October 2015

Wang Qiang and Colleagues have used Sonchus yellow net rhabdovirus (SYNV) to develop the first reverse genetics system reported for a plant negative strand RNA virus. The SYNV genome was cloned and a derivative expressing GFP (rSYNV-GFP) was constructed and used to infect plants. The image shows GFP fluorescence against a red chloroplast autofluorescence background in a Nicotiana benthamiana plant systemically infected with rSYNV-GFP. Li et al.

Image Credit: Li et al.

Opinions

Effectively Communicating the Uncertainties Surrounding Ebola Virus Transmission

Andy Kilianski, Nicholas G. Evans

PLOS Pathogens: published October 29, 2015 | https://doi.org/10.1371/journal.ppat.1005097

Addressing the Complications of Ebola and Other Viral Hemorrhagic Fever Infections: Using Insights from Bacterial and Fungal Sepsis

Judith Hellman

PLOS Pathogens: published October 1, 2015 | https://doi.org/10.1371/journal.ppat.1005088

Pearls

Dimensions of Horizontal Gene Transfer in Eukaryotic Microbial Pathogens

Emile Gluck-Thaler, Jason C. Slot

PLOS Pathogens: published October 29, 2015 | https://doi.org/10.1371/journal.ppat.1005156

Time for Chocolate: Current Understanding and New Perspectives on Cacao Witches’ Broom Disease Research

Paulo José Pereira Lima Teixeira, Daniela Paula de Toledo Thomazella, Gonçalo Amarante Guimarães Pereira

PLOS Pathogens: published October 22, 2015 | https://doi.org/10.1371/journal.ppat.1005130

Papillomavirus E6 Oncoproteins Take Common Structural Approaches to Solve Different Biological Problems

Scott Vande Pol

PLOS Pathogens: published October 15, 2015 | https://doi.org/10.1371/journal.ppat.1005138

A Gut Odyssey: The Impact of the Microbiota on Clostridium difficile Spore Formation and Germination

Aimee Shen

PLOS Pathogens: published October 15, 2015 | https://doi.org/10.1371/journal.ppat.1005157

Chronobiomics: The Biological Clock as a New Principle in Host–Microbial Interactions

Christoph A. Thaiss, Maayan Levy, Eran Elinav

PLOS Pathogens: published October 8, 2015 | https://doi.org/10.1371/journal.ppat.1005113

Interferon-γ: The Jekyll and Hyde of Malaria

Thayer King, Tracey Lamb

PLOS Pathogens: published October 1, 2015 | https://doi.org/10.1371/journal.ppat.1005118

Research Matters

Preparing for the Next Epidemic with Basic Virology

Michael S. Diamond

PLOS Pathogens: published October 22, 2015 | https://doi.org/10.1371/journal.ppat.1005182

Translating Basic Research into Clinical Applications: Malaria Research at an NIH Lab

Xin-zhuan Su

PLOS Pathogens: published October 8, 2015 | https://doi.org/10.1371/journal.ppat.1005190

Research Articles

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo

Natalia T. Freund, Joshua A. Horwitz, Lilian Nogueira, Stuart A. Sievers, Louise Scharf, Johannes F. Scheid, Anna Gazumyan, Cassie Liu, Klara Velinzon, Ariel Goldenthal, Rogier W. Sanders, John P. Moore, Pamela J. Bjorkman, Michael S. Seaman, Bruce D. Walker, Florian Klein, Michel C. Nussenzweig

PLOS Pathogens: published October 30, 2015 | https://doi.org/10.1371/journal.ppat.1005238

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

Jose M. Jimenez-Guardeño, Jose A. Regla-Nava, Jose L. Nieto-Torres, Marta L. DeDiego, Carlos Castaño-Rodriguez, Raul Fernandez-Delgado, Stanley Perlman, Luis Enjuanes

PLOS Pathogens: published October 29, 2015 | https://doi.org/10.1371/journal.ppat.1005215

Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention

Ziying Han, Jonathan J. Madara, Andrew Herbert, Laura I. Prugar, Gordon Ruthel, Jianhong Lu, Yuliang Liu, Wenbo Liu, Xiaohong Liu, Jay E. Wrobel, Allen B. Reitz, John M. Dye, Ronald N. Harty, Bruce D. Freedman

