Calcineurin: The Achilles’ heel of fungal pathogens

Vikas Yadav, Joseph Heitman

PLOS Pathogens: published July 6, 2023 | https://doi.org/10.1371/journal.ppat.1011445

Anti-influenza A virus restriction factors that shape the human species barrier and virus evolution

Philipp Peter Petric, Martin Schwemmle, Laura Graf

PLOS Pathogens: published July 6, 2023 | https://doi.org/10.1371/journal.ppat.1011450

Fusarium phytopathogens as insect mutualists

Aileen Berasategui, Shounak Jagdale, Hassan Salem

PLOS Pathogens: published July 27, 2023 | https://doi.org/10.1371/journal.ppat.1011497

To eat or not to eat mitochondria? How do host cells cope with mitophagy upon bacterial infection?

Jérémy Verbeke, Xavier De Bolle, Thierry Arnould

PLOS Pathogens: published July 6, 2023 | https://doi.org/10.1371/journal.ppat.1011471

Advances in new target molecules against schistosomiasis: A comprehensive discussion of physiological structure and nutrient intake

Peng Zhu, Kaijuan Wu, Chaobin Zhang, Syeda Sundas Batool, Anqiao Li, Zheng Yu, Jing Huang

PLOS Pathogens: published July 27, 2023 | https://doi.org/10.1371/journal.ppat.1011498

The synergistic effect of residues 32T and 550L in the PA protein of H5 subtype avian influenza virus contributes to viral pathogenicity in mice

Hui Yang, Yurui Dong, Ying Bian, Chenzhi Huo, Chuncheng Zhu, Tao Qin, Sujuan Chen, Daxin Peng, Xiufan Liu

PLOS Pathogens: published July 3, 2023 | https://doi.org/10.1371/journal.ppat.1011489

Adaptation of a transmitted/founder simian-human immunodeficiency virus for enhanced replication in rhesus macaques

Anya Bauer, Emily Lindemuth, Francesco Elia Marino, Ryan Krause, Jaimy Joy, Steffen S. Docken, Suvadip Mallick, Kevin McCormick, Clinton Holt, Ivelin Georgiev, Barbara Felber, Brandon F. Keele, Ronald Veazey, Miles P. Davenport, Hui Li, George M. Shaw, Katharine J. Bar

PLOS Pathogens: published July 3, 2023 | https://doi.org/10.1371/journal.ppat.1011059

Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis

Aleksandra W. Debowski, Nicole M. Bzdyl, David R. Thomas, Nichollas E. Scott, Christopher H. Jenkins, Jua Iwasaki, Emily A. Kibble, Chen Ai Khoo, Nicolas J. Scheuplein, Pamela M. Seibel, Theresa Lohr, Georgie Metters, Charles S. Bond, Isobel H. Norville, Keith A. Stubbs, Nicholas J. Harmer, Ulrike Holzgrabe, Hayley J. Newton, Mitali Sarkar-Tyson

PLOS Pathogens: published July 3, 2023 | https://doi.org/10.1371/journal.ppat.1011491

L-selectin-dependent and -independent homing of naïve lymphocytes through the lung draining lymph node support T cell response to pulmonary Mycobacterium tuberculosis infection

Lina Daniel, Claudio Counoupas, Nayan D. Bhattacharyya, James A. Triccas, Warwick J. Britton, Carl G. Feng

PLOS Pathogens: published July 5, 2023 | https://doi.org/10.1371/journal.ppat.1011460

The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression

Jin Wei, Mia Madel Alfajaro, Wesley L. Cai, Vincent R. Graziano, Madison S. Strine, Renata B. Filler, Scott B. Biering, Sylvia A. Sarnik, Sonam Patel, Bridget L. Menasche, Susan R. Compton, Silvana Konermann, Patrick D. Hsu, Robert C. Orchard, Qin Yan, Craig B. Wilen

PLOS Pathogens: published July 6, 2023 | https://doi.org/10.1371/journal.ppat.1011351

Changes in SUMO-modified proteins in Epstein-Barr virus infection identifies reciprocal regulation of TRIM24/28/33 complexes and the lytic switch BZLF1

Carlos F. De La Cruz-Herrera, Michael H. Tatham, Umama Z. Siddiqi, Kathy Shire, Edyta Marcon, Jack F. Greenblatt, Ronald T. Hay, Lori Frappier

PLOS Pathogens: published July 6, 2023 | https://doi.org/10.1371/journal.ppat.1011477

USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16

Yuling Fu, Xiaoxia Zhan, Xiaolong You, Dingnai Nie, Haiyan Mai, Yitian Chen, Shitong He, Junli Sheng, Zhijie Zeng, Hongwei Li, Jinlong Li, Shengfeng Hu

PLOS Pathogens: published July 6, 2023 | https://doi.org/10.1371/journal.ppat.1011480

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NOG1 downregulates type I interferon production by targeting phosphorylated interferon regulatory factor 3

Qiao Xue, Zixiang Zhu, Zhaoning Xue, Fan Yang, Weijun Cao, Xiangtao Liu, Huisheng Liu, Haixue Zheng

PLOS Pathogens: published July 6, 2023 | https://doi.org/10.1371/journal.ppat.1011511

An acidic microenvironment in Tuberculosis increases extracellular matrix degradation by regulating macrophage inflammatory responses

Ashley M. Whittington, Frances S. Turner, Friedrich Baark, Sam Templeman, Daniela E. Kirwan, Candice Roufosse, Nitya Krishnan, Brian D. Robertson, Deborah L. W. Chong, Joanna C. Porter, Robert H. Gilman, Jon S. Friedland

PLOS Pathogens: published July 7, 2023 | https://doi.org/10.1371/journal.ppat.1011495

Type-I interferons promote innate immune tolerance in macrophages exposed to Mycobacterium ulcerans vesicles

Quentin Bernard, Maïssa Goumeidane, Emmanuel Chaumond, Marie Robbe-Saule, Yan Boucaud, Lucille Esnault, Anne Croué, Jerome Jullien, Laurent Marsollier, Estelle Marion

PLOS Pathogens: published July 10, 2023 | https://doi.org/10.1371/journal.ppat.1011479

Glucose-enhanced oxidative stress resistance—A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection

Daniel E. Larcombe, Iryna M. Bohovych, Arnab Pradhan, Qinxi Ma, Emer Hickey, Ian Leaves, Gary Cameron, Gabriela M. Avelar, Leandro J. de Assis, Delma S. Childers, Judith M. Bain, Katherine Lagree, Aaron P. Mitchell, Mihai G. Netea, Lars P. Erwig, Neil A. R. Gow, Alistair J. P. Brown

PLOS Pathogens: published July 10, 2023 | https://doi.org/10.1371/journal.ppat.1011505

Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis

Sevan N. Alwan, Alexander B. Taylor, Jayce Rhodes, Michael Tidwell, Stanton F. McHardy, Philip T. LoVerde

PLOS Pathogens: published July 10, 2023 | https://doi.org/10.1371/journal.ppat.1011018

Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA

Jens Kleinehr, Michael Schöfbänker, Katharina Daniel, Franziska Günl, Fakry Fahmy Mohamed, Josua Janowski, Linda Brunotte, Yvonne Boergeling, Marie Liebmann, Matthias Behrens, Andrea Gerdemann, Luisa Klotz, Melanie Esselen, Hans-Ulrich Humpf, Stephan Ludwig, Eike R. Hrincius

PLOS Pathogens: published July 13, 2023 | https://doi.org/10.1371/journal.ppat.1010986

Impact of the pentose phosphate pathway on metabolism and pathogenesis of Staphylococcus aureus

Jisun Kim, Gyu-Lee Kim, Javiera Norambuena, Jeffrey M. Boyd, Dane Parker

PLOS Pathogens: published July 13, 2023 | https://doi.org/10.1371/journal.ppat.1011531

Aminopeptidase MNP-1 triggers intestine protease production by activating daf-16 nuclear location to degrade pore-forming toxins in Caenorhabditis elegans

Feng Chen, Cuiyun Pang, Ziqiang Zheng, Wei Zhou, Zhiqing Guo, Danyang Xiao, Hongwen Du, Alejandra Bravo, Mario Soberón, Ming Sun, Donghai Peng

PLOS Pathogens: published July 13, 2023 | https://doi.org/10.1371/journal.ppat.1011507

Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

Wladimir Malaga, Delphine Payros, Eva Meunier, Wafa Frigui, Fadel Sayes, Alexandre Pawlik, Mickael Orgeur, Céline Berrone, Flavie Moreau, Serge Mazères, Jesus Gonzalo-Asensio, David Rengel, Carlos Martin, Catherine Astarie-Dequeker, Lionel Mourey, Roland Brosch, Christophe Guilhot

PLOS Pathogens: published July 14, 2023 | https://doi.org/10.1371/journal.ppat.1011437

