August 2015

Localization of the MyoA-glideosome at the periphery of the parasite (stained with GAP45 in red) and the MyoC-glideosome at the basal polar ring (stained with IAP1-3Ty in green). Frenal et al.

Image Credit: Dominique Soldati-Favre

Opinion

Interdisciplinarity and Infectious Diseases: An Ebola Case Study

Vanessa O. Ezenwa, Anne-Helene Prieur-Richard, Benjamin Roche, Xavier Bailly, Pierre Becquart, Gabriel E. García-Peña, Parviez R. Hosseini, Felicia Keesing, Annapaola Rizzoli, Gerardo Suzán, Marco Vignuzzi, Marion Vittecoq, James N. Mills, Jean-François Guégan

PLOS Pathogens: published August 6, 2015 | https://doi.org/10.1371/journal.ppat.1004992

Pearls

Chemical Signals and Mechanosensing in Bacterial Responses to Their Environment

Akshay K. Harapanahalli, Jessica A. Younes, Elaine Allan, Henny C. van der Mei, Henk J. Busscher

PLOS Pathogens: published August 27, 2015 | https://doi.org/10.1371/journal.ppat.1005057

Riding the R Train into the Cell

Daniel DiMaio, Christopher G. Burd, Kylia Goodner

PLOS Pathogens: published August 20, 2015 | https://doi.org/10.1371/journal.ppat.1005036

Are Human Intestinal Eukaryotes Beneficial or Commensals?

Julius Lukeš, Christen Rune Stensvold, Kateřina Jirků-Pomajbíková, Laura Wegener Parfrey

PLOS Pathogens: published August 13, 2015 | https://doi.org/10.1371/journal.ppat.1005039

Plasticity and Redundancy in Proteins Important for Toxoplasma Invasion

Karine Frénal, Dominique Soldati-Favre

PLOS Pathogens: published August 13, 2015 | https://doi.org/10.1371/journal.ppat.1005069

Illuminating Targets of Bacterial Secretion

Roger D. Pechous, William E. Goldman

PLOS Pathogens: published August 6, 2015 | https://doi.org/10.1371/journal.ppat.1004981

Fungi That Infect Insects: Altering Host Behavior and Beyond

Yanfang Shang, Peng Feng, Chengshu Wang

PLOS Pathogens: published August 6, 2015 | https://doi.org/10.1371/journal.ppat.1005037

Review

Hepcidin and Host Defense against Infectious Diseases

Kathryn Michels, Elizabeta Nemeth, Tomas Ganz, Borna Mehrad

PLOS Pathogens: published August 20, 2015 | https://doi.org/10.1371/journal.ppat.1004998

Research Matters

The Long and Winding Road (Apologies to the Beatles)

Hank Seifert

PLOS Pathogens: published August 27, 2015 | https://doi.org/10.1371/journal.ppat.1005094

The Ebola Virus: From Basic Research to a Global Health Crisis

Robert V. Stahelin

PLOS Pathogens: published August 13, 2015 | https://doi.org/10.1371/journal.ppat.1005093

Research Articles

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway

Pierre-Emmanuel Joubert, Kenneth Stapleford, Florence Guivel-Benhassine, Marco Vignuzzi, Olivier Schwartz, Matthew L. Albert

PLOS Pathogens: published August 28, 2015 | https://doi.org/10.1371/journal.ppat.1005091

Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania donovani

Natalya Kraeva, Anzhelika Butenko, Jana Hlaváčová, Alexei Kostygov, Jitka Myškova, Danyil Grybchuk, Tereza Leštinová, Jan Votýpka, Petr Volf, Fred Opperdoes, Pavel Flegontov, Julius Lukeš, Vyacheslav Yurchenko

PLOS Pathogens: published August 28, 2015 | https://doi.org/10.1371/journal.ppat.1005127

Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways

Nora Grahl, Elora G. Demers, Allia K. Lindsay, Colleen E. Harty, Sven D. Willger, Amy E. Piispanen, Deborah A. Hogan

PLOS Pathogens: published August 28, 2015 | https://doi.org/10.1371/journal.ppat.1005133

The Hos2 Histone Deacetylase Controls Ustilago maydis Virulence through Direct Regulation of Mating-Type Genes