PLOS Pathogens: published October 29, 2015 | https://doi.org/10.1371/journal.ppat.1005220

C-di-GMP Regulates Motile to Sessile Transition by Modulating MshA Pili Biogenesis and Near-Surface Motility Behavior in Vibrio cholerae

Christopher J. Jones, Andrew Utada, Kimberly R. Davis, Wiriya Thongsomboon, David Zamorano Sanchez, Vinita Banakar, Lynette Cegelski, Gerard C. L. Wong, Fitnat H. Yildiz

PLOS Pathogens: published October 27, 2015 | https://doi.org/10.1371/journal.ppat.1005068

Structure Analysis Uncovers a Highly Diverse but Structurally Conserved Effector Family in Phytopathogenic Fungi

Karine de Guillen, Diana Ortiz-Vallejo, Jérome Gracy, Elisabeth Fournier, Thomas Kroj, André Padilla

PLOS Pathogens: published October 27, 2015 | https://doi.org/10.1371/journal.ppat.1005228

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems

Kevin G. Roelofs, Christopher J. Jones, Sarah R. Helman, Xiaoran Shang, Mona W. Orr, Jonathan R. Goodson, Michael Y. Galperin, Fitnat H. Yildiz, Vincent T. Lee

PLOS Pathogens: published October 27, 2015 | https://doi.org/10.1371/journal.ppat.1005232

Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins

Toshio Shibata, Kouki Maki, Jinki Hadano, Takumi Fujikawa, Kazuki Kitazaki, Takumi Koshiba, Shun-ichiro Kawabata

PLOS Pathogens: published October 27, 2015 | https://doi.org/10.1371/journal.ppat.1005244

TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus

Ruth E. Watkinson, William A. McEwan, Jerry C. H. Tam, Marina Vaysburd, Leo C. James

PLOS Pathogens: published October 27, 2015 | https://doi.org/10.1371/journal.ppat.1005253

Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells

Ruian Ke, Sharon R. Lewin, Julian H Elliott, Alan S. Perelson

PLOS Pathogens: published October 23, 2015 | https://doi.org/10.1371/journal.ppat.1005237

Identification of a Novel Lipoprotein Regulator of Clostridium difficile Spore Germination

Kelly A. Fimlaid, Owen Jensen, M. Lauren Donnelly, Michael B. Francis, Joseph A. Sorg, Aimee Shen

PLOS Pathogens: published October 23, 2015 | https://doi.org/10.1371/journal.ppat.1005239

Yersinia pestis Requires Host Rab1b for Survival in Macrophages

Michael G. Connor, Amanda R. Pulsifer, Christopher T. Price, Yousef Abu Kwaik, Matthew B. Lawrenz

PLOS Pathogens: published October 23, 2015 | https://doi.org/10.1371/journal.ppat.1005241

Immunologic Control of Mus musculus Papillomavirus Type 1

Joshua W. Wang, Rosie Jiang, Shiwen Peng, Yung-Nien Chang, Chien-Fu Hung, Richard B. S. Roden

PLOS Pathogens: published October 23, 2015 | https://doi.org/10.1371/journal.ppat.1005243

The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps

Mark J. Lee, Hong Liu, Bridget M. Barker, Brendan D. Snarr, Fabrice N. Gravelat, Qusai Al Abdallah, Christina Gavino, Shane R. Baistrocchi, Hanna Ostapska, Tianli Xiao, Benjamin Ralph, Norma V. Solis, Mélanie Lehoux, Stefanie D. Baptista, Arsa Thammahong, Robert P. Cerone, Susan G. W. Kaminskyj, Marie-Christine Guiot, Jean-Paul Latgé, Thierry Fontaine, Donald C. Vinh, Scott G. Filler, Donald C. Sheppard

PLOS Pathogens: published October 22, 2015 | https://doi.org/10.1371/journal.ppat.1005187

Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein

Berlin Londono-Renteria, Andrea Troupin, Michael J Conway, Diana Vesely, Michael Ledizet, Christopher M. Roundy, Erin Cloherty, Samuel Jameson, Dana Vanlandingham, Stephen Higgs, Erol Fikrig, Tonya M. Colpitts

