July 2010

False color transmission electron micrograph showing abnormal development during parasite proliferation in the RAB11B mutant. While nuclear division and the formation of the daughter apical organelles occurs, the inner membrane complex, which delineates individual daughters and is essential for daughter formation, fails to form, resulting in a disorganized structure incapable of division. This contrasts with the wild type, where inner membrane complex formation provides the template for the formation of the polarized daughters (see Agop-Nersesian et al., doi:10.1371/journal.ppat.1001029).

Image Credit: David J. P. Ferguson, University of Oxford

Opinions

The Mouse Resistance Protein Irgm1 (LRG-47): A Regulator or an Effector of Pathogen Defense?

Julia P. Hunn, Jonathan C. Howard

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1001008

Can Bacteria Evolve Resistance to Quorum Sensing Disruption?

Tom Defoirdt, Nico Boon, Peter Bossier

PLOS Pathogens: published July 8, 2010 | https://doi.org/10.1371/journal.ppat.1000989

Pearls

The Role of Chemokines during Viral Infection of the CNS

Martin P. Hosking, Thomas E. Lane

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1000937

RNA Virus Replication Complexes

Yizhi Jane Tao, Qiaozhen Ye

PLOS Pathogens: published July 22, 2010 | https://doi.org/10.1371/journal.ppat.1000943

Reviews

Quasispecies Theory and the Behavior of RNA Viruses

Adam S. Lauring, Raul Andino

PLOS Pathogens: published July 22, 2010 | https://doi.org/10.1371/journal.ppat.1001005

Inositol Hexakisphosphate-Induced Autoprocessing of Large Bacterial Protein Toxins

Martina Egerer, Karla J. F. Satchell

PLOS Pathogens: published July 8, 2010 | https://doi.org/10.1371/journal.ppat.1000942

Research Articles

Murine Gamma-Herpesvirus 68 Hijacks MAVS and IKKβ to Initiate Lytic Replication

Xiaonan Dong, Hao Feng, Qinmiao Sun, Haiyan Li, Ting-Ting Wu, Ren Sun, Scott A. Tibbetts, Zhijian J. Chen, Pinghui Feng

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001001

Transduction of Human T Cells with a Novel T-Cell Receptor Confers Anti-HCV Reactivity

Yi Zhang, Yeuying Liu, Kelly M. Moxley, Lucy Golden-Mason, Michael G. Hughes Jr, Tongxin Liu, Mirjam H. M. Heemskerk, Hugo R. Rosen, Michael I. Nishimura

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001018

Interaction and Modulation of Two Antagonistic Cell Wall Enzymes of Mycobacteria

Erik C. Hett, Michael C. Chao, Eric J. Rubin

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001020

Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions

Ronan Jambou, Valery Combes, Marie-Jose Jambou, Babeth B. Weksler, Pierre-Olivier Couraud, Georges E. Grau

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001021

Oseltamivir–Resistant Pandemic H1N1/2009 Influenza Virus Possesses Lower Transmissibility and Fitness in Ferrets

Susu Duan, David A. Boltz, Patrick Seiler, Jiang Li, Karoline Bragstad, Lars P. Nielsen, Richard J. Webby, Robert G. Webster, Elena A. Govorkova

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001022

Bottlenecks and the Maintenance of Minor Genotypes during the Life Cycle of Trypanosoma brucei

Michael Oberle, Oliver Balmer, Reto Brun, Isabel Roditi

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001023

Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized Patient

Els van der Meijden, René W. A. Janssens, Chris Lauber, Jan Nico Bouwes Bavinck, Alexander E. Gorbalenya, Mariet C. W. Feltkamp

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001024

The Role of Coupled Positive Feedback in the Expression of the SPI1 Type Three Secretion System in Salmonella

