Figures
Complement recruitment in rabbit lungs following reinfection with MERS-CoV
Following secondary (re-)infection with MERS-CoV in the absence of neutralizing antibodies, complement protein is recruited to the lungs of rabbits and contributes to an increased inflammatory response. Immunofluorescence image of a MERS-CoV infected rabbit lung showing MERS-CoV N antigen (green) and complement C9 protein (red) following reinfection with MERS-CoV EMC/2012. Reinfection led to increased complement recruitment, with viral antigen and C9 protein visible within the inflammatory milieu surrounding many small vessels and alveoli within the lung tissue. Image is from day 3 post-infection at 40x, bar equivalent to 20μm. Subbarao et al.
Image Credit: Ian N Moore, Infectious Disease Pathogenesis Section, NIAID, NIH
Citation: (2017) PLoS Pathogens Issue Image | Vol. 13(8) August 2017. PLoS Pathog 13(8): ev13.i08. https://doi.org/10.1371/image.ppat.v13.i08
Published: August 31, 2017
Copyright: © 2017 Moore. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Following secondary (re-)infection with MERS-CoV in the absence of neutralizing antibodies, complement protein is recruited to the lungs of rabbits and contributes to an increased inflammatory response. Immunofluorescence image of a MERS-CoV infected rabbit lung showing MERS-CoV N antigen (green) and complement C9 protein (red) following reinfection with MERS-CoV EMC/2012. Reinfection led to increased complement recruitment, with viral antigen and C9 protein visible within the inflammatory milieu surrounding many small vessels and alveoli within the lung tissue. Image is from day 3 post-infection at 40x, bar equivalent to 20μm. Subbarao et al.
Image Credit: Ian N Moore, Infectious Disease Pathogenesis Section, NIAID, NIH