PLOS Pathogens: published October 22, 2015 | https://doi.org/10.1371/journal.ppat.1005202

Crystal Structures of a Piscine Betanodavirus: Mechanisms of Capsid Assembly and Viral Infection

Nai-Chi Chen, Masato Yoshimura, Hong-Hsiang Guan, Ting-Yu Wang, Yuko Misumi, Chien-Chih Lin, Phimonphan Chuankhayan, Atsushi Nakagawa, Sunney I. Chan, Tomitake Tsukihara, Tzong-Yueh Chen, Chun-Jung Chen

PLOS Pathogens: published October 22, 2015 | https://doi.org/10.1371/journal.ppat.1005203

Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes

Martin Zoltner, Ka Fai Leung, Sam Alsford, David Horn, Mark C. Field

PLOS Pathogens: published October 22, 2015 | https://doi.org/10.1371/journal.ppat.1005236

Depletion of M. tuberculosis GlmU from Infected Murine Lungs Effects the Clearance of the Pathogen

Vijay Soni, Sandeep Upadhayay, Priyanka Suryadevara, Ganesh Samla, Archana Singh, Perumal Yogeeswari, Dharmarajan Sriram, Vinay Kumar Nandicoori

PLOS Pathogens: published October 21, 2015 | https://doi.org/10.1371/journal.ppat.1005235

Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

Luigi De Colibus, Xiangxi Wang, Aloys Tijsma, Johan Neyts, John A. B. Spyrou, Jingshan Ren, Jonathan M. Grimes, Gerhard Puerstinger, Pieter Leyssen, Elizabeth E. Fry, Zihe Rao, David I. Stuart

PLOS Pathogens: published October 20, 2015 | https://doi.org/10.1371/journal.ppat.1005165

CD39 Expression Identifies Terminally Exhausted CD8⁺ T Cells

Prakash K. Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E. Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G. Junger, Simon C. Robson, E. John Wherry, Galit Alter, Philip J. R. Goulder, Paul Klenerman, Arlene H. Sharpe, Georg M. Lauer, W. Nicholas Haining

PLOS Pathogens: published October 20, 2015 | https://doi.org/10.1371/journal.ppat.1005177

Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia

Michael J. Smout, Javier Sotillo, Thewarach Laha, Atiroch Papatpremsiri, Gabriel Rinaldi, Rafael N. Pimenta, Lai Yue Chan, Michael S. Johnson, Lynne Turnbull, Cynthia B. Whitchurch, Paul R. Giacomin, Corey S. Moran, Jonathan Golledge, Norelle Daly, Banchob Sripa, Jason P. Mulvenna, Paul J. Brindley, Alex Loukas

PLOS Pathogens: published October 20, 2015 | https://doi.org/10.1371/journal.ppat.1005209

Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection

Matthew D. Martin, Marie T. Kim, Qiang Shan, Ramakrishna Sompallae, Hai-Hui Xue, John T. Harty, Vladimir P. Badovinac

PLOS Pathogens: published October 20, 2015 | https://doi.org/10.1371/journal.ppat.1005219

Dissociation of Tissue Destruction and Bacterial Expansion during Bubonic Plague

Françoise Guinet, Patrick Avé, Sofia Filali, Christèle Huon, Cyril Savin, Michel Huerre, Laurence Fiette, Elisabeth Carniel

PLOS Pathogens: published October 20, 2015 | https://doi.org/10.1371/journal.ppat.1005222

Rescue of a Plant Negative-Strand RNA Virus from Cloned cDNA: Insights into Enveloped Plant Virus Movement and Morphogenesis

Qiang Wang, Xiaonan Ma, ShaSha Qian, Xin Zhou, Kai Sun, Xiaolan Chen, Xueping Zhou, Andrew O. Jackson, Zhenghe Li

PLOS Pathogens: published October 20, 2015 | https://doi.org/10.1371/journal.ppat.1005223

PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8⁺ T Cell Killing

Ilseyar Akhmetzyanova, Malgorzata Drabczyk, C. Preston Neff, Kathrin Gibbert, Kirsten K. Dietze, Tanja Werner, Jia Liu, Lieping Chen, Karl S. Lang, Brent E. Palmer, Ulf Dittmer, Gennadiy Zelinskyy

