Figures
CD4+ T-cell infiltration into the epithelial layers of the vagina in a DMPA-treated macaque
Deconvolution fluorescence microscopy identifies changes in the mucosal immune environment of the vaginal epithelial barrier in rhesus macaques after hormonal treatment. CD4+ T-cells (red, OKT4), target cells for HIV-1, are found in abundance in the vaginal epidermis in Depo Provera (DMPA)-treated macaques. This highlights injectable hormonal contraceptives and high progesterone as a potential HIV-1 risk factor for increased acquisition. Carias et al.
Image Credit: Ann M. Carias and Thomas J. Hope, Feinberg School of Medicine, Northwestern University.
Citation: (2016) PLoS Pathogens Issue Image | Vol. 12(9) September 2016. PLoS Pathog 12(9): ev12.i09. https://doi.org/10.1371/image.ppat.v12.i09
Published: September 30, 2016
Copyright: © 2016 Carias and Hope. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Deconvolution fluorescence microscopy identifies changes in the mucosal immune environment of the vaginal epithelial barrier in rhesus macaques after hormonal treatment. CD4+ T-cells (red, OKT4), target cells for HIV-1, are found in abundance in the vaginal epidermis in Depo Provera (DMPA)-treated macaques. This highlights injectable hormonal contraceptives and high progesterone as a potential HIV-1 risk factor for increased acquisition. Carias et al.
Image Credit: Ann M. Carias and Thomas J. Hope, Feinberg School of Medicine, Northwestern University.