Adherent Invasive E. coli (AIEC), associated with the dysbiosis observed during Crohn’s disease, survive and replicate inside macrophages. In this aggressive environment they immediately halt their cell cycle thanks to the installation of stringent response. Several hours later, when stringent response dissipates, cell cycle restarts but it frequently leads to new non-replicating bacteria. In this non-replicating state AIEC tolerate antibiotic’s treatment. The image shows non-replicating (green) and replicating (red) AIEC 24 hours post infection of human macrophages (magenta). Demarre, et al.
Image Credit: Demarre G, et al. (2019)
Opinion
Chlamydia trachomatis and human herpesvirus 6 infections in ovarian cancer—Casual or causal?
PLOS Pathogens: published November 7, 2019 | https://doi.org/10.1371/journal.ppat.1008055
Pearls
Ammonium transceptors: Novel regulators of fungal development
PLOS Pathogens: published November 7, 2019 | https://doi.org/10.1371/journal.ppat.1008059
The power of saliva: Antimicrobial and beyond
PLOS Pathogens: published November 14, 2019 | https://doi.org/10.1371/journal.ppat.1008058
Review
Mitochondrial dynamics in parasitic protists
PLOS Pathogens: published November 21, 2019 | https://doi.org/10.1371/journal.ppat.1008008
Research Articles
Alphaherpesvirus infection of mice primes PNS neurons to an inflammatory state regulated by TLR2 and type I IFN signaling
PLOS Pathogens: published November 1, 2019 | https://doi.org/10.1371/journal.ppat.1008087
The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response
PLOS Pathogens: published November 4, 2019 | https://doi.org/10.1371/journal.ppat.1007634
Modulation of flagellar rotation in surface-attached bacteria: A pathway for rapid surface-sensing after flagellar attachment
PLOS Pathogens: published November 4, 2019 | https://doi.org/10.1371/journal.ppat.1008149
Candida albicans triggers NADPH oxidase-independent neutrophil extracellular traps through dectin-2
PLOS Pathogens: published November 6, 2019 | https://doi.org/10.1371/journal.ppat.1008096
The male mosquito contribution towards malaria transmission: Mating influences the Anopheles female midgut transcriptome and increases female susceptibility to human malaria parasites
PLOS Pathogens: published November 7, 2019 | https://doi.org/10.1371/journal.ppat.1008063
Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins
PLOS Pathogens: published November 7, 2019 | https://doi.org/10.1371/journal.ppat.1008061
Aging boosts antiviral CD8+T cell memory through improved engagement of diversified recall response determinants
PLOS Pathogens: published November 7, 2019 | https://doi.org/10.1371/journal.ppat.1008144
Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1
PLOS Pathogens: published November 7, 2019 | https://doi.org/10.1371/journal.ppat.1008124
Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages
PLOS Pathogens: published November 8, 2019 | https://doi.org/10.1371/journal.ppat.1008069
Trypanosoma brucei infection protects mice against malaria
PLOS Pathogens: published November 8, 2019 | https://doi.org/10.1371/journal.ppat.1008145
Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL
PLOS Pathogens: published November 8, 2019 | https://doi.org/10.1371/journal.ppat.1008014
NEDD4 family ubiquitin ligases associate with LCMV Z’s PPXY domain and are required for virus budding, but not via direct ubiquitination of Z
PLOS Pathogens: published November 11, 2019 | https://doi.org/10.1371/journal.ppat.1008100
14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases
PLOS Pathogens: published November 11, 2019 | https://doi.org/10.1371/journal.ppat.1008146
Host nutritional status affects alphavirus virulence, transmission, and evolution
PLOS Pathogens: published November 11, 2019 | https://doi.org/10.1371/journal.ppat.1008089
The Crohn’s disease-associated Escherichia coli strain LF82 relies on SOS and stringent responses to survive, multiply and tolerate antibiotics within macrophages
PLOS Pathogens: published November 14, 2019 | https://doi.org/10.1371/journal.ppat.1008123
Chromatin dynamics and the transcriptional competence of HSV-1 genomes during lytic infections
PLOS Pathogens: published November 14, 2019 | https://doi.org/10.1371/journal.ppat.1008076
Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency
PLOS Pathogens: published November 14, 2019 | https://doi.org/10.1371/journal.ppat.1008037
Related Articles
HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation
PLOS Pathogens: published November 14, 2019 | https://doi.org/10.1371/journal.ppat.1007854
Related Articles
Subclinical in utero Zika virus infection is associated with interferon alpha sequelae and sex-specific molecular brain pathology in asymptomatic porcine offspring
PLOS Pathogens: published November 14, 2019 | https://doi.org/10.1371/journal.ppat.1008038
Activation of Shigella flexneri type 3 secretion requires a host-induced conformational change to the translocon pore
PLOS Pathogens: published November 14, 2019 | https://doi.org/10.1371/journal.ppat.1007928
EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production
PLOS Pathogens: published November 15, 2019 | https://doi.org/10.1371/journal.ppat.1008142
N-glycosylation of the protein disulfide isomerase Pdi1 ensures full Ustilago maydis virulence
PLOS Pathogens: published November 15, 2019 | https://doi.org/10.1371/journal.ppat.1007687
Influenza viruses that require 10 genomic segments as antiviral therapeutics
PLOS Pathogens: published November 15, 2019 | https://doi.org/10.1371/journal.ppat.1008098
Trickle infection and immunity to Trichuris muris
PLOS Pathogens: published November 15, 2019 | https://doi.org/10.1371/journal.ppat.1007926
Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive enterovirus A71 virulence in mice
PLOS Pathogens: published November 15, 2019 | https://doi.org/10.1371/journal.ppat.1007863
Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus
PLOS Pathogens: published November 18, 2019 | https://doi.org/10.1371/journal.ppat.1007862
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus
PLOS Pathogens: published November 18, 2019 | https://doi.org/10.1371/journal.ppat.1008169
Kinetics of HTLV-1 reactivation from latency quantified by single-molecule RNA FISH and stochastic modelling
PLOS Pathogens: published November 18, 2019 | https://doi.org/10.1371/journal.ppat.1008164
Regulation of macrophage activity by surface receptors contained within Borrelia burgdorferi-enriched phagosomal fractions
PLOS Pathogens: published November 18, 2019 | https://doi.org/10.1371/journal.ppat.1008163
NCOA2 promotes lytic reactivation of Kaposi’s sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA
PLOS Pathogens: published November 21, 2019 | https://doi.org/10.1371/journal.ppat.1008160
Amblyomma americanum ticks utilizes countervailing pro and anti-inflammatory proteins to evade host defense
PLOS Pathogens: published November 22, 2019 | https://doi.org/10.1371/journal.ppat.1008128
The mosquito melanization response requires hierarchical activation of non-catalytic clip domain serine protease homologs
PLOS Pathogens: published November 25, 2019 | https://doi.org/10.1371/journal.ppat.1008194
CDR3α drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection
PLOS Pathogens: published November 25, 2019 | https://doi.org/10.1371/journal.ppat.1008122
Corrections
Correction: Eight RGS and RGS-like Proteins Orchestrate Growth, Differentiation, and Pathogenicity of Magnaporthe oryzae
PLOS Pathogens: published November 15, 2019 | https://doi.org/10.1371/journal.ppat.1008187
Related Articles
Correction: The bZIP Transcription Factor MoAP1 Mediates the Oxidative Stress Response and is Critical for Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae
PLOS Pathogens: published November 20, 2019 | https://doi.org/10.1371/journal.ppat.1008196