PLOS Pathogens: published October 20, 2015 | https://doi.org/10.1371/journal.ppat.1005224

Crystal Structure of the Human Cytomegalovirus Glycoprotein B

Heidi G. Burke, Ekaterina E. Heldwein

PLOS Pathogens: published October 20, 2015 | https://doi.org/10.1371/journal.ppat.1005227

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies

Claudio Ciferri, Sumana Chandramouli, Alexander Leitner, Danilo Donnarumma, Michael A. Cianfrocco, Rachel Gerrein, Kristian Friedrich, Yukti Aggarwal, Giuseppe Palladino, Ruedi Aebersold, Nathalie Norais, Ethan C. Settembre, Andrea Carfi

PLOS Pathogens: published October 20, 2015 | https://doi.org/10.1371/journal.ppat.1005230

Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6

Yoshihisa Ueno, Riichiro Yoshida, Mitsuko Kishi-Kaboshi, Akane Matsushita, Chang-Jie Jiang, Shingo Goto, Akira Takahashi, Hirohiko Hirochika, Hiroshi Takatsuji

PLOS Pathogens: published October 20, 2015 | https://doi.org/10.1371/journal.ppat.1005231

Structural and Functional Analysis of Murine Polyomavirus Capsid Proteins Establish the Determinants of Ligand Recognition and Pathogenicity

Michael H. C. Buch, A. Manuel Liaci, Samantha D. O’Hara, Robert L. Garcea, Ursula Neu, Thilo Stehle

PLOS Pathogens: published October 16, 2015 | https://doi.org/10.1371/journal.ppat.1005104

Ganglioside and Non-ganglioside Mediated Host Responses to the Mouse Polyomavirus

John You, Samantha D. O’Hara, Palanivel Velupillai, Sherry Castle, Steven Levery, Robert L. Garcea, Thomas Benjamin

PLOS Pathogens: published October 16, 2015 | https://doi.org/10.1371/journal.ppat.1005175

Shigella Effector OspB Activates mTORC1 in a Manner That Depends on IQGAP1 and Promotes Cell Proliferation

Richard Lu, Bobby Brooke Herrera, Heather D. Eshleman, Yang Fu, Alexander Bloom, Zhigang Li, David B. Sacks, Marcia B. Goldberg

PLOS Pathogens: published October 16, 2015 | https://doi.org/10.1371/journal.ppat.1005200

Peripheral Vγ9Vδ2 T Cells Are a Novel Reservoir of Latent HIV Infection

Natalia Soriano-Sarabia, Nancie M. Archin, Rosalie Bateson, Noelle P. Dahl, Amanda M. Crooks, JoAnn D. Kuruc, Carolina Garrido, David M. Margolis

PLOS Pathogens: published October 16, 2015 | https://doi.org/10.1371/journal.ppat.1005201

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface

Pierre-Mehdi Hammoudi, Damien Jacot, Christina Mueller, Manlio Di Cristina, Sunil Kumar Dogga, Jean-Baptiste Marq, Julia Romano, Nicolò Tosetti, Juan Dubrot, Yalin Emre, Matteo Lunghi, Isabelle Coppens, Masahiro Yamamoto, Daniel Sojka, Paco Pino, Dominique Soldati-Favre

PLOS Pathogens: published October 16, 2015 | https://doi.org/10.1371/journal.ppat.1005211

Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33

Jordy Saravia, Dahui You, Bishwas Shrestha, Sridhar Jaligama, David Siefker, Greg I. Lee, Jeffrey N. Harding, Tamekia L. Jones, Cynthia Rovnaghi, Bindiya Bagga, John P. DeVincenzo, Stephania A. Cormier

PLOS Pathogens: published October 16, 2015 | https://doi.org/10.1371/journal.ppat.1005217

The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways

Michael Tscherner, Florian Zwolanek, Sabrina Jenull, Fritz J. Sedlazeck, Andriy Petryshyn, Ingrid E. Frohner, John Mavrianos, Neeraj Chauhan, Arndt von Haeseler, Karl Kuchler

PLOS Pathogens: published October 16, 2015 | https://doi.org/10.1371/journal.ppat.1005218

Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma

Francesco Abate, Maria Raffaella Ambrosio, Lucia Mundo, Maria Antonella Laginestra, Fabio Fuligni, Maura Rossi, Sakellarios Zairis, Sara Gazaneo, Giulia De Falco, Stefano Lazzi, Cristiana Bellan, Bruno Jim Rocca, Teresa Amato, Elena Marasco, Maryam Etebari, Martin Ogwang, Valeria Calbi, Isaac Ndede, Kirtika Patel, David Chumba, Pier Paolo Piccaluga, Stefano Pileri, Lorenzo Leoncini, Raul Rabadan

PLOS Pathogens: published October 15, 2015 | https://doi.org/10.1371/journal.ppat.1005158

CCR2⁺ Inflammatory Dendritic Cells and Translocation of Antigen by Type III Secretion Are Required for the Exceptionally Large CD8⁺ T Cell Response to the Protective YopE_69-77 Epitope during Yersinia Infection

Yue Zhang, Jason W. Tam, Patricio Mena, Adrianus W. M. van der Velden, James B. Bliska

PLOS Pathogens: published October 15, 2015 | https://doi.org/10.1371/journal.ppat.1005167

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy

David A. Tumbarello, Paul T. Manna, Mark Allen, Mark Bycroft, Susan D. Arden, John Kendrick-Jones, Folma Buss

PLOS Pathogens: published October 9, 2015 | https://doi.org/10.1371/journal.ppat.1005174

Comparative Life Cycle Transcriptomics Revises Leishmania mexicana Genome Annotation and Links a Chromosome Duplication with Parasitism of Vertebrates

Michael Fiebig, Steven Kelly, Eva Gluenz

PLOS Pathogens: published October 9, 2015 | https://doi.org/10.1371/journal.ppat.1005186

IL-4 Induced Innate CD8⁺ T Cells Control Persistent Viral Infection

Ara Lee, Seung Pyo Park, Chan Hee Park, Byung Hyun Kang, Seong Hoe Park, Sang-Jun Ha, Kyeong Cheon Jung

PLOS Pathogens: published October 9, 2015 | https://doi.org/10.1371/journal.ppat.1005193

Influenza Transmission in the Mother-Infant Dyad Leads to Severe Disease, Mammary Gland Infection, and Pathogenesis by Regulating Host Responses

Stéphane G. Paquette, David Banner, Stephen S. H. Huang, Raquel Almansa, Alberto Leon, Luoling Xu, Jessica Bartoszko, David J. Kelvin, Alyson A. Kelvin

PLOS Pathogens: published October 8, 2015 | https://doi.org/10.1371/journal.ppat.1005173

Influenza Virus Reassortment Is Enhanced by Semi-infectious Particles but Can Be Suppressed by Defective Interfering Particles

Judith M. Fonville, Nicolle Marshall, Hui Tao, John Steel, Anice C. Lowen

PLOS Pathogens: published October 6, 2015 | https://doi.org/10.1371/journal.ppat.1005204

BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAM^low CD11b^high Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming

Vishnu Priya Bollampalli, Lívia Harumi Yamashiro, Xiaogang Feng, Damiën Bierschenk, Yu Gao, Hans Blom, Birgitta Henriques-Normark, Susanne Nylén, Antonio Gigliotti Rothfuchs

PLOS Pathogens: published October 6, 2015 | https://doi.org/10.1371/journal.ppat.1005206

Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells

Kristina S. Burrack, Jeslin J. L. Tan, Mary K. McCarthy, Zhisheng Her, Jennifer N. Berger, Lisa F. P. Ng, Thomas E. Morrison

PLOS Pathogens: published October 5, 2015 | https://doi.org/10.1371/journal.ppat.1005191

The Dual Role of an ESCRT-0 Component HGS in HBV Transcription and Naked Capsid Secretion

Shu-Fan Chou, Ming-Lin Tsai, Jyun-Yuan Huang, Ya-Shu Chang, Chiaho Shih

PLOS Pathogens: published October 2, 2015 | https://doi.org/10.1371/journal.ppat.1005123

Antigen-Specific Th17 Cells Are Primed by Distinct and Complementary Dendritic Cell Subsets in Oropharyngeal Candidiasis

