March 2011

Wood mice (Apodemus sylvaticus) are a natural host for murine gammaherpesvirus 68 (MHV-68). A captive-bred wood mouse was infected intranasally with MHV-68. At day 7 post-infection, lung tissue was analyzed by RNA in situ hybridisation using probes specific for the MHV-68 M3 open reading frame, which encodes a viral chemokine binding protein. M3 transcripts (dark purple signals) were detected within lymphocytes in perivascular infiltrates and circulating lymphocytes attached to endothelial cells of an artery (see Hughes et al., doi:10.1371/journal.ppat.1001321).

Image Credit: Anja Kipar, University of Liverpool

Pearls

Viral Encephalomyelitis

Diane E. Griffin

PLOS Pathogens: published March 24, 2011 | https://doi.org/10.1371/journal.ppat.1002004

Review

The Staphylococcus aureus RNome and Its Commitment to Virulence

Brice Felden, François Vandenesch, Philippe Bouloc, Pascale Romby

PLOS Pathogens: published March 10, 2011 | https://doi.org/10.1371/journal.ppat.1002006

Research Articles

The Lectin Receptor Kinase LecRK-I.9 Is a Novel Phytophthora Resistance Component and a Potential Host Target for a RXLR Effector

Klaas Bouwmeester, Mara de Sain, Rob Weide, Anne Gouget, Sofieke Klamer, Herve Canut, Francine Govers

PLOS Pathogens: published March 31, 2011 | https://doi.org/10.1371/journal.ppat.1001327

A Novel Toxoplasma gondii Nuclear Factor TgNF3 Is a Dynamic Chromatin-Associated Component, Modulator of Nucleolar Architecture and Parasite Virulence

Alejandro Olguin-Lamas, Edwige Madec, Agnes Hovasse, Elisabeth Werkmeister, Isabelle Callebaut, Christian Slomianny, Stephane Delhaye, Thomas Mouveaux, Christine Schaeffer-Reiss, Alain Van Dorsselaer, Stanislas Tomavo

PLOS Pathogens: published March 31, 2011 | https://doi.org/10.1371/journal.ppat.1001328

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

Lisheng Peng, William H. Tepp, Eric A. Johnson, Min Dong

PLOS Pathogens: published March 31, 2011 | https://doi.org/10.1371/journal.ppat.1002008

The Stealth Episome: Suppression of Gene Expression on the Excised Genomic Island PPHGI-1 from Pseudomonas syringae pv. phaseolicola

Scott A. C. Godfrey, Helen C. Lovell, John W. Mansfield, David S. Corry, Robert W. Jackson, Dawn L. Arnold

PLOS Pathogens: published March 31, 2011 | https://doi.org/10.1371/journal.ppat.1002010

Novel Escape Mutants Suggest an Extensive TRIM5α Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid Protein

Sadayuki Ohkura, David C. Goldstone, Melvyn W. Yap, Kate Holden-Dye, Ian A. Taylor, Jonathan P. Stoye

PLOS Pathogens: published March 31, 2011 | https://doi.org/10.1371/journal.ppat.1002011

Metabolite Cross-Feeding Enhances Virulence in a Model Polymicrobial Infection

Matthew M. Ramsey, Kendra P. Rumbaugh, Marvin Whiteley

PLOS Pathogens: published March 31, 2011 | https://doi.org/10.1371/journal.ppat.1002012

A Pseudomonas aeruginosa Toxin that Hijacks the Host Ubiquitin Proteolytic System

Jennifer M. Bomberger, Siying Ye, Daniel P. MacEachran, Katja Koeppen, Roxanna L. Barnaby, George A. O'Toole, Bruce A. Stanton

PLOS Pathogens: published March 24, 2011 | https://doi.org/10.1371/journal.ppat.1001325

Dynamic Imaging of the Effector Immune Response to Listeria Infection In Vivo

Janelle C. Waite, Ingrid Leiner, Peter Lauer, Chris S. Rae, Gaetan Barbet, Huan Zheng, Daniel A. Portnoy, Eric G. Pamer, Michael L. Dustin

PLOS Pathogens: published March 24, 2011 | https://doi.org/10.1371/journal.ppat.1001326

Rhesus TRIM5α Disrupts the HIV-1 Capsid at the InterHexamer Interfaces

Gongpu Zhao, Danxia Ke, Thomas Vu, Jinwoo Ahn, Vaibhav B. Shah, Ruifeng Yang, Christopher Aiken, Lisa M. Charlton, Angela M. Gronenborn, Peijun Zhang

