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PLoS Pathogens Issue Image | Vol. 21(12) January 2026

Colony of Mycoplasma mycoides – Periodic Acid- Schiff stained

Image of a polysaccharide stain of an individual colony of the ruminant pathogen Mycoplasma mycoides grown on low nutrient media and taken with a Nikon SMZ18 stereo microscope. The image reveals the presence (stained dark sectors) or absence of polysaccharide coating within the colony. The ON/OFF expression of polysaccharide contributes to phenotypic diversity and is associated with distinct host immune responses. Yimthin et al. 2025

Image Credit: Thatcha Yimthin

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Colony of Mycoplasma mycoides – Periodic Acid- Schiff stained

Image of a polysaccharide stain of an individual colony of the ruminant pathogen Mycoplasma mycoides grown on low nutrient media and taken with a Nikon SMZ18 stereo microscope. The image reveals the presence (stained dark sectors) or absence of polysaccharide coating within the colony. The ON/OFF expression of polysaccharide contributes to phenotypic diversity and is associated with distinct host immune responses. Yimthin et al. 2025

Image Credit: Thatcha Yimthin

https://doi.org/10.1371/image.ppat.v21.i12.g001