Kerstin Trautwein-Weidner, André Gladiator, Florian R. Kirchner, Simone Becattini, Thomas Rülicke, Federica Sallusto, Salomé LeibundGut-Landmann

PLOS Pathogens: published October 2, 2015 | https://doi.org/10.1371/journal.ppat.1005164

Trans-generational Immune Priming Protects the Eggs Only against Gram-Positive Bacteria in the Mealworm Beetle

Aurore Dubuffet, Caroline Zanchi, Gwendoline Boutet, Jérôme Moreau, Maria Teixeira, Yannick Moret

PLOS Pathogens: published October 2, 2015 | https://doi.org/10.1371/journal.ppat.1005178

The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

Yorihiro Nishimura, Noel P. McLaughlin, Jieyan Pan, Sara Goldstein, Susan Hafenstein, Hiroyuki Shimizu, Jeffrey D. Winkler, Jeffrey M. Bergelson

PLOS Pathogens: published October 2, 2015 | https://doi.org/10.1371/journal.ppat.1005184

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

Fikadu G. Tafesse, Ali Rashidfarrokhi, Florian I. Schmidt, Elizaveta Freinkman, Stephanie Dougan, Michael Dougan, Alexandre Esteban, Takeshi Maruyama, Karin Strijbis, Hidde L. Ploegh

PLOS Pathogens: published October 2, 2015 | https://doi.org/10.1371/journal.ppat.1005188

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

Laurence H. Arnold, Harriet C. T. Groom, Simone Kunzelmann, David Schwefel, Sarah J. Caswell, Paula Ordonez, Melanie C. Mann, Sabrina Rueschenbaum, David C. Goldstone, Simon Pennell, Steven A. Howell, Jonathan P. Stoye, Michelle Webb, Ian A. Taylor, Kate N. Bishop

PLOS Pathogens: published October 2, 2015 | https://doi.org/10.1371/journal.ppat.1005194

Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells

Dhananjay M. Nawandar, Anqi Wang, Kathleen Makielski, Denis Lee, Shidong Ma, Elizabeth Barlow, Jessica Reusch, Ru Jiang, Coral K. Wille, Deborah Greenspan, John S. Greenspan, Janet E. Mertz, Lindsey Hutt-Fletcher, Eric C. Johannsen, Paul F. Lambert, Shannon C. Kenney

PLOS Pathogens: published October 2, 2015 | https://doi.org/10.1371/journal.ppat.1005195

Geminivirus Activates ASYMMETRIC LEAVES 2 to Accelerate Cytoplasmic DCP2-Mediated mRNA Turnover and Weakens RNA Silencing in Arabidopsis

Jian Ye, Junyi Yang, Yanwei Sun, Pingzhi Zhao, Shiqiang Gao, Choonkyun Jung, Jing Qu, Rongxiang Fang, Nam-Hai Chua

PLOS Pathogens: published October 2, 2015 | https://doi.org/10.1371/journal.ppat.1005196

The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses

Shaniya H. Khan, Matthew D. Martin, Gabriel R. Starbeck-Miller, Hai-Hui Xue, John T. Harty, Vladimir P. Badovinac

PLOS Pathogens: published October 2, 2015 | https://doi.org/10.1371/journal.ppat.1005199

The White-Nose Syndrome Transcriptome: Activation of Anti-fungal Host Responses in Wing Tissue of Hibernating Little Brown Myotis

Kenneth A. Field, Joseph S. Johnson, Thomas M. Lilley, Sophia M. Reeder, Elizabeth J. Rogers, Melissa J. Behr, DeeAnn M. Reeder

PLOS Pathogens: published October 1, 2015 | https://doi.org/10.1371/journal.ppat.1005168

Expression of Concern

Expression of Concern: Misregulation of AUXIN RESPONSE FACTOR 8 Underlies the Developmental Abnormalities Caused by Three Distinct Viral Silencing Suppressors in Arabidopsis

The PLOS Pathogens Editors

PLOS Pathogens: published October 9, 2015 | https://doi.org/10.1371/journal.ppat.1005234

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Fluorescence in a tobacco plant infected with a recombinant plant negative strand RNA virus carrying the GFP gene.

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