PLOS Pathogens: published March 24, 2011 | https://doi.org/10.1371/journal.ppat.1002009

The Strain-Encoded Relationship between PrP^Sc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

Jacob I. Ayers, Charles R. Schutt, Ronald A. Shikiya, Adriano Aguzzi, Anthony E. Kincaid, Jason C. Bartz

PLOS Pathogens: published March 17, 2011 | https://doi.org/10.1371/journal.ppat.1001317

Dendritic Cells and Hepatocytes Use Distinct Pathways to Process Protective Antigen from Plasmodium in vivo

Ian A. Cockburn, Sze-Wah Tse, Andrea J. Radtke, Prakash Srinivasan, Yun-Chi Chen, Photini Sinnis, Fidel Zavala

PLOS Pathogens: published March 17, 2011 | https://doi.org/10.1371/journal.ppat.1001318

Sheep and Goat BSE Propagate More Efficiently than Cattle BSE in Human PrP Transgenic Mice

Danielle Padilla, Vincent Béringue, Juan Carlos Espinosa, Olivier Andreoletti, Emilie Jaumain, Fabienne Reine, Laetitia Herzog, Alfonso Gutierrez-Adan, Belen Pintado, Hubert Laude, Juan Maria Torres

PLOS Pathogens: published March 17, 2011 | https://doi.org/10.1371/journal.ppat.1001319

Blood Meal-Derived Heme Decreases ROS Levels in the Midgut of Aedes aegypti and Allows Proliferation of Intestinal Microbiota

Jose Henrique M. Oliveira, Renata L. S. Gonçalves, Flavio A. Lara, Felipe A. Dias, Ana Caroline P. Gandara, Rubem F. S. Menna-Barreto, Meredith C. Edwards, Francisco R. M. Laurindo, Mário A. C. Silva-Neto, Marcos H. F. Sorgine, Pedro L. Oliveira

PLOS Pathogens: published March 17, 2011 | https://doi.org/10.1371/journal.ppat.1001320

Chemokine Binding Protein M3 of Murine Gammaherpesvirus 68 Modulates the Host Response to Infection in a Natural Host

David J. Hughes, Anja Kipar, Gail H. Leeming, Elaine Bennett, Deborah Howarth, Joanne A. Cummerson, Rita Papoula-Pereira, Brian F. Flanagan, Jeffery T. Sample, James P. Stewart

PLOS Pathogens: published March 17, 2011 | https://doi.org/10.1371/journal.ppat.1001321

Host Iron Withholding Demands Siderophore Utilization for Candida glabrata to Survive Macrophage Killing

Tracy Nevitt, Dennis J. Thiele

PLOS Pathogens: published March 17, 2011 | https://doi.org/10.1371/journal.ppat.1001322

Multiple Helminth Infection of the Skin Causes Lymphocyte Hypo-Responsiveness Mediated by Th2 Conditioning of Dermal Myeloid Cells

Peter C. Cook, Sarah A. Aynsley, Joseph D. Turner, Gavin R. Jenkins, Nico Van Rooijen, Mosiuoa Leeto, Frank Brombacher, Adrian P. Mountford

PLOS Pathogens: published March 17, 2011 | https://doi.org/10.1371/journal.ppat.1001323

The Coxsackievirus B 3C^pro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

Amitava Mukherjee, Stefanie A. Morosky, Elizabeth Delorme-Axford, Naomi Dybdahl-Sissoko, M. Steven Oberste, Tianyi Wang, Carolyn B. Coyne

PLOS Pathogens: published March 10, 2011 | https://doi.org/10.1371/journal.ppat.1001311

Longistatin, a Plasminogen Activator, Is Key to the Availability of Blood-Meals for Ixodid Ticks

Anisuzzaman, M. Khyrul Islam, M. Abdul Alim, Takeharu Miyoshi, Takeshi Hatta, Kayoko Yamaji, Yasunobu Matsumoto, Kozo Fujisaki, Naotoshi Tsuji

PLOS Pathogens: published March 10, 2011 | https://doi.org/10.1371/journal.ppat.1001312

HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2

Karen E. Ocwieja, Troy L. Brady, Keshet Ronen, Alyssa Huegel, Shoshannah L. Roth, Torsten Schaller, Leo C. James, Greg J. Towers, John A. T. Young, Sumit K. Chanda, Renate König, Nirav Malani, Charles C. Berry, Frederic D. Bushman

PLOS Pathogens: published March 10, 2011 | https://doi.org/10.1371/journal.ppat.1001313

The Danger Signal S100B Integrates Pathogen– and Danger–Sensing Pathways to Restrain Inflammation