Alberto Elías-Villalobos, Alfonso Fernández-Álvarez, Ismael Moreno-Sánchez, Dominique Helmlinger, José I. Ibeas

PLOS Pathogens: published August 28, 2015 | https://doi.org/10.1371/journal.ppat.1005134

The Activation of Phytophthora Effector Avr3b by Plant Cyclophilin is Required for the Nudix Hydrolase Activity of Avr3b

Guanghui Kong, Yao Zhao, Maofeng Jing, Jie Huang, Jin Yang, Yeqiang Xia, Liang Kong, Wenwu Ye, Qin Xiong, Yongli Qiao, Suomeng Dong, Wenbo Ma, Yuanchao Wang

PLOS Pathogens: published August 28, 2015 | https://doi.org/10.1371/journal.ppat.1005139

Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors

Tonya Kueck, Toshana L. Foster, Julia Weinelt, Jonathan C. Sumner, Suzanne Pickering, Stuart J. D. Neil

PLOS Pathogens: published August 28, 2015 | https://doi.org/10.1371/journal.ppat.1005141

Twenty-Eight Years of Poliovirus Replication in an Immunodeficient Individual: Impact on the Global Polio Eradication Initiative

Glynis Dunn, Dimitra Klapsa, Thomas Wilton, Lindsay Stone, Philip D. Minor, Javier Martin

PLOS Pathogens: published August 27, 2015 | https://doi.org/10.1371/journal.ppat.1005114

The Rsb Phosphoregulatory Network Controls Availability of the Primary Sigma Factor in Chlamydia trachomatis and Influences the Kinetics of Growth and Development

Christopher C. Thompson, Cherry Griffiths, Sophie S. Nicod, Nicole M. Lowden, Sivaramesh Wigneshweraraj, Derek J. Fisher, Myra O. McClure

PLOS Pathogens: published August 27, 2015 | https://doi.org/10.1371/journal.ppat.1005125

Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment

Elsa N. Bou Ghanem, Stacie Clark, Sara E. Roggensack, Sally R. McIver, Pilar Alcaide, Philip G. Haydon, John M. Leong

PLOS Pathogens: published August 27, 2015 | https://doi.org/10.1371/journal.ppat.1005126

Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis

Eduardo Lopez-Medina, Di Fan, Laura A. Coughlin, Evi X. Ho, Iain L. Lamont, Cornelia Reimmann, Lora V. Hooper, Andrew Y. Koh

PLOS Pathogens: published August 27, 2015 | https://doi.org/10.1371/journal.ppat.1005129

Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect

Tzu-Chun Chen, Chung-Han Hsieh, Peter Sarnow

PLOS Pathogens: published August 25, 2015 | https://doi.org/10.1371/journal.ppat.1005116

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria

Dor Salomon, John A. Klimko, David C. Trudgian, Lisa N. Kinch, Nick V. Grishin, Hamid Mirzaei, Kim Orth

PLOS Pathogens: published August 25, 2015 | https://doi.org/10.1371/journal.ppat.1005128

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses

Nathan Erdmann, Victor Y. Du, Jonathan Carlson, Malinda Schaefer, Alexander Jureka, Sarah Sterrett, Ling Yue, Dario Dilernia, Shabir Lakhi, Jianming Tang, John Sidney, Jill Gilmour, Susan Allen, Eric Hunter, Sonya Heath, Anju Bansal, Paul A. Goepfert

PLOS Pathogens: published August 24, 2015 | https://doi.org/10.1371/journal.ppat.1005111

Trichodysplasia spinulosa-Associated Polyomavirus Uses a Displaced Binding Site on VP1 to Engage Sialylated Glycolipids

Luisa J. Ströh, Gretchen V. Gee, Bärbel S. Blaum, Aisling S. Dugan, Mariet C. W. Feltkamp, Walter J. Atwood, Thilo Stehle

PLOS Pathogens: published August 24, 2015 | https://doi.org/10.1371/journal.ppat.1005112

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection

Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F. Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K. Sandberg

PLOS Pathogens: published August 21, 2015 | https://doi.org/10.1371/journal.ppat.1005072

Inhibiting the Recruitment of PLCγ1 to Kaposi’s Sarcoma Herpesvirus K15 Protein Reduces the Invasiveness and Angiogenesis of Infected Endothelial Cells

