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Table of Contents

September 2008

Cover

Identification of complexes of streptococcal M1 protein, IgG, and fibrinogen in a tissue biopsy obtained from a patient with severe Streptococcus pyogenes infection.

Issue Image

Specific IgG antibodies against the M1 protein were demonstrated to give rise to large complexes containing M1 protein (yellow), fibrinogen (magenta), and IgG (green). Such complexes promote a massive release of heparin-binding protein, which is an important inducer of vascular leakage and chock. Hence, antibodies against a bacterial antigen were found to contribute to a life-threatening inflammatory response (see Kahn et al., doi:10.1371/journal.ppat.1000149).

Image Credit: Anette Hofmann and Anna Norrby-Teglund, Karolinska Institutet.

Editorial

PLoS Pathogens at Three Years

Kasturi Haldar, Grant McFadden

PLOS Pathogens: published September 26, 2008 | https://doi.org/10.1371/journal.ppat.1000167

Review

Interfering RNA and HIV: Reciprocal Interferences

Pierre Corbeau

PLOS Pathogens: published September 26, 2008 | https://doi.org/10.1371/journal.ppat.1000162

Research Articles

Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

Luke Uebelhoer, Jin-Hwan Han, Benoit Callendret, Guaniri Mateu, Naglaa H. Shoukry, Holly L. Hanson, Charles M. Rice, Christopher M. Walker, Arash Grakoui

PLOS Pathogens: published September 5, 2008 | https://doi.org/10.1371/journal.ppat.1000143

PerR Confers Phagocytic Killing Resistance and Allows Pharyngeal Colonization by Group A Streptococcus

Ioannis Gryllos, Renata Grifantini, Annalisa Colaprico, Max E. Cary, Anders Hakansson, David W. Carey, Maria Suarez-Chavez, Leslie A. Kalish, Paul D. Mitchell, Gary L. White, Michael R. Wessels

PLOS Pathogens: published September 5, 2008 | https://doi.org/10.1371/journal.ppat.1000145

A New Perspective on Listeria monocytogenes Evolution

Marie Ragon, Thierry Wirth, Florian Hollandt, Rachel Lavenir, Marc Lecuit, Alban Le Monnier, Sylvain Brisse

PLOS Pathogens: published September 5, 2008 | https://doi.org/10.1371/journal.ppat.1000146

The Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved Structure

Michael M. Klein, Apostolos G. Gittis, Hua-Poo Su, Morris O. Makobongo, Jaime M. Moore, Sanjay Singh, Louis H. Miller, David N. Garboczi

PLOS Pathogens: published September 5, 2008 | https://doi.org/10.1371/journal.ppat.1000147

Human Papillomavirus Type 16 Entry: Retrograde Cell Surface Transport along Actin-Rich Protrusions

Mario Schelhaas, Helge Ewers, Minna-Liisa Rajamäki, Patricia M. Day, John T. Schiller, Ari Helenius

PLOS Pathogens: published September 5, 2008 | https://doi.org/10.1371/journal.ppat.1000148

Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenes

Paul D. Cotter, Lorraine A. Draper, Elaine M. Lawton, Karen M. Daly, David S. Groeger, Pat G. Casey, R. Paul Ross, Colin Hill

PLOS Pathogens: published September 12, 2008 | https://doi.org/10.1371/journal.ppat.1000144

Antibodies against a Surface Protein of Streptococcus pyogenes Promote a Pathological Inflammatory Response

Fredrik Kahn, Matthias Mörgelin, Oonagh Shannon, Anna Norrby-Teglund, Heiko Herwald, Anders I. Olin, Lars Björck

PLOS Pathogens: published September 12, 2008 | https://doi.org/10.1371/journal.ppat.1000149

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

Markus Mordstein, Georg Kochs, Laure Dumoutier, Jean-Christophe Renauld, Søren R. Paludan, Kevin Klucher, Peter Staeheli

PLOS Pathogens: published September 12, 2008 | https://doi.org/10.1371/journal.ppat.1000151

Endothelial Cells Support Persistent Gammaherpesvirus 68 Infection

Andrea Luísa Suárez, Linda Faye van Dyk

PLOS Pathogens: published September 12, 2008 | https://doi.org/10.1371/journal.ppat.1000152

Sub-Telomere Directed Gene Expression during Initiation of Invasive Aspergillosis

Andrew McDonagh, Natalie D. Fedorova, Jonathan Crabtree, Yan Yu, Stanley Kim, Dan Chen, Omar Loss, Timothy Cairns, Gustavo Goldman, Darius Armstrong-James, Ken Haynes, Hubertus Haas, Markus Schrettl, Gregory May, William C. Nierman, Elaine Bignell

