Figures
Experimental acute cystitis — an Interleukin-1β-driven, hyper-inflammatory disease
Mucosal inflammation is visualized in bladder sections from Asc-/- mice, infected with uropathogenic E. coli. Infection triggered a massive recruitment of neutrophils (red) to the mucosa. In susceptible mice, large numbers of bacteria were detected in the mucosa (green) and were shown to colocalize with neutrophil aggregates in micro-abscesses (yellow). Frozen tissue sections were stained for immunohistochemistry with specific antibodies to neutrophils and E. coli. Nuclei were counterstained with DAPI (cyan). Ambite et al.
Image Credit: Manoj Puthia, Biomedical Centre, Lund University, Sweden
Citation: (2016) PLoS Pathogens Issue Image | Vol. 12(10) October 2016. PLoS Pathog 12(10): ev12.i10. https://doi.org/10.1371/image.ppat.v12.i10
Published: October 28, 2016
Copyright: © 2016 Manoj Puthia, Biomedical Centre, Lund University, Sweden. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mucosal inflammation is visualized in bladder sections from Asc-/- mice, infected with uropathogenic E. coli. Infection triggered a massive recruitment of neutrophils (red) to the mucosa. In susceptible mice, large numbers of bacteria were detected in the mucosa (green) and were shown to colocalize with neutrophil aggregates in micro-abscesses (yellow). Frozen tissue sections were stained for immunohistochemistry with specific antibodies to neutrophils and E. coli. Nuclei were counterstained with DAPI (cyan). Ambite et al.
Image Credit: Manoj Puthia, Biomedical Centre, Lund University, Sweden