The immune battlefield: The impact of inflammatory cytokines on CD8⁺ T-cell immunity

Stephanie A. Condotta, Martin J. Richer

PLOS Pathogens: published October 26, 2017 | https://doi.org/10.1371/journal.ppat.1006618

Do fungi have an innate immune response? An NLR-based comparison to plant and animal immune systems

Jessie Uehling, Aurélie Deveau, Mathieu Paoletti

PLOS Pathogens: published October 26, 2017 | https://doi.org/10.1371/journal.ppat.1006578

Circadian rhythms in parasites

Filipa Rijo-Ferreira, Joseph S. Takahashi, Luisa M. Figueiredo

PLOS Pathogens: published October 12, 2017 | https://doi.org/10.1371/journal.ppat.1006590

The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer

Jennifer M. Noto, Richard M. Peek Jr.

PLOS Pathogens: published October 5, 2017 | https://doi.org/10.1371/journal.ppat.1006573

Combining epidemiology with basic biology of sand flies, parasites, and hosts to inform leishmaniasis transmission dynamics and control

Orin Courtenay, Nathan C. Peters, Matthew E. Rogers, Caryn Bern

PLOS Pathogens: published October 19, 2017 | https://doi.org/10.1371/journal.ppat.1006571

Pivotal role for the ESCRT-II complex subunit EAP30/SNF8 in IRF3-dependent innate antiviral defense

Kattareeya Kumthip, Darong Yang, Nan L. Li, Yunzhi Zhang, Meiyun Fan, Aarti Sethuraman, Kui Li

PLOS Pathogens: published October 30, 2017 | https://doi.org/10.1371/journal.ppat.1006713

Attaching and effacing (A/E) lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors

Massiel Cepeda-Molero, Cedric N. Berger, Alistair D. S. Walsham, Samuel J. Ellis, Simon Wemyss-Holden, Stephanie Schüller, Gad Frankel, Luis Ángel Fernández

PLOS Pathogens: published October 30, 2017 | https://doi.org/10.1371/journal.ppat.1006706

Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication

Aastha Sindhwani, Subhash B. Arya, Harmeet Kaur, Divya Jagga, Amit Tuli, Mahak Sharma

PLOS Pathogens: published October 30, 2017 | https://doi.org/10.1371/journal.ppat.1006700

Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection

Benoit Besson, Florian Sonthonnax, Magalie Duchateau, Youcef Ben Khalifa, Florence Larrous, Hyeju Eun, Véronique Hourdel, Mariette Matondo, Julia Chamot-Rooke, Regis Grailhe, Hervé Bourhy

PLOS Pathogens: published October 30, 2017 | https://doi.org/10.1371/journal.ppat.1006697

miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence

Yingpu Yu, Troels K. H. Scheel, Joseph M. Luna, Hachung Chung, Eiko Nishiuchi, Margaret A. Scull, Natalia Echeverría, Inna Ricardo-Lax, Amit Kapoor, Ian W. Lipkin, Thomas J. Divers, Douglas F. Antczak, Bud C. Tennant, Charles M. Rice

PLOS Pathogens: published October 30, 2017 | https://doi.org/10.1371/journal.ppat.1006694

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1. Correction: miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence

KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation

Nishi R. Sharma, Vladimir Majerciak, Michael J. Kruhlak, Zhi-Ming Zheng

PLOS Pathogens: published October 30, 2017 | https://doi.org/10.1371/journal.ppat.1006677

Membrane alterations induced by nonstructural proteins of human norovirus

Sylvie Y. Doerflinger, Mirko Cortese, Inés Romero-Brey, Zach Menne, Thibault Tubiana, Christian Schenk, Peter A. White, Ralf Bartenschlager, Stéphane Bressanelli, Grant S. Hansman, Volker Lohmann

PLOS Pathogens: published October 27, 2017 | https://doi.org/10.1371/journal.ppat.1006705

In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA)

David Sychantha, Carys S. Jones, Dustin J. Little, Patrick J. Moynihan, Howard Robinson, Nicola F. Galley, David I. Roper, Christopher G. Dowson, P. Lynne Howell, Anthony J. Clarke

PLOS Pathogens: published October 27, 2017 | https://doi.org/10.1371/journal.ppat.1006667

ISG15 governs mitochondrial function in macrophages following vaccinia virus infection

