Figures
A scheme for inhibition of AasS by C10-AMS
The AasS acyl-ACP synthetase is an exogenous fatty acid scavenger of versatility, and potentially dampens the druggable pathway of bacterial type II fatty acid synthesis. The C10-AMS compound is a newly-identified inhibitor for AasS action. This study showed complex structure of AasS hexamer liganded with C10-AMS inhibitor, of which each protomer is locked in a closed form. Huang et al
Image Credit: Youjun Feng
Citation: (2024) PLoS Pathogens Issue Image | Vol. 20(7) August 2024. PLoS Pathog 20(7): ev20.i07. https://doi.org/10.1371/image.ppat.v20.i07
Published: August 1, 2024
Copyright: © 2024 Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The AasS acyl-ACP synthetase is an exogenous fatty acid scavenger of versatility, and potentially dampens the druggable pathway of bacterial type II fatty acid synthesis. The C10-AMS compound is a newly-identified inhibitor for AasS action. This study showed complex structure of AasS hexamer liganded with C10-AMS inhibitor, of which each protomer is locked in a closed form. Huang et al
Image Credit: Youjun Feng