Gram-positive bacterial membrane lipids at the host–pathogen interface

Luke R. Joyce, Kelly S. Doran

PLOS Pathogens: published January 5, 2023 | https://doi.org/10.1371/journal.ppat.1011026

Last but not yeast—The many forms of Cryptococcus neoformans

Piotr R. Stempinski, Gracen R. Gerbig, Seth D. Greengo, Arturo Casadevall

PLOS Pathogens: published January 5, 2023 | https://doi.org/10.1371/journal.ppat.1011048

Natural product ligands of FKBP12: Immunosuppressive antifungal agents FK506, rapamycin, and beyond

Angela Rivera, Joseph Heitman

PLOS Pathogens: published January 12, 2023 | https://doi.org/10.1371/journal.ppat.1011056

SERINC5: One antiviral factor to bind them all

Uddhav Timilsina, Spyridon Stavrou

PLOS Pathogens: published January 19, 2023 | https://doi.org/10.1371/journal.ppat.1011076

Insect egg-induced innate immunity: Who benefits?

Elia Stahl, Louis-Philippe Maier, Philippe Reymond

PLOS Pathogens: published January 19, 2023 | https://doi.org/10.1371/journal.ppat.1011072

Making the best of research investment in pathogens control through biocontrol. How is research correlated with agricultural microbial biological control product availability?

Florența-Elena Helepciuc, Arpad Todor

PLOS Pathogens: published January 26, 2023 | https://doi.org/10.1371/journal.ppat.1011071

Race and ethnicity: Risk factors for fungal infections?

Jeffrey D. Jenks, Chioma Inyang Aneke, Mohanad M. Al-Obaidi, Matthias Egger, Lorena Garcia, Tommi Gaines, Martin Hoenigl, George R. Thompson III

PLOS Pathogens: published January 5, 2023 | https://doi.org/10.1371/journal.ppat.1011025

Food for thought—The link between Clostridioides difficile metabolism and pathogenesis

Andrew Marshall, John W. McGrath, Robert Graham, Geoff McMullan

PLOS Pathogens: published January 5, 2023 | https://doi.org/10.1371/journal.ppat.1011034

The mechanism of genome replication and transcription in bunyaviruses

Hélène Malet, Harry M. Williams, Stephen Cusack, Maria Rosenthal

PLOS Pathogens: published January 12, 2023 | https://doi.org/10.1371/journal.ppat.1011060

Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities

Rahul Kumar, Öznur Aktay-Cetin, Vaughn Craddock, Daniel Morales-Cano, Djuro Kosanovic, Angel Cogolludo, Francisco Perez-Vizcaino, Sergey Avdeev, Ashok Kumar, Anil Kumar Ram, Stuti Agarwal, Ananya Chakraborty, Rajkumar Savai, Vinicio de Jesus Perez, Brian B. Graham, Ghazwan Butrous, Navneet K. Dhillon

PLOS Pathogens: published January 12, 2023 | https://doi.org/10.1371/journal.ppat.1011063

ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence

Shishir Singh, Mateo Murillo-León, Niklas Sebastian Endres, Ailan Farid Arenas Soto, Jorge Enrique Gómez-Marín, Florence Melbert, Thirumala-Devi Kanneganti, Masahiro Yamamoto, Claudia Campos, Jonathan Charles Howard, Gregory Alan Taylor, Tobias Steinfeldt

PLOS Pathogens: published January 5, 2023 | https://doi.org/10.1371/journal.ppat.1011003

A dsRNA-binding mutant reveals only a minor role of exonuclease activity in interferon antagonism by the arenavirus nucleoprotein

Patrick Bohn, Irke Waßmann, Lisa Wendt, Anne Leske, Thomas Hoenen, Birke A. Tews, Allison Groseth

PLOS Pathogens: published January 5, 2023 | https://doi.org/10.1371/journal.ppat.1011049

Nuclear accumulation of host transcripts during Zika Virus Infection

Kristoffer E. Leon, Mir M. Khalid, Ryan A. Flynn, Krystal A. Fontaine, Thong T. Nguyen, G. Renuka Kumar, Camille R. Simoneau, Sakshi Tomar, David Jimenez-Morales, Mariah Dunlap, Julia Kaye, Priya S. Shah, Steven Finkbeiner, Nevan J. Krogan, Carolyn Bertozzi, Jan E. Carette, Melanie Ott

