Does the Arthropod Microbiota Impact the Establishment of Vector-Borne Diseases in Mammalian Hosts?

Constance A. M. Finney, Shaden Kamhawi, James D. Wasmuth

PLOS Pathogens: published April 9, 2015 | https://doi.org/10.1371/journal.ppat.1004646

Ebola Virus Entry: A Curious and Complex Series of Events

Sven Moller-Tank, Wendy Maury

PLOS Pathogens: published April 30, 2015 | https://doi.org/10.1371/journal.ppat.1004731

The Ebola Epidemic Crystallizes the Potential of Passive Antibody Therapy for Infectious Diseases

Arturo Casadevall, Liise-anne Pirofski

PLOS Pathogens: published April 23, 2015 | https://doi.org/10.1371/journal.ppat.1004717

Pathogens as Biological Weapons of Invasive Species

Andreas Vilcinskas

PLOS Pathogens: published April 9, 2015 | https://doi.org/10.1371/journal.ppat.1004714

Viral Inhibition of the Transporter Associated with Antigen Processing (TAP): A Striking Example of Functional Convergent Evolution

Marieke C. Verweij, Daniëlle Horst, Bryan D. Griffin, Rutger D. Luteijn, Andrew J. Davison, Maaike E. Ressing, Emmanuel J. H. J. Wiertz

PLOS Pathogens: published April 16, 2015 | https://doi.org/10.1371/journal.ppat.1004743

Heterologous Expression in Remodeled C. elegans: A Platform for Monoaminergic Agonist Identification and Anthelmintic Screening

Wenjing Law, Leah M. Wuescher, Amanda Ortega, Vera M. Hapiak, Patricia R. Komuniecki, Richard Komuniecki

PLOS Pathogens: published April 30, 2015 | https://doi.org/10.1371/journal.ppat.1004794

Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection

Ann E. Lin, Federico C. Beasley, Joshua Olson, Nadia Keller, Robert A. Shalwitz, Thomas J. Hannan, Scott J. Hultgren, Victor Nizet

PLOS Pathogens: published April 30, 2015 | https://doi.org/10.1371/journal.ppat.1004818

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

Josephine M. Reynaud, Dal Young Kim, Svetlana Atasheva, Aliaksandra Rasalouskaya, James P. White, Michael S. Diamond, Scott C. Weaver, Elena I. Frolova, Ilya Frolov

PLOS Pathogens: published April 30, 2015 | https://doi.org/10.1371/journal.ppat.1004863

Borna Disease Virus Phosphoprotein Impairs the Developmental Program Controlling Neurogenesis and Reduces Human GABAergic Neurogenesis

Chloé Scordel, Alexandra Huttin, Marielle Cochet-Bernoin, Marion Szelechowski, Aurélie Poulet, Jennifer Richardson, Alexandra Benchoua, Daniel Gonzalez-Dunia, Marc Eloit, Muriel Coulpier

PLOS Pathogens: published April 29, 2015 | https://doi.org/10.1371/journal.ppat.1004859

Sigma Factor SigB Is Crucial to Mediate Staphylococcus aureus Adaptation during Chronic Infections

Lorena Tuchscherr, Markus Bischoff, Santiago M. Lattar, Mariangeles Noto Llana, Henrike Pförtner, Silke Niemann, Jennifer Geraci, Hélène Van de Vyver, Martin J. Fraunholz, Ambrose L. Cheung, Mathias Herrmann, Uwe Völker, Daniel O. Sordelli, Georg Peters, Bettina Löffler

PLOS Pathogens: published April 29, 2015 | https://doi.org/10.1371/journal.ppat.1004870

Optineurin Regulates the Interferon Response in a Cell Cycle-Dependent Manner

Pierre Génin, Frédérique Cuvelier, Sandrine Lambin, Josina Côrte-Real Filipe, Elodie Autrusseau, Christine Laurent, Emmanuel Laplantine, Robert Weil

PLOS Pathogens: published April 29, 2015 | https://doi.org/10.1371/journal.ppat.1004877

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A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes

Xiaoping Xiao, Rudian Zhang, Xiaojing Pang, Guodong Liang, Penghua Wang, Gong Cheng

PLOS Pathogens: published April 27, 2015 | https://doi.org/10.1371/journal.ppat.1004848

