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A fluorescence-based biosensor detects increased alkyl-quinolone accumulation in surface-attached Pseudomonas aeruginosa populations
Fluorescence-microscopy image of bacterial biosensor cells doped into a population of surface-attached P. aeruginosa. Only biosensor cells are shown. Precise alkyl-quinolone quantification enabled the authors to show that attachment of P. aeruginosa to biotic and abiotic surfaces stimulates the production of cytotoxic alkyl-quinolones, which become more potent when packaged and delivered to host cells in secreted outer-membrane vesicles. Vrla et al.
Image Credit: Vrla G (2020)
Citation: (2020) PLoS Pathogens Issue Image | Vol. 16(9) September 2020. PLoS Pathog 16(9): ev16.i09. https://doi.org/10.1371/image.ppat.v16.i09
Published: September 30, 2020
Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fluorescence-microscopy image of bacterial biosensor cells doped into a population of surface-attached P. aeruginosa. Only biosensor cells are shown. Precise alkyl-quinolone quantification enabled the authors to show that attachment of P. aeruginosa to biotic and abiotic surfaces stimulates the production of cytotoxic alkyl-quinolones, which become more potent when packaged and delivered to host cells in secreted outer-membrane vesicles. Vrla et al.
Image Credit: Vrla G (2020)