Figures
EM image of patient-derived exosomes
Gene ontology analysis of signature exosomal miRNA targets revealed several signaling pathways that are known to be important in Kaposi's sarcoma-associated herpesvirus (KSHV) pathogenesis. Functional analysis of endothelial cells exposed to patient-derived exosomes demonstrated enhanced cell migration and IL-6 secretion. This suggests that exosomes derived from KSHV-associated malignancies are functional and contain a distinct subset of miRNAs. See Chugh et al.
Image Credit: Pauline E. Chugh, Sezgin Ozgur and Dirk P. Dittmer, UNC Lineberger Comprehensive Cancer Center
Citation: (2013) PLOS Pathogens Issue Image | Vol. 9(7) July 2013. PLOS Pathog 9(7): ev09.i07. https://doi.org/10.1371/image.ppat.v09.i07
Published: July 25, 2013
Copyright: © 2013 Chugh et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Gene ontology analysis of signature exosomal miRNA targets revealed several signaling pathways that are known to be important in Kaposi's sarcoma-associated herpesvirus (KSHV) pathogenesis. Functional analysis of endothelial cells exposed to patient-derived exosomes demonstrated enhanced cell migration and IL-6 secretion. This suggests that exosomes derived from KSHV-associated malignancies are functional and contain a distinct subset of miRNAs. See Chugh et al.
Image Credit: Pauline E. Chugh, Sezgin Ozgur and Dirk P. Dittmer, UNC Lineberger Comprehensive Cancer Center