An Effector Peptide Family Required for Drosophila Toll-Mediated Immunity

Alexa W. Clemmons, Scott A. Lindsay, Steven A. Wasserman

PLOS Pathogens: published April 27, 2015 | https://doi.org/10.1371/journal.ppat.1004876

Bacterial Cooperation Causes Systematic Errors in Pathogen Risk Assessment due to the Failure of the Independent Action Hypothesis

Daniel M. Cornforth, Andrew Matthews, Sam P. Brown, Ben Raymond

PLOS Pathogens: published April 24, 2015 | https://doi.org/10.1371/journal.ppat.1004775

The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection

Chunyang Li, Shaozhuo Jiao, Guojun Wang, Yunzhen Gao, Chang Liu, Xijun He, Chi Zhang, Jun Xiao, Weiyun Li, Guoquan Zhang, Bin Wei, Hualan Chen, Hongyan Wang

PLOS Pathogens: published April 24, 2015 | https://doi.org/10.1371/journal.ppat.1004824

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence

Liliana Losada, Janyce A. Sugui, Michael A. Eckhaus, Yun C. Chang, Stephanie Mounaud, Abigail Figat, Vinita Joardar, Suman B. Pakala, Suchitra Pakala, Pratap Venepally, Natalie Fedorova, William C. Nierman, Kyung J. Kwon-Chung

PLOS Pathogens: published April 24, 2015 | https://doi.org/10.1371/journal.ppat.1004834

Wolbachia Utilize Host Actin for Efficient Maternal Transmission in Drosophila melanogaster

Irene L. G. Newton, Oleksandr Savytskyy, Kathy B. Sheehan

PLOS Pathogens: published April 23, 2015 | https://doi.org/10.1371/journal.ppat.1004798

EphrinA2 Receptor (EphA2) Is an Invasion and Intracellular Signaling Receptor for Chlamydia trachomatis

Prema Subbarayal, Karthika Karunakaran, Ann-Cathrin Winkler, Marion Rother, Erik Gonzalez, Thomas F. Meyer, Thomas Rudel

PLOS Pathogens: published April 23, 2015 | https://doi.org/10.1371/journal.ppat.1004846

Dual miRNA Targeting Restricts Host Range and Attenuates Neurovirulence of Flaviviruses

Konstantin A. Tsetsarkin, Guangping Liu, Heather Kenney, Jose Bustos-Arriaga, Christopher T. Hanson, Stephen S. Whitehead, Alexander G. Pletnev

PLOS Pathogens: published April 23, 2015 | https://doi.org/10.1371/journal.ppat.1004852

Hepatitis D Virus Infection of Mice Expressing Human Sodium Taurocholate Co-transporting Polypeptide

Wenhui He, Bijie Ren, Fengfeng Mao, Zhiyi Jing, Yunfei Li, Yang Liu, Bo Peng, Huan Yan, Yonghe Qi, Yinyan Sun, Ju-Tao Guo, Jianhua Sui, Fengchao Wang, Wenhui Li

PLOS Pathogens: published April 22, 2015 | https://doi.org/10.1371/journal.ppat.1004840

GATA-Dependent Glutaminolysis Drives Appressorium Formation in Magnaporthe oryzae by Suppressing TOR Inhibition of cAMP/PKA Signaling

Margarita Marroquin-Guzman, Richard A. Wilson

PLOS Pathogens: published April 22, 2015 | https://doi.org/10.1371/journal.ppat.1004851

Spatial Structure, Transmission Modes and the Evolution of Viral Exploitation Strategies

Thomas W. Berngruber, Sébastien Lion, Sylvain Gandon

PLOS Pathogens: published April 21, 2015 | https://doi.org/10.1371/journal.ppat.1004810

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Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung

Hock L. Tay, Gerard E. Kaiko, Maximilian Plank, JingJing Li, Steven Maltby, Ama-Tawiah Essilfie, Andrew Jarnicki, Ming Yang, Joerg Mattes, Philip M. Hansbro, Paul S. Foster

PLOS Pathogens: published April 20, 2015 | https://doi.org/10.1371/journal.ppat.1004549

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Neutrophil Recruitment to Lymph Nodes Limits Local Humoral Response to Staphylococcus aureus

Olena Kamenyeva, Cedric Boularan, Juraj Kabat, Gordon Y. C. Cheung, Claudia Cicala, Anthony J. Yeh, June L. Chan, Saravanan Periasamy, Michael Otto, John H. Kehrl

