Figures
Inhibition of calcineurin phosphatase activity enhances Varicella-Zoster-Virus induced cell-cell fusion
Varicella-Zoster Virus infection leads to fusion between infected cells and the formation of multinucleated cells. Inhibition of calcineurin phosphatase activity using pimecrolimus causes exaggerated cell fusion and reduced virus spread. Live cell confocal microscopy imaging of VZV infected human cells treated with pimecrolimus; VZV infected cells (red), F-actin (green), and nuclei (blue). Zhou et al.
Image Credit: Zhou M (2020)
Citation: (2020) PLoS Pathogens Issue Image | Vol. 16(11) November 2020. PLoS Pathog 16(11): ev16.i11. https://doi.org/10.1371/image.ppat.v16.i11
Published: November 30, 2020
Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Varicella-Zoster Virus infection leads to fusion between infected cells and the formation of multinucleated cells. Inhibition of calcineurin phosphatase activity using pimecrolimus causes exaggerated cell fusion and reduced virus spread. Live cell confocal microscopy imaging of VZV infected human cells treated with pimecrolimus; VZV infected cells (red), F-actin (green), and nuclei (blue). Zhou et al.
Image Credit: Zhou M (2020)