Figures
Intermittent bulk release of Human Cytomegalovirus
Human Cytomegalovirus uses multivesicular structures to release large amounts of virus products in pulses from infected cells. This route differs from classical mechanisms proposed for herpesvirus secondary envelopment and egress. The characteristics of this process seem to vary between virus strains, suggesting a role in divergent phenotypes in viral spreading. The image shows correlative light- and electron microscopy (CLEM) data of an HCMV infected cell. The virus is a dual-fluorescent variant of the HCMV strain Merlin expressing fluorescent gM-Cherry (membrane glycoprotein/ magenta) and pp150-EGFP (tegument protein/ green). The inserts depict HCMV particles in different stages of the maturation process. Flomm et al
Image Credit: Felix J Flomm and Jens B. Bosse, Hannover Medical School at CSSB Hamburg, Germany.
Citation: (2022) PLoS Pathogens Issue Image | Vol. 18(8) September 2022. PLoS Pathog 18(8): ev18.i08. https://doi.org/10.1371/image.ppat.v18.i08
Published: September 1, 2022
Copyright: © 2022 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Human Cytomegalovirus uses multivesicular structures to release large amounts of virus products in pulses from infected cells. This route differs from classical mechanisms proposed for herpesvirus secondary envelopment and egress. The characteristics of this process seem to vary between virus strains, suggesting a role in divergent phenotypes in viral spreading. The image shows correlative light- and electron microscopy (CLEM) data of an HCMV infected cell. The virus is a dual-fluorescent variant of the HCMV strain Merlin expressing fluorescent gM-Cherry (membrane glycoprotein/ magenta) and pp150-EGFP (tegument protein/ green). The inserts depict HCMV particles in different stages of the maturation process. Flomm et al
Image Credit: Felix J Flomm and Jens B. Bosse, Hannover Medical School at CSSB Hamburg, Germany.