PLOS Pathogens: published April 17, 2015 | https://doi.org/10.1371/journal.ppat.1004827

A Redox Regulatory System Critical for Mycobacterial Survival in Macrophages and Biofilm Development

Kerstin A. Wolff, Andres H. de la Peña, Hoa T. Nguyen, Thanh H. Pham, L. Mario Amzel, Sandra B. Gabelli, Liem Nguyen

PLOS Pathogens: published April 17, 2015 | https://doi.org/10.1371/journal.ppat.1004839

Endopeptidase-Mediated Beta Lactam Tolerance

Tobias Dörr, Brigid M. Davis, Matthew K. Waldor

PLOS Pathogens: published April 17, 2015 | https://doi.org/10.1371/journal.ppat.1004850

The Epigenetic Regulator G9a Mediates Tolerance to RNA Virus Infection in Drosophila

Sarah H. Merkling, Alfred W. Bronkhorst, Jamie M. Kramer, Gijs J. Overheul, Annette Schenck, Ronald P. Van Rij

PLOS Pathogens: published April 16, 2015 | https://doi.org/10.1371/journal.ppat.1004692

Transgenic Fatal Familial Insomnia Mice Indicate Prion Infectivity-Independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease

Ihssane Bouybayoune, Susanna Mantovani, Federico Del Gallo, Ilaria Bertani, Elena Restelli, Liliana Comerio, Laura Tapella, Francesca Baracchi, Natalia Fernández-Borges, Michela Mangieri, Cinzia Bisighini, Galina V. Beznoussenko, Alessandra Paladini, Claudia Balducci, Edoardo Micotti, Gianluigi Forloni, Joaquín Castilla, Fabio Fiordaliso, Fabrizio Tagliavini, Luca Imeri, Roberto Chiesa

PLOS Pathogens: published April 16, 2015 | https://doi.org/10.1371/journal.ppat.1004796

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Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

Kipyegon Kitur, Dane Parker, Pamela Nieto, Danielle S. Ahn, Taylor S. Cohen, Samuel Chung, Sarah Wachtel, Susan Bueno, Alice Prince

PLOS Pathogens: published April 16, 2015 | https://doi.org/10.1371/journal.ppat.1004820

Neofunctionalization of the Sec1 α1,2fucosyltransferase Paralogue in Leporids Contributes to Glycan Polymorphism and Resistance to Rabbit Hemorrhagic Disease Virus

Kristina Nyström, Joana Abrantes, Ana Margarida Lopes, Béatrice Le Moullac-Vaidye, Stéphane Marchandeau, Jézabel Rocher, Nathalie Ruvoën-Clouet, Pedro J. Esteves, Jacques Le Pendu

PLOS Pathogens: published April 15, 2015 | https://doi.org/10.1371/journal.ppat.1004759

Conserved Streptococcus pneumoniae Spirosomes Suggest a Single Type of Transformation Pilus in Competence

Raphaël Laurenceau, Petya V. Krasteva, Amy Diallo, Sahra Ouarti, Magalie Duchateau, Christian Malosse, Julia Chamot-Rooke, Rémi Fronzes

PLOS Pathogens: published April 15, 2015 | https://doi.org/10.1371/journal.ppat.1004835

Quadruple Quorum-Sensing Inputs Control Vibrio cholerae Virulence and Maintain System Robustness

Sarah A. Jung, Christine A. Chapman, Wai-Leung Ng

PLOS Pathogens: published April 15, 2015 | https://doi.org/10.1371/journal.ppat.1004837

Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141

Jye-Lin Hsu, Dick J. H. van den Boomen, Peter Tomasec, Michael P. Weekes, Robin Antrobus, Richard J. Stanton, Eva Ruckova, Daniel Sugrue, Gavin S. Wilkie, Andrew J. Davison, Gavin W. G. Wilkinson, Paul J. Lehner

PLOS Pathogens: published April 14, 2015 | https://doi.org/10.1371/journal.ppat.1004811

Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions

Jiri G. Safar, Xiangzhu Xiao, Mohammad E. Kabir, Shugui Chen, Chae Kim, Tracy Haldiman, Yvonne Cohen, Wei Chen, Mark L. Cohen, Witold K. Surewicz

PLOS Pathogens: published April 14, 2015 | https://doi.org/10.1371/journal.ppat.1004832

