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Editorial Note

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Editorial Note: Recruitment of a SAP18-HDAC1 Complex into HIV-1 Virions and Its Requirement for Viral Replication

  • The PLOS Pathogens Editors

The PLOS Pathogens Editors issue this Editorial Note to update readers that all blot panels in the upper six right-hand panels of Fig 1A and in Fig 3A of [1] and in Fig 2B of [2] are derived from the same sequentially-probed single experimental replicate blot, with the data re-used in [1] to represent some of the same results and reporting the same experimental conditions as previously reported in [2].

Specifically,

  • In Fig 1A, the top right-hand INI1, BRG1, and BAF 155 panels are from the same blot as lanes 1–2 and 7–8 in the INI1, BRG1, and BAF 155 panels, respectively, of Fig 3A.
  • In Fig 1A, the top right-hand INI1 and gp41 panels are from the same blot as lanes 1–2 and 7–8 in the INI1/hSNF5 and gp41 panels in Fig 2B of an earlier publication by some of the same authors [2].
  • The INI1 panel in Fig 3A is from the same blot as the INI1/hSNF5 panel in Fig 2B of an earlier publication by some of the same authors [2]

The text in the first paragraph of the Results section of [1] indicates that the INI1 results in Fig 1A of [1] are consistent with the previous reported findings in [2]. Upon follow-up, the corresponding author stated that images in the upper six right-hand panels of Fig 1A and in Fig 3A were generated from re-probing the same blot as reported in Fig 2B of [2] to conserve samples. They stated that a fresh set of antibodies was used to sequentially re-probe the blot for INI1, p24 and gp41, as well as probing for additional protein targets using anti-BRG1, anti-BAF155, anti-BAF170, anti-SAP18, anti-SAP30, and anti-HDAC1. The left-hand panels and lower INI1 and hBRM panels of Fig 1A represent new blots.

The top right HIV-1MN – INI1 and gp41 panels of Fig 1A and the INI1 panel of Fig 3A in [1] were previously published by an overlapping author group [2]; Copyright © 2004 American Society for Microbiology. The American Society for Microbiology granted permissions for this content to be republished in PLOS Pathogens under a CC BY license. Please provide due attribution to the original publication when referring to this content.

References

  1. 1. Sorin M, Cano J, Das S, Mathew S, Wu X, Davies KP, et al. Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication. PLoS Pathog. 2009;5(6):e1000463. pmid:19503603
  2. 2. Yung E, Sorin M, Wang E-J, Perumal S, Ott D, Kalpana GV. Specificity of interaction of INI1/hSNF5 with retroviral integrases and its functional significance. J Virol. 2004;78(5):2222–31. pmid:14963118

Citation: The PLOS Pathogens Editors (2026) Editorial Note: Recruitment of a SAP18-HDAC1 Complex into HIV-1 Virions and Its Requirement for Viral Replication. PLoS Pathog 22(5): e1014251. https://doi.org/10.1371/journal.ppat.1014251

Published: May 26, 2026

Copyright: © 2026 The PLOS Pathogens Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.