Supreet Saini, Jeremy R. Ellermeier, James M. Slauch, Christopher V. Rao

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001025

DNA Damage Triggers Genetic Exchange in Helicobacter pylori

Marion S. Dorer, Jutta Fero, Nina R. Salama

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001026

The Meningococcal Vaccine Candidate Neisserial Surface Protein A (NspA) Binds to Factor H and Enhances Meningococcal Resistance to Complement

Lisa A. Lewis, Jutamas Ngampasutadol, Ruth Wallace, Jane E. A. Reid, Ulrich Vogel, Sanjay Ram

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001027

Biogenesis of the Inner Membrane Complex Is Dependent on Vesicular Transport by the Alveolate Specific GTPase Rab11B

Carolina Agop-Nersesian, Saskia Egarter, Gordon Langsley, Bernardo J. Foth, David J. P. Ferguson, Markus Meissner

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001029

Unexpected Inheritance: Multiple Integrations of Ancient Bornavirus and Ebolavirus/Marburgvirus Sequences in Vertebrate Genomes

Vladimir A. Belyi, Arnold J. Levine, Anna Marie Skalka

PLOS Pathogens: published July 29, 2010 | https://doi.org/10.1371/journal.ppat.1001030

Uropathogenic Escherichia coli Modulates Immune Responses and Its Curli Fimbriae Interact with the Antimicrobial Peptide LL-37

Ylva Kai-Larsen, Petra Lüthje, Milan Chromek, Verena Peters, Xiaoda Wang, Åsa Holm, Lavinia Kádas, Kjell-Olof Hedlund, Jan Johansson, Matthew R. Chapman, Stefan H. Jacobson, Ute Römling, Birgitta Agerberth, Annelie Brauner

PLOS Pathogens: published July 22, 2010 | https://doi.org/10.1371/journal.ppat.1001010

Network Modeling Reveals Prevalent Negative Regulatory Relationships between Signaling Sectors in Arabidopsis Immune Signaling

Masanao Sato, Kenichi Tsuda, Lin Wang, John Coller, Yuichiro Watanabe, Jane Glazebrook, Fumiaki Katagiri

PLOS Pathogens: published July 22, 2010 | https://doi.org/10.1371/journal.ppat.1001011

Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

Kazuhide Onoguchi, Koji Onomoto, Shiori Takamatsu, Michihiko Jogi, Azumi Takemura, Shiho Morimoto, Ilkka Julkunen, Hideo Namiki, Mitsutoshi Yoneyama, Takashi Fujita

PLOS Pathogens: published July 22, 2010 | https://doi.org/10.1371/journal.ppat.1001012

Epigenetic Analysis of KSHV Latent and Lytic Genomes

Zsolt Toth, Dennis T. Maglinte, Sun Hwa Lee, Hye-Ra Lee, Lai-Yee Wong, Kevin F. Brulois, Stacy Lee, Jonathan D. Buckley, Peter W. Laird, Victor E. Marquez, Jae U. Jung

PLOS Pathogens: published July 22, 2010 | https://doi.org/10.1371/journal.ppat.1001013

PB1-F2 Proteins from H5N1 and 20^th Century Pandemic Influenza Viruses Cause Immunopathology

Julie L. McAuley, Jerry E. Chipuk, Kelli L. Boyd, Nick Van De Velde, Douglas R. Green, Jonathan A. McCullers

PLOS Pathogens: published July 22, 2010 | https://doi.org/10.1371/journal.ppat.1001014

Oseltamivir-Resistant Pandemic A/H1N1 Virus Is as Virulent as Its Wild-Type Counterpart in Mice and Ferrets

Marie-Ève Hamelin, Mariana Baz, Yacine Abed, Christian Couture, Philippe Joubert, Édith Beaulieu, Nathalie Bellerose, Martin Plante, Corey Mallett, Gregg Schumer, Gary P. Kobinger, Guy Boivin

PLOS Pathogens: published July 22, 2010 | https://doi.org/10.1371/journal.ppat.1001015

