February 2006

Toxoplasma gondii, an obligate intracellular human parasite, has a unique cytoskeletal apparatus that is probably used for invading host cells and for parasite replication. Shown here are images of T. gondii constructing daughter scaffolds within the mother cell. Cyan: YFP-α-Tubulin; yellow: mRFP-TgMORN1 (see Hu et al).

Image Credit: Image provided by Ke Hu and John Murray.

Opinion

The Scientific Response to a Pandemic

Gigi Kwik Gronvall, Richard E Waldhorn, D. A Henderson

PLOS Pathogens: published February 24, 2006 | https://doi.org/10.1371/journal.ppat.0020009

Review

Modulation of Tumor Necrosis Factor by Microbial Pathogens

Masmudur M Rahman, Grant McFadden

PLOS Pathogens: published February 24, 2006 | https://doi.org/10.1371/journal.ppat.0020004

Research Articles

Two Key Residues in EphrinB3 Are Critical for Its Use as an Alternative Receptor for Nipah Virus

Oscar A Negrete, Mike C Wolf, Hector C Aguilar, Sven Enterlein, Wei Wang, Elke Mühlberger, Stephen V Su, Andrea Bertolotti-Ciarlet, Ramon Flick, Benhur Lee

PLOS Pathogens: published February 10, 2006 | https://doi.org/10.1371/journal.ppat.0020007

Why Do HIV-1 and HIV-2 Use Different Pathways to Develop AZT Resistance?

Paul L Boyer, Stefan G Sarafianos, Patrick K Clark, Eddy Arnold, Stephen H Hughes

PLOS Pathogens: published February 17, 2006 | https://doi.org/10.1371/journal.ppat.0020010

Genome-Wide Screen for Salmonella Genes Required for Long-Term Systemic Infection of the Mouse

Trevor D Lawley, Kaman Chan, Lucinda J Thompson, Charles C Kim, Gregory R Govoni, Denise M Monack

PLOS Pathogens: published February 24, 2006 | https://doi.org/10.1371/journal.ppat.0020011

Efficient Transmission and Characterization of Creutzfeldt–Jakob Disease Strains in Bank Voles

Romolo Nonno, Michele A. Di Bari, Franco Cardone, Gabriele Vaccari, Paola Fazzi, Giacomo Dell'Omo, Claudia Cartoni, Loredana Ingrosso, Aileen Boyle, Roberta Galeno, Marco Sbriccoli, Hans-Peter Lipp, Moira Bruce, Maurizio Pocchiari, Umberto Agrimi

PLOS Pathogens: published February 24, 2006 | https://doi.org/10.1371/journal.ppat.0020012

Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii

Ke Hu, Jeff Johnson, Laurence Florens, Martin Fraunholz, Sapna Suravajjala, Camille DiLullo, John Yates, David S Roos, John M Murray

PLOS Pathogens: published February 24, 2006 | https://doi.org/10.1371/journal.ppat.0020013

Downregulation of the Drosophila Immune Response by Peptidoglycan-Recognition Proteins SC1 and SC2

Vincent Bischoff, Cécile Vignal, Bernard Duvic, Ivo G Boneca, Jules A Hoffmann, Julien Royet

PLOS Pathogens: published February 24, 2006 | https://doi.org/10.1371/journal.ppat.0020014

Correction

Correction: Functional and Genetic Analysis of Coronavirus Replicase-Transcriptase Proteins

Stanley G Sawicki, Dorothea L Sawicki, Diane Younker, Yvonne Meyer, Volker Thiel, Helen Stokes, Stuart G Siddell

PLOS Pathogens: published February 24, 2006 | https://doi.org/10.1371/journal.ppat.0020017

Cover

T. gondii daughter scaffolds