Human Papillomaviruses Activate and Recruit SMC1 Cohesin Proteins for the Differentiation-Dependent Life Cycle through Association with CTCF Insulators

Kavi Mehta, Vignesh Gunasekharan, Ayano Satsuka, Laimonis A. Laimins

PLOS Pathogens: published April 13, 2015 | https://doi.org/10.1371/journal.ppat.1004763

Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons

Russell D. Bradford, Young-Gun Yoo, Mijo Golemac, Ester Pernjak Pugel, Stipan Jonjic, William J. Britt

PLOS Pathogens: published April 13, 2015 | https://doi.org/10.1371/journal.ppat.1004774

The Aspartate-Less Receiver (ALR) Domains: Distribution, Structure and Function

Andrew F. Maule, David P. Wright, Joshua J. Weiner, Lanlan Han, Francis C. Peterson, Brian F. Volkman, Nicholas R. Silvaggi, Andrew T. Ulijasz

PLOS Pathogens: published April 13, 2015 | https://doi.org/10.1371/journal.ppat.1004795

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Relay of Herpes Simplex Virus between Langerhans Cells and Dermal Dendritic Cells in Human Skin

Min Kim, Naomi R. Truong, Virginia James, Lidija Bosnjak, Kerrie J. Sandgren, Andrew N. Harman, Najla Nasr, Kirstie M. Bertram, Norman Olbourne, Shailandra Sawleshwarkar, Kaylene McKinnon, Ralph C. Cohen, Anthony L. Cunningham

PLOS Pathogens: published April 13, 2015 | https://doi.org/10.1371/journal.ppat.1004812

Prospective Large-Scale Field Study Generates Predictive Model Identifying Major Contributors to Colony Losses

Merav Gleit Kielmanowicz, Alex Inberg, Inbar Maayan Lerner, Yael Golani, Nicholas Brown, Catherine Louise Turner, Gerald J. R. Hayes, Joan M. Ballam

PLOS Pathogens: published April 13, 2015 | https://doi.org/10.1371/journal.ppat.1004816

Hepatitis C Virus RNA Replication Depends on Specific Cis- and Trans-Acting Activities of Viral Nonstructural Proteins

Teymur Kazakov, Feng Yang, Harish N. Ramanathan, Andrew Kohlway, Michael S. Diamond, Brett D. Lindenbach

PLOS Pathogens: published April 13, 2015 | https://doi.org/10.1371/journal.ppat.1004817

Phosphorylation at the Homotypic Interface Regulates Nucleoprotein Oligomerization and Assembly of the Influenza Virus Replication Machinery

Arindam Mondal, Gregory K. Potts, Anthony R. Dawson, Joshua J. Coon, Andrew Mehle

PLOS Pathogens: published April 13, 2015 | https://doi.org/10.1371/journal.ppat.1004826

Interleukin 21 Signaling in B Cells Is Required for Efficient Establishment of Murine Gammaherpesvirus Latency

Christopher M. Collins, Samuel H. Speck

PLOS Pathogens: published April 13, 2015 | https://doi.org/10.1371/journal.ppat.1004831

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A Temporal Gate for Viral Enhancers to Co-opt Toll-Like-Receptor Transcriptional Activation Pathways upon Acute Infection

Kai A. Kropp, Wei Yuan Hsieh, Elena Isern, Thorsten Forster, Eva Krause, Wolfram Brune, Ana Angulo, Peter Ghazal

PLOS Pathogens: published April 9, 2015 | https://doi.org/10.1371/journal.ppat.1004737

The EBNA3 Family of Epstein-Barr Virus Nuclear Proteins Associates with the USP46/USP12 Deubiquitination Complexes to Regulate Lymphoblastoid Cell Line Growth

Makoto Ohashi, Amy M. Holthaus, Michael A. Calderwood, Chiou-Yan Lai, Bryan Krastins, David Sarracino, Eric Johannsen

PLOS Pathogens: published April 9, 2015 | https://doi.org/10.1371/journal.ppat.1004822

Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis

Joseph N. Jarvis, Graeme Meintjes, Tihana Bicanic, Viviana Buffa, Louise Hogan, Stephanie Mo, Gillian Tomlinson, Pascale Kropf, Mahdad Noursadeghi, Thomas S. Harrison

PLOS Pathogens: published April 8, 2015 | https://doi.org/10.1371/journal.ppat.1004754

