Figures
Trypanosoma cruzi induces genotoxic stress in HeLa cells
Trypanosoma cruzi, the etiologic agent of Chagas' disease, causes massive oxidative stress during infection leading to host cell DNA damage. This fluorescence microscopy image shows intracellular parasites, expressing GFP, multiplying in host cell cytosol. The red foci presented in infected HeLa cell nuclei (stained with DAPI, blue) reveals the phosphorylation of Histone H2Ax, an important signal of genotoxic stress and DNA lesions, caused by the parasite. Florentino et al.
Image Credit: Florentino PTV, Mortara, RA, 2021
Citation: (2021) PLoS Pathogens Issue Image | Vol. 17(4) May 2021. PLoS Pathog 17(4): ev17.i04. https://doi.org/10.1371/image.ppat.v17.i04
Published: May 3, 2021
Copyright: © 2021 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Trypanosoma cruzi, the etiologic agent of Chagas' disease, causes massive oxidative stress during infection leading to host cell DNA damage. This fluorescence microscopy image shows intracellular parasites, expressing GFP, multiplying in host cell cytosol. The red foci presented in infected HeLa cell nuclei (stained with DAPI, blue) reveals the phosphorylation of Histone H2Ax, an important signal of genotoxic stress and DNA lesions, caused by the parasite. Florentino et al.
Image Credit: Florentino PTV, Mortara, RA, 2021