The mitophagy receptor NIX induces vIRF-1 oligomerization and interaction with GABARAPL1 for the promotion of HHV-8 reactivation-induced mitophagy

Mai Tram Vo, Chang-Yong Choi, Young Bong Choi

PLOS Pathogens: published July 17, 2023 | https://doi.org/10.1371/journal.ppat.1011548

Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes

Douglas O. Escrivani, Viktor Scheidt, Michele Tinti, Joana Faria, David Horn

PLOS Pathogens: published July 17, 2023 | https://doi.org/10.1371/journal.ppat.1011530

Characterization of two novel proteins involved in mitochondrial DNA anchoring in Trypanosoma brucei

Simona Amodeo, Irina Bregy, Anneliese Hoffmann, Albert Fradera-Sola, Mara Kern, Hélène Baudouin, Benoît Zuber, Falk Butter, Torsten Ochsenreiter

PLOS Pathogens: published July 17, 2023 | https://doi.org/10.1371/journal.ppat.1011486

HIV-1 virological synapse formation enhances infection spread by dysregulating Aurora Kinase B

James W. Bruce, Eunju Park, Chris Magnano, Mark Horswill, Alicia Richards, Gregory Potts, Alexander Hebert, Nafisah Islam, Joshua J. Coon, Anthony Gitter, Nathan Sherer, Paul Ahlquist

PLOS Pathogens: published July 17, 2023 | https://doi.org/10.1371/journal.ppat.1011492

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

Fakhar H. Waqas, Mahmoud Shehata, Walid A. M. Elgaher, Antoine Lacour, Naziia Kurmasheva, Fabio Begnini, Anders E. Kiib, Julia Dahlmann, Chutao Chen, Andreas Pavlou, Thomas B. Poulsen, Sylvia Merkert, Ulrich Martin, Ruth Olmer, David Olagnier, Anna K. H. Hirsch, Stephan Pleschka, Frank Pessler

PLOS Pathogens: published July 17, 2023 | https://doi.org/10.1371/journal.ppat.1011506

Multiple pals gene modules control a balance between immunity and development in Caenorhabditis elegans

Vladimir Lažetić, Michael J. Blanchard, Theresa Bui, Emily R. Troemel

PLOS Pathogens: published July 18, 2023 | https://doi.org/10.1371/journal.ppat.1011120

Membrane-dependent actin polymerization mediated by the Legionella pneumophila effector protein MavH

Qing Zhang, Min Wan, Elena Kudryashova, Dmitri S. Kudryashov, Yuxin Mao

PLOS Pathogens: published July 18, 2023 | https://doi.org/10.1371/journal.ppat.1011512

14^th century Yersinia pestis genomes support emergence of pestis secunda within Europe

Cody E. Parker, Alina N. Hiss, Maria A. Spyrou, Gunnar U. Neumann, Philip Slavin, Elizabeth A. Nelson, Sarah Nagel, Xandra Dalidowski, Susanne Friederich, Johannes Krause, Alexander Herbig, Wolfgang Haak, Kirsten I. Bos

PLOS Pathogens: published July 18, 2023 | https://doi.org/10.1371/journal.ppat.1011404

Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress

Caitlyn L. Holmes, Alexis E. Wilcox, Valerie Forsyth, Sara N. Smith, Bridget S. Moricz, Lavinia V. Unverdorben, Sophia Mason, Weisheng Wu, Lili Zhao, Harry L. T. Mobley, Michael A. Bachman

PLOS Pathogens: published July 18, 2023 | https://doi.org/10.1371/journal.ppat.1011233

S100A9 is indispensable for survival of pneumococcal pneumonia in mice

Lena Ostermann, Benjamin Seeliger, Sascha David, Carolin Flasche, Regina Maus, Marieke S. Reinboth, Martin Christmann, Konstantin Neumann, Korbinian Brand, Stephan Seltmann, Frank Bühling, James C. Paton, Johannes Roth, Thomas Vogl, Dorothee Viemann, Tobias Welte, Ulrich A. Maus

PLOS Pathogens: published July 19, 2023 | https://doi.org/10.1371/journal.ppat.1011493

A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites

Jenni A. Hayward, F. Victor Makota, Daniela Cihalova, Rachel A. Leonard, Esther Rajendran, Soraya M. Zwahlen, Laura Shuttleworth, Ursula Wiedemann, Christina Spry, Kevin J. Saliba, Alexander G. Maier, Giel G. van Dooren

