Figures
The occurrence of the N123I mutation of gp85 coincided with the timeline of the ALV-J epidemic outbreak
Avian leukosis virus subgroup J (ALV-J), a retrovirus, undergoes significant genetic evolution. Our study finds for the first time that the N123I mutation within the RBD region of gp85 enhances the replication ability of ALV-J, making it more easily transmissible and potentially causing large-scale epidemics. The picture shows the phylogenetic tree illustrating the evolutionary relationships between the gp85 gene in various ALV-J strains. Broiler, layer, and local chicken strains are primarily in groups 1, 2, and 3, respectively. The N123I mutation (in red) is an adaptive mutation. Yu et al 2024
Image Credit: Yulong Gao
Citation: (2024) PLoS Pathogens Issue Image | Vol. 20(2) March 2024. PLoS Pathog 20(2): ev20.i02. https://doi.org/10.1371/image.ppat.v20.i02
Published: March 1, 2024
Copyright: © 2024 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Avian leukosis virus subgroup J (ALV-J), a retrovirus, undergoes significant genetic evolution. Our study finds for the first time that the N123I mutation within the RBD region of gp85 enhances the replication ability of ALV-J, making it more easily transmissible and potentially causing large-scale epidemics. The picture shows the phylogenetic tree illustrating the evolutionary relationships between the gp85 gene in various ALV-J strains. Broiler, layer, and local chicken strains are primarily in groups 1, 2, and 3, respectively. The N123I mutation (in red) is an adaptive mutation. Yu et al 2024
Image Credit: Yulong Gao