Figures
Herpes Simplex Virus requires the host nuclear transport factor importin alpha 1 for infection of neurons
Herpesviruses depend on host nuclear transport factors for efficient nuclear import of viral and host components. Alphaherpesviruses such as Herpes Simplex Viruses (HSV) cause many disease upon productive infection of epithelial and fibroblastic cells as well as neurons. Immunofluorescence microscopy images of neurons (red; white, middle panel) infected with an HSV-1 reporter strain expressing GFP (green; white, right panel). Neurons were cultured in microfluidic chambers which separate the axonal compartment on the top from the somal compartment on the bottom by microgrooves through which the axons had grown, and infected via the axonal compartment. Sodeik et al.
Image Credit: Anna Buch and Beate Sodeik, Institute of Virology, Hannover Medical School, Hannover, Germany.
Citation: (2018) PLoS Pathogens Issue Image | Vol. 14(1) January 2018. PLoS Pathog 14(1): ev14.i01. https://doi.org/10.1371/image.ppat.v14.i01
Published: January 31, 2018
Copyright: © 2018 Buch and Sodeik. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Herpesviruses depend on host nuclear transport factors for efficient nuclear import of viral and host components. Alphaherpesviruses such as Herpes Simplex Viruses (HSV) cause many disease upon productive infection of epithelial and fibroblastic cells as well as neurons. Immunofluorescence microscopy images of neurons (red; white, middle panel) infected with an HSV-1 reporter strain expressing GFP (green; white, right panel). Neurons were cultured in microfluidic chambers which separate the axonal compartment on the top from the somal compartment on the bottom by microgrooves through which the axons had grown, and infected via the axonal compartment. Sodeik et al.
Image Credit: Anna Buch and Beate Sodeik, Institute of Virology, Hannover Medical School, Hannover, Germany.