Figures
Chronic bacterial cystitis predisposes to recurrent urinary tract infection (UTI) with uropathogenic E. coli.
Epifluorescence micrograph of the murine urinary bladder epithelium during chronic bacterial cystitis with uropathogenic E. coli (UPEC). The image demonstrates the ongoing bladder epithelial inflammation (epithelial and immune cell nuclei are counterstained blue and epithelial cells autofluoresce green) after 4 weeks of UPEC infection. Bacteria appear yellow-orange due to indirect antibody co-staining with anti-E. coli (red) and anti-FimH for type 1 pili (green). Persistent extracellular colonization of the bladder with UPEC and accompanying chronic inflammatory responses induce changes to the bladder wall that persist long after clearance of infection with antibiotics and leave mice vulnerable to severe recurrent UTI (see Hannan et al., doi:10.1371/journal.ppat.1001042).
Image Credit: Thomas J. Hannan, Washington University
Citation: (2010) PLoS Pathogens Issue Image | Vol. 6(8) August 2010. PLoS Pathog 6(8): ev06.i08. https://doi.org/10.1371/image.ppat.v06.i08
Published: August 26, 2010
Copyright: © 2010 Thomas J. Hannan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Epifluorescence micrograph of the murine urinary bladder epithelium during chronic bacterial cystitis with uropathogenic E. coli (UPEC). The image demonstrates the ongoing bladder epithelial inflammation (epithelial and immune cell nuclei are counterstained blue and epithelial cells autofluoresce green) after 4 weeks of UPEC infection. Bacteria appear yellow-orange due to indirect antibody co-staining with anti-E. coli (red) and anti-FimH for type 1 pili (green). Persistent extracellular colonization of the bladder with UPEC and accompanying chronic inflammatory responses induce changes to the bladder wall that persist long after clearance of infection with antibiotics and leave mice vulnerable to severe recurrent UTI (see Hannan et al., doi:10.1371/journal.ppat.1001042).
Image Credit: Thomas J. Hannan, Washington University