Sara Baldanta, Mercedes Fernández-Escobar, Rebeca Acín-Perez, Manuel Albert, Emilio Camafeita, Inmaculada Jorge, Jesús Vázquez, José Antonio Enríquez, Susana Guerra

PLOS Pathogens: published October 27, 2017 | https://doi.org/10.1371/journal.ppat.1006651

Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection

Adam L. Bailey, Connor R. Buechler, Daniel R. Matson, Eric J. Peterson, Kevin G. Brunner, Mariel S. Mohns, Meghan Breitbach, Laurel M. Stewart, Adam J. Ericsen, Christina M. Newman, Michelle R. Koenig, Emma Mohr, John Tan, Saverio Capuano III, Heather A. Simmons, David T. Yang, David H. O’Connor

PLOS Pathogens: published October 26, 2017 | https://doi.org/10.1371/journal.ppat.1006692

Single-cell analysis identifies cellular markers of the HIV permissive cell

Sylvie Rato, Antonio Rausell, Miguel Muñoz, Amalio Telenti, Angela Ciuffi

PLOS Pathogens: published October 26, 2017 | https://doi.org/10.1371/journal.ppat.1006678

Comparative genomics of geographically distant Fusarium fujikuroi isolates revealed two distinct pathotypes correlating with secondary metabolite profiles

Eva-Maria Niehaus, Hee-Kyoung Kim, Martin Münsterkötter, Slavica Janevska, Birgit Arndt, Svetlana A. Kalinina, Petra M. Houterman, Il-Pyung Ahn, Ilaria Alberti, Stefano Tonti, Da-Woon Kim, Christian M. K. Sieber, Hans-Ulrich Humpf, Sung-Hwan Yun, Ulrich Güldener, Bettina Tudzynski

PLOS Pathogens: published October 26, 2017 | https://doi.org/10.1371/journal.ppat.1006670

Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing

Orkide O. Koyuncu, Margaret A. MacGibeny, Ian B. Hogue, Lynn W. Enquist

PLOS Pathogens: published October 26, 2017 | https://doi.org/10.1371/journal.ppat.1006608

The yeast form of the fungus Candida albicans promotes persistence in the gut of gnotobiotic mice

Lena Böhm, Sanda Torsin, Su Hlaing Tint, Marie Therese Eckstein, Tobias Ludwig, J. Christian Pérez

PLOS Pathogens: published October 25, 2017 | https://doi.org/10.1371/journal.ppat.1006699

Macavirus latency-associated protein evades immune detection through regulation of protein synthesis in cis depending upon its glycin/glutamate-rich domain

Océane Sorel, Ting Chen, Françoise Myster, Justine Javaux, Alain Vanderplasschen, Benjamin G. Dewals

PLOS Pathogens: published October 23, 2017 | https://doi.org/10.1371/journal.ppat.1006691

Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling

Sudarshan Seshadri, David S. J. Allan, James R. Carlyle, Lauren A. Zenewicz

PLOS Pathogens: published October 23, 2017 | https://doi.org/10.1371/journal.ppat.1006690

Co-opting ATP-generating glycolytic enzyme PGK1 phosphoglycerate kinase facilitates the assembly of viral replicase complexes

K. Reddisiva Prasanth, Chingkai Chuang, Peter D. Nagy

PLOS Pathogens: published October 23, 2017 | https://doi.org/10.1371/journal.ppat.1006689

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine

Nicholas C. Wu, Seth J. Zost, Andrew J. Thompson, David Oyen, Corwin M. Nycholat, Ryan McBride, James C. Paulson, Scott E. Hensley, Ian A. Wilson

PLOS Pathogens: published October 23, 2017 | https://doi.org/10.1371/journal.ppat.1006682

Parallel and costly changes to cellular immunity underlie the evolution of parasitoid resistance in three Drosophila species

John E. McGonigle, Alexandre B. Leitão, Sarah Ommeslag, Sophie Smith, Jonathan P. Day, Francis M. Jiggins

PLOS Pathogens: published October 19, 2017 | https://doi.org/10.1371/journal.ppat.1006683

MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock

Muhamuda Kader, Mounia Alaoui-EL-Azher, Jennie Vorhauer, Bhushan B Kode, Jakob Z. Wells, Donna Stolz, George Michalopoulos, Alan Wells, Melanie Scott, Nahed Ismail

PLOS Pathogens: published October 19, 2017 | https://doi.org/10.1371/journal.ppat.1006644