PLOS Pathogens: published September 12, 2008 | https://doi.org/10.1371/journal.ppat.1000154

BSE Case Associated with Prion Protein Gene Mutation

Jürgen A. Richt, S. Mark Hall

PLOS Pathogens: published September 12, 2008 | https://doi.org/10.1371/journal.ppat.1000156

Protective Effect of Toll-like Receptor 4 in Pulmonary Vaccinia Infection

Martha A. Hutchens, Kathryn E. Luker, Joanne Sonstein, Gabriel Núñez, Jeffrey L. Curtis, Gary D. Luker

PLOS Pathogens: published September 19, 2008 | https://doi.org/10.1371/journal.ppat.1000153

Importance of Mitochondria in Survival of Cryptococcus neoformans Under Low Oxygen Conditions and Tolerance to Cobalt Chloride

Susham S. Ingavale, Yun C. Chang, Hyeseung Lee, Carol M. McClelland, Madeline L. Leong, Kyung J. Kwon-Chung

PLOS Pathogens: published September 19, 2008 | https://doi.org/10.1371/journal.ppat.1000155

Kaposi's Sarcoma-Associated Herpesvirus K7 Induces Viral G Protein-Coupled Receptor Degradation and Reduces Its Tumorigenicity

Hao Feng, Xiaonan Dong, Ashley Negaard, Pinghui Feng

PLOS Pathogens: published September 19, 2008 | https://doi.org/10.1371/journal.ppat.1000157

VCAM-1 and VLA-4 Modulate Dendritic Cell IL-12p40 Production in Experimental Visceral Leishmaniasis

Amanda C. Stanley, Jane E. Dalton, Susanna H. Rossotti, Kelli P. MacDonald, Yonghong Zhou, Fabian Rivera, Wayne A. Schroder, Asher Maroof, Geoff R. Hill, Paul M. Kaye, Christian R. Engwerda

PLOS Pathogens: published September 19, 2008 | https://doi.org/10.1371/journal.ppat.1000158

Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization

Ying-Jie Lu, Jane Gross, Debby Bogaert, Adam Finn, Linda Bagrade, Qibo Zhang, Jay K. Kolls, Amit Srivastava, Anna Lundgren, Sophie Forte, Claudette M. Thompson, Kathleen F. Harney, Porter W. Anderson, Marc Lipsitch, Richard Malley

PLOS Pathogens: published September 19, 2008 | https://doi.org/10.1371/journal.ppat.1000159

Origin, Spread and Demography of the Mycobacterium tuberculosis Complex

Thierry Wirth, Falk Hildebrand, Caroline Allix-Béguec, Florian Wölbeling, Tanja Kubica, Kristin Kremer, Dick van Soolingen, Sabine Rüsch-Gerdes, Camille Locht, Sylvain Brisse, Axel Meyer, Philip Supply, Stefan Niemann

PLOS Pathogens: published September 26, 2008 | https://doi.org/10.1371/journal.ppat.1000160

Evolutionary Dynamics and Emergence of Panzootic H5N1 Influenza Viruses

Dhanasekaran Vijaykrishna, Justin Bahl, Steven Riley, Lian Duan, Jin Xia Zhang, Honglin Chen, J. S. Malik Peiris, Gavin J. D. Smith, Yi Guan

PLOS Pathogens: published September 26, 2008 | https://doi.org/10.1371/journal.ppat.1000161

Rapid Identification of Known and New RNA Viruses from Animal Tissues

Joseph G. Victoria, Amit Kapoor, Kent Dupuis, David P. Schnurr, Eric L. Delwart

PLOS Pathogens: published September 26, 2008 | https://doi.org/10.1371/journal.ppat.1000163

Capnocytophaga canimorsus: A Human Pathogen Feeding at the Surface of Epithelial Cells and Phagocytes

Manuela Mally, Hwain Shin, Cécile Paroz, Regine Landmann, Guy R. Cornelis

PLOS Pathogens: published September 26, 2008 | https://doi.org/10.1371/journal.ppat.1000164

Related Articles

  1. Correction: Capnocytophaga canimorsus: A Human Pathogen Feeding at the Surface of Epithelial Cells and Phagocytes

Substrate Binding Mode and Its Implication on Drug Design for Botulinum Neurotoxin A

Desigan Kumaran, Richa Rawat, S. Ashraf Ahmed, Subramanyam Swaminathan

PLOS Pathogens: published September 26, 2008 | https://doi.org/10.1371/journal.ppat.1000165

The Pseudomonas Quinolone Signal (PQS) Balances Life and Death in Pseudomonas aeruginosa Populations

Susanne Häussler, Tanja Becker

PLOS Pathogens: published September 26, 2008 | https://doi.org/10.1371/journal.ppat.1000166