS Pathogens: published September 25, 2023 | https://doi.org/10.1371/journal.ppat.1011487

Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection

Baxolele Mhlekude, Dylan Postmus, Saskia Stenzel, January Weiner 3rd, Jenny Jansen, Francisco J. Zapatero-Belinchón, Ruth Olmer, Anja Richter, Julian Heinze, Nicolas Heinemann, Barbara Mühlemann, Simon Schroeder, Terry C. Jones, Marcel A. Müller, Christian Drosten, Andreas Pich, Volker Thiel, Ulrich Martin, Daniela Niemeyer, Gisa Gerold, Dieter Beule, Christine Goffinet

PLOS Pathogens: published September 25, 2023 | https://doi.org/10.1371/journal.ppat.1011657

Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake

Rodger de Miranda, Bonnie J. Cuthbert, Thaís Klevorn, Alex Chao, Jessica Mendoza, Mark Arbing, Paul J. Sieminski, Kadamba Papavinasasundaram, Sumer Abdul-Hafiz, Sum Chan, Christopher M. Sassetti, Sabine Ehrt, Celia W. Goulding

PLOS Pathogens: published September 25, 2023 | https://doi.org/10.1371/journal.ppat.1011650

Host-derived reactive oxygen species trigger activation of the Candida albicans transcription regulator Rtg1/3

Mazen Oneissi, Melissa R. Cruz, Bernardo Ramírez-Zavala, Elena Lindemann-Perez, Joachim Morschhäuser, Danielle A. Garsin, J. Christian Perez

PLOS Pathogens: published September 28, 2023 | https://doi.org/10.1371/journal.ppat.1011692

Acinetobacter type VI secretion system comprises a non-canonical membrane complex

Ona Kandolo, Yassine Cherrak, Isaac Filella-Merce, Hugo Le Guenno, Artemis Kosta, Leon Espinosa, Pierre Santucci, Christophe Verthuy, Régine Lebrun, Michael Nilges, Riccardo Pellarin, Eric Durand

PLOS Pathogens: published September 28, 2023 | https://doi.org/10.1371/journal.ppat.1011687

SifA SUMOylation governs Salmonella Typhimurium intracellular survival via modulation of lysosomal function

Hridya Chandrasekhar, Gayatree Mohapatra, Kirti Kajal, Mukesh Singh, Kshitiz Walia, Sarika Rana, Navneet Kaur, Sheetal Sharma, Amit Tuli, Prasenjit Das, Chittur V. Srikanth

PLOS Pathogens: published September 29, 2023 | https://doi.org/10.1371/journal.ppat.1011686

Correction: Effects of chronic exposure to arsenic on the fecal carriage of antibiotic-resistant Escherichia coli among people in rural Bangladesh

Mohammed Badrul Amin, Prabhat Kumar Talukdar, Muhammad Asaduzzaman, Subarna Roy, Brandon M. Flatgard, Md. Rayhanul Islam, Sumita Rani Saha, Yushuf Sharker, Zahid Hayat Mahmud, Tala Navab-Daneshmand, Molly L. Kile, Karen Levy, Timothy R. Julian, Mohammad Aminul Islam

PLOS Pathogens: published September 29, 2023 | https://doi.org/10.1371/journal.ppat.1011690

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1. Effects of chronic exposure to arsenic on the fecal carriage of antibiotic-resistant Escherichia coli among people in rural Bangladesh