The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut

Tiffani Alvey Jones, Diane Z. Hernandez, Zoë C. Wong, Anica M. Wandler, Karen Guillemin

PLOS Pathogens: published October 19, 2017 | https://doi.org/10.1371/journal.ppat.1006631

TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter

Deepa Rajagopalan, Amit Kumar Pandey, Magdalene Claire Xiuzhen, Kwok Kin Lee, Shainan Hora, Yanzhou Zhang, Boon Haow Chua, Hui Si Kwok, Shreshtha Sailesh Bhatia, Lih Wen Deng, Daniel G. Tenen, Dennis Kappei, Sudhakar Jha

PLOS Pathogens: published October 18, 2017 | https://doi.org/10.1371/journal.ppat.1006681

TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition

Marcin D. Roganowicz, Sevnur Komurlu, Santanu Mukherjee, Jacek Plewka, Steven L. Alam, Katarzyna A. Skorupka, Yueping Wan, Damian Dawidowski, David S. Cafiso, Barbie K. Ganser-Pornillos, Edward M. Campbell, Owen Pornillos

PLOS Pathogens: published October 17, 2017 | https://doi.org/10.1371/journal.ppat.1006686

Mycobacterium tuberculosis infection modulates adipose tissue biology

Macarena Beigier-Bompadre, Georgina N. Montagna, Anja A. Kühl, Laura Lozza, January Weiner III, Andreas Kupz, Alexis Vogelzang, Hans-Joachim Mollenkopf, Delia Löwe, Silke Bandermann, Anca Dorhoi, Volker Brinkmann, Kai Matuschewski, Stefan H. E. Kaufmann

PLOS Pathogens: published October 17, 2017 | https://doi.org/10.1371/journal.ppat.1006676

Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy

Jose-Andres C. Portillo, Luis Muniz-Feliciano, Yalitza Lopez Corcino, So Jung Lee, Jennifer Van Grol, Sarah J. Parsons, William P. Schiemman, Carlos S. Subauste

PLOS Pathogens: published October 16, 2017 | https://doi.org/10.1371/journal.ppat.1006671

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

Jingwei Cheng, Donglim Esther Park, Christian Berrios, Elizabeth A. White, Reety Arora, Rosa Yoon, Timothy Branigan, Tengfei Xiao, Thomas Westerling, Alexander Federation, Rhamy Zeid, Benjamin Strober, Selene K. Swanson, Laurence Florens, James E. Bradner, Myles Brown, Peter M. Howley, Megha Padi, Michael P. Washburn, James A. DeCaprio

PLOS Pathogens: published October 13, 2017 | https://doi.org/10.1371/journal.ppat.1006668

Reduced accumulation of defective viral genomes contributes to severe outcome in influenza virus infected patients

Jasmina Vasilijevic, Noelia Zamarreño, Juan Carlos Oliveros, Ariel Rodriguez-Frandsen, Guillermo Gómez, Guadalupe Rodriguez, Mercedes Pérez-Ruiz, Sonia Rey, Isabel Barba, Francisco Pozo, Inmaculada Casas, Amelia Nieto, Ana Falcón

PLOS Pathogens: published October 12, 2017 | https://doi.org/10.1371/journal.ppat.1006650

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor

Rachel S. Leibman, Max W. Richardson, Christoph T. Ellebrecht, Colby R. Maldini, Joshua A. Glover, Anthony J. Secreto, Irina Kulikovskaya, Simon F. Lacey, Sarah R. Akkina, Yanjie Yi, Farida Shaheen, Jianbin Wang, Keith A. Dufendach, Michael C. Holmes, Ronald G. Collman, Aimee S. Payne, James L. Riley

PLOS Pathogens: published October 12, 2017 | https://doi.org/10.1371/journal.ppat.1006613

A conserved fungal glycosyltransferase facilitates pathogenesis of plants by enabling hyphal growth on solid surfaces

Robert King, Martin Urban, Rebecca P. Lauder, Nichola Hawkins, Matthew Evans, Amy Plummer, Kirstie Halsey, Alison Lovegrove, Kim Hammond-Kosack, Jason J. Rudd

PLOS Pathogens: published October 11, 2017 | https://doi.org/10.1371/journal.ppat.1006672

