Malaria parasites proliferate by closed endomitosis, with genome replication and division occurring prior to cytokinesis within a nucleus bounded by a persistent envelope. Plasmodium kinesin-8X is located on putative microtubule organising centres (MTOCs) and mitotic spindles during cell division. The kinesin-8X gene is essential during mosquito stages of the life cycle and its deletion blocks parasite transmission. The image shows an ookinete with surface protein p28 stained red, nuclear DNA stained blue and kinesin-8X-GFP stained green. Zeeshan et al.
Image Credit: M Zeeshan and Rita Tewari (2019)
Opinion
Parasite microbiome project: Grand challenges
PLOS Pathogens: published October 10, 2019 | https://doi.org/10.1371/journal.ppat.1008028
Pearls
Does rotavirus turn on type 1 diabetes?
PLOS Pathogens: published October 10, 2019 | https://doi.org/10.1371/journal.ppat.1007965
Reviews
Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses
PLOS Pathogens: published October 17, 2019 | https://doi.org/10.1371/journal.ppat.1007984
Diet–microbiome–disease: Investigating diet’s influence on infectious disease resistance through alteration of the gut microbiome
PLOS Pathogens: published October 31, 2019 | https://doi.org/10.1371/journal.ppat.1007891
Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain
PLOS Pathogens: published October 31, 2019 | https://doi.org/10.1371/journal.ppat.1008042
Research Articles
Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer
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Shiga toxin sub-type 2a increases the efficiency of Escherichia coli O157 transmission between animals and restricts epithelial regeneration in bovine enteroids
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PLOS Pathogens: published October 4, 2019 | https://doi.org/10.1371/journal.ppat.1008062
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Phage resistance at the cost of virulence: Listeria monocytogenes serovar 4b requires galactosylated teichoic acids for InlB-mediated invasion
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Corrections
Correction: A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes
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