Rabies Virus Infection Induces Type I Interferon Production in an IPS-1 Dependent Manner While Dendritic Cell Activation Relies on IFNAR Signaling

Elizabeth J. Faul, Celestine N. Wanjalla, Mehul S. Suthar, Michael Gale Jr, Christoph Wirblich, Matthias J. Schnell

PLOS Pathogens: published July 22, 2010 | https://doi.org/10.1371/journal.ppat.1001016

A Systems Immunology Approach to Plasmacytoid Dendritic Cell Function in Cytopathic Virus Infections

Gennady Bocharov, Roland Züst, Luisa Cervantes-Barragan, Tatyana Luzyanina, Egor Chiglintsev, Valery A. Chereshnev, Volker Thiel, Burkhard Ludewig

PLOS Pathogens: published July 22, 2010 | https://doi.org/10.1371/journal.ppat.1001017

Hepatitis B Virus Polymerase Blocks Pattern Recognition Receptor Signaling via Interaction with DDX3: Implications for Immune Evasion

Haifeng Wang, Wang-Shick Ryu

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1000986

Endothelial Galectin-1 Binds to Specific Glycans on Nipah Virus Fusion Protein and Inhibits Maturation, Mobility, and Function to Block Syncytia Formation

Omai B. Garner, Hector C. Aguilar, Jennifer A. Fulcher, Ernest L. Levroney, Rebecca Harrison, Lacey Wright, Lindsey R. Robinson, Vanessa Aspericueta, Maria Panico, Stuart M. Haslam, Howard R. Morris, Anne Dell, Benhur Lee, Linda G. Baum

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1000993

A Spatio-Temporal Analysis of Matrix Protein and Nucleocapsid Trafficking during Vesicular Stomatitis Virus Uncoating

Chad E. Mire, Judith M. White, Michael A. Whitt

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1000994

Histone Methylation by NUE, a Novel Nuclear Effector of the Intracellular Pathogen Chlamydia trachomatis

Meghan E. Pennini, Stéphanie Perrinet, Alice Dautry-Varsat, Agathe Subtil

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1000995

Viral Protein Inhibits RISC Activity by Argonaute Binding through Conserved WG/GW Motifs

Ana Giner, Lóránt Lakatos, Meritxell García-Chapa, Juan José López-Moya, József Burgyán

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1000996

The Conserved Tarp Actin Binding Domain Is Important for Chlamydial Invasion

Travis J. Jewett, Natalie J. Miller, Cheryl A. Dooley, Ted Hackstadt

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1000997

Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

Nathan W. Schmidt, Noah S. Butler, Vladimir P. Badovinac, John T. Harty

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1000998

A Metazoan/Plant-like Capping Enzyme and Cap Modified Nucleotides in the Unicellular Eukaryote Trichomonas vaginalis

Augusto Simoes-Barbosa, Robert P. Hirt, Patricia J. Johnson

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1000999

The Virulence Protein SopD2 Regulates Membrane Dynamics of Salmonella-Containing Vacuoles

Nina Schroeder, Thomas Henry, Chantal de Chastellier, Weidong Zhao, Aude-Agnès Guilhon, Jean-Pierre Gorvel, Stéphane Méresse

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1001002

Activation of Akt Signaling Reduces the Prevalence and Intensity of Malaria Parasite Infection and Lifespan in Anopheles stephensi Mosquitoes

Vanessa Corby-Harris, Anna Drexler, Laurel Watkins de Jong, Yevgeniya Antonova, Nazzy Pakpour, Rolf Ziegler, Frank Ramberg, Edwin E. Lewis, Jessica M. Brown, Shirley Luckhart, Michael A. Riehle

PLOS Pathogens: published July 15, 2010 | https://doi.org/10.1371/journal.ppat.1001003

Vaccinia Virus–Encoded Ribonucleotide Reductase Subunits Are Differentially Required for Replication and Pathogenesis

Don B. Gammon, Branawan Gowrishankar, Sophie Duraffour, Graciela Andrei, Chris Upton, David H. Evans