PLOS Pathogens: published January 5, 2023 | https://doi.org/10.1371/journal.ppat.1011070

Structure-guided mutagenesis of the capsid protein indicates that a nanovirus requires assembled viral particles for systemic infection

Stefano Trapani, Eijaz Ahmed Bhat, Michel Yvon, Joséphine Lai-Kee-Him, François Hoh, Marie-Stéphanie Vernerey, Elodie Pirolles, Mélia Bonnamy, Guy Schoehn, Jean-Louis Zeddam, Stéphane Blanc, Patrick Bron

PLOS Pathogens: published January 9, 2023 | https://doi.org/10.1371/journal.ppat.1011086

Conformational diversity in purified prions produced in vitro

Daniel J. Walsh, Abigail M. Schwind, Geoffrey P. Noble, Surachai Supattapone

PLOS Pathogens: published January 10, 2023 | https://doi.org/10.1371/journal.ppat.1011083

Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus

Cameron Adams, Derek L. Carbaugh, Bo Shu, Thiam-Seng Ng, Izabella N. Castillo, Ryan Bhowmik, Bruno Segovia-Chumbez, Ana C. Puhl, Stephen Graham, Sean A. Diehl, Helen M. Lazear, Shee-mei Lok, Aravinda M. de Silva, Lakshmanane Premkumar

PLOS Pathogens: published January 10, 2023 | https://doi.org/10.1371/journal.ppat.1010814

CRISPR/FnCas12a-mediated efficient multiplex and iterative genome editing in bacterial plant pathogens without donor DNA templates

Fang Yan, Jingwen Wang, Sujie Zhang, Zhenwan Lu, Shaofang Li, Zhiyuan Ji, Congfeng Song, Gongyou Chen, Jin Xu, Jie Feng, Xueping Zhou, Huanbin Zhou

PLOS Pathogens: published January 10, 2023 | https://doi.org/10.1371/journal.ppat.1010961

New insight into Epstein-Barr virus infection using models of stratified epithelium

Ian R. Hayman, Rachel M. Temple, Cole K. Burgess, Mary Ferguson, Jason Liao, Craig Meyers, Clare E. Sample

PLOS Pathogens: published January 11, 2023 | https://doi.org/10.1371/journal.ppat.1011040

G-quadruplexes formed by Varicella-Zoster virus reiteration sequences suppress expression of glycoprotein C and regulate viral cell-to-cell spread

Woo-Chang Chung, Subramaniyam Ravichandran, Daegyu Park, Gwang Myeong Lee, Young-Eui Kim, Youngju Choi, Moon Jung Song, Kyeong Kyu Kim, Jin-Hyun Ahn

PLOS Pathogens: published January 11, 2023 | https://doi.org/10.1371/journal.ppat.1011095

Exosomes mediate Coxsackievirus B3 transmission and expand the viral tropism

Yuxuan Fu, Sidong Xiong

PLOS Pathogens: published January 12, 2023 | https://doi.org/10.1371/journal.ppat.1011090

Kaposi’s sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies

Carolyn-Ann Robinson, Gillian K. Singh, Mariel Kleer, Thalia Katsademas, Elizabeth L. Castle, Bre Q. Boudreau, Jennifer A. Corcoran

PLOS Pathogens: published January 12, 2023 | https://doi.org/10.1371/journal.ppat.1011080

Oncolytic strategy using new bifunctional HDACs/BRD4 inhibitors against virus-associated lymphomas

Jungang Chen, Zhengyu Wang, Tran Phuc, Zhigang Xu, Donglin Yang, Zhengzhu Chen, Zhen Lin, Samantha Kendrick, Lu Dai, Hong-yu Li, Zhiqiang Qin

PLOS Pathogens: published January 13, 2023 | https://doi.org/10.1371/journal.ppat.1011089

Ebola virus disrupts the inner blood-retinal barrier by induction of vascular endothelial growth factor in pericytes