PLOS Pathogens: published July 20, 2023 | https://doi.org/10.1371/journal.ppat.1011517

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Genomic and phenotypic evolution of nematode-infecting microsporidia

Lina Wadi, Hala Tamim El Jarkass, Tuan D. Tran, Nizar Islah, Robert J. Luallen, Aaron W. Reinke

PLOS Pathogens: published July 20, 2023 | https://doi.org/10.1371/journal.ppat.1011510

Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication

Danielle M. Pierce, Frazer J. T. Buchanan, Fraser L. Macrae, Jake T. Mills, Abigail Cox, Khadijah M. Abualsaoud, Joseph C. Ward, Robert A. S. Ariëns, Mark Harris, Nicola J. Stonehouse, Morgan R. Herod

PLOS Pathogens: published July 21, 2023 | https://doi.org/10.1371/journal.ppat.1011529

Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

Merve S. Zeden, Laura A. Gallagher, Emilio Bueno, Aaron C. Nolan, Jongsam Ahn, Dhananjay Shinde, Fareha Razvi, Margaret Sladek, Órla Burke, Eoghan O’Neill, Paul D. Fey, Felipe Cava, Vinai C. Thomas, James P. O’Gara

PLOS Pathogens: published July 24, 2023 | https://doi.org/10.1371/journal.ppat.1011536

MPL36, a major plasminogen (PLG) receptor in pathogenic Leptospira, has an essential role during infection

Weinan Zhu, Felipe J. Passalia, Camila Hamond, Cecília M. Abe, Albert I. Ko, Angela S. Barbosa, Elsio A. Wunder Jr.

PLOS Pathogens: published July 24, 2023 | https://doi.org/10.1371/journal.ppat.1011313

Proliferating cell nuclear antigen inhibitors block distinct stages of herpes simplex virus infection

Jessica E. Packard, Maya R. Williams, Daniel P. Fromuth, Jill A. Dembowski

PLOS Pathogens: published July 24, 2023 | https://doi.org/10.1371/journal.ppat.1011539

Streptococcus pneumoniae drives specific and lasting Natural Killer cell memory

Tiphaine M. N. Camarasa, Júlia Torné, Christine Chevalier, Orhan Rasid, Melanie A. Hamon

PLOS Pathogens: published July 24, 2023 | https://doi.org/10.1371/journal.ppat.1011159

Isotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection

Maia J. Baskerville, Yekaterina Kovalyova, Raquel Mejías-Luque, Markus Gerhard, Stavroula K. Hatzios

PLOS Pathogens: published July 26, 2023 | https://doi.org/10.1371/journal.ppat.1011526

Suppression of viral RNA polymerase activity is necessary for persistent infection during the transformation of measles virus into SSPE virus

Kento Sakamoto, Miho Konami, Shinra Kameda, Yuto Satoh, Hiroshi Wakimoto, Yoshinori Kitagawa, Bin Gotoh, Da-Peng Jiang, Hak Hotta, Masae Itoh

PLOS Pathogens: published July 26, 2023 | https://doi.org/10.1371/journal.ppat.1011528

Fusogenic structural changes in arenavirus glycoproteins are associated with viroporin activity

You Zhang, Joanne York, Melinda A. Brindley, Jack H. Nunberg, Gregory B. Melikyan

PLOS Pathogens: published July 26, 2023 | https://doi.org/10.1371/journal.ppat.1011217

Reverse-zoonoses of 2009 H1N1 pandemic influenza A viruses and evolution in United States swine results in viruses with zoonotic potential

Alexey Markin, Giovana Ciacci Zanella, Zebulun W. Arendsee, Jianqiang Zhang, Karen M. Krueger, Phillip C. Gauger, Amy L. Vincent Baker, Tavis K. Anderson

PLOS Pathogens: published July 27, 2023 | https://doi.org/10.1371/journal.ppat.1011476

Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2

Aniuska Becerra-Artiles, Padma P. Nanaware, Khaja Muneeruddin, Grant C. Weaver, Scott A. Shaffer, J. Mauricio Calvo-Calle, Lawrence J. Stern

PLOS Pathogens: published July 27, 2023 | https://doi.org/10.1371/journal.ppat.1011032

Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication

Yixiang Hu, Xinru Chen, Yuehuan Ling, Kun Zhou, Meiqing Han, Xingbo Wang, Min Yue, Yan Li

PLOS Pathogens: published July 27, 2023 | https://doi.org/10.1371/journal.ppat.1011550

Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma

Tatiana C. Paredes-Santos, Mebratu A. Bitew, Christopher Swale, Felipe Rodriguez, Shruthi Krishnamurthy, Yifan Wang, Parag Maru, Lamba Omar Sangaré, Jeroen P. J. Saeij

PLOS Pathogens: published July 27, 2023 | https://doi.org/10.1371/journal.ppat.1011543

Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance

Xiaofang Cheng, Wei Jiang, Yeying Chen, Benkun Zou, Zhiyan Wang, Lu Gan, Zeling Xiao, Changshun Li, Cheng-Yun Yu, Yimeng Lu, Zeyao Han, Jiashun Zeng, Jie Gu, Tianqing Chu, Mingsheng Fu, Yiwei Chu, Wenhong Zhang, Jianguo Tang, Mingfang Lu

PLOS Pathogens: published July 27, 2023 | https://doi.org/10.1371/journal.ppat.1011556

How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell

Janaina F. Nascimento, Rodolpho O. O. Souza, Mayke B. Alencar, Sabrina Marsiccobetre, Ana M. Murillo, Flávia S. Damasceno, Richard B. M. M. Girard, Letícia Marchese, Luis A. Luévano-Martinez, Renan W. Achjian, Jurgen R. Haanstra, Paul A. M. Michels, Ariel M. Silber

PLOS Pathogens: published July 27, 2023 | https://doi.org/10.1371/journal.ppat.1011522

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Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the hepatitis C virus

Minh-Tu Pham, Ji-Young Lee, Christian Ritter, Roman Thielemann, Janis Meyer, Uta Haselmann, Charlotta Funaya, Vibor Laketa, Karl Rohr, Ralf Bartenschlager

PLOS Pathogens: published July 28, 2023 | https://doi.org/10.1371/journal.ppat.1011052

Ethanolaminephosphate cytidylyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major

Somrita Basu, Mattie C. Pawlowic, Fong-Fu Hsu, Geoff Thomas, Kai Zhang

PLOS Pathogens: published July 28, 2023 | https://doi.org/10.1371/journal.ppat.1011112

Novel integrated computational AMP discovery approaches highlight diversity in the helminth AMP repertoire

Allister Irvine, Darrin McKenzie, Ciaran J. McCoy, Robert L. J. Graham, Ciaren Graham, Sharon A. Huws, Louise E. Atkinson, Angela Mousley

PLOS Pathogens: published July 31, 2023 | https://doi.org/10.1371/journal.ppat.1011508

PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum

Thorey K. Jonsdottir, Brendan Elsworth, Simon Cobbold, Mikha Gabriela, Ellen Ploeger, Molly Parkyn Schneider, Sarah C. Charnaud, Madeline G. Dans, Malcolm McConville, Hayley E. Bullen, Brendan S. Crabb, Paul R. Gilson

PLOS Pathogens: published July 31, 2023 | https://doi.org/10.1371/journal.ppat.1011006

Identification of an autotransporter peptidase of Rickettsia rickettsii responsible for maturation of surface exposed autotransporters

Adam M. Nock, Karin Aistleitner, Tina R. Clark, Dan Sturdevant, Stacy Ricklefs, Kimmo Virtaneva, Yixiang Zhang, Naila Gulzar, Neelam Redekar, Amitiva Roy, Ted Hackstadt

PLOS Pathogens: published July 31, 2023 | https://doi.org/10.1371/journal.ppat.1011527

Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals

Jithesh Kottur, Kris M. White, M. Luis Rodriguez, Olga Rechkoblit, Richard Quintana-Feliciano, Ahana Nayar, Adolfo García-Sastre, Aneel K. Aggarwal

PLOS Pathogens: published July 31, 2023 | https://doi.org/10.1371/journal.ppat.1011546

A 14^th century CE Brucella melitensis genome and the recent expansion of the Western Mediterranean clade

George S. Long, Jessica Hider, Ana T. Duggan, Jennifer Klunk, Katherine Eaton, Emil Karpinski, Valentina Giuffra, Luca Ventura, Tracy L. Prowse, Antonio Fornaciari, Gino Fornaciari, Edward C. Holmes, G. Brian Golding, Hendrik N. Poinar

PLOS Pathogens: published July 31, 2023 | https://doi.org/10.1371/journal.ppat.1011538

The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle

Aris E. N. Aristodemou, David S. Rueda, Graham P. Taylor, Charles R. M. Bangham

PLOS Pathogens: published July 31, 2023 | https://doi.org/10.1371/journal.ppat.1011494