Metal piracy by Neisseria gonorrhoeae to overcome human nutritional immunity

Ian K. Liyayi, Amy L. Forehand, Jocelyn C. Ray, Alison K. Criss

PLOS Pathogens: published February 2, 2023 | https://doi.org/10.1371/journal.ppat.1011091

From magic spot ppGpp to MESH1: Stringent response from bacteria to metazoa

Jen-Tsan Chi, Pei Zhou

PLOS Pathogens: published February 2, 2023 | https://doi.org/10.1371/journal.ppat.1011105

Host populations, challenges, and commercialization of cryptococcal vaccines

Maurizio Del Poeta, Floyd L. Wormley Jr, Xiaorong Lin

PLOS Pathogens: published February 9, 2023 | https://doi.org/10.1371/journal.ppat.1011115

Plant immune receptor pathways as a united front against pathogens

Minhang Yuan, Boying Cai, Xiu-Fang Xin

PLOS Pathogens: published February 9, 2023 | https://doi.org/10.1371/journal.ppat.1011106

Group B Streptococcus and diabetes: Finding the sweet spot

Rebecca A. Keogh, Kelly S. Doran

PLOS Pathogens: published February 16, 2023 | https://doi.org/10.1371/journal.ppat.1011133

Viral dew: Phase separation and the formation of viral replication compartments

Jens B. Bosse, Wolfram Brune

PLOS Pathogens: published February 16, 2023 | https://doi.org/10.1371/journal.ppat.1011145

The Cryptococcus wall: A different wall for a unique lifestyle

Liliane Mukaremera

PLOS Pathogens: published February 23, 2023 | https://doi.org/10.1371/journal.ppat.1011141

Programmed DNA elimination in the parasitic nematode Ascaris

Brandon Estrem, Jianbin Wang

PLOS Pathogens: published February 2, 2023 | https://doi.org/10.1371/journal.ppat.1011087

Biogenesis of extracellular vesicles in protozoan parasites: The ESCRT complex in the trafficking fast lane?

Abel Cruz Camacho, Daniel Alfandari, Ewa Kozela, Neta Regev-Rudzki

PLOS Pathogens: published February 23, 2023 | https://doi.org/10.1371/journal.ppat.1011140

High-throughput saturation mutagenesis generates a high-affinity antibody against SARS-CoV-2 variants using protein surface display assay on a human cell

Ye Yang, Shuo Liu, Yufeng Luo, Bolun Wang, Junyi Wang, Juan Li, Jiaxin Li, Buqing Ye, Youchun Wang, Jianzhong Jeff Xi

PLOS Pathogens: published February 1, 2023 | https://doi.org/10.1371/journal.ppat.1011119

A cercarial invadolysin interferes with the host immune response and facilitates infection establishment of Schistosoma mansoni

Jacob R. Hambrook, Patrick C. Hanington

PLOS Pathogens: published February 2, 2023 | https://doi.org/10.1371/journal.ppat.1010884

An NlpC/P60 protein catalyzes a key step in peptidoglycan recycling at the intersection of energy recovery, cell division and immune evasion in the intracellular pathogen Chlamydia trachomatis

Jula Reuter, Christian Otten, Nicolas Jacquier, Junghoon Lee, Dominique Mengin-Lecreulx, Iris Löckener, Robert Kluj, Christoph Mayer, Federico Corona, Julia Dannenberg, Sébastien Aeby, Henrike Bühl, Gilbert Greub, Waldemar Vollmer, Scot P. Ouellette, Tanja Schneider, Beate Henrichfreise

PLOS Pathogens: published February 2, 2023 | https://doi.org/10.1371/journal.ppat.1011047

Phage production is blocked in the adherent-invasive Escherichia coli LF82 upon macrophage infection

Pauline Misson, Emma Bruder, Jeffrey K. Cornuault, Marianne De Paepe, Pierre Nicolas, Gaëlle Demarre, Goran Lakisic, Marie-Agnès Petit, Olivier Espeli, François Lecointe

PLOS Pathogens: published February 2, 2023 | https://doi.org/10.1371/journal.ppat.1011127

Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL responses

Atsuhiko Hasegawa, Megumi Murata, Tomoka Fujikawa, Kuniko Katagiri, Yoshiko Nagano, Takao Masuda, Madoka Kuramitsu, Shinsuke Nakajima, Jun-ichi Fujisawa, Kazu Okuma, Poonam Grover, Maureen Kidiga, Hirofumi Akari, Mari Kannagi

