Figures
Poxviruses lateral bodies enable early strike on host immune defenses.
Poxviruses, including smallpox and monkeypox, carry two proteinaceous structures called lateral bodies. During assembly, viral immunomodulatory proteins are packaged into these structures and subsequently released into newly infected cells during virus entry. Using this strategy, poxviruses begin to combat host cell defenses prior to initiating viral gene expression. Shown is a correlative STORM-TEM image of the poxvirus effector protein A19 (orange) residing within the lateral bodies of a mature vaccinia virus virion (grey). Bidgood et al 2022
Image Credit: Susanna Bidgood, Jemima Burden and David Albrecht.
Citation: (2022) PLoS Pathogens Issue Image | Vol. 18(7) August 2022. PLoS Pathog 18(7): ev18.i07. https://doi.org/10.1371/image.ppat.v18.i07
Published: August 1, 2022
Copyright: © 2022 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Poxviruses, including smallpox and monkeypox, carry two proteinaceous structures called lateral bodies. During assembly, viral immunomodulatory proteins are packaged into these structures and subsequently released into newly infected cells during virus entry. Using this strategy, poxviruses begin to combat host cell defenses prior to initiating viral gene expression. Shown is a correlative STORM-TEM image of the poxvirus effector protein A19 (orange) residing within the lateral bodies of a mature vaccinia virus virion (grey). Bidgood et al 2022
Image Credit: Susanna Bidgood, Jemima Burden and David Albrecht.