Figures
Three-dimensional structure of Nipah virus nucleocapsid assembly
Nipah virus is a highly pathogenic RNA virus, which, along with the closely related Hendra virus, has the potential to escalate into a pandemic. The figure shows the cryo-electron microscopy structure of a 13-subunit segment of the Nipah nucleocapsid protein assembly with RNA, with the RNA (purple neon) bound in a groove between an inner oligomerisation (pink) and outer exposed (green) domains. This helical ribonucleoprotein assembly serves to safeguard the viral genome by protecting it from degradation and host immune detection, and facilitating the packaging of the viral genome into new virion. Ker et al.
Image Credit: Nair S R, 2021
Citation: (2021) PLoS Pathogens Issue Image | Vol. 17(7) July 2021. PLoS Pathog 17(7): ev17.i07. https://doi.org/10.1371/image.ppat.v17.i07
Published: July 28, 2021
Copyright: © 2021 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Nipah virus is a highly pathogenic RNA virus, which, along with the closely related Hendra virus, has the potential to escalate into a pandemic. The figure shows the cryo-electron microscopy structure of a 13-subunit segment of the Nipah nucleocapsid protein assembly with RNA, with the RNA (purple neon) bound in a groove between an inner oligomerisation (pink) and outer exposed (green) domains. This helical ribonucleoprotein assembly serves to safeguard the viral genome by protecting it from degradation and host immune detection, and facilitating the packaging of the viral genome into new virion. Ker et al.
Image Credit: Nair S R, 2021