September 2005

In this issue, research by Gutierrez et al and by Jian et al gives important new insights into the origin and virulence of Mycobacterium tuberculosis, a major human pathogen. Shown here is the bacterium in a sputum sample which has been stained.

Image Credit: Image courtesy of United States Centers for Disease Control and Prevention; cover image design by Sapna Khandwala.

Editorial

PLoS Pathogens—A High-Impact Journal for Pathogen Research

John A. T Young

PLOS Pathogens: published September 30, 2005 | https://doi.org/10.1371/journal.ppat.0010012

Opinion

Why Provide an Opinions Section in PLoS Pathogens?

Marianne Manchester

PLOS Pathogens: published September 30, 2005 | https://doi.org/10.1371/journal.ppat.0010013

Research Articles

The Role of Innate Immune Responses in the Outcome of Interspecies Competition for Colonization of Mucosal Surfaces

Elena S Lysenko, Adam J Ratner, Aaron L Nelson, Jeffrey N Weiser

PLOS Pathogens: published July 22, 2005 | https://doi.org/10.1371/journal.ppat.0010001

Interaction between Polyketide Synthase and Transporter Suggests Coupled Synthesis and Export of Virulence Lipid in M. tuberculosis

Madhulika Jain, Jeffery S Cox

PLOS Pathogens: published September 30, 2005 | https://doi.org/10.1371/journal.ppat.0010002

SIVsm Quasispecies Adaptation to a New Simian Host

Linda J Demma, John M Logsdon Jr., Thomas H Vanderford, Mark B Feinberg, Silvija I Staprans

PLOS Pathogens: published September 30, 2005 | https://doi.org/10.1371/journal.ppat.0010003

Influenza Virus PB1-F2 Protein Induces Cell Death through Mitochondrial ANT3 and VDAC1

Dmitriy Zamarin, Adolfo García-Sastre, Xiaoyao Xiao, Rong Wang, Peter Palese

PLOS Pathogens: published September 30, 2005 | https://doi.org/10.1371/journal.ppat.0010004

Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis

M. Cristina Gutierrez, Sylvain Brisse, Roland Brosch, Michel Fabre, Bahia Omaïs, Magali Marmiesse, Philip Supply, Veronique Vincent

PLOS Pathogens: published August 19, 2005 | https://doi.org/10.1371/journal.ppat.0010005

Natural Variation in Vif: Differential Impact on APOBEC3G/3F and a Potential Role in HIV-1 Diversification

Viviana Simon, Veronique Zennou, Deya Murray, Yaoxing Huang, David D Ho, Paul D Bieniasz

PLOS Pathogens: published July 22, 2005 | https://doi.org/10.1371/journal.ppat.0010006

Inhibition of MHC Class I Is a Virulence Factor in Herpes Simplex Virus Infection of Mice

Mark T Orr, Kurt H Edelmann, Jeffrey Vieira, Lawrence Corey, David H Raulet, Christopher B Wilson

PLOS Pathogens: published September 30, 2005 | https://doi.org/10.1371/journal.ppat.0010007

Vibrio cholerae Infection of Drosophila melanogaster Mimics the Human Disease Cholera

Nathan S Blow, Robert N Salomon, Kerry Garrity, Isabelle Reveillaud, Alan Kopin, F. Rob Jackson, Paula I Watnick

PLOS Pathogens: published September 30, 2005 | https://doi.org/10.1371/journal.ppat.0010008

Exit of Plasmodium Sporozoites from Oocysts Is an Active Process That Involves the Circumsporozoite Protein

Qian Wang, Hisashi Fujioka, Victor Nussenzweig

PLOS Pathogens: published September 30, 2005 | https://doi.org/10.1371/journal.ppat.0010009

A Surface Groove Essential for Viral Bcl-2 Function During Chronic Infection In Vivo

Joy Loh, Qiulong Huang, Andrew M Petros, David Nettesheim, Linda F. van Dyk, Lucia Labrada, Samuel H Speck, Beth Levine, Edward T Olejniczak, Herbert W Virgin IV

PLOS Pathogens: published September 30, 2005 | https://doi.org/10.1371/journal.ppat.0010010

Cover

Bacterium in a sputum sample