A confocal image of a Nicotiana benthamiana epidermis cell expressing XopL (yellow), an effector derived from the plant pathogen Xanthomonas euvesicatoria. XopL localizes to, and typically destroys the microtubule network, but microtubules have been partially rescued in this cell through treatments with the microtubule stabilizing drug taxol. The chloroplasts are visible in magenta. Ortmann et al
Image Credit: Jessica Lee Erickson
Pearls
More complicated than it seems: The diversity of cryptococcal glucuronoxylomannan
PLOS Pathogens: published August 3, 2023 | https://doi.org/10.1371/journal.ppat.1011521
Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii
PLOS Pathogens: published August 10, 2023 | https://doi.org/10.1371/journal.ppat.1011520
The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome
PLOS Pathogens: published August 17, 2023 | https://doi.org/10.1371/journal.ppat.1011523
The dengue virus NS1 protein; new roles in pathogenesis due to similarities with and affinity for the high-density lipoprotein (HDL)?
PLOS Pathogens: published August 24, 2023 | https://doi.org/10.1371/journal.ppat.1011587
Azole potentiation in Candida species
PLOS Pathogens: published August 31, 2023 | https://doi.org/10.1371/journal.ppat.1011583
Reviews
Epigenetic regulation of nuclear processes in fungal plant pathogens
PLOS Pathogens: published August 3, 2023 | https://doi.org/10.1371/journal.ppat.1011525
Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics
PLOS Pathogens: published August 31, 2023 | https://doi.org/10.1371/journal.ppat.1011588
Research Articles
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates
PLOS Pathogens: published August 2, 2023 | https://doi.org/10.1371/journal.ppat.1011532
Phages on filaments: A genetic screen elucidates the complex interactions between Salmonella enterica flagellin and bacteriophage Chi
PLOS Pathogens: published August 3, 2023 | https://doi.org/10.1371/journal.ppat.1011537
Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype
PLOS Pathogens: published August 3, 2023 | https://doi.org/10.1371/journal.ppat.1011545
Shift in vacuolar to cytosolic regime of infecting Salmonella from a dual proteome perspective
PLOS Pathogens: published August 3, 2023 | https://doi.org/10.1371/journal.ppat.1011183
Hepatitis C virus non-structural proteins modulate cellular kinases for increased cytoplasmic abundance of host factor HuR and facilitate viral replication
PLOS Pathogens: published August 4, 2023 | https://doi.org/10.1371/journal.ppat.1011552
Effects of Capsular Polysaccharide amount on Pneumococcal-Host interactions
PLOS Pathogens: published August 4, 2023 | https://doi.org/10.1371/journal.ppat.1011509
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Structural and functional characterization of the Sin Nombre virus L protein
PLOS Pathogens: published August 7, 2023 | https://doi.org/10.1371/journal.ppat.1011533
Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2
PLOS Pathogens: published August 7, 2023 | https://doi.org/10.1371/journal.ppat.1011328
Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model
PLOS Pathogens: published August 7, 2023 | https://doi.org/10.1371/journal.ppat.1011274
The genetic basis of variation in immune defense against Lysinibacillus fusiformis infection in Drosophila melanogaster
PLOS Pathogens: published August 7, 2023 | https://doi.org/10.1371/journal.ppat.1010934
Impact of stabilizing mutations on the antigenic profile and glycosylation of membrane-expressed HIV-1 envelope glycoprotein
PLOS Pathogens: published August 7, 2023 | https://doi.org/10.1371/journal.ppat.1011452
Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope
PLOS Pathogens: published August 9, 2023 | https://doi.org/10.1371/journal.ppat.1011554
Insect fungal pathogens secrete a cell wall-associated glucanase that acts to help avoid recognition by the host immune system
PLOS Pathogens: published August 9, 2023 | https://doi.org/10.1371/journal.ppat.1011578
Importation of Alpha and Delta variants during the SARS-CoV-2 epidemic in Switzerland: Phylogenetic analysis and intervention scenarios
PLOS Pathogens: published August 10, 2023 | https://doi.org/10.1371/journal.ppat.1011553
Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface
PLOS Pathogens: published August 10, 2023 | https://doi.org/10.1371/journal.ppat.1011571
Drosophila immune priming to Enterococcus faecalis relies on immune tolerance rather than resistance
PLOS Pathogens: published August 11, 2023 | https://doi.org/10.1371/journal.ppat.1011567
The MGF300-2R protein of African swine fever virus is associated with viral pathogenicity by promoting the autophagic degradation of IKKα and IKKβ through the recruitment of TOLLIP
PLOS Pathogens: published August 11, 2023 | https://doi.org/10.1371/journal.ppat.1011580
The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells
PLOS Pathogens: published August 14, 2023 | https://doi.org/10.1371/journal.ppat.1011562
A conserved microtubule-binding region in Xanthomonas XopL is indispensable for induced plant cell death reactions
PLOS Pathogens: published August 14, 2023 | https://doi.org/10.1371/journal.ppat.1011263
Single-cell mutation rate of turnip crinkle virus (-)-strand replication intermediates
PLOS Pathogens: published August 14, 2023 | https://doi.org/10.1371/journal.ppat.1011395
Viral burden is associated with age, vaccination, and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection-related sampling bias
PLOS Pathogens: published August 14, 2023 | https://doi.org/10.1371/journal.ppat.1011461
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NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli
PLOS Pathogens: published August 16, 2023 | https://doi.org/10.1371/journal.ppat.1011563
Contrasting effects of filamin A and B proteins in modulating filovirus entry
PLOS Pathogens: published August 16, 2023 | https://doi.org/10.1371/journal.ppat.1011595
Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation
PLOS Pathogens: published August 16, 2023 | https://doi.org/10.1371/journal.ppat.1011591
ABCH2 transporter mediates deltamethrin uptake and toxicity in the malaria vector Anopheles coluzzii
PLOS Pathogens: published August 16, 2023 | https://doi.org/10.1371/journal.ppat.1011226
Pathogenesis and outcome of VA1 astrovirus infection in the human brain are defined by disruption of neural functions and imbalanced host immune responses
PLOS Pathogens: published August 18, 2023 | https://doi.org/10.1371/journal.ppat.1011544
Targeting FoxO proteins induces lytic reactivation of KSHV for treating herpesviral primary effusion lymphoma
PLOS Pathogens: published August 18, 2023 | https://doi.org/10.1371/journal.ppat.1011581
The circRNA circVAMP3 restricts influenza A virus replication by interfering with NP and NS1 proteins
PLOS Pathogens: published August 21, 2023 | https://doi.org/10.1371/journal.ppat.1011577
The emergence of SARS-CoV-2 lineages and associated saliva antibody responses among asymptomatic individuals in a large university community
PLOS Pathogens: published August 21, 2023 | https://doi.org/10.1371/journal.ppat.1011596
Widespread infection, diversification and old host associations of Nosema Microsporidia in European freshwater gammarids (Amphipoda)
PLOS Pathogens: published August 21, 2023 | https://doi.org/10.1371/journal.ppat.1011560
Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice
PLOS Pathogens: published August 21, 2023 | https://doi.org/10.1371/journal.ppat.1011600
The small non-coding RNA B11 regulates multiple facets of Mycobacterium abscessus virulence
PLOS Pathogens: published August 21, 2023 | https://doi.org/10.1371/journal.ppat.1011575
Variation among strains of Borrelia burgdorferi in host tissue abundance and lifetime transmission determine the population strain structure in nature
PLOS Pathogens: published August 22, 2023 | https://doi.org/10.1371/journal.ppat.1011572
SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b
PLOS Pathogens: published August 22, 2023 | https://doi.org/10.1371/journal.ppat.1011582
Treponema pallidum promoted microglia apoptosis and prevented itself from clearing by human microglia via blocking autophagic flux
PLOS Pathogens: published August 23, 2023 | https://doi.org/10.1371/journal.ppat.1011594
Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection
PLOS Pathogens: published August 23, 2023 | https://doi.org/10.1371/journal.ppat.1011579
Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids
PLOS Pathogens: published August 24, 2023 | https://doi.org/10.1371/journal.ppat.1011559
Pseudomonas aeruginosa pulmonary infection results in S100A8/A9-dependent cardiac dysfunction
PLOS Pathogens: published August 25, 2023 | https://doi.org/10.1371/journal.ppat.1011573
Germline-encoded specificities and the predictability of the B cell response
PLOS Pathogens: published August 25, 2023 | https://doi.org/10.1371/journal.ppat.1011603
DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection
PLOS Pathogens: published August 28, 2023 | https://doi.org/10.1371/journal.ppat.1011616
Designed nanoparticles elicit cross-reactive antibody responses to conserved influenza virus hemagglutinin stem epitopes
PLOS Pathogens: published August 28, 2023 | https://doi.org/10.1371/journal.ppat.1011514
Hemin treatment drives viral reactivation and plasma cell differentiation of EBV latently infected B cells
PLOS Pathogens: published August 28, 2023 | https://doi.org/10.1371/journal.ppat.1011561
Modelling BK Polyomavirus dissemination and cytopathology using polarized human renal tubule epithelial cells
PLOS Pathogens: published August 28, 2023 | https://doi.org/10.1371/journal.ppat.1011622
An integrated multi-omics analysis of identifies distinct molecular characteristics in pulmonary infections of Pseudomonas aeruginosa
PLOS Pathogens: published August 29, 2023 | https://doi.org/10.1371/journal.ppat.1011570
Characterization of molecular mechanisms driving Merkel cell polyomavirus oncogene transcription and tumorigenic potential
PLOS Pathogens: published August 30, 2023 | https://doi.org/10.1371/journal.ppat.1011598
Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination
PLOS Pathogens: published August 31, 2023 | https://doi.org/10.1371/journal.ppat.1011243
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo
PLOS Pathogens: published August 31, 2023 | https://doi.org/10.1371/journal.ppat.1011614
Function and regulation of a steroidogenic CYP450 enzyme in the mitochondrion of Toxoplasma gondii
PLOS Pathogens: published August 31, 2023 | https://doi.org/10.1371/journal.ppat.1011566
A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations
PLOS Pathogens: published August 31, 2023 | https://doi.org/10.1371/journal.ppat.1011592
Corrections
Correction: Effector-mediated subversion of proteasome activator (PA)28αβ enhances host defense against Legionella pneumophila under inflammatory and oxidative stress conditions
PLOS Pathogens: published August 22, 2023 | https://doi.org/10.1371/journal.ppat.1011604
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Correction: How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell
PLOS Pathogens: published August 30, 2023 | https://doi.org/10.1371/journal.ppat.1011617