Targeted mutagenesis in a human-parasitic nematode

Spencer S. Gang, Michelle L. Castelletto, Astra S. Bryant, Emily Yang, Nicholas Mancuso, Jacqueline B. Lopez, Matteo Pellegrini, Elissa A. Hallem

PLOS Pathogens: published October 10, 2017 | https://doi.org/10.1371/journal.ppat.1006675

Enterovirus 71 protease 2A^pro and 3C^pro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication

Tao Wang, Bei Wang, He Huang, Chongyang Zhang, Yuanmei Zhu, Bin Pei, Chaofei Cheng, Lei Sun, Jianwei Wang, Qi Jin, Zhendong Zhao

PLOS Pathogens: published October 6, 2017 | https://doi.org/10.1371/journal.ppat.1006674

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development

Molly Parkyn Schneider, Boyin Liu, Philipp Glock, Annika Suttie, Emma McHugh, Dean Andrew, Steven Batinovic, Nicholas Williamson, Eric Hanssen, Paul McMillan, Marion Hliscs, Leann Tilley, Matthew W. A. Dixon

PLOS Pathogens: published October 6, 2017 | https://doi.org/10.1371/journal.ppat.1006659

Rice stripe virus NS3 protein regulates primary miRNA processing through association with the miRNA biogenesis factor OsDRB1 and facilitates virus infection in rice

Lijia Zheng, Chao Zhang, Chaonan Shi, Zhirui Yang, Yu Wang, Tong Zhou, Feng Sun, Hong Wang, Shanshan Zhao, Qingqing Qin, Rui Qiao, Zuomei Ding, Chunhong Wei, Lianhui Xie, Jianguo Wu, Yi Li

PLOS Pathogens: published October 4, 2017 | https://doi.org/10.1371/journal.ppat.1006662

Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways

Morgan R. Herod, Sarah Gold, Lidia Lasecka-Dykes, Caroline Wright, Joseph C. Ward, Thomas C. McLean, Sophie Forrest, Terry Jackson, Tobias J. Tuthill, David J. Rowlands, Nicola J. Stonehouse

PLOS Pathogens: published October 2, 2017 | https://doi.org/10.1371/journal.ppat.1006666

EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells

Laura V. Glaser, Simone Rieger, Sybille Thumann, Sophie Beer, Cornelia Kuklik-Roos, Dietmar E. Martin, Kerstin C. Maier, Marie L. Harth-Hertle, Björn Grüning, Rolf Backofen, Stefan Krebs, Helmut Blum, Ralf Zimmer, Florian Erhard, Bettina Kempkes

PLOS Pathogens: published October 2, 2017 | https://doi.org/10.1371/journal.ppat.1006664

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

Mohammed Atif, Argel Estrada-Mondragon, Bindi Nguyen, Joseph W. Lynch, Angelo Keramidas

PLOS Pathogens: published October 2, 2017 | https://doi.org/10.1371/journal.ppat.1006663

KDM6A addiction of cervical carcinoma cell lines is triggered by E7 and mediated by p21^CIP1 suppression of replication stress

David R. Soto, Christopher Barton, Karl Munger, Margaret E. McLaughlin-Drubin

PLOS Pathogens: published October 2, 2017 | https://doi.org/10.1371/journal.ppat.1006661

Sp100 colocalizes with HPV replication foci and restricts the productive stage of the infectious cycle

Wesley H. Stepp, James D. Stamos, Simran Khurana, Alix Warburton, Alison A. McBride

PLOS Pathogens: published October 2, 2017 | https://doi.org/10.1371/journal.ppat.1006660

IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3⁺ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection

Rajesh M. Valanparambil, Mifong Tam, Pierre-Paul Gros, Jean-Philippe Auger, Mariela Segura, Philippe Gros, Armando Jardim, Timothy G. Geary, Keiko Ozato, Mary M. Stevenson

PLOS Pathogens: published October 2, 2017 | https://doi.org/10.1371/journal.ppat.1006647

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection

Pierre Wallet, Sacha Benaoudia, Amandine Mosnier, Brice Lagrange, Amandine Martin, Helena Lindgren, Igor Golovliov, Fanny Michal, Pauline Basso, Sophia Djebali, Angelina Provost, Omran Allatif, Etienne Meunier, Petr Broz, Masahiro Yamamoto, Bénédicte F. Py, Eric Faudry, Anders Sjöstedt, Thomas Henry

PLOS Pathogens: published October 2, 2017 | https://doi.org/10.1371/journal.ppat.1006630