Figures
Reversible structural changes in murine norovirus
The capsid structure of murine noroviruses changes in response to aqueous conditions. By twisting the flexible hinge connecting two domains, the protruding (P) domain reversibly rises off the shell (S) domain in solutions of higher pH, but rests on the S domain in solutions of lower pH. Metal ions help to stabilize the resting conformation in this process. This image shows the two structures of the norovirus reconstructed by cryo-electron microscopy and the morphology of the resting or rising P domains on the S domain. Song et al.
Image Credit: Song C, Murata K (2020)
Citation: (2020) PLoS Pathogens Issue Image | Vol. 16(7) July 2020. PLoS Pathog 16(7): ev16.i07. https://doi.org/10.1371/image.ppat.v16.i07
Published: July 31, 2020
Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The capsid structure of murine noroviruses changes in response to aqueous conditions. By twisting the flexible hinge connecting two domains, the protruding (P) domain reversibly rises off the shell (S) domain in solutions of higher pH, but rests on the S domain in solutions of lower pH. Metal ions help to stabilize the resting conformation in this process. This image shows the two structures of the norovirus reconstructed by cryo-electron microscopy and the morphology of the resting or rising P domains on the S domain. Song et al.
Image Credit: Song C, Murata K (2020)