Figures
DGAT2 modulates the hepatitis C virus replication organelle.
Recent research has uncovered the important role of lipid droplets in pathogen replication. In the case of hepatitis C virus (HCV), lipid droplets (depicted here in yellow) are entangled in the viral replication organelle and support virus morphogenesis. In this context, it was unexpected that excessive expression of DGAT2 (magenta), which boosts lipid droplet accumulation, strongly impaired HCV replication. This study indicates that lipid fluxes between endoplasmic reticulum (ER) and lipid droplets affect the formation of HCV replication organelle. Reichert et al., 2024.
Image Credit: Isabelle Reichert
Citation: (2024) PLoS Pathogens Issue Image | Vol. 20(9) October 2024. PLoS Pathog 20(9): ev20.i09. https://doi.org/10.1371/image.ppat.v20.i09
Published: October 3, 2024
Copyright: © 2024 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recent research has uncovered the important role of lipid droplets in pathogen replication. In the case of hepatitis C virus (HCV), lipid droplets (depicted here in yellow) are entangled in the viral replication organelle and support virus morphogenesis. In this context, it was unexpected that excessive expression of DGAT2 (magenta), which boosts lipid droplet accumulation, strongly impaired HCV replication. This study indicates that lipid fluxes between endoplasmic reticulum (ER) and lipid droplets affect the formation of HCV replication organelle. Reichert et al., 2024.
Image Credit: Isabelle Reichert