Macrocyclic Lactones Differ in Interaction with Recombinant P-Glycoprotein 9 of the Parasitic Nematode Cylicocylus elongatus and Ketoconazole in a Yeast Growth Assay

Maximiliane Kaschny, Janina Demeler, I. Jana I. Janssen, Tetiana A. Kuzmina, Bruno Besognet, Theo Kanellos, Dominique Kerboeuf, Georg von Samson-Himmelstjerna, Jürgen Krücken

PLOS Pathogens: published April 7, 2015 | https://doi.org/10.1371/journal.ppat.1004781

Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections

Tanel Mahlakõiv, Pedro Hernandez, Konrad Gronke, Andreas Diefenbach, Peter Staeheli

PLOS Pathogens: published April 7, 2015 | https://doi.org/10.1371/journal.ppat.1004782

The Extracytoplasmic Linker Peptide of the Sensor Protein SaeS Tunes the Kinase Activity Required for Staphylococcal Virulence in Response to Host Signals

Qian Liu, Hoonsik Cho, Won-Sik Yeo, Taeok Bae

PLOS Pathogens: published April 7, 2015 | https://doi.org/10.1371/journal.ppat.1004799

TGF-β Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex

Guoxin Liang, Guangyan Liu, Kouichi Kitamura, Zhe Wang, Sajeda Chowdhury, Ahasan Md Monjurul, Kousho Wakae, Miki Koura, Miyuki Shimadu, Kazuo Kinoshita, Masamichi Muramatsu

PLOS Pathogens: published April 2, 2015 | https://doi.org/10.1371/journal.ppat.1004780

Hantaan Virus Infection Induces Both Th1 and ThGranzyme B+ Cell Immune Responses That Associated with Viral Control and Clinical Outcome in Humans

Ying Ma, Bin Yuan, Ran Zhuang, Yusi Zhang, Bei Liu, Chunmei Zhang, Yun Zhang, Haitao Yu, Jing Yi, Angang Yang, Boquan Jin

PLOS Pathogens: published April 2, 2015 | https://doi.org/10.1371/journal.ppat.1004788

Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign

Eldin Talundzic, Sheila Akinyi Okoth, Kanungnit Congpuong, Mateusz M. Plucinski, Lindsay Morton, Ira F. Goldman, Patrick S. Kachur, Chansuda Wongsrichanalai, Wichai Satimai, John W. Barnwell, Venkatachalam Udhayakumar

PLOS Pathogens: published April 2, 2015 | https://doi.org/10.1371/journal.ppat.1004789

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Global Genome and Transcriptome Analyses of Magnaporthe oryzae Epidemic Isolate 98-06 Uncover Novel Effectors and Pathogenicity-Related Genes, Revealing Gene Gain and Lose Dynamics in Genome Evolution

Yanhan Dong, Ying Li, Miaomiao Zhao, Maofeng Jing, Xinyu Liu, Muxing Liu, Xianxian Guo, Xing Zhang, Yue Chen, Yongfeng Liu, Yanhong Liu, Wenwu Ye, Haifeng Zhang, Yuanchao Wang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang

PLOS Pathogens: published April 2, 2015 | https://doi.org/10.1371/journal.ppat.1004801

A Strategy for O-Glycoproteomics of Enveloped Viruses—the O-Glycoproteome of Herpes Simplex Virus Type 1

Ieva Bagdonaite, Rickard Nordén, Hiren J. Joshi, Sally Dabelsteen, Kristina Nyström, Sergey Y. Vakhrushev, Sigvard Olofsson, Hans H. Wandall

PLOS Pathogens: published April 1, 2015 | https://doi.org/10.1371/journal.ppat.1004784

Ubiquitous Promoter-Localization of Essential Virulence Regulators in Francisella tularensis

Kathryn M. Ramsey, Melisa L. Osborne, Irina O. Vvedenskaya, Cathy Su, Bryce E. Nickels, Simon L. Dove

PLOS Pathogens: published April 1, 2015 | https://doi.org/10.1371/journal.ppat.1004793

Novel Disease Susceptibility Factors for Fungal Necrotrophic Pathogens in Arabidopsis

Albor Dobón, Juan Vicente Canet, Javier García-Andrade, Carlos Angulo, Lutz Neumetzler, Staffan Persson, Pablo Vera

PLOS Pathogens: published April 1, 2015 | https://doi.org/10.1371/journal.ppat.1004800