Guglielmo Sorci, Gloria Giovannini, Francesca Riuzzi, Pierluigi Bonifazi, Teresa Zelante, Silvia Zagarella, Francesco Bistoni, Rosario Donato, Luigina Romani

PLOS Pathogens: published March 10, 2011 | https://doi.org/10.1371/journal.ppat.1001315

KIR Polymorphisms Modulate Peptide-Dependent Binding to an MHC Class I Ligand with a Bw6 Motif

Arnaud D. Colantonio, Benjamin N. Bimber, William J. Neidermyer Jr, R. Keith Reeves, Galit Alter, Marcus Altfeld, R. Paul Johnson, Mary Carrington, David H. O'Connor, David T. Evans

PLOS Pathogens: published March 10, 2011 | https://doi.org/10.1371/journal.ppat.1001316

The Moving Junction Protein RON8 Facilitates Firm Attachment and Host Cell Invasion in Toxoplasma gondii

Kurtis W. Straub, Eric D. Peng, Bettina E. Hajagos, Jessica S. Tyler, Peter J. Bradley

PLOS Pathogens: published March 10, 2011 | https://doi.org/10.1371/journal.ppat.1002007

Antigenic Variation in Plasmodium falciparum Malaria Involves a Highly Structured Switching Pattern

Mario Recker, Caroline O. Buckee, Andrew Serazin, Sue Kyes, Robert Pinches, Zóe Christodoulou, Amy L. Springer, Sunetra Gupta, Chris I. Newbold

PLOS Pathogens: published March 3, 2011 | https://doi.org/10.1371/journal.ppat.1001306

Human Macrophage Responses to Clinical Isolates from the Mycobacterium tuberculosis Complex Discriminate between Ancient and Modern Lineages

Damien Portevin, Sébastien Gagneux, Iñaki Comas, Douglas Young

PLOS Pathogens: published March 3, 2011 | https://doi.org/10.1371/journal.ppat.1001307

Spatial Distribution and Risk Factors of Highly Pathogenic Avian Influenza (HPAI) H5N1 in China

Vincent Martin, Dirk U. Pfeiffer, Xiaoyan Zhou, Xiangming Xiao, Diann J. Prosser, Fusheng Guo, Marius Gilbert

PLOS Pathogens: published March 3, 2011 | https://doi.org/10.1371/journal.ppat.1001308

Sex and Death: The Effects of Innate Immune Factors on the Sexual Reproduction of Malaria Parasites

Ricardo S. Ramiro, João Alpedrinha, Lucy Carter, Andy Gardner, Sarah E. Reece

PLOS Pathogens: published March 3, 2011 | https://doi.org/10.1371/journal.ppat.1001309

Global Functional Analyses of Cellular Responses to Pore-Forming Toxins

Cheng-Yuan Kao, Ferdinand C. O. Los, Danielle L. Huffman, Shinichiro Wachi, Nicole Kloft, Matthias Husmann, Valbona Karabrahimi, Jean-Louis Schwartz, Audrey Bellier, Christine Ha, Youn Sagong, Hui Fan, Partho Ghosh, Mindy Hsieh, Chih-Shen Hsu, Li Chen, Raffi V. Aroian

PLOS Pathogens: published March 3, 2011 | https://doi.org/10.1371/journal.ppat.1001314

Invasive Extravillous Trophoblasts Restrict Intracellular Growth and Spread of Listeria monocytogenes

Varvara B. Zeldovich, Jennifer R. Robbins, Mirhan Kapidzic, Peter Lauer, Anna I. Bakardjiev

PLOS Pathogens: published March 3, 2011 | https://doi.org/10.1371/journal.ppat.1002005

Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway

Erik de Vries, Donna M. Tscherne, Marleen J. Wienholts, Viviana Cobos-Jiménez, Florine Scholte, Adolfo García-Sastre, Peter J. M. Rottier, Cornelis A. M. de Haan

PLOS Pathogens: published March 31, 2011 | https://doi.org/10.1371/journal.ppat.1001329

Lung Adenocarcinoma Originates from Retrovirus Infection of Proliferating Type 2 Pneumocytes during Pulmonary Post-Natal Development or Tissue Repair

Claudio Murgia, Marco Caporale, Ousman Ceesay, Gabriella Di Francesco, Nicola Ferri, Vincenzo Varasano, Marcelo de las Heras, Massimo Palmarini

PLOS Pathogens: published March 31, 2011 | https://doi.org/10.1371/journal.ppat.1002014

Cover

Localization of murine gammaherpesvirus 68 M3 transcripts in lung tissue.