Silvia Gramolelli, Magdalena Weidner-Glunde, Bizunesh Abere, Abel Viejo-Borbolla, Kiran Bala, Jessica Rückert, Elisabeth Kremmer, Thomas F. Schulz

PLOS Pathogens: published August 21, 2015 | https://doi.org/10.1371/journal.ppat.1005105

Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen

Brandon Sit, Shauna M. Crowley, Kirandeep Bhullar, Christine Chieh-Lin Lai, Calvin Tang, Yogesh Hooda, Charles Calmettes, Husain Khambati, Caixia Ma, John H. Brumell, Anthony B. Schryvers, Bruce A. Vallance, Trevor F. Moraes

PLOS Pathogens: published August 21, 2015 | https://doi.org/10.1371/journal.ppat.1005107

Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice

Yu Mitagami, Jun-ichirou Yasunaga, Haruka Kinosada, Koichi Ohshima, Masao Matsuoka

PLOS Pathogens: published August 21, 2015 | https://doi.org/10.1371/journal.ppat.1005120

STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control

Karoly Toth, Sang R. Lee, Baoling Ying, Jacqueline F. Spencer, Ann E. Tollefson, John E. Sagartz, Il-Keun Kong, Zhongde Wang, William S. M. Wold

PLOS Pathogens: published August 20, 2015 | https://doi.org/10.1371/journal.ppat.1005084

Evolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid Interface

Kevin R. McCarthy, Andrea Kirmaier, Patrick Autissier, Welkin E. Johnson

PLOS Pathogens: published August 20, 2015 | https://doi.org/10.1371/journal.ppat.1005085

sRNA-Mediated Regulation of P-Fimbriae Phase Variation in Uropathogenic Escherichia coli

Surabhi Khandige, Tina Kronborg, Bernt Eric Uhlin, Jakob Møller-Jensen

PLOS Pathogens: published August 20, 2015 | https://doi.org/10.1371/journal.ppat.1005109

Which Way In? The RalF Arf-GEF Orchestrates Rickettsia Host Cell Invasion

Kristen E. Rennoll-Bankert, M. Sayeedur Rahman, Joseph J. Gillespie, Mark L. Guillotte, Simran J. Kaur, Stephanie S. Lehman, Magda Beier-Sexton, Abdu F. Azad

PLOS Pathogens: published August 20, 2015 | https://doi.org/10.1371/journal.ppat.1005115

Parsimonious Determination of the Optimal Infectious Dose of a Pathogen for Nonhuman Primate Models

Mario Roederer

PLOS Pathogens: published August 18, 2015 | https://doi.org/10.1371/journal.ppat.1005100

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation

Yik-Khuan Ho, Huijun Zhi, Tara Bowlin, Batsukh Dorjbal, Subha Philip, Muhammad Atif Zahoor, Hsiu-Ming Shih, Oliver John Semmes, Brian Schaefer, J. N. Mark Glover, Chou-Zen Giam

PLOS Pathogens: published August 18, 2015 | https://doi.org/10.1371/journal.ppat.1005102

Goblet Cell Derived RELM-β Recruits CD4⁺ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation

Kirk S. B. Bergstrom, Vijay Morampudi, Justin M. Chan, Ganive Bhinder, Jennifer Lau, Hyungjun Yang, Caixia Ma, Tina Huang, Natasha Ryz, Ho Pan Sham, Maryam Zarepour, Colby Zaph, David Artis, Meera Nair, Bruce A. Vallance

PLOS Pathogens: published August 18, 2015 | https://doi.org/10.1371/journal.ppat.1005108

Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission

Martina Kovarova, Olivia D. Council, Abhijit A. Date, Julie M. Long, Tomonori Nochii, Michael Belshan, Annemarie Shibata, Heather Vincent, Caroline E. Baker, William O. Thayer, Guenter Kraus, Sophie Lachaud-Durand, Peter Williams, Christopher J. Destache, J. Victor Garcia

PLOS Pathogens: published August 13, 2015 | https://doi.org/10.1371/journal.ppat.1005075

Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIV_mac251 Rectal Challenge

Iskra Tuero, Venkatramanan Mohanram, Thomas Musich, Leia Miller, Diego A. Vargas-Inchaustegui, Thorsten Demberg, David Venzon, Irene Kalisz, V. S. Kalyanaraman, Ranajit Pal, Maria Grazia Ferrari, Celia LaBranche, David C. Montefiori, Mangala Rao, Monica Vaccari, Genoveffa Franchini, Susan W. Barnett, Marjorie Robert-Guroff

PLOS Pathogens: published August 12, 2015 | https://doi.org/10.1371/journal.ppat.1005101

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies

Laura E. McCoy, Emilia Falkowska, Katie J. Doores, Khoa Le, Devin Sok, Marit J. van Gils, Zelda Euler, Judith A. Burger, Michael S. Seaman, Rogier W. Sanders, Hanneke Schuitemaker, Pascal Poignard, Terri Wrin, Dennis R. Burton

PLOS Pathogens: published August 12, 2015 | https://doi.org/10.1371/journal.ppat.1005110

E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3

Nicholas M. Chesarino, Temet M. McMichael, Jacob S. Yount

PLOS Pathogens: published August 11, 2015 | https://doi.org/10.1371/journal.ppat.1005095

Type I IFN Induction via Poly-ICLC Protects Mice against Cryptococcosis

Edward Sionov, Katrin D. Mayer-Barber, Yun C. Chang, Keith D. Kauffman, Michael A. Eckhaus, Andres M. Salazar, Daniel L. Barber, Kyung J. Kwon-Chung

PLOS Pathogens: published August 7, 2015 | https://doi.org/10.1371/journal.ppat.1005040

Widespread Reassortment Shapes the Evolution and Epidemiology of Bluetongue Virus following European Invasion

Kyriaki Nomikou, Joseph Hughes, Rachael Wash, Paul Kellam, Emmanuel Breard, Stéphan Zientara, Massimo Palmarini, Roman Biek, Peter Mertens

PLOS Pathogens: published August 7, 2015 | https://doi.org/10.1371/journal.ppat.1005056

A Novel Virus Causes Scale Drop Disease in Lates calcarifer

Ad de Groof, Lars Guelen, Martin Deijs, Yorick van der Wal, Masato Miyata, Kah Sing Ng, Lotte van Grinsven, Bartjan Simmelink, Yvonne Biermann, Luc Grisez, Jan van Lent, Anthony de Ronde, Siow Foong Chang, Carla Schrier, Lia van der Hoek

PLOS Pathogens: published August 7, 2015 | https://doi.org/10.1371/journal.ppat.1005074

Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates

Enric Vidal, Natalia Fernández-Borges, Belén Pintado, Hasier Eraña, Montserrat Ordóñez, Mercedes Márquez, Francesca Chianini, Dolors Fondevila, Manuel A. Sánchez-Martín, Olivier Andreoletti, Mark P. Dagleish, Martí Pumarola, Joaquín Castilla

PLOS Pathogens: published August 6, 2015 | https://doi.org/10.1371/journal.ppat.1004977

Transgenic Rabbits Expressing Ovine PrP Are Susceptible to Scrapie

Pierre Sarradin, Céline Viglietta, Claude Limouzin, Olivier Andréoletti, Nathalie Daniel-Carlier, Céline Barc, Mathieu Leroux-Coyau, Patricia Berthon, Jérôme Chapuis, Christelle Rossignol, Jean-Luc Gatti, Maya Belghazi, Valérie Labas, Jean-Luc Vilotte, Vincent Béringue, Frédéric Lantier, Hubert Laude, Louis-Marie Houdebine

PLOS Pathogens: published August 6, 2015 | https://doi.org/10.1371/journal.ppat.1005077

Intracellular Uropathogenic E. coli Exploits Host Rab35 for Iron Acquisition and Survival within Urinary Bladder Cells

Neha Dikshit, Pradeep Bist, Shannon N. Fenlon, Niyas Kudukkil Pulloor, Christelle En Lin Chua, Marci A. Scidmore, Jason A. Carlyon, Bor Luen Tang, Swaine L. Chen, Bindu Sukumaran

PLOS Pathogens: published August 6, 2015 | https://doi.org/10.1371/journal.ppat.1005083

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

Sebastian P. Fuchs, José M. Martinez-Navio, Michael Piatak Jr., Jeffrey D. Lifson, Guangping Gao, Ronald C. Desrosiers