Jiawang Gao, Zhengyuan Guo, Wei Li, Xiaowei Zhang, Xian-En Zhang, Zongqiang Cui

PLOS Pathogens: published January 18, 2023 | https://doi.org/10.1371/journal.ppat.1011077

Proline transporters ProT and PutP are required for Staphylococcus aureus infection

McKenzie K. Lehman, Natalie A. Sturd, Fareha Razvi, Dianne L. Wellems, Steven D. Carson, Paul D. Fey

PLOS Pathogens: published January 18, 2023 | https://doi.org/10.1371/journal.ppat.1011098

Promiscuous feeding on multiple adult honey bee hosts amplifies the vectorial capacity of Varroa destructor

Zachary S. Lamas, Serhat Solmaz, Eugene V. Ryabov, Joseph Mowery, Matthew Heermann, Daniel Sonenshine, Jay D. Evans, David J. Hawthorne

PLOS Pathogens: published January 19, 2023 | https://doi.org/10.1371/journal.ppat.1011061

CRISPR mediated transactivation in the human disease vector Aedes aegypti

Michelle Bui, Elena Dalla Benetta, Yuemei Dong, Yunchong Zhao, Ting Yang, Ming Li, Igor A. Antoshechkin, Anna Buchman, Vanessa Bottino-Rojas, Anthony A. James, Michael W. Perry, George Dimopoulos, Omar S. Akbari

PLOS Pathogens: published January 19, 2023 | https://doi.org/10.1371/journal.ppat.1010842

Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition

Xiaojuan Li, Fan Wang, Xiaolin Zhang, Qinqin Sun, Ersheng Kuang

PLOS Pathogens: published January 19, 2023 | https://doi.org/10.1371/journal.ppat.1011103

Two novel genes identified by large-scale transcriptomic analysis are essential for biofilm and rugose colony development of Vibrio vulnificus

Hojun Lee, Hanhyeok Im, Seung-Ho Hwang, Duhyun Ko, Sang Ho Choi

PLOS Pathogens: published January 19, 2023 | https://doi.org/10.1371/journal.ppat.1011064

A fiber-enriched diet alleviates Staphylococcus aureus-induced mastitis by activating the HDAC3-mediated antimicrobial program in macrophages via butyrate production in mice

Caijun Zhao, Lijuan Bao, Yihong Zhao, Keyi Wu, Min Qiu, Lianjun Feng, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu

PLOS Pathogens: published January 19, 2023 | https://doi.org/10.1371/journal.ppat.1011108

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

Jennifer A. Jenks, Sharmi Amin, Madeline R. Sponholtz, Amit Kumar, Daniel Wrapp, Sravani Venkatayogi, Joshua J. Tu, Krithika Karthigeyan, Sarah M. Valencia, Megan Connors, Melissa J. Harnois, Bhavna Hora, Eric Rochat, Jason S. McLellan, Kevin Wiehe, Sallie R. Permar

PLOS Pathogens: published January 20, 2023 | https://doi.org/10.1371/journal.ppat.1011107

Latent CMV infection of Lymphatic endothelial cells is sufficient to drive CD8 T cell memory inflation

Michael W. Munks, Katherine Rott, Pavlo A. Nesterenko, Savannah M. Smart, Venasha Williams, Angela Tatum, Guangwu Xu, Tameka Smith, Susan E. Murray, Ann B. Hill

PLOS Pathogens: published January 23, 2023 | https://doi.org/10.1371/journal.ppat.1010351

The opportunistic pathogen Pseudomonas aeruginosa exploits bacterial biotin synthesis pathway to benefit its infectivity

Yu Shi, Qin Cao, Jingdu Sun, Xiaofang Hu, Zhi Su, Yongchang Xu, Huimin Zhang, Lefu Lan, Youjun Feng

PLOS Pathogens: published January 23, 2023 | https://doi.org/10.1371/journal.ppat.1011110

Effect of polymorphism in Rhinolophus affinis ACE2 on entry of SARS-CoV-2 related bat coronaviruses

Pei Li, Jiaxin Hu, Yan Liu, Xiuyuan Ou, Zhixia Mu, Xing Lu, Fuwen Zan, Mengmeng Cao, Lin Tan, Siwen Dong, Yao Zhou, Jian Lu, Qi Jin, Jianwei Wang, Zhiqiang Wu, Yingtao Zhang, Zhaohui Qian

