Figures
ATP6V0d2 controls the biogenesis of large Leishmania amazonensis parasitophorous vacuoles
Macrophage (white) hosting Leishmania amazonensis (red, parasite nuclei and kinetoplasts in orange) that multiply in spacious, large parasitophorous vacuoles (PVs). The volumetric expansion of PVs is controlled by different host cell factors, among which the d2 variant of V-ATPase subunit d (ATP6V0d2). Picture obtained from confocal images of immunostained samples (for host macrophage lysosomes using anti-Lamp-1 antibody and parasite surface using 2A3-26 antibody) and reconstructed in three-dimensional image. Pessoa et al.
Citation: (2019) PLoS Pathogens Issue Image | Vol. 15(6) July 2019. PLoS Pathog 15(6): ev15.i06. https://doi.org/10.1371/image.ppat.v15.i06
Published: July 2, 2019
Copyright: © 2019 Fernando Real. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Macrophage (white) hosting Leishmania amazonensis (red, parasite nuclei and kinetoplasts in orange) that multiply in spacious, large parasitophorous vacuoles (PVs). The volumetric expansion of PVs is controlled by different host cell factors, among which the d2 variant of V-ATPase subunit d (ATP6V0d2). Picture obtained from confocal images of immunostained samples (for host macrophage lysosomes using anti-Lamp-1 antibody and parasite surface using 2A3-26 antibody) and reconstructed in three-dimensional image. Pessoa et al.