PLOS Pathogens: published August 6, 2015 | https://doi.org/10.1371/journal.ppat.1005090

A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens

Abbas El Sahili, Si-Zhe Li, Julien Lang, Cornelia Virus, Sara Planamente, Mohammed Ahmar, Beatriz G. Guimaraes, Magali Aumont-Nicaise, Armelle Vigouroux, Laurent Soulère, John Reader, Yves Queneau, Denis Faure, Solange Moréra

PLOS Pathogens: published August 5, 2015 | https://doi.org/10.1371/journal.ppat.1005071

An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses

Claire A. Schreiber, Toshie Sakuma, Yoshihiro Izumiya, Sara J. Holditch, Raymond D. Hickey, Robert K. Bressin, Upamanyu Basu, Kazunori Koide, Aravind Asokan, Yasuhiro Ikeda

PLOS Pathogens: published August 5, 2015 | https://doi.org/10.1371/journal.ppat.1005082

A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane

Madhu Sudhan Ravindran, Parikshit Bagchi, Takamasa Inoue, Billy Tsai

PLOS Pathogens: published August 5, 2015 | https://doi.org/10.1371/journal.ppat.1005086

The Two-Phase Emergence of Non Pandemic HIV-1 Group O in Cameroon

Marie Leoz, Felix Feyertag, Anfumbom Kfutwah, Philippe Mauclère, Guillaume Lachenal, Florence Damond, Fabienne De Oliveira, Véronique Lemée, François Simon, David L Robertson, Jean-Christophe Plantier

PLOS Pathogens: published August 4, 2015 | https://doi.org/10.1371/journal.ppat.1005029

Tumor Progression Locus 2 Promotes Induction of IFNλ, Interferon Stimulated Genes and Antigen-Specific CD8⁺ T Cell Responses and Protects against Influenza Virus

Teneema Kuriakose, Ralph A. Tripp, Wendy T. Watford

PLOS Pathogens: published August 4, 2015 | https://doi.org/10.1371/journal.ppat.1005038

Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation

Aurélie Alleaume-Butaux, Simon Nicot, Mathéa Pietri, Anne Baudry, Caroline Dakowski, Philippe Tixador, Hector Ardila-Osorio, Anne-Marie Haeberlé, Yannick Bailly, Jean-Michel Peyrin, Jean-Marie Launay, Odile Kellermann, Benoit Schneider

PLOS Pathogens: published August 4, 2015 | https://doi.org/10.1371/journal.ppat.1005073

Hyperinvasive Meningococci Induce Intra-nuclear Cleavage of the NF-κB Protein p65/RelA by Meningococcal IgA Protease

Anissa Besbes, Salomé Le Goff, Ana Antunes, Aude Terrade, Eva Hong, Dario Giorgini, Muhamed-Kheir Taha, Ala-Eddine Deghmane

PLOS Pathogens: published August 4, 2015 | https://doi.org/10.1371/journal.ppat.1005078

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques

Sampa Santra, Georgia D. Tomaras, Ranjit Warrier, Nathan I. Nicely, Hua-Xin Liao, Justin Pollara, Pinghuang Liu, S. Munir Alam, Ruijun Zhang, Sarah L. Cocklin, Xiaoying Shen, Ryan Duffy, Shi-Mao Xia, Robert J. Schutte, Charles W. Pemble IV, S. Moses Dennison, Hui Li, Andrew Chao, Kora Vidnovic, Abbey Evans, Katja Klein, Amit Kumar, James Robinson, Gary Landucci, Donald N. Forthal, David C. Montefiori, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Merlin L. Robb, Nelson L. Michael, Jerome H. Kim, Kelly A. Soderberg, Elena E. Giorgi, Lily Blair, Bette T. Korber, Christiane Moog, Robin J. Shattock, Norman L. Letvin, Joern E. Schmitz, M. A. Moody, Feng Gao, Guido Ferrari, George M. Shaw, Barton F. Haynes

PLOS Pathogens: published August 3, 2015 | https://doi.org/10.1371/journal.ppat.1005042

Cover

Two glideosome motor complexes power invasion of T. gondii tachyzoites.

Opinion

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**Two glideosome motor complexes power invasion of T. gondii tachyzoites.**