PLOS Pathogens: published January 23, 2023 | https://doi.org/10.1371/journal.ppat.1011116

Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

Xiaoyuan Lin, Beibei Fu, Yan Xiong, Na Xing, Weiwei Xue, Dong Guo, Mohamed Zaky, Krishna Pavani, Dusan Kunec, Jakob Trimpert, Haibo Wu

PLOS Pathogens: published January 23, 2023 | https://doi.org/10.1371/journal.ppat.1011128

KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi’s sarcoma studies

Krista Tuohinto, Terri A. DiMaio, Elina A. Kiss, Pirjo Laakkonen, Pipsa Saharinen, Tara Karnezis, Michael Lagunoff, Päivi M. Ojala

PLOS Pathogens: published January 23, 2023 | https://doi.org/10.1371/journal.ppat.1010753

Fn-Dps, a novel virulence factor of Fusobacterium nucleatum, disrupts erythrocytes and promotes metastasis in colorectal cancer

Yixian Wu, Songhe Guo, Fangfang Chen, Yiqiu Li, Yuying Huang, Wanli Liu, Ge Zhang

PLOS Pathogens: published January 24, 2023 | https://doi.org/10.1371/journal.ppat.1011096

Characterization of a new CCCTC-binding factor binding site as a dual regulator of Epstein-Barr virus latent infection

Sun Hee Lee, Kyoung-Dong Kim, Miyeon Cho, Sora Huh, Seong Ho An, Donghyun Seo, Kyuhyun Kang, Minhee Lee, Hideki Tanizawa, Inuk Jung, Hyosun Cho, Hyojeung Kang

PLOS Pathogens: published January 25, 2023 | https://doi.org/10.1371/journal.ppat.1011078

TYMV and TRV infect Arabidopsis thaliana by expressing weak suppressors of RNA silencing and inducing host RNASE THREE LIKE1

Hayat Sehki, Agnès Yu, Taline Elmayan, Hervé Vaucheret

PLOS Pathogens: published January 25, 2023 | https://doi.org/10.1371/journal.ppat.1010482

Genome-wide screen in human plasma identifies multifaceted complement evasion of Pseudomonas aeruginosa

Manon Janet-Maitre, Stéphane Pont, Frerich M. Masson, Serena Sleiman, Julian Trouillon, Mylène Robert-Genthon, Benoît Gallet, Chantal Dumestre-Perard, Sylvie Elsen, Christine Moriscot, Bart W. Bardoel, Suzan H. M. Rooijakkers, François Cretin, Ina Attrée

PLOS Pathogens: published January 25, 2023 | https://doi.org/10.1371/journal.ppat.1011023

Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum

Michal Kucharski, Grennady Wirjanata, Sourav Nayak, Josephine Boentoro, Jerzy Michal Dziekan, Christina Assisi, Rob W. van der Pluijm, Olivo Miotto, Sachel Mok, Arjen M. Dondorp, Zbynek Bozdech

PLOS Pathogens: published January 25, 2023 | https://doi.org/10.1371/journal.ppat.1011118

Reinforcement amid genetic diversity in the Candida albicans biofilm regulatory network

Max V. Cravener, Eunsoo Do, Gemma May, Robert Zarnowski, David R. Andes, C. Joel McManus, Aaron P. Mitchell

PLOS Pathogens: published January 25, 2023 | https://doi.org/10.1371/journal.ppat.1011109

A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance

Nicola J. Beesley, Krystyna Cwiklinski, Katherine Allen, Rebecca C. Hoyle, Terry W. Spithill, E. James La Course, Diana J. L. Williams, Steve Paterson, Jane E. Hodgkinson

PLOS Pathogens: published January 26, 2023 | https://doi.org/10.1371/journal.ppat.1011081

Targeting RNA G-quadruplex with repurposed drugs blocks SARS-CoV-2 entry

Qiyu Tong, Geng Liu, Xiongbo Sang, Xinyue Zhu, Xiaoli Fu, Chao Dou, Yue Jian, Jiani Zhang, Sailan Zou, Guixiang Zhang, Xiao Du, Dan Liu, Shiqian Qi, Wei Cheng, Yan Tian, Xianghui Fu

