May 2006

Chlamydia trachomatis promotes survival of the infected host cell, allowing the bacteria to complete their infection cycle. Shown here are Chlamydia vacuoles (green) that have recruited the death-inducing protein BAD. When released from the vacuoles, BAD helps to initiate host-cell death (see Verbeke et al).

Image Credit: Photograph provided by David Ojcius.

Opinion

Host–Pathogen Interactions: A Biological Rendez-Vous of the Infectious Nonself and Danger Models?

Jean-Nicolas Tournier, Anne Quesnel-Hellmann

PLOS Pathogens: published May 26, 2006 | https://doi.org/10.1371/journal.ppat.0020044

Review

Crossing the Line: Selection and Evolution of Virulence Traits

Nat F Brown, Mark E Wickham, Brian K Coombes, B. Brett Finlay

PLOS Pathogens: published May 26, 2006 | https://doi.org/10.1371/journal.ppat.0020042

Research Articles

Effective Control of Chronic γ-Herpesvirus Infection by Unconventional MHC Class Ia–Independent CD8 T Cells

Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Scott A Tibbetts, Kelly B McClellan, Janko Nikolich-Zugich, Herbert W Virgin IV

PLOS Pathogens: published May 19, 2006 | https://doi.org/10.1371/journal.ppat.0020037

HIV-1 Vpu Promotes Release and Prevents Endocytosis of Nascent Retrovirus Particles from the Plasma Membrane

Stuart J. D Neil, Scott W Eastman, Nolwenn Jouvenet, Paul D Bieniasz

PLOS Pathogens: published May 12, 2006 | https://doi.org/10.1371/journal.ppat.0020039

Effect of DNA Repair Protein Rad18 on Viral Infection

Aliza G Lloyd, Satoshi Tateishi, Paul D Bieniasz, Mark A Muesing, Masaru Yamaizumi, Lubbertus C. F Mulder

PLOS Pathogens: published May 19, 2006 | https://doi.org/10.1371/journal.ppat.0020040

Human Retroviral Host Restriction Factors APOBEC3G and APOBEC3F Localize to mRNA Processing Bodies

Michael J Wichroski, G. Brett Robb, Tariq M Rana

PLOS Pathogens: published May 12, 2006 | https://doi.org/10.1371/journal.ppat.0020041

The Tripartite Associations between Bacteriophage, Wolbachia, and Arthropods

Seth R Bordenstein, Michelle L Marshall, Adam J Fry, Ulandt Kim, Jennifer J Wernegreen

PLOS Pathogens: published May 19, 2006 | https://doi.org/10.1371/journal.ppat.0020043

Recruitment of BAD by the Chlamydia trachomatis Vacuole Correlates with Host-Cell Survival

Philippe Verbeke, Lynn Welter-Stahl, Songmin Ying, Jon Hansen, Georg Häcker, Toni Darville, David M Ojcius

PLOS Pathogens: published May 19, 2006 | https://doi.org/10.1371/journal.ppat.0020045

Legionella pneumophila Exploits PI(4)P to Anchor Secreted Effector Proteins to the Replicative Vacuole

Stefan S Weber, Curdin Ragaz, Katrin Reus, Yves Nyfeler, Hubert Hilbi

PLOS Pathogens: published May 19, 2006 | https://doi.org/10.1371/journal.ppat.0020046

Extreme Sequence Divergence but Conserved Ligand-Binding Specificity in Streptococcus pyogenes M Protein

Jenny Persson, Bernard Beall, Sara Linse, Gunnar Lindahl

PLOS Pathogens: published May 26, 2006 | https://doi.org/10.1371/journal.ppat.0020047

Transcriptional Silencing of Multiple Genes in Trophozoites of Entamoeba histolytica

Rivka Bracha, Yael Nuchamowitz, Michael Anbar, David Mirelman

PLOS Pathogens: published May 26, 2006 | https://doi.org/10.1371/journal.ppat.0020048

The Malarial Host-Targeting Signal Is Conserved in the Irish Potato Famine Pathogen

Souvik Bhattacharjee, N. Luisa Hiller, Konstantinos Liolios, Joe Win, Thirumala-Devi Kanneganti, Carolyn Young, Sophien Kamoun, Kasturi Haldar

PLOS Pathogens: published May 26, 2006 | https://doi.org/10.1371/journal.ppat.0020050

Cover

Chlamydia recruits BAD protein