PLOS Pathogens: published July 8, 2010 | https://doi.org/10.1371/journal.ppat.1000984

Integration Preferences of Wildtype AAV-2 for Consensus Rep-Binding Sites at Numerous Loci in the Human Genome

Daniela Hüser, Andreas Gogol-Döring, Timo Lutter, Stefan Weger, Kerstin Winter, Eva-Maria Hammer, Toni Cathomen, Knut Reinert, Regine Heilbronn

PLOS Pathogens: published July 8, 2010 | https://doi.org/10.1371/journal.ppat.1000985

Intergenomic Arms Races: Detection of a Nuclear Rescue Gene of Male-Killing in a Ladybird

Tamsin M. O. Majerus, Michael E. N. Majerus

PLOS Pathogens: published July 8, 2010 | https://doi.org/10.1371/journal.ppat.1000987

Functional Genetic Diversity among Mycobacterium tuberculosis Complex Clinical Isolates: Delineation of Conserved Core and Lineage-Specific Transcriptomes during Intracellular Survival

Susanne Homolka, Stefan Niemann, David G. Russell, Kyle H. Rohde

PLOS Pathogens: published July 8, 2010 | https://doi.org/10.1371/journal.ppat.1000988

Protection from the 2009 H1N1 Pandemic Influenza by an Antibody from Combinatorial Survivor-Based Libraries

Arun K. Kashyap, John Steel, Adam Rubrum, Angeles Estelles, Raffaella Briante, Natalia A. Ilyushina, Li Xu, Ryann E. Swale, Aleksandr M. Faynboym, Pamela K. Foreman, Michael Horowitz, Lawrence Horowitz, Richard Webby, Peter Palese, Richard A. Lerner, Ramesh R. Bhatt

PLOS Pathogens: published July 8, 2010 | https://doi.org/10.1371/journal.ppat.1000990

Plus- and Minus-End Directed Microtubule Motors Bind Simultaneously to Herpes Simplex Virus Capsids Using Different Inner Tegument Structures

Kerstin Radtke, Daniela Kieneke, André Wolfstein, Kathrin Michael, Walter Steffen, Tim Scholz, Axel Karger, Beate Sodeik

PLOS Pathogens: published July 8, 2010 | https://doi.org/10.1371/journal.ppat.1000991

TOPO3α Influences Antigenic Variation by Monitoring Expression-Site-Associated VSG Switching in Trypanosoma brucei

Hee-Sook Kim, George A. M. Cross

PLOS Pathogens: published July 8, 2010 | https://doi.org/10.1371/journal.ppat.1000992

An Outer Membrane Receptor of Neisseria meningitidis Involved in Zinc Acquisition with Vaccine Potential

Michiel Stork, Martine P. Bos, Ilse Jongerius, Natasja de Kok, Ingrid Schilders, Vincent E. Weynants, Jan T. Poolman, Jan Tommassen

PLOS Pathogens: published July 1, 2010 | https://doi.org/10.1371/journal.ppat.1000969

Balanced Nuclear and Cytoplasmic Activities of EDS1 Are Required for a Complete Plant Innate Immune Response

Ana V. García, Servane Blanvillain-Baufumé, Robin P. Huibers, Marcel Wiermer, Guangyong Li, Enrico Gobbato, Steffen Rietz, Jane E. Parker

PLOS Pathogens: published July 1, 2010 | https://doi.org/10.1371/journal.ppat.1000970

Genome-Wide Mutagenesis Reveals That ORF7 Is a Novel VZV Skin-Tropic Factor

Zhen Zhang, Anca Selariu, Charles Warden, Grace Huang, Ying Huang, Oluleke Zaccheus, Tong Cheng, Ningshao Xia, Hua Zhu

PLOS Pathogens: published July 1, 2010 | https://doi.org/10.1371/journal.ppat.1000971

