July 2007

Uropathogenic Escherichia coli (blue) expressing type 1 pili invade bladder epithelial cells by engaging α3β1 integrin receptors (green) and F-actin (red). Similar interactions may facilitate the uptake of other type 1–piliated bacterial pathogens in diverse niches throughout the host (see Eto et al, e100).

Image Credit: Micrograph by Danelle Eto. Processed using a craquelure filter with Adobe Photoshop software.

Review

Exploiting Amoeboid and Non-Vertebrate Animal Model Systems to Study the Virulence of Human Pathogenic Fungi

Eleftherios Mylonakis, Arturo Casadevall, Frederick M Ausubel

PLOS Pathogens: published July 27, 2007 | https://doi.org/10.1371/journal.ppat.0030101

Research Articles

HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4A^VPRBP E3 Ubiquitin Ligase

Jean-Philippe Belzile, Ghislaine Duisit, Nicole Rougeau, Johanne Mercier, Andrés Finzi, Éric A Cohen

PLOS Pathogens: published July 13, 2007 | https://doi.org/10.1371/journal.ppat.0030085

Oral Transmissibility of Prion Disease Is Enhanced by Binding to Soil Particles

Christopher J Johnson, Joel A Pedersen, Rick J Chappell, Debbie McKenzie, Judd M Aiken

PLOS Pathogens: published July 6, 2007 | https://doi.org/10.1371/journal.ppat.0030093

Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

Zabrina L Brumme, Chanson J Brumme, David Heckerman, Bette T Korber, Marcus Daniels, Jonathan Carlson, Carl Kadie, Tanmoy Bhattacharya, Celia Chui, James Szinger, Theresa Mo, Robert S Hogg, Julio S. G Montaner, Nicole Frahm, Christian Brander, Bruce D Walker, P. Richard Harrigan

PLOS Pathogens: published July 6, 2007 | https://doi.org/10.1371/journal.ppat.0030094

A Challenge to the Ancient Origin of SIVagm Based on African Green Monkey Mitochondrial Genomes

Joel O Wertheim, Michael Worobey

PLOS Pathogens: published July 6, 2007 | https://doi.org/10.1371/journal.ppat.0030095

Plasmodium Strain Determines Dendritic Cell Function Essential for Survival from Malaria

Michelle N Wykes, Xue Q Liu, Lynette Beattie, Danielle I Stanisic, Katryn J Stacey, Mark J Smyth, Ranjeny Thomas, Michael F Good

PLOS Pathogens: published July 6, 2007 | https://doi.org/10.1371/journal.ppat.0030096

The OmpA-Like Protein Loa22 Is Essential for Leptospiral Virulence

Paula Ristow, Pascale Bourhy, Flávia Weykamp da Cruz McBride, Claudio Pereira Figueira, Michel Huerre, Patrick Ave, Isabelle Saint Girons, Albert I Ko, Mathieu Picardeau

PLOS Pathogens: published July 13, 2007 | https://doi.org/10.1371/journal.ppat.0030097

A Very Late Viral Protein Triggers the Lytic Release of SV40

Robert Daniels, Dorota Sadowicz, Daniel N Hebert

PLOS Pathogens: published July 20, 2007 | https://doi.org/10.1371/journal.ppat.0030098

Microfluidic Modeling of Cell−Cell Interactions in Malaria Pathogenesis

Meher Antia, Thurston Herricks, Pradipsinh K Rathod

PLOS Pathogens: published July 20, 2007 | https://doi.org/10.1371/journal.ppat.0030099

Integrin-Mediated Host Cell Invasion by Type 1–Piliated Uropathogenic Escherichia coli

Danelle S Eto, Tiffani A Jones, Jamie L Sundsbak, Matthew A Mulvey

PLOS Pathogens: published July 13, 2007 | https://doi.org/10.1371/journal.ppat.0030100

Molecular Basis of Resistance to Muramidase and Cationic Antimicrobial Peptide Activity of Lysozyme in Staphylococci

Silvia Herbert, Agnieszka Bera, Christiane Nerz, Dirk Kraus, Andreas Peschel, Christiane Goerke, Michael Meehl, Ambrose Cheung, Friedrich Götz

PLOS Pathogens: published July 27, 2007 | https://doi.org/10.1371/journal.ppat.0030102

Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions

Eike Steinmann, Francois Penin, Stephanie Kallis, Arvind H Patel, Ralf Bartenschlager, Thomas Pietschmann

PLOS Pathogens: published July 20, 2007 | https://doi.org/10.1371/journal.ppat.0030103

Regulated Degradation of the HIV-1 Vpu Protein through a βTrCP-Independent Pathway Limits the Release of Viral Particles

Emilie Estrabaud, Erwann Le Rouzic, Sandra Lopez-Vergès, Marina Morel, Nadia Belaïdouni, Richard Benarous, Catherine Transy, Clarisse Berlioz-Torrent, Florence Margottin-Goguet

PLOS Pathogens: published July 27, 2007 | https://doi.org/10.1371/journal.ppat.0030104

Cell-Specific IRF-3 Responses Protect against West Nile Virus Infection by Interferon-Dependent and -Independent Mechanisms

Stephane Daffis, Melanie A Samuel, Brian C Keller, Michael Gale Jr., Michael S Diamond

PLOS Pathogens: published July 27, 2007 | https://doi.org/10.1371/journal.ppat.0030106

Mycobacterium tuberculosis nuoG Is a Virulence Gene That Inhibits Apoptosis of Infected Host Cells

Kamalakannan Velmurugan, Bing Chen, Jessica L Miller, Sharon Azogue, Serdar Gurses, Tsungda Hsu, Michael Glickman, William R Jacobs Jr., Steven A Porcelli, Volker Briken

PLOS Pathogens: published July 20, 2007 | https://doi.org/10.1371/journal.ppat.0030110

Cover

Uropathogenic E. coli