PLOS Pathogens: published February 2, 2023 | https://doi.org/10.1371/journal.ppat.1011104

Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication

Huisheng Liu, Zixiang Zhu, Qiao Xue, Fan Yang, Weijun Cao, Zhaoning Xue, Xiangtao Liu, Haixue Zheng

PLOS Pathogens: published February 3, 2023 | https://doi.org/10.1371/journal.ppat.1011126

Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses

David Scheibner, Ahmed H. Salaheldin, Ola Bagato, Luca M. Zaeck, Ahmed Mostafa, Ulrike Blohm, Christin Müller, Ahmed F. Eweas, Kati Franzke, Axel Karger, Alexander Schäfer, Marcel Gischke, Donata Hoffmann, Solène Lerolle, Xuguang Li, Hatem S. Abd El-Hamid, Jutta Veits, Angele Breithaupt, Geert-Jan Boons, Mikhail Matrosovich, Stefan Finke, Stephan Pleschka, Thomas C. Mettenleiter, Robert P. de Vries, Elsayed M. Abdelwhab

PLOS Pathogens: published February 6, 2023 | https://doi.org/10.1371/journal.ppat.1011135

The cauliflower mosaic virus transmission helper protein P2 modifies directly the probing behavior of the aphid vector Myzus persicae to facilitate transmission

Maxime Verdier, Quentin Chesnais, Elodie Pirolles, Stéphane Blanc, Martin Drucker

PLOS Pathogens: published February 6, 2023 | https://doi.org/10.1371/journal.ppat.1011161

The APOBEC3B cytidine deaminase is an adenovirus restriction factor

Noémie Lejeune, Sarah Mathieu, Alexandra Decloux, Florian Poulain, Zoé Blockx, Kyle A. Raymond, Kévin Willemart, Jean-Pierre Vartanian, Rodolphe Suspène, Nicolas A. Gillet

PLOS Pathogens: published February 6, 2023 | https://doi.org/10.1371/journal.ppat.1011156

Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA release

Huisheng Liu, Zixiang Zhu, Qiao Xue, Fan Yang, Zongqiang Li, Zhaoning Xue, Weijun Cao, Jijun He, Jianhong Guo, Xiangtao Liu, Andrew E. Shaw, Donald P. King, Haixue Zheng

PLOS Pathogens: published February 6, 2023 | https://doi.org/10.1371/journal.ppat.1011132

The alphaherpesvirus conserved pUS10 is important for natural infection and its expression is regulated by the conserved Herpesviridae protein kinase (CHPK)

Nagendraprabhu Ponnuraj, Haji Akbar, Justine V. Arrington, Stephen J. Spatz, Balaji Nagarajan, Umesh R. Desai, Keith W. Jarosinski

PLOS Pathogens: published February 7, 2023 | https://doi.org/10.1371/journal.ppat.1010959

Human cytomegalovirus pUL97 upregulates SOCS3 expression via transcription factor RFX7 in neural progenitor cells

Xian-Zhang Wang, Le Wen, Yue-Peng Zhou, Sheng-Nan Huang, Bo Yang, Shuang Cheng, Wen-Bo Zeng, Meng-Jie Mei, Jin-Yan Sun, Xuan Jiang, Han Cheng, Min-Hua Luo

PLOS Pathogens: published February 8, 2023 | https://doi.org/10.1371/journal.ppat.1011166

An eggshell-localised annexin plays a key role in the coordination of the life cycle of a plant-parasitic nematode with its host

James A. Price, Mohammad Farhan Ali, Louise L. Major, Terry K. Smith, John T. Jones

PLOS Pathogens: published February 13, 2023 | https://doi.org/10.1371/journal.ppat.1011147

PbAP2-FG2 and PbAP2R-2 function together as a transcriptional repressor complex essential for Plasmodium female development

Tsubasa Nishi, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda

PLOS Pathogens: published February 13, 2023 | https://doi.org/10.1371/journal.ppat.1010890

Complete functional analysis of type IV pilus components of a reemergent plant pathogen reveals neofunctionalization of paralog genes

Marcus V. Merfa, Xinyu Zhu, Deepak Shantharaj, Laura M. Gomez, Eber Naranjo, Neha Potnis, Paul A. Cobine, Leonardo De La Fuente

PLOS Pathogens: published February 13, 2023 | https://doi.org/10.1371/journal.ppat.1011154

The Aedes aegypti peritrophic matrix controls arbovirus vector competence through HPx1, a heme–induced peroxidase

Octavio A. C. Talyuli, Jose Henrique M. Oliveira, Vanessa Bottino-Rojas, Gilbert O. Silveira, Patricia H. Alvarenga, Ana Beatriz F. Barletta, Asher M. Kantor, Gabriela O. Paiva-Silva, Carolina Barillas-Mury, Pedro L. Oliveira

PLOS Pathogens: published February 13, 2023 | https://doi.org/10.1371/journal.ppat.1011149

Recent transposable element bursts are associated with the proximity to genes in a fungal plant pathogen

Ursula Oggenfuss, Daniel Croll

PLOS Pathogens: published February 14, 2023 | https://doi.org/10.1371/journal.ppat.1011130

Simultaneous membrane and RNA binding by tick-borne encephalitis virus capsid protein

Lauri Ilmari Aurelius Pulkkinen, Sarah Victoria Barrass, Marie Lindgren, Hudson Pace, Anna K. Överby, Maria Anastasina, Marta Bally, Richard Lundmark, Sarah Jane Butcher

PLOS Pathogens: published February 14, 2023 | https://doi.org/10.1371/journal.ppat.1011125

NS5A domain I antagonises PKR to facilitate the assembly of infectious hepatitis C virus particles

Shucheng Chen, Mark Harris

PLOS Pathogens: published February 16, 2023 | https://doi.org/10.1371/journal.ppat.1010812

Transcriptionally active nasopharyngeal commensals and opportunistic microbial dynamics define mild symptoms in the COVID 19 vaccination breakthroughs

Priti Devi, Pallawi Kumari, Aanchal Yadav, Bansidhar Tarai, Sandeep Budhiraja, Uzma Shamim, Rajesh Pandey

PLOS Pathogens: published February 17, 2023 | https://doi.org/10.1371/journal.ppat.1011160

Broad protective vaccination against systemic Escherichia coli with autotransporter antigens

Yikun Xing, Justin R. Clark, James D. Chang, Dylan M. Chirman, Sabrina Green, Jacob J. Zulk, Joseph Jelinski, Kathryn A. Patras, Anthony W. Maresso

PLOS Pathogens: published February 17, 2023 | https://doi.org/10.1371/journal.ppat.1011082

Tripartite interactions between filamentous Pf4 bacteriophage, Pseudomonas aeruginosa, and bacterivorous nematodes

Caleb M. Schwartzkopf, Autumn J. Robinson, Mary Ellenbecker, Dominick R. Faith, Amelia K. Schmidt, Diane M. Brooks, Lincoln Lewerke, Ekaterina Voronina, Ajai A. Dandekar, Patrick R. Secor

PLOS Pathogens: published February 17, 2023 | https://doi.org/10.1371/journal.ppat.1010925

Wbm0076, a candidate effector protein of the Wolbachia endosymbiont of Brugia malayi, disrupts eukaryotic actin dynamics

Michael K. Mills, Lindsey G. McCabe, Eugenie M. Rodrigue, Karl F. Lechtreck, Vincent J. Starai

PLOS Pathogens: published February 17, 2023 | https://doi.org/10.1371/journal.ppat.1010777

Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1

Wai-Yin Lui, Aradhana Bharti, Nok-Hei Mickey Wong, Sonia Jangra, Michael G. Botelho, Kit-San Yuen, Dong-Yan Jin

PLOS Pathogens: published February 21, 2023 | https://doi.org/10.1371/journal.ppat.1011186

Antagonism of ALAS1 by the Measles Virus V protein contributes to degradation of the mitochondrial network and promotes interferon response

Pierre Khalfi, Rodolphe Suspène, Kyle A. Raymond, Vincent Caval, Grégory Caignard, Noémie Berry, Valérie Thiers, Chantal Combredet, Claude Rufie, Stéphane Rigaud, Amine Ghozlane, Stevenn Volant, Anastassia V. Komarova, Frédéric Tangy, Jean-Pierre Vartanian

PLOS Pathogens: published February 21, 2023 | https://doi.org/10.1371/journal.ppat.1011170

Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation

Dan-Ni Wang, Jin-Jing Ni, Jian-Hui Li, Ya-Qi Gao, Fang-Jing Ni, Zhen-Zhen Zhang, Jing-Yuan Fang, Jie Lu, Yu-Feng Yao

PLOS Pathogens: published February 22, 2023 | https://doi.org/10.1371/journal.ppat.1011189

Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements

John N. Snouwaert, Leigh A. Jania, Trang Nguyen, David R. Martinez, Alexandra Schäfer, Nicholas J. Catanzaro, Kendra L. Gully, Ralph S. Baric, Mark Heise, Martin T. Ferris, Elizabeth Anderson, Katia Pressey, Jacob A. Dillard, Sharon Taft-Benz, Victoria K. Baxter, Jenny P-Y Ting, Beverly H. Koller

PLOS Pathogens: published February 22, 2023 | https://doi.org/10.1371/journal.ppat.1011168

Architecture and matrix assembly determinants of Bordetella pertussis biofilms on primary human airway epithelium

Audra R. Fullen, Jessica L. Gutierrez-Ferman, Rachael E. Rayner, Sun Hee Kim, Phylip Chen, Purnima Dubey, Daniel J. Wozniak, Mark E. Peeples, Estelle Cormet-Boyaka, Rajendar Deora

PLOS Pathogens: published February 23, 2023 | https://doi.org/10.1371/journal.ppat.1011193

Flagella-driven motility is a target of human Paneth cell defensin activity

Douglas T. Akahoshi, Dean E. Natwick, Weirong Yuan, Wuyuan Lu, Sean R. Collins, Charles L. Bevins

PLOS Pathogens: published February 23, 2023 | https://doi.org/10.1371/journal.ppat.1011200

HBZ upregulates myoferlin expression to facilitate HTLV-1 infection

Nicholas Polakowski, Md Abu Kawsar Sarker, Kimson Hoang, Georgina Boateng, Amanda W. Rushing, Wesley Kendle, Claudine Pique, Patrick L. Green, Amanda R. Panfil, Isabelle Lemasson

PLOS Pathogens: published February 24, 2023 | https://doi.org/10.1371/journal.ppat.1011202

BA.1, BA.2 and BA.2.75 variants show comparable replication kinetics, reduced impact on epithelial barrier and elicit cross-neutralizing antibodies

Janmejay Singh, Anbalagan Anantharaj, Aleksha Panwar, Chitra Rani, Monika Bhardwaj, Parveen Kumar, Partha Chattopadhyay, Priti Devi, Ranjeet Maurya, Pallavi Mishra, Anil Kumar Pandey, Rajesh Pandey, Guruprasad R. Medigeshi

PLOS Pathogens: published February 24, 2023 | https://doi.org/10.1371/journal.ppat.1011196

Capsid structure of a fungal dsRNA megabirnavirus reveals its previously unidentified surface architecture

Han Wang, Lakha Salaipeth, Naoyuki Miyazaki, Nobuhiro Suzuki, Kenta Okamoto

PLOS Pathogens: published February 27, 2023 | https://doi.org/10.1371/journal.ppat.1011162

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling

Emmely E. Treffers, Ali Tas, Florine E. M. Scholte, Arnoud H. de Ru, Eric J. Snijder, Peter A. van Veelen, Martijn J. van Hemert

PLOS Pathogens: published February 27, 2023 | https://doi.org/10.1371/journal.ppat.1011179

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis

Manickam Yogavel, Alexandre Bougdour, Siddhartha Mishra, Nipun Malhotra, Jyoti Chhibber-Goel, Valeria Bellini, Karl Harlos, Benoît Laleu, Mohamed-Ali Hakimi, Amit Sharma

PLOS Pathogens: published February 28, 2023 | https://doi.org/10.1371/journal.ppat.1011124

Correction: The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation

Nannan Wu, Xuan-Nhi Nguyen, Li Wang, Romain Appourchaux, Chengfei Zhang, Baptiste Panthu, Henri Gruffat, Chloé Journo, Sandrine Alais, Juliang Qin, Na Zhang, Kevin Tartour, Frédéric Catez, Renaud Mahieux, Theophile Ohlmann, Mingyao Liu, Bing Du, Andrea Cimarelli

PLOS Pathogens: published February 16, 2023 | https://doi.org/10.1371/journal.ppat.1011176

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1. The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation

Correction: On the relationship between Pathogenic Potential and Infective Inoculum

Daniel F. Q. Smith, Arturo Casadevall

PLOS Pathogens: published February 23, 2023 | https://doi.org/10.1371/journal.ppat.1011191

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1. On the relationship between Pathogenic Potential and Infective Inoculum