PLOS Pathogens: published January 26, 2023 | https://doi.org/10.1371/journal.ppat.1011131

Southern rice black-streaked dwarf virus induces incomplete autophagy for persistence in gut epithelial cells of its vector insect

Lu Zhang, Wenwen Liu, Nan Wu, Hui Wang, Zhongkai Zhang, Yule Liu, Xifeng Wang

PLOS Pathogens: published January 27, 2023 | https://doi.org/10.1371/journal.ppat.1011134

A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy

Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao, Congli Jiang, Yuanfei Zhu, Teng Li, Lu Lu, Junqi Zhang, Heng Yang, Jian Feng, Zhifeng Gu, Hong Tang, Lubin Jiang, Dianfan Li, Dimitri Lavillette, Xiaoming Zhang

PLOS Pathogens: published January 27, 2023 | https://doi.org/10.1371/journal.ppat.1011085

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

Emily Hsieh, Derek H. Janssens, Patrick J. Paddison, Edward P. Browne, Steve Henikoff, Molly OhAinle, Michael Emerman

PLOS Pathogens: published January 27, 2023 | https://doi.org/10.1371/journal.ppat.1011101

Verticillium dahliae Vta3 promotes ELV1 virulence factor gene expression in xylem sap, but tames Mtf1-mediated late stages of fungus-plant interactions and microsclerotia formation

Isabel Maurus, Rebekka Harting, Cornelia Herrfurth, Jessica Starke, Alexandra Nagel, Lennart Mohnike, Ying-Yu Chen, Kerstin Schmitt, Emmanouil Bastakis, Marian T. Süß, Miriam Leonard, Kai Heimel, Oliver Valerius, Ivo Feussner, James W. Kronstad, Gerhard H. Braus

PLOS Pathogens: published January 30, 2023 | https://doi.org/10.1371/journal.ppat.1011100

African swine fever virus transmembrane protein pEP84R guides core assembly

Alí Alejo, Mayte García-Castey, Milagros Guerra, Bruno Hernáez, Verónica Martín, Tania Matamoros, Germán Andrés

PLOS Pathogens: published January 30, 2023 | https://doi.org/10.1371/journal.ppat.1011136

Haem transporter HRG-1 is essential in the barber’s pole worm and an intervention target candidate

Yi Yang, Jingru Zhou, Fei Wu, Danni Tong, Xueqiu Chen, Shengjun Jiang, Yu Duan, Chaoqun Yao, Tao Wang, Aifang Du, Robin B. Gasser, Guangxu Ma

PLOS Pathogens: published January 30, 2023 | https://doi.org/10.1371/journal.ppat.1011129

Pneumococcal capsule expression is controlled through a conserved, distal cis-regulatory element during infection

David G. Glanville, Ozcan Gazioglu, Michela Marra, Valerie L. Tokars, Tatyana Kushnir, Medhanie Habtom, Nicholas J. Croucher, Yaffa Mizrachi Nebenzahl, Alfonso Mondragón, Hasan Yesilkaya, Andrew T. Ulijasz

PLOS Pathogens: published January 31, 2023 | https://doi.org/10.1371/journal.ppat.1011035

Developing Wolbachia-based disease interventions for an extreme environment

Perran A. Ross, Samia Elfekih, Sophie Collier, Melissa J. Klein, Su Shyan Lee, Michael Dunn, Sarah Jackson, Yexin Zhang, Jason K. Axford, Xinyue Gu, Jessica L. Home, Majed S. Nassar, Prasad N. Paradkar, Essam A. Tawfik, Francis M. Jiggins, Abdulaziz M. Almalik, Mohamed B. Al-Fageeh, Ary A. Hoffmann

PLOS Pathogens: published January 31, 2023 | https://doi.org/10.1371/journal.ppat.1011117

Correction: Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

Tim Krischuns, Catherine Isel, Petra Drncova, Maria Lukarska, Alexander Pflug, Sylvain Paisant, Vincent Navratil, Stephen Cusack, Nadia Naffakh

PLOS Pathogens: published January 4, 2023 | https://doi.org/10.1371/journal.ppat.1011073

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1. Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD