November 2006

Transcriptional reprogramming characterizes systemic acquired resistance in wild-type Arabidopsis plants. Upregulated genes are shown in red and downregulated genes in green. This reprogramming is dramatically blocked in the npr1 mutant, leading to enhanced disease susceptibility against multiple pathogens, including Pseudomonas syringae. WRKY transcription factors involved in this regulation are characterized. (See Wang et al)

Image Credit: Generated using GeneSpring software.

Opinions

Anthrax, but Not Bacillus anthracis?

Richard Okinaka, Talima Pearson, Paul Keim

PLOS Pathogens: published November 24, 2006 | https://doi.org/10.1371/journal.ppat.0020122

Dissecting the WRKY Web of Plant Defense Regulators

Thomas Eulgem

PLOS Pathogens: published November 24, 2006 | https://doi.org/10.1371/journal.ppat.0020126

Research Articles

A Translocated Bacterial Protein Protects Vascular Endothelial Cells from Apoptosis

Michael C Schmid, Florine Scheidegger, Michaela Dehio, Nadège Balmelle-Devaux, Ralf Schulein, Patrick Guye, Cuddapah S Chennakesava, Barbara Biedermann, Christoph Dehio

PLOS Pathogens: published November 24, 2006 | https://doi.org/10.1371/journal.ppat.0020115

Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates Erythrocyte Invasion

Kailash C Pandey, Naresh Singh, Shirin Arastu-Kapur, Matthew Bogyo, Philip J Rosenthal

PLOS Pathogens: published November 3, 2006 | https://doi.org/10.1371/journal.ppat.0020117

Potent Nonnucleoside Reverse Transcriptase Inhibitors Target HIV-1 Gag-Pol

Anna Figueiredo, Katie L Moore, Johnson Mak, Nicolas Sluis-Cremer, Marie-Pierre de Bethune, Gilda Tachedjian

PLOS Pathogens: published November 10, 2006 | https://doi.org/10.1371/journal.ppat.0020119

Direct Inhibition of T-Cell Responses by the Cryptococcus Capsular Polysaccharide Glucuronoxylomannan

Lauren E Yauch, Jennifer S Lam, Stuart M Levitz

PLOS Pathogens: published November 10, 2006 | https://doi.org/10.1371/journal.ppat.0020120

A Genomic Approach to Identify Regulatory Nodes in the Transcriptional Network of Systemic Acquired Resistance in Plants

Dong Wang, Nita Amornsiripanitch, Xinnian Dong

PLOS Pathogens: published November 10, 2006 | https://doi.org/10.1371/journal.ppat.0020123

Epitope Mapping and Topographic Analysis of VAR2CSA DBL3X Involved in P. falciparum Placental Sequestration

Madeleine Dahlbäck, Thomas S Rask, Pernille H Andersen, Morten A Nielsen, Nicaise T Ndam, Mafalda Resende, Louise Turner, Philippe Deloron, Lars Hviid, Ole Lund, Anders Gorm Pedersen, Thor G Theander, Ali Salanti

PLOS Pathogens: published November 17, 2006 | https://doi.org/10.1371/journal.ppat.0020124

Cover

Systemic acquired resistence in wild type Arabidopsis