Identification of GBV-D, a Novel GB-like Flavivirus from Old World Frugivorous Bats (Pteropus giganteus) in Bangladesh

Jonathan H. Epstein, Phenix-Lan Quan, Thomas Briese, Craig Street, Omar Jabado, Sean Conlan, Shahneaz Ali Khan, Dawn Verdugo, M. Jahangir Hossain, Stephen K. Hutchison, Michael Egholm, Stephen P. Luby, Peter Daszak, W. Ian Lipkin

PLOS Pathogens: published July 1, 2010 | https://doi.org/10.1371/journal.ppat.1000972

Adaptive Evolution of Mus Apobec3 Includes Retroviral Insertion and Positive Selection at Two Clusters of Residues Flanking the Substrate Groove

Bradley Sanville, Michael A. Dolan, Kurt Wollenberg, Yuhe Yan, Carrie Martin, Man Lung Yeung, Klaus Strebel, Alicia Buckler-White, Christine A. Kozak

PLOS Pathogens: published July 1, 2010 | https://doi.org/10.1371/journal.ppat.1000974

HIV gp41 Engages gC1qR on CD4+ T Cells to Induce the Expression of an NK Ligand through the PIP3/H2O2 Pathway

Hugues Fausther-Bovendo, Vincent Vieillard, Sandrine Sagan, Georges Bismuth, Patrice Debré

PLOS Pathogens: published July 1, 2010 | https://doi.org/10.1371/journal.ppat.1000975

Distinct Roles for Dectin-1 and TLR4 in the Pathogenesis of Aspergillus fumigatus Keratitis

Sixto M. Leal Jr, Susan Cowden, Yen-Cheng Hsia, Mahmoud A. Ghannoum, Michelle Momany, Eric Pearlman

PLOS Pathogens: published July 1, 2010 | https://doi.org/10.1371/journal.ppat.1000976

Oxidation of Helix-3 Methionines Precedes the Formation of PK Resistant PrP^Sc

Tamar Canello, Kati Frid, Ronen Gabizon, Silvia Lisa, Assaf Friedler, Jackob Moskovitz, María Gasset, Ruth Gabizon

PLOS Pathogens: published July 1, 2010 | https://doi.org/10.1371/journal.ppat.1000977

Adaptation of Hepatitis C Virus to Mouse CD81 Permits Infection of Mouse Cells in the Absence of Human Entry Factors

Julia Bitzegeio, Dorothea Bankwitz, Kathrin Hueging, Sibylle Haid, Christiane Brohm, Mirjam B. Zeisel, Eva Herrmann, Marcus Iken, Michael Ott, Thomas F. Baumert, Thomas Pietschmann

PLOS Pathogens: published July 1, 2010 | https://doi.org/10.1371/journal.ppat.1000978

Leprosy and the Adaptation of Human Toll-Like Receptor 1

Sunny H. Wong, Sailesh Gochhait, Dheeraj Malhotra, Fredrik H. Pettersson, Yik Y. Teo, Chiea C. Khor, Anna Rautanen, Stephen J. Chapman, Tara C. Mills, Amit Srivastava, Aleksey Rudko, Maxim B. Freidin, Valery P. Puzyrev, Shafat Ali, Shweta Aggarwal, Rupali Chopra, Belum S. N. Reddy, Vijay K. Garg, Suchismita Roy, Sarah Meisner, Sunil K. Hazra, Bibhuti Saha, Sian Floyd, Brendan J. Keating, Cecilia Kim, Benjamin P. Fairfax, Julian C. Knight, Philip C. Hill, Richard A. Adegbola, Hakon Hakonarson, Paul E. M. Fine, Ramasamy M. Pitchappan, Rameshwar N. K. Bamezai, Adrian V. S. Hill, Fredrik O. Vannberg

PLOS Pathogens: published July 1, 2010 | https://doi.org/10.1371/journal.ppat.1000979

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Toxoplasma gondii tachyzoite.

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